Research Topics
Genomes and GenesSpecies | Judith E AdamsSummaryAffiliation: University of Manchester Country: UK Publications
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Detail Information
Publications
Quantitative computed tomographyJudith E Adams
Department of Radiology, The Royal Infirmary and University, Manchester, UK
Eur J Radiol 71:415-24. 2009..Such research studies contribute importantly to the understanding of bone growth and development, the effect of disease and treatment on the skeleton and the biomechanics of bone strength and fracture...
Advances in bone imaging for osteoporosisJudith E Adams
Manchester Academic Health Science Centre, The Royal Infirmary and University of Manchester, Department of Radiology, The Royal Infirmary, Manchester M13 9WL, UK
Nat Rev Endocrinol 9:28-42. 2013..Although these methods provide detailed insights into the effects of disease and therapies on bone, they are technically challenging and not widely available, so they are unlikely to be used in clinical practice...
Radiogrammetry and radiographic absorptiometryJudith E Adams
Manchester Royal Infirmary, Central Manchester Universities Hospitals NHS Foundation Trust, Oxford Road, Manchester, UK
Radiol Clin North Am 48:531-40. 2010..Evidence for limited normal reference data and the ability to predict future fractures in osteoporosis and reflect activity and predict outcomes in rheumatoid arthritis are presented...
Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in menDelnaz Roshandel
Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, UK
Calcif Tissue Int 89:446-55. 2011..90 [0.92-16.88], P = 0.029). No significant association was observed between RANKL SNPs and pQCT parameters. Our findings suggest that genetic variation in OPG and RANK influences radius vBMD and geometry in men...
Polymorphisms in genes involved in the NF-κB signalling pathway are associated with bone mineral density, geometry and turnover in menDelnaz Roshandel
Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
PLoS ONE 6:e28031. 2011....
The ESR1 (6q25) locus is associated with calcaneal ultrasound parameters and radial volumetric bone mineral density in European menKate L Holliday
Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
PLoS ONE 6:e22037. 2011....
Influence of insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3 on bone health: results from the European Male Ageing StudyStephen R Pye
Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, UK
Calcif Tissue Int 88:503-10. 2011..IGFBP-1 was associated with bone health, though the effect could be explained by other factors. IGFBP-3 and IGF-I were independent determinants of bone health in middle-aged and elderly European men...
A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing StudyDelnaz Roshandel
Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
BMC Med Genet 12:19. 2011..The association between these SNPs and bone mineral density (BMD) measured using dual-energy X-ray absorptiometry (DXA) was also tested...
Do the effects of testosterone on muscle strength, physical function, body composition, and quality of life persist six months after treatment in intermediate-frail and frail elderly men?Matthew D L O'Connell
Andrology Research Unit, Manchester Academic Health Science Centre, Manchester Royal Infirmary, The University of Manchester, Manchester, United Kingdom
J Clin Endocrinol Metab 96:454-8. 2011..Short-term testosterone (T) treatment in frail elderly men improves muscle mass and strength. It is unclear whether these effects can be maintained post treatment...
Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in menDelnaz Roshandel
Arthritis Research UK, Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
J Bone Miner Res 25:1830-8. 2010..02, p = 6.06 x 10(-8)) and higher ultrasound BMD at the calcaneus (beta = 0.01, p = .037). Our findings suggest that genetic variation in the RANKL/RANK/OPG signaling pathway influences bone turnover and BMD in European men...
The relationship between the OSTEODENT index and hip fracture risk assessment using FRAXKeith Horner
School of Dentistry, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110:243-9. 2010....
Vitamin D status and bone mass in UK South Asian womenDipak K Roy
Arthritis Research Campaign Epidemiology Unit, Stopford Building, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
Bone 40:200-4. 2007..The aim of this study was to determine the association between serum PTH, 25OHD and bone mass in a population based sample of young UK South Asian women...
Postpartum bone status in teenage mothers assessed using peripheral quantitative computed tomographyKate A Ward
Clinical Radiology, Imaging Sciences Research Group, University of Manchester, St Mary s Hospital, Oxford Road, Manchester M13 9PT, UK
J Clin Densitom 12:219-23. 2009..These data suggest that pregnancy might have a detrimental effect on teenage mothers' future skeletal health. The results of this study require confirmation and provide pilot data for further investigations...
UK reference data for the Hologic QDR Discovery dual-energy x ray absorptiometry scanner in healthy children and young adults aged 6-17 yearsKate A Ward
Department of Clinical Radiology, Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
Arch Dis Child 92:53-9. 2007..Ideally, such data should be matched for sex, chronological age, height, weight, pubertal development and ethnicity...
Bone status during adolescence, pregnancy and lactationKate A Ward
Clinical Radiology, Imaging Science and Biomedical Engineering, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
Curr Opin Obstet Gynecol 17:435-9. 2005..This review aims to describe the adaptive mechanisms of the female skeleton to pregnancy and lactation, which ensure optimal fetal skeletal mineralization without compromise to maternal bone strength...
Influence of lifestyle factors on quantitative heel ultrasound measurements in middle-aged and elderly menStephen R Pye
ARC Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
Calcif Tissue Int 86:211-9. 2010..Modification of lifestyle, including increasing physical activity and stopping smoking, may help optimize bone strength and reduce the risk of fracture in middle-aged and elderly European men...
Segmentation of lumbar vertebrae using part-based graphs and active appearance modelsMartin G Roberts
School of Imaging Science, University of Manchester, UK
Med Image Comput Comput Assist Interv 12:1017-24. 2009..The accuracy of this fully automatic method is assessed by comparing the results to a gold standard of manual annotation by expert radiologists...
Genetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS)Kate L Limer
ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
J Bone Miner Res 24:314-23. 2009....
Lumbar disc degeneration: association between osteophytes, end-plate sclerosis and disc space narrowingStephen R Pye
ARC Epidemiology Unit, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
Ann Rheum Dis 66:330-3. 2007..Lumbar disc degeneration is characterised radiologically by the presence of osteophytes, end-plate sclerosis and disc space narrowing...
Under-reporting of osteoporotic vertebral fractures on computed tomographyAlexandra L Williams
Department of Radiology, Manchester Royal Infirmary, Oxford Road, Manchester, UK
Eur J Radiol 69:179-83. 2009..Our aim was to assess the value of computed tomography (CT) in the diagnosis of vertebral fracture and identify the frequency with which significant fractures are missed...
Vertebral morphometry: semiautomatic determination of detailed shape from dual-energy X-ray absorptiometry images using active appearance modelsMartin Roberts
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
Invest Radiol 41:849-59. 2006..Manual point placement for vertebral morphometry is time-consuming and imprecise. We evaluated the accuracy of semiautomatic computer determination of the detailed vertebral shape...
Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled studyUpendram Srinivas-Shankar
Andrology Research Unit, Department of Medicine and Endocrinology, University of Manchester, Manchester Royal Infirmary, Grafton Street, Manchester, United Kingdom M13 9WL
J Clin Endocrinol Metab 95:639-50. 2010..Further investigations are warranted to extend these results...
Application of a triage approach to peripheral bone densitometry reduces the requirement for central DXA but is not cost effectiveElizabeth J Harrison
Clinical Radiology, Imaging Science and Biomedical Engineering, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK
Calcif Tissue Int 79:199-206. 2006..Therefore an alternative more cost-effective method has been suggested...
Randomised double blind placebo controlled trial investigating the effect of calcium and vitamin D supplementation on bone mineral density and bone metabolism in adult patients with cystic fibrosisCharles S Haworth
Manchester Adult Cystic Fibrosis Unit, South Manchester University Hospitals NHS Trust, Wythenshawe Hospital, Southmoor Road, Manchester, M23 9LT, UK
J Cyst Fibros 3:233-6. 2004..The aim of this study was to investigate the effect of calcium and vitamin D supplementation on BMD and bone metabolism in these subjects...
Bone mineral density in childhood survivors of acute lymphoblastic leukemia treated without cranial irradiationBernadette M D Brennan
Department of Hematology and Oncology, Royal Manchester Children s Hospital, Manchester, UK
J Clin Endocrinol Metab 90:689-94. 2005....
