Asif Ahmed

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1
    Melissa J Cudmore
    University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Eur Heart J 33:1150-8. 2012
  2. pmc Is inflammation the cause of pre-eclampsia?
    Wenda Ramma
    University BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Biochem Soc Trans 39:1619-27. 2011
  3. doi New insights into the etiology of preeclampsia: identification of key elusive factors for the vascular complications
    Asif Ahmed
    Gustav Born Centre for Vascular Biology, UoE BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh EH164TJ, United Kingdom
    Thromb Res 127:S72-5. 2011
  4. pmc Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis
    Shakil Ahmad
    University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Vasc Cell 3:15. 2011
  5. doi Multiple roles of angiopoietins in atherogenesis
    Asif Ahmed
    UoE BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Curr Opin Lipidol 22:380-5. 2011
  6. doi The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis
    Melissa J Cudmore
    University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Nat Commun 3:972. 2012
  7. doi Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta
    Melissa J Cudmore
    University British Heart Foundation Center for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    Am J Obstet Gynecol 206:253.e10-5. 2012
  8. ncbi Erratum to: The elevation in maternal anti-angiogenic factors is independent of markers of neutrophil activation and systemic inflammation in preeclampsia
    Wenda Ramma
    University BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Angiogenesis 15:341-8. 2012
  9. doi Angiopoietin-1 induces migration of monocytes in a tie-2 and integrin-independent manner
    Shakil Ahmad
    Gustav Born Centre for Vascular Biology, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Hypertension 56:477-83. 2010
  10. pmc The elevation in circulating anti-angiogenic factors is independent of markers of neutrophil activation in preeclampsia
    Wenda Ramma
    University BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Angiogenesis 15:333-40. 2012

Collaborators

Detail Information

Publications10

  1. pmc Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1
    Melissa J Cudmore
    University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Eur Heart J 33:1150-8. 2012
    ..To identify therapeutic targets, we sought to assess whether these two regulators act to suppress soluble endoglin (sEng), an antagonist of transforming growth factor-β (TGF-β) signalling, which is known to be elevated in preeclampsia...
  2. pmc Is inflammation the cause of pre-eclampsia?
    Wenda Ramma
    University BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Biochem Soc Trans 39:1619-27. 2011
    ..Inflammation may enhance the pathology induced by the imbalance in the angiogenic factors, but does not by itself cause pre-eclampsia. Development of therapies based on the angiogenic and cytoprotective mechanisms seems more promising...
  3. doi New insights into the etiology of preeclampsia: identification of key elusive factors for the vascular complications
    Asif Ahmed
    Gustav Born Centre for Vascular Biology, UoE BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh EH164TJ, United Kingdom
    Thromb Res 127:S72-5. 2011
    ..The StAmP trial is underway to address this and if positive, its outcome will lead to the very first therapeutic intervention to prolong affected pregnancies...
  4. pmc Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis
    Shakil Ahmad
    University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Vasc Cell 3:15. 2011
    ..abstract:..
  5. doi Multiple roles of angiopoietins in atherogenesis
    Asif Ahmed
    UoE BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Curr Opin Lipidol 22:380-5. 2011
    ..However, very little is known about the role of these vascular morphogenic molecules in the pathogenesis of atherosclerosis. Here, we summarize the recent research into angiopoietins in atherosclerosis...
  6. doi The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis
    Melissa J Cudmore
    University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Nat Commun 3:972. 2012
    ..These findings indicate that VEGFR-1 subunits modulate VEGF activity predominantly by forming heterodimer receptors with VEGFR-2 subunits and such heterodimers regulate endothelial cell homeostasis...
  7. doi Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta
    Melissa J Cudmore
    University British Heart Foundation Center for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    Am J Obstet Gynecol 206:253.e10-5. 2012
    ..Resveratrol, a plant phytoalexin, has antiinflammatory and cardioprotective properties. We sought to determine the effect of resveratrol on sFlt-1 release...
  8. ncbi Erratum to: The elevation in maternal anti-angiogenic factors is independent of markers of neutrophil activation and systemic inflammation in preeclampsia
    Wenda Ramma
    University BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Angiogenesis 15:341-8. 2012
    ....
  9. doi Angiopoietin-1 induces migration of monocytes in a tie-2 and integrin-independent manner
    Shakil Ahmad
    Gustav Born Centre for Vascular Biology, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Hypertension 56:477-83. 2010
    ..The ability of Ang-1 to recruit monocytes suggests it may play a role in inflammatory angiogenesis and may promote atherosclerosis...
  10. pmc The elevation in circulating anti-angiogenic factors is independent of markers of neutrophil activation in preeclampsia
    Wenda Ramma
    University BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Angiogenesis 15:333-40. 2012
    ....