Peter Adams

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. doi request reprint Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence
    Peter D Adams
    Cancer Research UK Beatson Labs, University of Glasgow, Glasgow G61 1BD, UK
    Mol Cell 36:2-14. 2009
  2. doi request reprint HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia
    Taranjit Singh Rai
    Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom Institute of Biomedical and Environmental Health Research, University of West of Scotland, Paisley PA1 2BE, United Kingdom
    Genes Dev 28:2712-25. 2014
  3. pmc Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment
    Lynsey Howard
    British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, 126 University Place, Glasgow, UK G12 8TA
    Stem Cell Res Ther 4:36. 2013
  4. pmc Lysosome-mediated processing of chromatin in senescence
    Andre Ivanov
    Institute of Cancer Sciences, CR UK Beatson Laboratories, University of Glasgow, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 202:129-43. 2013
  5. pmc Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci
    Alyssa L Kennedy
    CR UK Beatson Labs, Glasgow University, Glasgow, UK
    Cell Div 5:16. 2010
  6. ncbi request reprint A damage limitation exercise
    Andrejs Ivanov
    Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Labs, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, U K
    Nat Cell Biol 13:193-5. 2011
  7. pmc Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex
    Taranjit Singh Rai
    Institute of Cancer Sciences, CR UK Beatson Labs, University of Glasgow, Switchback Road, Bearsden G61 1BD, United Kingdom
    Mol Cell Biol 31:4107-18. 2011

Collaborators

  • Taranjit Singh Rai
  • Tony McBryan
  • Andre Ivanov
  • Nikolay A Pchelintsev
  • John van Tuyn
  • David M Nelson
  • Indrani Manoharan
  • Lynsey Howard
  • Andrejs Ivanov
  • Alyssa L Kennedy
  • William J Faller
  • Nicholas Morrice
  • Claire Brock
  • Maria Grazia Vizioli
  • Ayala King
  • Rachael N Hewitt
  • Mark E Drotar
  • Karen Blyth
  • Orchi Anannya
  • John J Cole
  • Dina Dikovskaya
  • Owen J Sansom
  • Kurt I Anderson
  • William Clark
  • Colin Nixon
  • Martin W McBride
  • Hong Wu
  • Jeff Pawlikowski
  • Ruth M Mackenzie
  • Graeme Milligan
  • Viktor I Korolchuk
  • Joao F Passos
  • Parisha P Shah
  • Shelley L Berger
  • Nicole M Kane
  • John D McClure
  • Graeme Hewitt
  • Andrew H Baker
  • Yong Tang
  • Aastha Puri
  • David C Schultz
  • Ronen Marmorstein
  • Jason Hoffman
  • Greg H Enders
  • F Brad Johnson
  • Rugang Zhang

Detail Information

Publications7

  1. doi request reprint Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence
    Peter D Adams
    Cancer Research UK Beatson Labs, University of Glasgow, Glasgow G61 1BD, UK
    Mol Cell 36:2-14. 2009
    ..Tumor suppression, wound healing, and aging are each associated with inflammation, and here it is proposed that cellular senescence contributes to a "nonimmune cell" component of the tissue inflammatory response...
  2. doi request reprint HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia
    Taranjit Singh Rai
    Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom Institute of Biomedical and Environmental Health Research, University of West of Scotland, Paisley PA1 2BE, United Kingdom
    Genes Dev 28:2712-25. 2014
    ..These results show that HIRA controls a specialized, dynamic H4K16ac-decorated chromatin landscape in senescent cells and enforces tumor suppression. ..
  3. pmc Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment
    Lynsey Howard
    British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, 126 University Place, Glasgow, UK G12 8TA
    Stem Cell Res Ther 4:36. 2013
    ....
  4. pmc Lysosome-mediated processing of chromatin in senescence
    Andre Ivanov
    Institute of Cancer Sciences, CR UK Beatson Laboratories, University of Glasgow, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 202:129-43. 2013
    ..We conclude that senescent cells process their chromatin via an autophagy/lysosomal pathway and that this might contribute to stability of senescence and tumor suppression...
  5. pmc Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci
    Alyssa L Kennedy
    CR UK Beatson Labs, Glasgow University, Glasgow, UK
    Cell Div 5:16. 2010
    ..SAHF are thought to repress expression of proliferation-promoting genes, thereby contributing to senescence-associated proliferation arrest. We asked whether this Wnt2-HIRA-SAHF pathway is conserved in mouse fibroblasts...
  6. ncbi request reprint A damage limitation exercise
    Andrejs Ivanov
    Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Labs, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, U K
    Nat Cell Biol 13:193-5. 2011
    ..Senescence-associated heterochromatin is now shown to limit DDR, thus reducing apoptosis and promoting survival of senescent cells...
  7. pmc Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex
    Taranjit Singh Rai
    Institute of Cancer Sciences, CR UK Beatson Labs, University of Glasgow, Switchback Road, Bearsden G61 1BD, United Kingdom
    Mol Cell Biol 31:4107-18. 2011
    ..3. In sum, these data demonstrate that CABIN1 is a functional member of the human HUCA complex and so is the likely ortholog of yeast Hir3p...