M A Adams

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Experimental determination of stress distributions in articular cartilage before and after sustained loading
    M A Adams
    Department of Anatomy, University of Bristol, UK
    Clin Biomech (Bristol, Avon) 14:88-96. 1999
  2. ncbi request reprint Intervertebral disc degeneration can predispose to anterior vertebral fractures in the thoracolumbar spine
    Michael A Adams
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    J Bone Miner Res 21:1409-16. 2006
  3. pmc Intervertebral disc degeneration: evidence for two distinct phenotypes
    Michael A Adams
    Centre for Comparative and Clinical Anatomy, University of Bristol, UK
    J Anat 221:497-506. 2012
  4. ncbi request reprint Point of view
    Michael A Adams
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    Spine (Phila Pa 1976) 31:E525-6; discussion E527. 2006
  5. ncbi request reprint Personal risk factors for first-time low back pain
    M A Adams
    Department of Anatomy, University of Bristol, United Kingdom
    Spine (Phila Pa 1976) 24:2497-505. 1999
  6. doi request reprint The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology
    Michael A Adams
    Department of Anatomy, University of Bristol, Bristol, UK
    Matrix Biol 28:384-9. 2009
  7. doi request reprint Healing of a painful intervertebral disc should not be confused with reversing disc degeneration: implications for physical therapies for discogenic back pain
    Michael A Adams
    Centre for Comparative and Clinical Anatomy, University of Bristol, Bristol, UK
    Clin Biomech (Bristol, Avon) 25:961-71. 2010
  8. ncbi request reprint What is intervertebral disc degeneration, and what causes it?
    Michael A Adams
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    Spine (Phila Pa 1976) 31:2151-61. 2006
  9. doi request reprint Biomechanics of vertebral compression fractures and clinical application
    Michael A Adams
    Centre for Comparative and Clinical Anatomy, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    Arch Orthop Trauma Surg 131:1703-10. 2011
  10. ncbi request reprint The mechanical environment of chondrocytes in articular cartilage
    Michael A Adams
    University of Bristol, Department of Anatomy, UK
    Biorheology 43:537-45. 2006

Collaborators

  • P Dolan
  • Kan Min
  • I Kingma
  • H M Toussaint
  • J F Tarlton
  • F Lintz
  • M Sharif
  • Donal S McNally
  • A F Mannion
  • P Roughley
  • Fengdong Zhao
  • K M Clements
  • Jin Luo
  • Phillip Pollintine
  • Phill Pollintine
  • Deborah J Annesley-Williams
  • Daniel Skrzypiec
  • Daniel M Skrzypiec
  • Andrzej Przybyla
  • P Pollintine
  • P Lama
  • Rochard K S Beharry
  • J Y Chu
  • Jeremy P W Heaton
  • Andrzej S Przybyla
  • Johanna L Hannan
  • S Jeson Sangaralingham
  • Alex J Kerin
  • C L Le Maitre
  • I J Harding
  • Wendy Bertram
  • Davinder Sangar
  • Luke Daines
  • Alexander Charalambous
  • Taben M Hale
  • Rany Shamloul
  • D Skrzypiec
  • Maria Tarala
  • Romuald Bedzinski
  • Gordon Findlay
  • Jon H Tobias
  • A S Przybyla
  • Brian J Pak
  • C Smallegange
  • Stephen C Pang
  • Michael R Wisnom
  • Alexis Coleman
  • Ekaterini Angelis
  • M Yat Tse

Detail Information

Publications45

  1. ncbi request reprint Experimental determination of stress distributions in articular cartilage before and after sustained loading
    M A Adams
    Department of Anatomy, University of Bristol, UK
    Clin Biomech (Bristol, Avon) 14:88-96. 1999
    ..To test the hypotheses that stress concentrations exist within articular cartilage, and are intensified by sustained 'creep' loading...
  2. ncbi request reprint Intervertebral disc degeneration can predispose to anterior vertebral fractures in the thoracolumbar spine
    Michael A Adams
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    J Bone Miner Res 21:1409-16. 2006
    ..Flexed postures concentrated loading on the weakened anterior vertebral body, leading to compressive failure at reduced load...
  3. pmc Intervertebral disc degeneration: evidence for two distinct phenotypes
    Michael A Adams
    Centre for Comparative and Clinical Anatomy, University of Bristol, UK
    J Anat 221:497-506. 2012
    ....
  4. ncbi request reprint Point of view
    Michael A Adams
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    Spine (Phila Pa 1976) 31:E525-6; discussion E527. 2006
  5. ncbi request reprint Personal risk factors for first-time low back pain
    M A Adams
    Department of Anatomy, University of Bristol, United Kingdom
    Spine (Phila Pa 1976) 24:2497-505. 1999
    ..A prospective study of personal risk factors for first-time low back pain...
  6. doi request reprint The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology
    Michael A Adams
    Department of Anatomy, University of Bristol, Bristol, UK
    Matrix Biol 28:384-9. 2009
    ..In this way, injury to chondroid tissues can initiate a 'vicious circle' of abnormal matrix stresses, abnormal metabolism, weakened matrix, and further injury, which explains many features of their degeneration...
  7. doi request reprint Healing of a painful intervertebral disc should not be confused with reversing disc degeneration: implications for physical therapies for discogenic back pain
    Michael A Adams
    Centre for Comparative and Clinical Anatomy, University of Bristol, Bristol, UK
    Clin Biomech (Bristol, Avon) 25:961-71. 2010
    ..Much is known about intervertebral disc degeneration, but little effort has been made to relate this information to the clinical problem of discogenic back pain, and how it might be treated...
  8. ncbi request reprint What is intervertebral disc degeneration, and what causes it?
    Michael A Adams
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    Spine (Phila Pa 1976) 31:2151-61. 2006
    ..Review and reinterpretation of existing literature...
  9. doi request reprint Biomechanics of vertebral compression fractures and clinical application
    Michael A Adams
    Centre for Comparative and Clinical Anatomy, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    Arch Orthop Trauma Surg 131:1703-10. 2011
    ..The presence of cement can limit endplate deformation, and thereby partially reverse the adverse changes in load-sharing which follow vertebral fracture. Cement also reduces time-dependent "creep" deformation of damaged vertebrae...
  10. ncbi request reprint The mechanical environment of chondrocytes in articular cartilage
    Michael A Adams
    University of Bristol, Department of Anatomy, UK
    Biorheology 43:537-45. 2006
    ..The mechanical environment of chondrocytes can best be reproduced in vitro by direct compression of the articular surface of cartilage which is supported naturally by adjacent cartilage and subchondral bone...
  11. ncbi request reprint An EMG technique for measuring spinal loading during asymmetric lifting
    P Dolan
    Department of Anatomy, University of Bristol, Southwell Street, BS2 8EJ, Bristol, UK
    Clin Biomech (Bristol, Avon) 16:S17-24. 2001
    ....
  12. ncbi request reprint Effects of backward bending on lumbar intervertebral discs. Relevance to physical therapy treatments for low back pain
    M A Adams
    Department of Anatomy, University of Bristol, United Kingdom
    Spine (Phila Pa 1976) 25:431-7; discussion 438. 2000
    ..Mechanical testing of cadaveric motion segments...
  13. ncbi request reprint Can intervertebral disc prolapse be predicted by disc mechanics?
    D S McNally
    Department of Anatomy, University of Bristol, United Kingdom
    Spine (Phila Pa 1976) 18:1525-30. 1993
    ..It was concluded that some discs are predisposed to prolapse because of damaging, localized concentrations of stress in the posterior anulus in combined anterolateral bending and compression...
  14. ncbi request reprint Mechanical initiation of intervertebral disc degeneration
    M A Adams
    University of Bristol, United Kingdom
    Spine (Phila Pa 1976) 25:1625-36. 2000
    ..CONCLUSIONS: Minor damage to a vertebral body endplate leads to progressive structural changes in the adjacent intervertebral discs...
  15. ncbi request reprint The strength in anterior bending of lumbar intervertebral discs
    M A Adams
    Comparative Orthopaedic Research Unit, University of Bristol, Bristol, United Kingdom
    Spine (Phila Pa 1976) 19:2197-203. 1994
    ..CONCLUSIONS. Disc failure in bending occurs through overstretching of the outer anulus in the vertical direction. In life, the posterior elements may not adequately protect the posterior anulus from fatigue damage...
  16. ncbi request reprint Internal intervertebral disc mechanics as revealed by stress profilometry
    D S McNally
    Department of Anatomy, University of Bristol, England
    Spine (Phila Pa 1976) 17:66-73. 1992
    ..The new insight into internal disc mechanics revealed by stress profilometry may lead to a greater understanding of the mechanisms of disc function and failure...
  17. ncbi request reprint Sudden and unexpected loading generates high forces on the lumbar spine
    A F Mannion
    Schulthess Klinik, Zurich, Switzerland, and the University of Bristol, Bristol, United Kingdom
    Spine (Phila Pa 1976) 25:842-52. 2000
    ..A cross-sectional study of spinal loading in healthy volunteers...
  18. ncbi request reprint Can compressive stress be measured experimentally within the annulus fibrosus of degenerated intervertebral discs?
    J Y Chu
    Department of Anatomy, University of Bristol, Bristol, UK
    Proc Inst Mech Eng H 222:161-70. 2008
    ..The tissue is sufficiently deformable to allow efficient coupling of stress between the matrix and transducer membrane. Damage to the transducer can give misleading results...
  19. ncbi request reprint Neural arch load-bearing in old and degenerated spines
    P Pollintine
    Department of Anatomy, University of Bristol, Bristol BS2 8EJ, UK
    J Biomech 37:197-204. 2004
    ..Multiple regression showed that neural arch load bearing (%)=14.4 x disc degeneration score+0.46 x age-35. These results indicate a substantial shift in vertebral load-bearing with increasing age and degeneration...
  20. ncbi request reprint Sustained loading generates stress concentrations in lumbar intervertebral discs
    M A Adams
    Comparative Orthopaedic Research Unit, University of Bristol, United Kingdom
    Spine (Phila Pa 1976) 21:434-8. 1996
    ..Stress concentrations may lead to pain, structural disruption, and alterations in chondrocyte metabolism. Disc mechanics depend on loading history as well as applied load...
  21. ncbi request reprint Recent advances in lumbar spinal mechanics and their significance for modelling
    P Dolan
    Department of Anatomy, University of Bristol, Southwell Street, BS2 8EJ, Bristol, UK
    Clin Biomech (Bristol, Avon) 16:S8-S16. 2001
    ..Incorporating this information into mathematical models will make them better able to identify which activities are most likely to injure the lumbar spine in life...
  22. ncbi request reprint Dynamic forces acting on the lumbar spine during manual handling. Can they be estimated using electromyographic techniques alone?
    P Dolan
    Department of Anatomy, University of Bristol, United Kingdom
    Spine (Phila Pa 1976) 24:698-703. 1999
    ..Compressive loading of the lumbar spine was analyzed using electromyographic, movement analysis, and force-plate techniques...
  23. ncbi request reprint When are intervertebral discs stronger than their adjacent vertebrae?
    Daniel Skrzypiec
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    Spine (Phila Pa 1976) 32:2455-61. 2007
    ..Mechanical testing of cadaveric tissues...
  24. doi request reprint Do intervertebral discs degenerate before they herniate, or after?
    P Lama
    University of Bristol, Centre for Comparative and Clinical Anatomy, Bristol, UK
    Bone Joint J 95:1127-33. 2013
    ..In conclusion, it should not be assumed that degenerative changes always precede disc herniation. Cite this article: Bone Joint J 2013;95-B:1127-33. ..
  25. ncbi request reprint Mechanical testing of the spine. An appraisal of methodology, results, and conclusions
    M A Adams
    Department of Anatomy, University of Bristol, United Kingdom
    Spine (Phila Pa 1976) 20:2151-6. 1995
    ....
  26. ncbi request reprint Intervertebral disc degeneration can lead to "stress-shielding" of the anterior vertebral body: a cause of osteoporotic vertebral fracture?
    Phill Pollintine
    Department of Anatomy, Rheumatology Unit, University of Bristol, UK
    Spine (Phila Pa 1976) 29:774-82. 2004
    ..Mechanical testing of cadaveric lumbar motion segments...
  27. ncbi request reprint Mechanical efficacy of vertebroplasty: influence of cement type, BMD, fracture severity, and disc degeneration
    Jin Luo
    Department of Anatomy, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    Bone 40:1110-9. 2007
    ....
  28. ncbi request reprint Psychological questionnaires: do "abnormal" scores precede or follow first-time low back pain?
    A F Mannion
    Department of Anatomy, University of Bristol, United Kingdom
    Spine (Phila Pa 1976) 21:2603-11. 1996
    ..A prospective study of psychological risk factors for first-time low back pain with repeated use of psychological questionnaires...
  29. ncbi request reprint How severe must repetitive loading be to kill chondrocytes in articular cartilage?
    K M Clements
    Department of Anatomy, University of Bristol, Bristol, UK
    Osteoarthritis Cartilage 9:499-507. 2001
    ..We hypothesize that repetitive loading can kill cartilage chondrocytes in a dose-related manner...
  30. ncbi request reprint Intradiscal electrothermal therapy can alter compressive stress distributions inside degenerated intervertebral discs
    Phill Pollintine
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    Spine (Phila Pa 1976) 30:E134-9. 2005
    ..Mechanical testing of cadaveric motion segments...
  31. doi request reprint Is kyphoplasty better than vertebroplasty in restoring normal mechanical function to an injured spine?
    Jin Luo
    Department of Anatomy, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    Bone 46:1050-7. 2010
    ..In a cadaveric study, we compare the ability of vertebroplasty and kyphoplasty to restore spine mechanical function, and vertebral body shape, following vertebral fracture...
  32. ncbi request reprint Spine biomechanics
    Michael A Adams
    Department of Anatomy, University of Bristol, UK
    J Biomech 38:1972-83. 2005
    ..Precise characterisation and manipulation of this environment will be a major challenge for spine biomechanics...
  33. doi request reprint Vertebroplasty: only small cement volumes are required to normalize stress distributions on the vertebral bodies
    Jin Luo
    Department of Anatomy, University of Bristol, Bristol, Avon, United Kingdom
    Spine (Phila Pa 1976) 34:2865-73. 2009
    ..Cement leakage, IDP and compressive stiffness all increased with percentage fill...
  34. doi request reprint The role of Plantaris Longus in Achilles tendinopathy: a biomechanical study
    F Lintz
    Avon Orthopaedic Center, Westbury on Trym, Bristol, BS10 5NB, United Kingdom
    Foot Ankle Surg 17:252-5. 2011
    ..The Plantaris Longus Tendon (PLT) may be implicated in Achilles (AT) tendinopathy. Different mechanical characteristics may be the cause. This study is designed to measure these...
  35. ncbi request reprint Fatigue of the erector spinae muscles. A quantitative assessment using "frequency banding" of the surface electromyography signal
    P Dolan
    Comparative Orthopaedic Research Unit, University of Bristol, United Kingdom
    Spine (Phila Pa 1976) 20:149-59. 1995
    ..In the erector spinae, the early effects of fatigue appear to be delayed by the recruitment of additional motor units...
  36. ncbi request reprint Strength of the cervical spine in compression and bending
    Andrzej S Przybyla
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    Spine (Phila Pa 1976) 32:1612-20. 2007
    ..Cadaveric motion segment experiment...
  37. ncbi request reprint Outer annulus tears have less effect than endplate fracture on stress distributions inside intervertebral discs: relevance to disc degeneration
    Andrzej Przybyla
    Department of Anatomy, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    Clin Biomech (Bristol, Avon) 21:1013-9. 2006
    ..The purpose of the present experiment is to compare the effects of outer annulus tears and endplate fracture on intradiscal stresses. We hypothesise that endplate fracture provides a greater stimulus for disc degeneration...
  38. ncbi request reprint Biomechanics of back pain
    Michael A Adams
    Department of Anatomy, University of Bristol, UK
    Acupunct Med 22:178-88. 2004
    ....
  39. ncbi request reprint Propagation of surface fissures in articular cartilage in response to cyclic loading in vitro
    Alex J Kerin
    Department of Anatomy, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    Clin Biomech (Bristol, Avon) 18:960-8. 2003
    ..Mechanical overloading of synovial joints can damage the articular cartilage surface and may lead to osteoarthritis. However, causal links between mechanical and biological events in cartilage are poorly understood...
  40. ncbi request reprint Cyclic loading can denature type II collagen in articular cartilage
    Kristen M Clements
    Department of Anatomy, University of Bristol, UK
    Connect Tissue Res 45:174-80. 2004
    ..We conclude that vigorous cyclic mechanical loading causes an immediate dose-related increase in collagen denaturation in bovine articular cartilage...
  41. ncbi request reprint Discogenic origins of spinal instability
    Fengdong Zhao
    Department of Orthopaedics, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou City, Zhejiang, People s Republic of China
    Spine (Phila Pa 1976) 30:2621-30. 2005
    ..Cadaveric motion segment experiment...
  42. pmc The internal mechanical properties of cervical intervertebral discs as revealed by stress profilometry
    Daniel M Skrzypiec
    Section of Biomechanics, Hamburg University of Technology, Hamburg, Germany
    Eur Spine J 16:1701-9. 2007
    ..This may be attributable to their fibrous texture. The small radial diameter of the cervical posterior annulus may facilitate buckling and thereby prevent it from sustaining high compressive stresses...
  43. ncbi request reprint Expression of the translational repressor NAT1 in experimental models of cardiac hypertrophy
    S Jeson Sangaralingham
    Department of Anatomy and Cell Biology, Queen s University, Kingston, ON, Canada
    Mol Cell Biochem 245:183-90. 2003
    ....
  44. doi request reprint Restoration of female genital vasocongestive arousal responses in young and aged rats
    Rochard K S Beharry
    Queen s University Department of Pharmacology and Toxicology, Kingston, Ontario, Canada
    J Sex Med 5:804-12. 2008
    ..Whether the treatments targeting these processes benefit female genital vasocongestive arousal (GVA) responses is currently not known...
  45. ncbi request reprint Recovery of erectile function in aging hypertensive and normotensive rats using exercise and caloric restriction
    Johanna L Hannan
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    J Sex Med 4:886-97. 2007
    ..Using kidney cross-transplantations, our findings revealed that the benefit of this treatment resulted from drug-induced changes specific to the penile circulation, and not to the kidney-mediated lowering of pressure...