Tariq Ahmad

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi The contribution of human leucocyte antigen complex genes to disease phenotype in ulcerative colitis
    T Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Woodstock Road, Oxford, UK
    Tissue Antigens 62:527-35. 2003
  2. ncbi The molecular classification of the clinical manifestations of Crohn's disease
    Tariq Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, United Kingdom
    Gastroenterology 122:854-66. 2002
  3. ncbi High resolution MIC genotyping: design and application to the investigation of inflammatory bowel disease susceptibility
    T Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, UK
    Tissue Antigens 60:164-79. 2002
  4. ncbi Haplotype-specific linkage disequilibrium patterns define the genetic topography of the human MHC
    Tariq Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK
    Hum Mol Genet 12:647-56. 2003
  5. ncbi Mapping the HLA association in Behçet's disease: a role for tumor necrosis factor polymorphisms?
    Tariq Ahmad
    Gastroenterology Unit, Gibson Laboratories, University of Oxford, Radcliffe Infirmary, Oxford, UK
    Arthritis Rheum 48:807-13. 2003
  6. doi Clinical and molecular characteristics of isolated colonic Crohn's disease
    Laura Hancock
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Inflamm Bowel Dis 14:1667-77. 2008
  7. ncbi Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype
    J R Fraser Cummings
    Wellcome Trust Centre for Human Genetics, University of Oxford, and Gastroenterology Unit, Gibson Laboratories, Radcliffe Infirmary, Oxford, UK
    Inflamm Bowel Dis 13:1063-8. 2007
  8. ncbi TUCAN (CARD8) genetic variants and inflammatory bowel disease
    Dermot P B McGovern
    Wellcome Trust Centre for Human Genetics, University of Oxford, Drive, Headington, Oxford OX3 7BN, England, UK
    Gastroenterology 131:1190-6. 2006
  9. ncbi Genetics of inflammatory bowel disease: the role of the HLA complex
    Tariq Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, UK
    World J Gastroenterol 12:3628-35. 2006
  10. ncbi Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1
    Jin Hong Low
    Gastroenterology Unit, Gibson Laboratories, Radcliffe Infirmary, University of Oxford, Oxford, UK
    Inflamm Bowel Dis 10:173-81. 2004

Detail Information

Publications41

  1. ncbi The contribution of human leucocyte antigen complex genes to disease phenotype in ulcerative colitis
    T Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Woodstock Road, Oxford, UK
    Tissue Antigens 62:527-35. 2003
    ..Genes in the HLA play a role in modifying disease phenotype. Further studies are required to dissect how these genes functionally interact with each other and with environmental factors to determine clinical patterns of disease..
  2. ncbi The molecular classification of the clinical manifestations of Crohn's disease
    Tariq Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, United Kingdom
    Gastroenterology 122:854-66. 2002
    ..No data regarding their contribution to specific disease subtypes exist. Here we report a detailed genotype-phenotype analysis of 244 accurately characterized patients...
  3. ncbi High resolution MIC genotyping: design and application to the investigation of inflammatory bowel disease susceptibility
    T Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, UK
    Tissue Antigens 60:164-79. 2002
    ..Linkage disequilibrium patterns between HLA-B, MICA and MICB are presented. Analysis by individual allele or by multilocus haplotype failed to identify any significant disease associations...
  4. ncbi Haplotype-specific linkage disequilibrium patterns define the genetic topography of the human MHC
    Tariq Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK
    Hum Mol Genet 12:647-56. 2003
    ....
  5. ncbi Mapping the HLA association in Behçet's disease: a role for tumor necrosis factor polymorphisms?
    Tariq Ahmad
    Gastroenterology Unit, Gibson Laboratories, University of Oxford, Radcliffe Infirmary, Oxford, UK
    Arthritis Rheum 48:807-13. 2003
    ..This genetic proximity to a gene that is already widely implicated in disease susceptibility led us to investigate the association between TNF promoter polymorphisms and susceptibility to BD...
  6. doi Clinical and molecular characteristics of isolated colonic Crohn's disease
    Laura Hancock
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Inflamm Bowel Dis 14:1667-77. 2008
    ....
  7. ncbi Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype
    J R Fraser Cummings
    Wellcome Trust Centre for Human Genetics, University of Oxford, and Gastroenterology Unit, Gibson Laboratories, Radcliffe Infirmary, Oxford, UK
    Inflamm Bowel Dis 13:1063-8. 2007
    ..We further investigated the relationship between IL23R and ulcerative colitis (UC)...
  8. ncbi TUCAN (CARD8) genetic variants and inflammatory bowel disease
    Dermot P B McGovern
    Wellcome Trust Centre for Human Genetics, University of Oxford, Drive, Headington, Oxford OX3 7BN, England, UK
    Gastroenterology 131:1190-6. 2006
    ..TUCAN (CARD8) is located beneath a CD peak of linkage on chromosome 19q. TUCAN is expressed in the gut and is a negative regulator of NFkappaB, making it an excellent candidate gene for gastrointestinal inflammation...
  9. ncbi Genetics of inflammatory bowel disease: the role of the HLA complex
    Tariq Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, UK
    World J Gastroenterol 12:3628-35. 2006
    ..This article reviews current knowledge of the role of HLA complex genes in IBD susceptibility and phenotype, and discusses the factors currently limiting the translation of this knowledge to clinical practice...
  10. ncbi Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1
    Jin Hong Low
    Gastroenterology Unit, Gibson Laboratories, Radcliffe Infirmary, University of Oxford, Oxford, UK
    Inflamm Bowel Dis 10:173-81. 2004
    ..7% vs 64.7%, Pc = 0.0040). These data support linkage for CD at 19p13 and suggest that the amino acid polymorphisms in ICAM-1 may be associated with IBD...
  11. ncbi The pharmacogenetics of methotrexate in inflammatory bowel disease
    Klaus R Herrlinger
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, UK
    Pharmacogenet Genomics 15:705-11. 2005
    ..An individual's response to MTX may in part be genetically determined by functional genetic variation in genes encoding these enzymes. We report a pharmacogenetic evaluation of MTX therapy in IBD...
  12. ncbi Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene
    J R Fraser Cummings
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Inflamm Bowel Dis 13:941-6. 2007
    ..The aims of the study were to replicate the association with CD, examine subphenotype associations and statistical interactions with CARD15, IL23R, and the IBD5 risk haplotype, as well as explore the association with UC...
  13. ncbi Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease
    Dermot P B McGovern
    Thw Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK
    Hum Mol Genet 14:1245-50. 2005
    ..04). These findings in two independent populations provide strong evidence for a role for NOD1 variants in IBD susceptibility and reinforce the role of the innate immune system in IBD pathogenesis...
  14. pmc Meta-analysis and imputation refines the association of 15q25 with smoking quantity
    Jason Z Liu
    Department of Statistics, University of Oxford, Oxford, UK
    Nat Genet 42:436-40. 2010
    ..Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3...
  15. ncbi Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behçet's disease
    X Yang
    Gastroenterology Unit, University of Oxford, Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, UK
    Eur J Immunogenet 31:11-4. 2004
    ..While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51...
  16. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  17. ncbi The contribution of HLA genes to IBD susceptibility and phenotype
    Lee Min Yap
    Gastroenterology Unit, Gibson Laboratories, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Best Pract Res Clin Gastroenterol 18:577-96. 2004
    ....
  18. pmc Genotype-phenotype analysis of the Crohn's disease susceptibility haplotype on chromosome 5q31
    A Armuzzi
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, UK
    Gut 52:1133-9. 2003
    ..No data regarding the contribution of this locus to clinical phenotype exist. In this case control study, we investigated the contribution of this haplotype to both susceptibility and phenotype of CD and UC...
  19. ncbi Clinical relevance of advances in genetics and pharmacogenetics of IBD
    Tariq Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, United Kingdom UK
    Gastroenterology 126:1533-49. 2004
    ..Current knowledge of the genetic basis for disease susceptibility, phenotype, and response to therapy is explored and the factors currently limiting the translation of this knowledge to clinical practice is discussed...
  20. ncbi Phenotype-determining genes in inflammatory bowel disease
    T Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6QX, UK
    Novartis Found Symp 263:17-29; discussion 29-40, 211-8. 2004
    ..Despite the considerable insights offered to investigators these advances have yet to impact on the clinical management of patients...
  21. ncbi The identification of three novel MICA alleles by sequence-based typing
    I Quiroga
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Tissue Antigens 67:321-5. 2006
    ..These samples were subsequently characterized by sequence-based typing (SBT). Here, we report the sequence of these three novel MICA alleles...
  22. ncbi Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes
    Timothy R Orchard
    Gastroenterology Unit, St Mary s Hospital, London, England
    Gastroenterology 123:714-8. 2002
    ..This study examined the clinical features and HLA-B, DR, and tumor necrosis factor alpha (TNF-alpha) associations of ocular inflammation and EN and their clinical and immunogenetic relationship to arthritis in IBD...
  23. pmc New IBD genes?
    D McGovern
    The Wellcome Trust Centre for Human Genetics and Gastroenterology Unit, University of Oxford, UK
    Gut 54:1060-1. 2005
  24. ncbi CARD15 polymorphisms in Behçet's disease
    T Ahmad
    Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, United Kingdom
    Scand J Rheumatol 34:233-7. 2005
    ..CARD15 has recently been identified as the first susceptibility gene in Crohn's disease (CD)...
  25. pmc Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    Jeffrey C Barrett
    Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 40:955-62. 2008
    ..The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development...
  26. ncbi Managing the long term care of inflammatory bowel disease patients: The cost to European health care providers
    James Buchanan
    Health Economics Research Centre, University of Oxford, Oxford, UK
    J Crohns Colitis 5:301-16. 2011
    ..The aim of this study is to estimate the cost of care for Crohn's Disease and Ulcerative Colitis patients in the United Kingdom and Western mainland Europe...
  27. doi Pneumococcal infection in patients with coeliac disease
    Harry J Thomas
    Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK
    Eur J Gastroenterol Hepatol 20:624-8. 2008
    ..Splenectomy is a risk factor for pneumococcal infection. Our objective was to determine the risk of invasive pneumococcal disease - septicaemia, pneumonia or meningitis - in patients with coeliac disease...
  28. ncbi Review article: the genetics of inflammatory bowel disease
    T Ahmad
    Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK
    Aliment Pharmacol Ther 15:731-48. 2001
    ..Hope continues that studies of inflammatory bowel disease genetics will provide fresh insight into disease pathogenesis and soon deliver clinical applications...
  29. ncbi Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease
    David A van Heel
    Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London, UK
    Lancet 365:1794-6. 2005
    ....
  30. ncbi HLA-DQB1*0201: a marker for good prognosis in British and Dutch patients with sarcoidosis
    Hiroe Sato
    Clinical Genomics Group, Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, National Heart and Lung Institute, London, United Kingdom
    Am J Respir Cell Mol Biol 27:406-12. 2002
    ....
  31. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  32. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  33. ncbi Association between heat shock protein 70/Hom genetic polymorphisms and uveitis in patients with sarcoidosis
    Paolo Spagnolo
    Clinical Genomic Group, National Heart and Lung Institute, Department of Occupational and Environmental Medicine, Imperial College, London, United Kingdom
    Invest Ophthalmol Vis Sci 48:3019-25. 2007
    ..HSP70 molecules play a key role in the immune response by functioning both as chaperones and as inducers of proinflammatory cytokine secretion...
  34. pmc Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    Miles Parkes
    Inflammatory Bowel Disease Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Genet 39:830-2. 2007
    ..We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13...
  35. pmc Further evidence of IBD5/CARD15 (NOD2) epistasis in the susceptibility to ulcerative colitis
    Dermot P B McGovern
    Am J Hum Genet 73:1465-6. 2003
  36. ncbi The TNF-863A allele strongly associates with anticentromere antibody positivity in scleroderma
    Hiroe Sato
    Imperial College of Science, Technology and Medicine, and the Royal Brompton Hospital and National Heart and Lung Institute, London, UK
    Arthritis Rheum 50:558-64. 2004
    ....
  37. pmc Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3
    Ali G Gharavi
    Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:2488-93. 2004
    ..These findings demonstrate a strong genetic influence on HIVAN and demonstrate a major renal disease susceptibility locus on mouse chromosome 3A1-3...
  38. ncbi The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB
    Xing Hua Gao
    Department of Dermatology, No 1 Hospital of China Medical University, Shenyang, China
    J Invest Dermatol 125:895-9. 2005
    ..In conclusion, HLA-DR and DQ antigens or their haplotypes appear to be involved in both susceptibility to and protection from LS...
  39. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  40. ncbi Role of tumor necrosis factor in Crohn's disease
    Srinivasan Ganesan
    Phase 1 Clinical Trials Unit, 119 Looseleigh Lane, Derriford, Plymouth, PL6 5HH, UK
    Curr Opin Investig Drugs 3:1297-300. 2002
    ..The first part of this article reviews the role of TNF alpha in CD...
  41. ncbi Therapeutic inhibitors of tumor necrosis factor in Crohn's disease
    Srinivasan Ganesan
    Phase 1 Clinical Trials Unit, 119 Looseleigh Lane, Derriford, Plymouth, PL6 5HH, UK
    Curr Opin Investig Drugs 3:1301-6. 2002
    ..New approaches, including the use of soluble TNF receptors, appear promising. This article reviews the evidence of therapeutic inhibition of TNF...