Massimiliano Agostini

Summary

Affiliation: MRC Toxicology Unit
Location: Leicester, UK
Summary:

Publications

  1. ncbi request reprint Cloning and expression of a short Fas ligand: A new alternatively spliced product of the mouse Fas ligand gene
    E Ayroldi
    Department of Clinical and Experimental Medicine, Section of Pharmacology, Perugia University Medical School, Perugia, Italy
    Blood 94:3456-67. 1999
  2. doi request reprint The GITRL-GITR system alters TLR-4 expression on DC during fungal infection
    Anna Vecchiarelli
    Department of Experimental Medicine and Biochemical Sciences, Microbiology Section, University of Perugia, Perugia, Italy
    Cell Immunol 257:13-22. 2009
  3. doi request reprint Silymarin suppress CD4+ T cell activation and proliferation: effects on NF-kappaB activity and IL-2 production
    Marjan Gharagozloo
    Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
    Pharmacol Res 61:405-9. 2010
  4. doi request reprint miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro
    Hailan Chen
    Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, PO Box 138, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 394:921-7. 2010
  5. pmc Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2
    Berna S Sayan
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 107:12877-82. 2010
  6. pmc p73 regulates maintenance of neural stem cell
    Massimiliano Agostini
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 403:13-7. 2010
  7. doi request reprint Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect
    Daniele Bano
    Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Ludwig Erhard Allee 2, 53175, Bonn, Germany
    Mol Neurobiol 43:124-30. 2011
  8. pmc p73: a multifunctional protein in neurobiology
    Richard Killick
    King s College London, Institute of Psychiatry, Old Age Psychiatry and Dementia, London, SE5 8AF, UK
    Mol Neurobiol 43:139-46. 2011
  9. doi request reprint miR-146a is modulated in human endothelial cell with aging
    Mariuca Vasa-Nicotera
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK
    Atherosclerosis 217:326-30. 2011
  10. pmc p73 in Cancer
    Alessandro Rufini
    Toxicology Unit, Medical Research Council, Leicester, LE1 9HN, United Kingdom
    Genes Cancer 2:491-502. 2011

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Cloning and expression of a short Fas ligand: A new alternatively spliced product of the mouse Fas ligand gene
    E Ayroldi
    Department of Clinical and Experimental Medicine, Section of Pharmacology, Perugia University Medical School, Perugia, Italy
    Blood 94:3456-67. 1999
    ..Thus, FasLs, a new alternative splicing of FasL, is involved in the regulation of Fas/FasL-mediated cell death...
  2. doi request reprint The GITRL-GITR system alters TLR-4 expression on DC during fungal infection
    Anna Vecchiarelli
    Department of Experimental Medicine and Biochemical Sciences, Microbiology Section, University of Perugia, Perugia, Italy
    Cell Immunol 257:13-22. 2009
    ....
  3. doi request reprint Silymarin suppress CD4+ T cell activation and proliferation: effects on NF-kappaB activity and IL-2 production
    Marjan Gharagozloo
    Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
    Pharmacol Res 61:405-9. 2010
    ..Moreover, silymarin inhibited p65/NF-kappaB phosphorylation in CD4+ T cell. These results suggest that silymarin is able to inhibit T cell activation and proliferation, notably acting on pathways of NF-kappaB activation/translocation...
  4. doi request reprint miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro
    Hailan Chen
    Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, PO Box 138, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 394:921-7. 2010
    ..These findings provide an important step toward further elucidation of miR function and miR-related gene regulatory networks in the mammalian central nervous system...
  5. pmc Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2
    Berna S Sayan
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 107:12877-82. 2010
    ..These results suggest that PIR2, by being induced by TAp73 and degrading DeltaNp73, differentially regulates TAp73/DeltaNp73 stability, and, hence, it may offer a therapeutic approach to enhance the chemosensitivity of tumor cells...
  6. pmc p73 regulates maintenance of neural stem cell
    Massimiliano Agostini
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 403:13-7. 2010
    ..In parallel with this in vitro data, the width of the neurogenic areas was reduced in the brains of embryonic and adult p73-/- mice. These data suggest that p73, and in particular TAp73, is important for maintenance of the NSC pool...
  7. doi request reprint Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect
    Daniele Bano
    Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Ludwig Erhard Allee 2, 53175, Bonn, Germany
    Mol Neurobiol 43:124-30. 2011
    ..Accordingly, tweaking ageing might be an attractive approach to prevent cognitive decline caused by age-related synaptic dysfunction...
  8. pmc p73: a multifunctional protein in neurobiology
    Richard Killick
    King s College London, Institute of Psychiatry, Old Age Psychiatry and Dementia, London, SE5 8AF, UK
    Mol Neurobiol 43:139-46. 2011
    ..Thus, in addition to its increasingly accepted contribution to tumorigenesis, the p73 subfamily also plays a role in neuronal development and neurodegeneration...
  9. doi request reprint miR-146a is modulated in human endothelial cell with aging
    Mariuca Vasa-Nicotera
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK
    Atherosclerosis 217:326-30. 2011
    ..MiRs modulate a variety of biological functions such as cell development, cell differentiation, and apoptosis. Moreover, several miRs involved in endothelial cell function have been identified...
  10. pmc p73 in Cancer
    Alessandro Rufini
    Toxicology Unit, Medical Research Council, Leicester, LE1 9HN, United Kingdom
    Genes Cancer 2:491-502. 2011
    ..Broadly, the data support the hypothesis that the ratio between TAp73 and ΔNp73 is crucial for tumor progression and therapeutic response...
  11. doi request reprint p63 in tooth development
    Alessandro Rufini
    Toxicology Unit, Medical Research Council, Leicester LE1 9HN, United Kingdom
    Biochem Pharmacol 82:1256-61. 2011
    ..Here we review the experimental evidence for the involvement of ΔNp63 in tooth development through its ability to sustain the molecular signalling that orchestrates epithelial-mesenchymal interaction...
  12. doi request reprint Cell death pathology: perspective for human diseases
    Massimiliano Agostini
    Medical Research Council, Toxicology Unit, Leicester, UK
    Biochem Biophys Res Commun 414:451-5. 2011
    ..Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies...
  13. pmc Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets
    Massimiliano Agostini
    Toxicology Unit, Medical Research Council, Leicester University, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 108:21093-8. 2011
    ..Notably, the axis TAp73/miR-34a/synaptotagmin-1 is conserved in brains from Alzheimer's patients. These data reinforce a role for TAp73 in neuronal development...
  14. pmc microRNA-34a regulates neurite outgrowth, spinal morphology, and function
    Massimiliano Agostini
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 108:21099-104. 2011
    ..Therefore, the TAp73/miR-34a axis has functional relevance in primary neurons. These data reinforce a role for miR-34a in neuronal development...
  15. doi request reprint Glucocorticoid-induced leucine zipper is protective in Th1-mediated models of colitis
    Lorenza Cannarile
    Department of Clinical and Experimental Medicine, Section of Pharmacology and Polo Scientifico e Didattico di Terni, University of Perugia, Perugia, Italy
    Gastroenterology 136:530-41. 2009
    ..Previous studies indicate that increased expression in transgenic mice of glucocorticoid-induced leucine zipper (GILZ), a gene rapidly induced by glucocorticoids, inhibits NF-kappaB and Th1 activity...
  16. pmc GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling
    Emira Ayroldi
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Perugia, Perugia, Italy
    J Clin Invest 117:1605-15. 2007
    ..Together, these findings indicate that GILZ serves as a negative regulator of Ras- and Raf-induced proliferation and is an important mediator of the antiproliferative effect of GCs...
  17. ncbi request reprint IL-2-driven natural killer cell generation: role of anti-H-2b monoclonal antibodies and stromal cells in controlling quantitative and repertoire changes
    M Agostini
    Department of Clinical and Experimental Medicine, University of Perugia, Italy
    J Chemother 13:527-34. 2001
    ..Allogeneic but not H-2b-deficient stromal cells decreased the expression of Ly-49C/I but not Ly49A, thus suggesting that stromal cell haplotypes qualitatively influence the expression of Ly49s repertoire...
  18. ncbi request reprint GILZ, a glucocorticoid hormone induced gene, modulates T lymphocytes activation and death through interaction with NF-kB
    C Riccardi
    Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122, Perugia, Italy
    Adv Exp Med Biol 495:31-9. 2001
  19. ncbi request reprint GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations
    Simona Ronchetti
    Eur J Immunol 34:613-22. 2004
    ..These results indicate a novel function for GITR as costimulatory molecule of T cell subsets...
  20. ncbi request reprint Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice
    Domenico Vittorio Delfino
    Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Blood 104:4134-41. 2004
    ..These results support the hypothesis that GILZ participates in the regulation of thymocyte apoptosis by glucocorticoids...
  21. ncbi request reprint Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritis
    Salvatore Cuzzocrea
    Dipartimento Clinico e Sperimentale di Medicina e Farmacologia, Torre Biologica, Policlinico Universitario, Messina, Italy
    FASEB J 19:1253-65. 2005
    ..In conclusion, GITR plays a critical role in the immunological response against CII and in the development of CIA...
  22. ncbi request reprint Increased GILZ expression in transgenic mice up-regulates Th-2 lymphokines
    Lorenza Cannarile
    Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Blood 107:1039-47. 2006
    ..These results indicate that Gilz contributes to CD4+ commitment toward a Th-2 phenotype and suggest this contribution may be another mechanism accounting for glucocorticoid immunomodulation...
  23. pmc The glucocorticoid-induced tumor necrosis factor receptor-related gene modulates the response to Candida albicans infection
    Massimiliano Agostini
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Infect Immun 73:7502-8. 2005
    ....
  24. ncbi request reprint Inhibited cell death, NF-kappaB activity and increased IL-10 in TCR-triggered thymocytes of transgenic mice overexpressing the glucocorticoid-induced protein GILZ
    Domenico Vittorio Delfino
    Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Int Immunopharmacol 6:1126-34. 2006
    ..These results support the hypothesis that GILZ regulates, at least in part, T-cell development by influencing thymus function at cellular and molecular levels...
  25. ncbi request reprint Mechanism of 2-chloroadenosine toxicity to PC3 cell line
    Alba Minelli
    Dipartimento di Medicina Sperimentale Scienze Biochimiche, Sezione Biochimica Cellulare, Via del Giochetto, Perugia, Italia
    Prostate 66:1425-36. 2006
    ..2-CADO inhibits the growth of several types of cells and causes apoptosis by a mechanism which involves adenosine receptors or cellular uptake or both...
  26. pmc GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice
    L Santucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Scienze Chirurgiche, Gastroenterologiche ed Epatologiche, Universita di Perugia, Policlinico Monteluce, 06122 Perugia, Italy
    Gut 56:52-60. 2007
    ..GITR triggering leads to activation of T effectors and reversal of suppressive function of regulatory T cells...
  27. ncbi request reprint Proinflammatory role of glucocorticoid-induced TNF receptor-related gene in acute lung inflammation
    Salvatore Cuzzocrea
    Dipartimento Clinico e Sperimentale di Medicina e Farmacologia, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    J Immunol 177:631-41. 2006
    ....
  28. ncbi request reprint Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoids
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine, School of Medicine, University of Messina, Messina, Italy
    Mol Pharmacol 71:132-44. 2007
    ..In conclusion, these results suggest that the in vivo anti-inflammatory property of DEX is also related to the ER-alpha...
  29. ncbi request reprint Genetic and pharmacological inhibition of GITR-GITRL interaction reduces chronic lung injury induced by bleomycin instillation
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina Italy
    FASEB J 21:117-29. 2007
    ..Our results clearly demonstrate that GITR-GITRL interaction plays an important role in the chronic lung injury induced by bleomycin in the mice...
  30. pmc Embryonic stem cells and inducible pluripotent stem cells: two faces of the same coin?
    Francesco Romeo
    Department of Experimental and Clinical Medicine, Magna Gracia University of Catanzaro, Salvatore Venuta Campus, 88100 Catanzaro, Italy
    Aging (Albany NY) 4:878-86. 2012
    ....