S C Afford
Affiliation: University of Birmingham
- CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejectionS C Afford
Liver Research Laboratories, The University of Birmingham, Institute of Clinical Science, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
J Exp Med 189:441-6. 1999..Thus, CD40 engagement triggers apoptosis of human hepatocytes and might amplify Fas-dependent hepatocyte apoptosis in chronic rejection and other inflammatory liver diseases in which Fas-mediated apoptosis is involved...
- CD40 activation-induced, Fas-dependent apoptosis and NF-kappaB/AP-1 signaling in human intrahepatic biliary epithelial cellsS C Afford
The Liver Research Laboratories, MRC Centre for Immune Regulation, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
FASEB J 15:2345-54. 2001..Sustained activation of AP-1 in the absence of NF-kappaB signaling may be a critical factor in determining the outcome of CD40 engagement...