A E Ades

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint The interpretation of random-effects meta-analysis in decision models
    A E Ades
    Medical Research Council, Health Services Research Collaboration, Canynge Hall, Bristol, UK
    Med Decis Making 25:646-54. 2005
  2. pmc Evidence synthesis for decision making 7: a reviewer's checklist
    A E Ades
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:679-91. 2013
  3. doi request reprint Model averaging in the presence of structural uncertainty about treatment effects: influence on treatment decision and expected value of information
    Malcolm J Price
    School of Social and Community Based Medicine, University of Bristol, Bristol, UK
    Value Health 14:205-18. 2011
  4. pmc Evidence synthesis for decision making 4: inconsistency in networks of evidence based on randomized controlled trials
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:641-56. 2013
  5. pmc Evidence synthesis for decision making 6: embedding evidence synthesis in probabilistic cost-effectiveness analysis
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:671-8. 2013
  6. pmc Evidence synthesis for decision making 3: heterogeneity--subgroups, meta-regression, bias, and bias-adjustment
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:618-40. 2013
  7. doi request reprint Mixture-of-exponentials models to explain heterogeneity in studies of the duration of Chlamydia trachomatis infection
    Malcolm J Price
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Stat Med 32:1547-60. 2013
  8. pmc Evidence synthesis for decision making 5: the baseline natural history model
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:657-70. 2013
  9. pmc Evidence synthesis for decision making 1: introduction
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:597-606. 2013
  10. ncbi request reprint Meta-analysis of mixed treatment comparisons at multiple follow-up times
    G Lu
    MRC Health Services Research Collaboration, University of Bristol, Bristol, UK
    Stat Med 26:3681-99. 2007

Detail Information

Publications45

  1. ncbi request reprint The interpretation of random-effects meta-analysis in decision models
    A E Ades
    Medical Research Council, Health Services Research Collaboration, Canynge Hall, Bristol, UK
    Med Decis Making 25:646-54. 2005
    ....
  2. pmc Evidence synthesis for decision making 7: a reviewer's checklist
    A E Ades
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:679-91. 2013
    ..The headings and implicit advice follow directly from the other tutorials in this series. A simple table is provided that could serve as a pro forma checklist. ..
  3. doi request reprint Model averaging in the presence of structural uncertainty about treatment effects: influence on treatment decision and expected value of information
    Malcolm J Price
    School of Social and Community Based Medicine, University of Bristol, Bristol, UK
    Value Health 14:205-18. 2011
    ..However, structural uncertainty about any chosen parameterization will remain and this may have implications for the resulting decision and the need for further research...
  4. pmc Evidence synthesis for decision making 4: inconsistency in networks of evidence based on randomized controlled trials
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:641-56. 2013
    ..Empirical indicators that can provide reassurance and the question of how to respond to inconsistency are also discussed. ..
  5. pmc Evidence synthesis for decision making 6: embedding evidence synthesis in probabilistic cost-effectiveness analysis
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:671-8. 2013
    ....
  6. pmc Evidence synthesis for decision making 3: heterogeneity--subgroups, meta-regression, bias, and bias-adjustment
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:618-40. 2013
    ..Illustrative examples of Bayesian meta-regression against a continuous covariate and meta-regression against "baseline" risk are provided. Annotated WinBUGS code is set out in an appendix. ..
  7. doi request reprint Mixture-of-exponentials models to explain heterogeneity in studies of the duration of Chlamydia trachomatis infection
    Malcolm J Price
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Stat Med 32:1547-60. 2013
    ..Differences in study recruitment and sampling mechanisms, acting through a mixture-of-exponentials model, better explains the apparent heterogeneity in duration...
  8. pmc Evidence synthesis for decision making 5: the baseline natural history model
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:657-70. 2013
    ....
  9. pmc Evidence synthesis for decision making 1: introduction
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:597-606. 2013
    ..We finish with some suggestions on how to present the evidence, the synthesis methods, and the results...
  10. ncbi request reprint Meta-analysis of mixed treatment comparisons at multiple follow-up times
    G Lu
    MRC Health Services Research Collaboration, University of Bristol, Bristol, UK
    Stat Med 26:3681-99. 2007
    ..The extent of between-trials heterogeneity in treatment effects depends on treatment contrast. In discussion we note that models of this type have a very wide potential application...
  11. doi request reprint Network meta-analysis with competing risk outcomes
    A E Ades
    Department of Community Based Medicine, University of Bristol, Cotham Hill, Bristol, UK
    Value Health 13:976-83. 2010
    ..Nevertheless, methods for synthesis of randomized controlled trials with competing risk outcomes are limited...
  12. doi request reprint Mixed treatment comparison analysis provides internally coherent treatment effect estimates based on overviews of reviews and can reveal inconsistency
    Deborah M Caldwell
    Department of Community Based Medicine, University of Bristol, Cotham House, Cotham Hill, Bristol BS6 6JL, UK
    J Clin Epidemiol 63:875-82. 2010
    ..To propose methods for mixed treatment comparisons (MTC) based on pooled summaries of the type produced in overviews of reviews...
  13. doi request reprint Checking consistency in mixed treatment comparison meta-analysis
    S Dias
    Academic Unit of Primary Care, Department of Community Based Medicine, University of Bristol, Cotham House, Cotham Hill, Bristol BS6 6JL, U K
    Stat Med 29:932-44. 2010
    ..We end with some considerations on the modelling assumptions being made, the problems with the extension of the back-calculation method to trial-level data and discuss our methods in the context of the existing literature...
  14. pmc Perinatal folate-related exposures and risk of psychotic symptoms in the ALSPAC birth cohort
    B Glaser
    The MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK
    Schizophr Res 120:177-83. 2010
    ..Our study examines the relationships between multiple determinants of perinatal folate-status and development of psychotic experiences in adolescence...
  15. doi request reprint Mixed treatment comparison with multiple outcomes reported inconsistently across trials: evaluation of antivirals for treatment of influenza A and B
    N J Welton
    Academic Unit of Primary Health Care, Department of Community Based Medicine, University of Bristol, Cotham House, Cotham Hill, Bristol BS6 6JL, U K
    Stat Med 27:5620-39. 2008
    ....
  16. pmc Simultaneous comparison of multiple treatments: combining direct and indirect evidence
    Deborah M Caldwell
    Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Bristol BS8 2PR
    BMJ 331:897-900. 2005
  17. doi request reprint Parameterization of treatment effects for meta-analysis in multi-state Markov models
    Malcolm J Price
    Department of Community Based Medicine, University of Bristol, Cotham House, Cotham Hill, Bristol, BS6 6JL, U K
    Stat Med 30:140-51. 2011
    ....
  18. pmc Coverage of neonatal screening: failure of coverage or failure of information system
    A E Ades
    Department of Epidemiology and Public Health, Institute of Child Health, 30 Guilford St, London WC1N 1EH, UK
    Arch Dis Child 84:476-9. 2001
    ..To evaluate neonatal screening coverage using data routinely collected on the laboratory computer...
  19. ncbi request reprint Markov chain Monte Carlo estimation of a multiparameter decision model: consistency of evidence and the accurate assessment of uncertainty
    A E Ades
    Medical Research Council, Health Services Research Collaboration, Department of Social Medicine, University of Bristol, United Kingdom
    Med Decis Making 22:359-71. 2002
    ..The authors demonstrate improved precision of estimates, and lower estimates of the expected value of perfect information, resulting from the use of all available data...
  20. ncbi request reprint Comparison of methods for analysing cluster randomized trials: an example involving a factorial design
    T J Peters
    Division of Primary Health Care, Department of Social Medicine, University of Bristol, Cotham House, Cotham Hill, Bristol BS6 6JL, UK
    Int J Epidemiol 32:840-6. 2003
    ..Various analytical methods were compared for a factorial cluster randomized trial (CRT) of two primary care-based interventions designed to increase breast screening attendance...
  21. ncbi request reprint Commentary: evidence synthesis and evidence consistency
    A E Ades
    MRC Health Research Collaboration, University of Bristol, Bristol BS8 2PR, UK
    Int J Epidemiol 33:426-7. 2004
  22. ncbi request reprint Expected value of sample information calculations in medical decision modeling
    A E Ades
    Medical Research Council Health Services Research Collaboration, Bristol, United Kingdom
    Med Decis Making 24:207-27. 2004
    ..Illustrative worked examples of EVSI calculations are given in an appendix...
  23. ncbi request reprint Combination of direct and indirect evidence in mixed treatment comparisons
    G Lu
    MRC HSRC, Department of Social Medicine, University of Bristol, Canynge Hall, White Ladies Road, Bristol BS8 2PR, U K
    Stat Med 23:3105-24. 2004
    ..We discuss model critique and model selection, illustrating the role of Bayesian deviance analysis, and node-based model criticism. The assumptions underlying the MTC models and their parameterization are also discussed...
  24. ncbi request reprint Estimation of markov chain transition probabilities and rates from fully and partially observed data: uncertainty propagation, evidence synthesis, and model calibration
    Nicky J Welton
    MRC Health Services Research Collaboration, Bristol, United Kingdom
    Med Decis Making 25:633-45. 2005
    ....
  25. pmc Evidence synthesis for decision making 2: a generalized linear modeling framework for pairwise and network meta-analysis of randomized controlled trials
    Sofia Dias
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Med Decis Making 33:607-17. 2013
    ..The approach is illustrated through a range of worked examples for commonly encountered evidence formats. ..
  26. doi request reprint Which health-related quality-of-life outcome when planning randomized trials: disease-specific or generic, or both? A common factor model
    A E Ades
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Value Health 16:185-94. 2013
    ..Information on mapping coefficients and on relative responsiveness should be collected more systematically to facilitate both evidence synthesis and trial design...
  27. ncbi request reprint Evidence synthesis, parameter correlation and probabilistic sensitivity analysis
    A E Ades
    MRC Health Services Collaboration, Canynge Hall, England, UK
    Health Econ 15:373-81. 2006
    ..It follows that, if health technology assessments are to be based on a correct analysis of all available data, then probabilistic methods must be used both for sensitivity analysis and for estimation of expected costs and benefits...
  28. pmc Simultaneous multioutcome synthesis and mapping of treatment effects to a common scale
    Guobing Lu
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Value Health 17:280-7. 2014
    ..It is underpinned by a structural equation model that includes measurement error and latent common treatment effect factor. Treatment effects can be expressed on any of the test instruments that have been used...
  29. doi request reprint Mapping from disease-specific to generic health-related quality-of-life scales: a common factor model
    Guobing Lu
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Value Health 16:177-84. 2013
    ..To develop a coherent method for estimating mappings between treatment effects on disease-specific measurement (DSM) instruments and generic health-related quality-of-life (QOL) measures, when both are subject to measurement errors...
  30. ncbi request reprint Research decisions in the face of heterogeneity: what can a new study tell us?
    Nicky Welton
    Social and Community Medicine, University of Bristol, Bristol, UK
    Health Econ 21:1196-200. 2012
    ..Careful consideration of the relationship between existing (and future) evidence and the CEA model is required to provide practical VOI methods that can help research funders prioritise new research in the face of heterogeneity...
  31. doi request reprint Consistency between direct and indirect trial evidence: is direct evidence always more reliable?
    Jason Madan
    University of Bristol, Bristol, UK
    Value Health 14:953-60. 2011
    ....
  32. doi request reprint Multiparameter evidence synthesis in epidemiology and medical decision-making
    A E Ades
    MRC Health Services Collaboration, Bristol, UK
    J Health Serv Res Policy 13:12-22. 2008
    ....
  33. ncbi request reprint A chain of evidence with mixed comparisons: models for multi-parameter synthesis and consistency of evidence
    A E Ades
    Medical Research Council, Health Services Research Collaboration, University of Bristol, Bristol, UK
    Stat Med 22:2995-3016. 2003
    ....
  34. ncbi request reprint Allowing for uncertainty due to missing data in meta-analysis--part 2: hierarchical models
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Stat Med 27:728-45. 2008
    ..By applying the method in three different data sets, we show that it is possible to appropriately capture the extra uncertainty due to missing data, and we discuss in what circumstances it is possible to learn about the IMOR...
  35. ncbi request reprint Probabilistic sensitivity analysis for decision trees with multiple branches: use of the Dirichlet distribution in a Bayesian framework
    Andrew H Briggs
    Health Economics Research Centre, University of Oxford, Institute of Health Sciences, Headington, Oxford OX3 7LF, United Kingdom
    Med Decis Making 23:341-50. 2003
    ..Furthermore, they demonstrate that by adopting a Bayesian approach, the problem of observing zero counts for transitions of interest can be overcome...
  36. ncbi request reprint Use of evidence in economic decision models: practical issues and methodological challenges
    N J Cooper
    Department of Health Sciences, University of Leicester, Leicester, UK
    Health Econ 16:1277-86. 2007
    ..Gaps in the established methodology knowledge base are identified for future research...
  37. pmc Epidemiology and detection of HIV-1 among pregnant women in the United Kingdom: results from national surveillance 1988-96
    A Nicoll
    AIDS and Sexually Transmitted Diseases Centre, PHLS Communicable Disease Surveillance Centre, London
    BMJ 316:253-8. 1998
    ..Levels of diagnosis in pregnant women have not improved. Surveillance data can monitor effectively the impact of initiatives to reduce preventable HIV-1 infections in children...
  38. ncbi request reprint Bayesian methods for evidence synthesis in cost-effectiveness analysis
    A E Ades
    Medical Research Council Health Services Research Collaboration, University of Bristol, Bristol, England
    Pharmacoeconomics 24:1-19. 2006
    ..This paper provides a worked example and a general overview of these methods with particular emphasis on their use in economic evaluation...
  39. ncbi request reprint Correction: interpretation of random effects meta-analysis in decision models
    N J Welton
    Med Decis Making 27:212-4. 2007
  40. pmc Delay between pregnancy confirmation and sickle cell and [corrected] thalassaemia screening: a population-based cohort study
    Elizabeth Dormandy
    Department of Psychology at Guy s, Health Psychology Section, Institute of Psychiatry, King s College London, London, UK
    Br J Gen Pract 58:154-9. 2008
    ..Antenatal sickle cell and thalassaemia screening sometimes occurs too late to allow couples a choice regarding termination of affected fetuses. The target gestational age for offering the test in the UK is 10 weeks...
  41. ncbi request reprint Prenatal screening and treatment strategies to prevent group B streptococcal and other bacterial infections in early infancy: cost-effectiveness and expected value of information analyses
    T Colbourn
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK
    Health Technol Assess 11:1-226, iii. 2007
    ..To determine the cost-effectiveness of prenatal strategies for preventing group B streptococci (GBS) and other serious bacterial infections in early infancy and to establish the expected value of further information...
  42. pmc Preventive strategies for group B streptococcal and other bacterial infections in early infancy: cost effectiveness and value of information analyses
    Tim E Colbourn
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London WC1N 1EH
    BMJ 335:655. 2007
    ..To determine the cost effectiveness of strategies for preventing neonatal infection with group B streptococci and other bacteria in the UK and the value of further information from research...
  43. ncbi request reprint Evaluation of networks of randomized trials
    Georgia Salanti
    Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    Stat Methods Med Res 17:279-301. 2008
    ..Finally, we discuss the implications of inconsistency, network geometry and asymmetry in informing the planning of future trials...
  44. ncbi request reprint Use of indirect and mixed treatment comparisons for technology assessment
    Alex Sutton
    Department of Health Sciences and NICE Decision Support Unit, University of Leicester, Leicester, UK
    Pharmacoeconomics 26:753-67. 2008
    ....
  45. ncbi request reprint Effect of prenatal treatment on the risk of intracranial and ocular lesions in children with congenital toxoplasmosis
    L Gras
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    Int J Epidemiol 30:1309-13. 2001
    ..However, larger, prospective studies, which determine the effect of prenatal treatment on long-term developmental outcomes are required to justify changes in clinical practice...