Peter Adams

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. doi request reprint Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence
    Peter D Adams
    Cancer Research UK Beatson Labs, University of Glasgow, Glasgow G61 1BD, UK
    Mol Cell 36:2-14. 2009
  2. pmc Lysosome-mediated processing of chromatin in senescence
    Andre Ivanov
    Institute of Cancer Sciences, CR UK Beatson Laboratories, University of Glasgow, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 202:129-43. 2013
  3. pmc Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci
    Alyssa L Kennedy
    CR UK Beatson Labs, Glasgow University, Glasgow, UK
    Cell Div 5:16. 2010
  4. ncbi request reprint A damage limitation exercise
    Andrejs Ivanov
    Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Labs, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, U K
    Nat Cell Biol 13:193-5. 2011
  5. pmc Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex
    Taranjit Singh Rai
    Institute of Cancer Sciences, CR UK Beatson Labs, University of Glasgow, Switchback Road, Bearsden G61 1BD, United Kingdom
    Mol Cell Biol 31:4107-18. 2011

Collaborators

  • Taranjit Singh Rai
  • Andre Ivanov
  • John van Tuyn
  • Andrejs Ivanov
  • Tony McBryan
  • Alyssa L Kennedy
  • Indrani Manoharan
  • Graeme Hewitt
  • Hong Wu
  • David M Nelson
  • Jeff Pawlikowski
  • Parisha P Shah
  • Joao F Passos
  • Viktor I Korolchuk
  • Shelley L Berger
  • Yong Tang
  • Aastha Puri
  • David C Schultz
  • Jason Hoffman
  • Nikolay A Pchelintsev
  • Ronen Marmorstein
  • F Brad Johnson
  • Rugang Zhang
  • Greg H Enders

Detail Information

Publications5

  1. doi request reprint Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence
    Peter D Adams
    Cancer Research UK Beatson Labs, University of Glasgow, Glasgow G61 1BD, UK
    Mol Cell 36:2-14. 2009
    ..Tumor suppression, wound healing, and aging are each associated with inflammation, and here it is proposed that cellular senescence contributes to a "nonimmune cell" component of the tissue inflammatory response...
  2. pmc Lysosome-mediated processing of chromatin in senescence
    Andre Ivanov
    Institute of Cancer Sciences, CR UK Beatson Laboratories, University of Glasgow, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 202:129-43. 2013
    ..We conclude that senescent cells process their chromatin via an autophagy/lysosomal pathway and that this might contribute to stability of senescence and tumor suppression...
  3. pmc Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci
    Alyssa L Kennedy
    CR UK Beatson Labs, Glasgow University, Glasgow, UK
    Cell Div 5:16. 2010
    ..SAHF are thought to repress expression of proliferation-promoting genes, thereby contributing to senescence-associated proliferation arrest. We asked whether this Wnt2-HIRA-SAHF pathway is conserved in mouse fibroblasts...
  4. ncbi request reprint A damage limitation exercise
    Andrejs Ivanov
    Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Labs, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, U K
    Nat Cell Biol 13:193-5. 2011
    ..Senescence-associated heterochromatin is now shown to limit DDR, thus reducing apoptosis and promoting survival of senescent cells...
  5. pmc Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex
    Taranjit Singh Rai
    Institute of Cancer Sciences, CR UK Beatson Labs, University of Glasgow, Switchback Road, Bearsden G61 1BD, United Kingdom
    Mol Cell Biol 31:4107-18. 2011
    ..3. In sum, these data demonstrate that CABIN1 is a functional member of the human HUCA complex and so is the likely ortholog of yeast Hir3p...

Research Grants9

  1. Regulation of Oncogene-Induced Senescence by Wnt-Signaling
    Peter D Adams; Fiscal Year: 2010
    ..Specifically, we will focus on melanoma and colon cancer, two cancers which between them kill about 60,000 people a year in the United States. ..
  2. INVESTIGATION OF A PUTATIVE NOVEL CYCLIN/CDK2 SUBSTRATE
    Peter Adams; Fiscal Year: 2005
    ..We will test this idea further. ..
  3. Formation of Heterochromatin and Cellular Senescence Driven by HIRA and ASF 1a
    Peter Adams; Fiscal Year: 2007
    ..Specific Aim 3. Investigate the role of GSK3 activity in localization of HIRA to PML bodies, formation of SAHF and onset of senescence. ..