Genomes and Genes
University of Newcastle
Organization: University of Newcastle
- Global aging and the brainThomas B L Kirkwood
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Nutr Rev 68:S65-9. 2010..Growing evidence indicates that the global aging process is more malleable than used to be thought. This needs to be taken into account in efforts to improve health and retention of mental capital across the life course...
- A re-evaluation of the electrophilic substitution reactions of the Ramirez ylideLee J Higham
School of Chemistry and Chemical Biology, Centre for Synthesis and Chemical Biology, Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
J Org Chem 72:8780-5. 2007....
- Assessing competency in dentoalveolar surgery: a 3-year study of cumulative experience in the undergraduate curriculumJ A Durham
Oral and Maxillofacial Sciences, School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK
Eur J Dent Educ 11:200-7. 2007..To assess and observe the development of competence in oral surgical skills during a 3-year undergraduate programme...
- Prevention and management of central venous catheter occlusion and thrombosis in children with cancerRoderick Skinner
Royal Victoria Infirmary, Newcastle upon Tyne, UK
Pediatr Blood Cancer 50:826-30. 2008..The views and clinical practice of children's cancer units were surveyed regarding management of central venous catheter (CVC) occlusion (CVC-occlusion), CVC-related thrombosis (CVC-thrombosis) and thromboembolism (CVC-thromboembolism)...
- Multivariate data analysis of pollutant profiles: PCB levels across EuropeDenise Howel
Institute of Health and Society, William Leech Building, The Medical School, Newcastle upon Tyne, NE2 4HH, UK
Chemosphere 67:1300-7. 2007..There was a significant difference between typical profiles from rural and urban areas such that urban samples (and those with high total PCBs) had higher proportions of tetra- and tri-PCBs compared to hexa- and hepta-PCBs...
- Collagenase gene regulation by pro-inflammatory cytokines in cartilageAndrew D Rowan
Musculoskeletal Research Group, School of Clinical Medical Sciences, Catherine Cookson Building, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
Front Biosci 12:536-50. 2007....
- Removing the health domain from the Index of Multiple Deprivation 2004-effect on measured inequalities in census measure of healthJ Adams
Institute of Health and Society, William Leech Building, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
J Public Health (Oxf) 28:379-83. 2006..These findings may not hold for other measures of health, and in the context of socioeconomic inequalities in health, removing the health domain from IMD 2004 probably represents best practice...
- What is the extent of prokaryotic diversity?Thomas P Curtis
School of Civil Engineering and Geosciences, University of Newcastle upon Tyne, Newcastle NE1 7RU, UK
Philos Trans R Soc Lond B Biol Sci 361:2023-37. 2006..However, if such models were properly validated, they could form invaluable tools for the prediction of microbial diversity and a basis for the systematic exploration of microbial diversity on the planet...
- Relaxin has a role in establishing a renal response in pregnancyMarie C Smith
School of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, Tyne and Wear, United Kingdom
Fertil Steril 86:253-5. 2006....
- How specific are therapeutic monoclonal antibodies?Colin H Self
Diagnostic and Therapeutic Technologies, School of Clinical and Laboratory Sciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
Lancet 367:1038-9. 2006
- Socioeconomic position and sleep quantity in UK adultsJean Adams
School of Population and Health Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
J Epidemiol Community Health 60:267-9. 2006..To investigate the association between markers of socioeconomic position (years of full time education, access to a car or van, and occupational social class) and mid-range sleep quantity (6.5 to 8.5 hours)...
- Effects of chemical lipid extraction and arithmetic lipid correction on stable isotope ratios of fish tissuesC J Sweeting
School of Marine Science and Technology, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
Rapid Commun Mass Spectrom 20:595-601. 2006..Application of mass balance arithmetic correction can lead to significant time and cost savings in trophodynamic studies, because the majority of delta13C and delta15N analyses would not need to be run separately...
- Comparative in vitro wear testing of PEEK and UHMWPE capped metacarpophalangeal prosthesesT J Joyce
School of Mechanical and Systems Engineering, University of Newcastle upon Tyre, NE1 7RU, UK
Biomed Mater Eng 16:1-10. 2006..Light scratches in the direction of sliding appeared on the articulating faces of all metacarpal and phalangeal test components, indicating slight abrasive wear...
- Transformation and other factors of the peptide mass spectrometry pairwise peak-list comparison processWitold E Wolski
Max Planck Institute for Molecular Genetics, Ihnestrasse 63 73, D 14195 Berlin, Germany
BMC Bioinformatics 6:285. 2005..In order to classify the underlying amino acid sequence, the acquired spectra are usually compared with synthetic ones. Development of suitable methods of direct peak-list comparison may be advantageous for many applications...
- "Popcorn worker's lung" in Britain in a man making potato crisp flavouringD J Hendrick
Royal Victoria Infirmary and University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4LP, UK
Thorax 63:267-8. 2008..Other similar cases are reviewed, and it is concluded that "food flavourer's lung" may be a more suitable diagnostic label...
- Dasl(n)e: the challenge of developing a regional database for autism spectrum disorderH McConachie
Newcastle University, School of Clinical Medical Sciences, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Arch Dis Child 94:38-41. 2009..Data checking has shown the information to be valid and case ascertainment broadly representative. The uses to which the data are being put and the continuing challenges are outlined...
- Fabrication of poly(ethylene glycol) hydrogel micropatterns with osteoinductive growth factors and evaluation of the effects on osteoblast activity and functionK Subramani
Institute for Nanoscale Science and Technology, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7AR, UK
Biomed Mater 1:144-54. 2006....
- Multiple channels for horizontal, but only one for vertical corrugations? A new look at the stereo anisotropyIgnacio Serrano-Pedraza
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
J Vis 10:10. 2010....
- Molecular and dietary regulation of beta,beta-carotene 15,15'-monooxygenase 1 (BCMO1)Georg Lietz
Newcastle University, School of Agriculture, Food and Rural Development, Human Nutrition Research Centre, Agriculture Building, Kings Road, Newcastle upon Tyne NE1 7RU, UK
Arch Biochem Biophys 502:8-16. 2010....
- Willingness to pay for a QALY: past, present and futureHelen Mason
Institute of Health and Society, 21 Claremont Place, Newcastle University, Newcastle upon Tyne, NE2 4AA, UK
Expert Rev Pharmacoecon Outcomes Res 8:575-82. 2008..The future of such work will be discussed, noting key issues for consideration and debate...
- Osteosarcoma: the European Osteosarcoma Intergroup (EOI) perspectiveAlan W Craft
Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK
Cancer Treat Res 152:263-74. 2009..The overall outcome has changed little in this time. Large multinational studies are needed to be able to answer these important questions in a timely fashion...
- Dok-7 promotes slow muscle integrity as well as neuromuscular junction formation in a zebrafish model of congenital myasthenic syndromesJuliane S Muller
Institute of Human Genetics, International Centre for Life, Newcastle University, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
Hum Mol Genet 19:1726-40. 2010..Our findings in the zebrafish model contribute to a better understanding of the signalling pathways at the NMJ and the pathomechanisms of DOK7 CMSs...
- Architecture of peptidoglycan: more data and more modelsWaldemar Vollmer
Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Trends Microbiol 18:59-66. 2010..However, many questions remain unanswered and, therefore, more data and more models are required to decipher the complex cell wall architecture in bacteria...
- The role of dopamine in bipolar disorderDavid A Cousins
Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
Bipolar Disord 11:787-806. 2009..This article examines the role of dopamine in bipolar disorder, incorporating recent advances into established models where possible...
- The impact of powered and manual toothbrushing on incipient gingival recessionGiles I McCracken
School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
J Clin Periodontol 36:950-7. 2009..To compare clinical effects of manual and powered toothbrushes on sites of localized gingival recession over 12 months. To evaluate patterns and the extent of toothbrush bristle wear...
- Antibody engineering to develop new antirheumatic therapiesJohn D Isaacs
Wilson Horne Immunotherapy Centre and Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
Arthritis Res Ther 11:225. 2009..This review will focus on antibody engineering as the key driver behind our current and developing range of antirheumatic treatments...
- Coma blisters in 2 children on anticonvulsant medicationAnna Basu
Department of Paediatric Neurology, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
J Child Neurol 24:1021-5. 2009..Our aims are to alert clinicians to the occurrence of coma blisters in children sedated on anticonvulsant medications and to report the new finding of recurrent coma blisters...
- Temporal changes in key maternal and fetal factors affecting birth outcomes: a 32-year population-based study in an industrial citySvetlana V Glinianaia
Institute of Health and Society, Newcastle University, William Leech Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
BMC Pregnancy Childbirth 8:39. 2008..The objective of this study was to describe temporal changes in key maternal and fetal factors affecting birth outcomes in Newcastle upon Tyne over three decades, 1961-1992...
- Epidermal neural crest stem cells (EPI-NCSC) and pluripotencyMaya Sieber-Blum
Institute of Human Genetics and North East England Stem Cell Institute, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE13BZ, UK
Stem Cell Rev 4:256-60. 2008..Since the patients' own EPI-NCSC could be used for autologous transplantation, this would avoid graft rejection...
- Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetesMichael I Trenell
Diabetes Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
Diabetes Care 31:1644-9. 2008..To determine whether increased daily physical activity improves mitochondrial function and/or lipid oxidation in type 2 diabetes...
- H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar TyphimuriumS Ugrinovic
Musculoskeletal Research Group, Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
Infect Immun 73:8002-8. 2005..It also expands the range of pathogens that induce H2-M3-restricted CD8 T cells to include an example of gram-negative bacteria...
- Differential experiences of the psychobiological sequelae of ecstasy use: quantitative and qualitative data from an internet studyJacqui Rodgers
School of Neurology, Neurobiology and Psychiatry, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
J Psychopharmacol 20:437-46. 2006..Participants also reported a number of effects that they regarded as beneficial. Future research should also take these aspects of use into account...
- The development of a computerised equipment and drug calculator for use in resuscitationT Shannon
Sunderland Royal Hospital, Sunderland, UK
Emerg Med J 19:215-8. 2002....
- Therapeutic targets in the management of Type 1 diabetesP D Home
Human Metabolism and Diabetes Research Centre, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Diabetes Metab Res Rev 18:S7-13. 2002..In many people with type 1 diabetes targets for blood pressure, LDL cholesterol, and serum triglycerides will also be appropriate, and need to be part of any protocol of management...
- Changing patterns and the need for qualityJ G Steele
Department of Restorative Dentistry, The Dental School, Newcastle upon Tyne
Br Dent J 192:144-8. 2002..Whoever reads them, we would ask to do so with an open mind. We have tried not to be dogmatic, and the techniques and materials described are not the only ones available, but are the ones which accord with the principles we describe...
- Achieving reuse of computable guideline systemsP Johnson
Sowerby Centre for Health Informatics at Newcastle, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK
Stud Health Technol Inform 84:99-103. 2001..Encouragingly further experiments in other areas of clinical decision support have not required extension of our interfaces...
- Sunscreens and UVA protection: a major issue of minor importanceB L Diffey
Regional Medical Physics Department, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
Photochem Photobiol 74:61-3. 2001..Less important is to spread it uniformly, and least important is the precise shape of the sunscreen-absorption spectrum, providing, of course, the spectrum extends into the UVA region...
- A retrospective study of treatment provided in the primary and secondary care services for children attending a dental hospital following complicated crown fracture in the permanent dentitionA Maguire
Department of Child Dental Health, School of Dentistry, University of Newcastle, Newcastle upon Tyne, UK
Int J Paediatr Dent 10:182-90. 2000..To investigate treatment provision in primary and secondary dental care following complicated crown fracture of permanent teeth...
- Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international studyI McKeith
Institute for the Health of the Elderly, University of Newcastle upon Tyne, UK
Lancet 356:2031-6. 2000..Rivastigmine, a cholinesterase inhibitor, was tested in a group of clinically characterised patients with Lewy-body dementia...
- Upwelling intensification as part of the Pliocene-Pleistocene climate transitionJ R Marlow
Department of Fossil Fuels and Environmental Geochemistry, Drummond Building, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
Science 290:2288-91. 2000..These observations imply that Atlantic Ocean surface water circulation was radically different during the mid-Pliocene...
- Stroke mortality in urban and rural Tanzania. Adult Morbidity and Mortality ProjectR W Walker
Department of Medicine, North Tyneside General Hospital, North Shields, Tyne and Wear, UK
Lancet 355:1684-7. 2000..We aimed to establish the contribution of cerebrovascular disease to all-cause mortality and cerebrovascular disease mortality rates in adults aged 15 years or more in one urban and two rural areas of Tanzania...
- Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseasesE Perry
Department of Neuropathology, MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, Newcastle, UK
Eur J Pharmacol 393:215-22. 2000..These findings indicate an early involvement of the alpha4 subunit in beta-amyloidosis but not in nigro-striatal dopaminergic degeneration...
- The blood-brain barrier and cerebrovascular pathology in Alzheimer's diseaseR N Kalaria
Institute for Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
Ann N Y Acad Sci 893:113-25. 1999..These vascular abnormalities are likely to worsen cognitive disability in AD...
- A confidential enquiry into certified asthma deaths in the North of England, 1994-96: influence of co-morbidity and diagnostic inaccuracyK Jones
Department of Primary Health Care, University of Newcastle upon Tyne, UK
Respir Med 93:923-7. 1999....
- Clinical guidelines in nursing, midwifery and the therapies: a systematic reviewL H Thomas
Centre for Health Services Research, University of Newcastle upon Tyne, Newcastle upon Tyne, England
J Adv Nurs 30:40-50. 1999..This paper describes characteristics of guidelines evaluated and the effectiveness of different dissemination and implementation strategies used...
- UNICEF's child injury league table. An analysis of legislation: more mixed messagesE Towner
Department of Child Health, University of Newcastle upon Tyne, UK
Inj Prev 8:97-100. 2002..This paper hopes to stimulate more widespread debate about the role of legislation in different countries...
- Characterization of the bacterial consortium associated with black band disease in coral using molecular microbiological techniquesRory P Cooney
Department of Marine Sciences and Coastal Management, Ridley Building, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU, UK
Environ Microbiol 4:401-13. 2002..To understand the pathogenesis of BBD, our attention should be focused on the pervasive ribotypes identified in this study (the Cyanobacterium sp., the Cytophaga sp. and the JOD pathogen)...
- Regulation of the NPT gene by a naturally occurring antisense transcriptAndreas Werner
Department of Physiological Sciences, University of Newcastle upon Tyne, UK
Cell Biochem Biophys 36:241-52. 2002..e., requiring supplementary factors like double-stranded RNA recognizing proteins or specific RNases). It is planned to test this hypothesis by a transgenic zebrafish approach and/or knockout mice...
- Palivizumab for preterm infants. Is it worth it?N D Embleton
Newcastle Neonatal Service, Department of Child Health, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
Arch Dis Child Fetal Neonatal Ed 90:F286-9. 2005..New treatments are rarely cost effective, and, in the absence of a comprehensive economic assessment, continued use for high risk infants may appear justified...
- Estimation of podocyte number: a comparison of methodsKathryn Elizabeth White
School of Clinical Medical Sciences, Medical School, Newcastle upon Tyne, United Kingdom
Kidney Int 66:663-7. 2004..In our studies we have used a more recent stereologic method--the disector/fractionator--that makes no assumptions about the shape or size of the cell nuclei and is therefore free of bias...
- Depression and vascular disease: what is the relationship?Alan J Thomas
Wolfson Research Centre, Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
J Affect Disord 79:81-95. 2004..the 'vascular depression' hypothesis proposes that vascular disease predisposes to, precipitates or perpetuates depression, and this proposal has stimulated further research into the relationship of depression to vascular disease...
- A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: the neuropsychiatric inventory median cutoff is a predictor of clinical outcomeClive G Ballard
Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
J Clin Psychiatry 65:114-9. 2004..Although few placebo-controlled neuroleptic discontinuation studies have been conducted in people with dementia, such studies are essential to inform key clinical decisions...
- Genes that shape the course of ageingThomas B L Kirkwood
Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
Trends Endocrinol Metab 14:345-7. 2003..An elegant new study of genes acting downstream of these signals in the nematode worm Caenorhabditis elegans reveals a plethora of information about the complex network of mechanisms that modulate the ageing process...
- Radioiodine uptake in normal female breasts and liver of a patient with differentiated thyroid cancer imaged by whole body scanningP Perros
Endocrine Unit, Freeman Hospital, Newcastle upon Tyne NE7 7N, United Kingdom
Thyroid 13:511. 2003
- Vascular endothelial growth factor and placental growth factor release in cultured trophoblast cells under different oxygen tensionsG E Lash
Department of Anatomy and Cell Biology 9th Floor, Botterell Hall, Queen s University Kingston, Ont, K7L 3N6, Canada
Growth Factors 20:189-96. 2002..These altered levels of secreted VEGF andPIGF may be released as compensatory molecules in the pathogenesis of diseases such as pre-eclampsia and intrauterine growth restriction...
- Use of thrombolytic streptokinase as a preflush in the NHBD procurementM A Gok
Renal/Liver Transplant Unit, The Freeman Hospital, Newcastle upon Tyne, UK
Transplant Proc 35:769-70. 2003
- 107th ENMC international workshop: the management of cardiac involvement in muscular dystrophy and myotonic dystrophy. 7th-9th June 2002, Naarden, the NetherlandsK Bushby
Department of Neuromuscular Genetics, Institute of Human Genetics, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
Neuromuscul Disord 13:166-72. 2003
- A randomized controlled trial of fluvoxamine in prostatodynia, a male somatoform pain disorderDouglas Turkington
Department of Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
J Clin Psychiatry 63:778-81. 2002..It presents with urogenital pain and urinary symptoms. Failure of conventional treatment and a successful uncontrolled pilot study with fluvoxamine in this condition prompted this study...
- Genetic effects on susceptibility, clinical expression, and treatment outcome of type 1 autoimmune hepatitisPeter T Donaldson
Centre for Liver Research, School of Clinical Medical Sciences, University of Newcastle, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Clin Liver Dis 6:707-25. 2002..Under these circumstances, genetic studies may be the most practical, low risk means to investigate the pathogenesis of type 1 AIH and many other autoimmune diseases...
- Acute myeloid leukaemia: optimising treatment in elderly patientsGraham H Jackson
Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Drugs Aging 19:571-81. 2002..Patients and their relatives should be counselled appropriately as to the prognosis of AML, the choices of treatment available and that intensive regimens are not an appropriate choice for many patients...
- A review and assessment of tributyltin contamination in the North Sea, based on surveys of butyltin tissue burdens and imposex/intersex in four species of neogastropodsA C Birchenough
Department of Marine Sciences and Coastal Management, Newcastle University, Cullercoats, Tyne and Wear, UK
Mar Pollut Bull 44:534-43. 2002..The impact is localised so that TBT contamination is low in coastal areas immediately adjacent to ports...
- Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowthF Kamali
Wolfson Unit of Clinical Pharmacology, University of Newcastle, Newcastle upon Tyne, UK
J Periodontal Res 34:145-53. 1999..The results suggest that the rapid metabolism and elimination of PHT and HPPH in the rat may enable it to become more resistant towards developing gingival overgrowth, compared to the cat and man...
- MECHANISMS OF NEURODEGENERATION AND REGENERATION IN POST-STROKE SURVIVORSRaj Kalaria; Fiscal Year: 2007....
- ELECTRONIC ATLAS OF FETAL BRAIN GENE EXPRESSIONTom Strachan; Fiscal Year: 2004..abstract_text> ..