Research Topics
Genomes and Genes
| Massimiliano AgostiniSummaryAffiliation: MRC Toxicology Unit Location: Leicester, UK Summary: Publications
| Collaborators
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Detail Information
Publications
Cloning and expression of a short Fas ligand: A new alternatively spliced product of the mouse Fas ligand geneE Ayroldi
Department of Clinical and Experimental Medicine, Section of Pharmacology, Perugia University Medical School, Perugia, Italy
Blood 94:3456-67. 1999..Thus, FasLs, a new alternative splicing of FasL, is involved in the regulation of Fas/FasL-mediated cell death...
The GITRL-GITR system alters TLR-4 expression on DC during fungal infectionAnna Vecchiarelli
Department of Experimental Medicine and Biochemical Sciences, Microbiology Section, University of Perugia, Perugia, Italy
Cell Immunol 257:13-22. 2009....- Silymarin suppress CD4+ T cell activation and proliferation: effects on NF-kappaB activity and IL-2 productionMarjan Gharagozloo
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Pharmacol Res 61:405-9. 2010..Moreover, silymarin inhibited p65/NF-kappaB phosphorylation in CD4+ T cell. These results suggest that silymarin is able to inhibit T cell activation and proliferation, notably acting on pathways of NF-kappaB activation/translocation... - miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitroHailan Chen
Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, PO Box 138, Leicester LE1 9HN, UK
Biochem Biophys Res Commun 394:921-7. 2010..These findings provide an important step toward further elucidation of miR function and miR-related gene regulatory networks in the mammalian central nervous system... 
Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2Berna S Sayan
Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom
Proc Natl Acad Sci U S A 107:12877-82. 2010..These results suggest that PIR2, by being induced by TAp73 and degrading DeltaNp73, differentially regulates TAp73/DeltaNp73 stability, and, hence, it may offer a therapeutic approach to enhance the chemosensitivity of tumor cells...- p73 regulates maintenance of neural stem cellMassimiliano Agostini
Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK
Biochem Biophys Res Commun 403:13-7. 2010..In parallel with this in vitro data, the width of the neurogenic areas was reduced in the brains of embryonic and adult p73-/- mice. These data suggest that p73, and in particular TAp73, is important for maintenance of the NSC pool... - Ageing, neuronal connectivity and brain disorders: an unsolved ripple effectDaniele Bano
Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Ludwig Erhard Allee 2, 53175, Bonn, Germany
Mol Neurobiol 43:124-30. 2011..Accordingly, tweaking ageing might be an attractive approach to prevent cognitive decline caused by age-related synaptic dysfunction... - p73: a multifunctional protein in neurobiologyRichard Killick
King s College London, Institute of Psychiatry, Old Age Psychiatry and Dementia, London, SE5 8AF, UK
Mol Neurobiol 43:139-46. 2011..Thus, in addition to its increasingly accepted contribution to tumorigenesis, the p73 subfamily also plays a role in neuronal development and neurodegeneration... - miR-146a is modulated in human endothelial cell with agingMariuca Vasa-Nicotera
Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK
Atherosclerosis 217:326-30. 2011..MiRs modulate a variety of biological functions such as cell development, cell differentiation, and apoptosis. Moreover, several miRs involved in endothelial cell function have been identified... - p73 in CancerAlessandro Rufini
Toxicology Unit, Medical Research Council, Leicester, LE1 9HN, United Kingdom
Genes Cancer 2:491-502. 2011..Broadly, the data support the hypothesis that the ratio between TAp73 and ΔNp73 is crucial for tumor progression and therapeutic response... - p63 in tooth developmentAlessandro Rufini
Toxicology Unit, Medical Research Council, Leicester LE1 9HN, United Kingdom
Biochem Pharmacol 82:1256-61. 2011..Here we review the experimental evidence for the involvement of ΔNp63 in tooth development through its ability to sustain the molecular signalling that orchestrates epithelial-mesenchymal interaction... - Cell death pathology: perspective for human diseasesMassimiliano Agostini
Medical Research Council, Toxicology Unit, Leicester, UK
Biochem Biophys Res Commun 414:451-5. 2011..Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies... - Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targetsMassimiliano Agostini
Toxicology Unit, Medical Research Council, Leicester University, Leicester LE1 9HN, United Kingdom
Proc Natl Acad Sci U S A 108:21093-8. 2011..Notably, the axis TAp73/miR-34a/synaptotagmin-1 is conserved in brains from Alzheimer's patients. These data reinforce a role for TAp73 in neuronal development... - Glucocorticoid-induced leucine zipper is protective in Th1-mediated models of colitisLorenza Cannarile
Department of Clinical and Experimental Medicine, Section of Pharmacology and Polo Scientifico e Didattico di Terni, University of Perugia, Perugia, Italy
Gastroenterology 136:530-41. 2009..Previous studies indicate that increased expression in transgenic mice of glucocorticoid-induced leucine zipper (GILZ), a gene rapidly induced by glucocorticoids, inhibits NF-kappaB and Th1 activity... - GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signalingEmira Ayroldi
Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Perugia, Perugia, Italy
J Clin Invest 117:1605-15. 2007..Together, these findings indicate that GILZ serves as a negative regulator of Ras- and Raf-induced proliferation and is an important mediator of the antiproliferative effect of GCs... - Genetic and pharmacological inhibition of GITR-GITRL interaction reduces chronic lung injury induced by bleomycin instillationSalvatore Cuzzocrea
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina Italy
FASEB J 21:117-29. 2007..Our results clearly demonstrate that GITR-GITRL interaction plays an important role in the chronic lung injury induced by bleomycin in the mice... - IL-2-driven natural killer cell generation: role of anti-H-2b monoclonal antibodies and stromal cells in controlling quantitative and repertoire changesM Agostini
Department of Clinical and Experimental Medicine, University of Perugia, Italy
J Chemother 13:527-34. 2001..Allogeneic but not H-2b-deficient stromal cells decreased the expression of Ly-49C/I but not Ly49A, thus suggesting that stromal cell haplotypes qualitatively influence the expression of Ly49s repertoire... - GILZ, a glucocorticoid hormone induced gene, modulates T lymphocytes activation and death through interaction with NF-kBC Riccardi
Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122, Perugia, Italy
Adv Exp Med Biol 495:31-9. 2001 - GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulationsSimona Ronchetti
Eur J Immunol 34:613-22. 2004..These results indicate a novel function for GITR as costimulatory molecule of T cell subsets... - Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic miceDomenico Vittorio Delfino
Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
Blood 104:4134-41. 2004..These results support the hypothesis that GILZ participates in the regulation of thymocyte apoptosis by glucocorticoids... - Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritisSalvatore Cuzzocrea
Dipartimento Clinico e Sperimentale di Medicina e Farmacologia, Torre Biologica, Policlinico Universitario, Messina, Italy
FASEB J 19:1253-65. 2005..In conclusion, GITR plays a critical role in the immunological response against CII and in the development of CIA... - Increased GILZ expression in transgenic mice up-regulates Th-2 lymphokinesLorenza Cannarile
Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
Blood 107:1039-47. 2006..These results indicate that Gilz contributes to CD4+ commitment toward a Th-2 phenotype and suggest this contribution may be another mechanism accounting for glucocorticoid immunomodulation... - The glucocorticoid-induced tumor necrosis factor receptor-related gene modulates the response to Candida albicans infectionMassimiliano Agostini
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
Infect Immun 73:7502-8. 2005.... - Inhibited cell death, NF-kappaB activity and increased IL-10 in TCR-triggered thymocytes of transgenic mice overexpressing the glucocorticoid-induced protein GILZDomenico Vittorio Delfino
Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
Int Immunopharmacol 6:1126-34. 2006..These results support the hypothesis that GILZ regulates, at least in part, T-cell development by influencing thymus function at cellular and molecular levels... - Mechanism of 2-chloroadenosine toxicity to PC3 cell lineAlba Minelli
Dipartimento di Medicina Sperimentale Scienze Biochimiche, Sezione Biochimica Cellulare, Via del Giochetto, Perugia, Italia
Prostate 66:1425-36. 2006..2-CADO inhibits the growth of several types of cells and causes apoptosis by a mechanism which involves adenosine receptors or cellular uptake or both... - GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in miceL Santucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Scienze Chirurgiche, Gastroenterologiche ed Epatologiche, Universita di Perugia, Policlinico Monteluce, 06122 Perugia, Italy
Gut 56:52-60. 2007..GITR triggering leads to activation of T effectors and reversal of suppressive function of regulatory T cells... - Proinflammatory role of glucocorticoid-induced TNF receptor-related gene in acute lung inflammationSalvatore Cuzzocrea
Dipartimento Clinico e Sperimentale di Medicina e Farmacologia, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
J Immunol 177:631-41. 2006.... - Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoidsSalvatore Cuzzocrea
Department of Clinical and Experimental Medicine, School of Medicine, University of Messina, Messina, Italy
Mol Pharmacol 71:132-44. 2007..In conclusion, these results suggest that the in vivo anti-inflammatory property of DEX is also related to the ER-alpha... - microRNA-34a regulates neurite outgrowth, spinal morphology, and functionMassimiliano Agostini
Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom
Proc Natl Acad Sci U S A 108:21099-104. 2011..Therefore, the TAp73/miR-34a axis has functional relevance in primary neurons. These data reinforce a role for miR-34a in neuronal development...