University of Leeds

..The instability is found to depend strongly on the strength of the coupling between the dipolar headgroups and the membrane tilt as well as the degree of dipolar ordering in the membrane...

..The results support the idea that functional coupling can occur between upper and lower arm rotations and thus provides further evidence for a higher order control system which is responsible for coordination of arm segment movement...

..Our experiments highlight the possibility that the same outcome may be achieved through different initial conditions (equifinality); an important consideration for reconstructed patterns of regional Mid-Pliocene climate...

..Understanding and taking account of these issues in research, health promotion and healthcare services should benefit the sexual health of both men and women...

..This short review summarizes knowledge of the cyanobacterial symbioses with liverworts and hornworts, with particular emphasis on the importance of pili and gliding motility for the symbiotic competence of hormogonia...

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..A better monitoring program is needed to give a more reliable trend. Scientists who use FRA data should check how the accuracy of their findings depends on errors in the data...

..The findings suggest misdiagnosis of PBS/IC may be widespread in the UK. The NIDDK criteria are complex and appear to be of little relevance in clinical practice highlighting the need for more clearly defined diagnostic criteria...

..The changes in DNA structure that accompany supercoiling suggest a number of mechanisms whereby changes in DNA topology in vivo might be used to influence gene expression...

..On the basis of urinary biomarker levels some individuals are predicted to exceed current recommended daily intakes of DON, and thus the health consequences of these exposures merit further investigation...

..It has confirmed that the 1,600 mg dose is safe and effective for breast cancer patients but may be suboptimal for the other tumors studied...

..Sixteen primary care health centres in Peru and Bolivia...

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..The vast majority of episodes of self-harm do not result in presentation to hospital and relatively little is known about to whom or where adolescents who harm themselves go for help...

..Here, the closest treatment location may simply be the one that best reflects their preferences...

..The purpose of this study was to determine the frequency of STBMS1 as a cause of primary nonsyndromic comitant esotropia (PNCE)...

..Anti- IL-7 is on the other hand proposed to treat conditions where IL-7 may play a more direct role in pathogenesis such as autoimmune disease like Rheumatoid Arthritis, Multiple Sclerosis or Inflammatory Bowel disease...

..A study was undertaken to investigate whether genetic variation within genes, encoding proteins in the p38 signalling network, contributes to the variable response to TNF antagonists...

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..This article reviews laboratory markers and imaging currently used in recognizing those patients at risk of nonreversible, destructive disease...

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..Therefore, this finding does not support the view that the sustained focused attention is needed to properly maintain feature bindings in VSTM...

..We discuss their potential to predict the efficacy of statin therapy and the likelihood that patients will experience adverse effects...

..To adapt the Components of Primary Care Index (CPCI) to be applicable to oncology outpatients and to assess the reliability and validity of the adapted instrument (renamed the Medical Care Questionnaire [MCQ])...

..In this case, political arguments clearly prevail over policy objectives, with hydraulic expertise providing decisive arbitration between the two...

..This framework may also be of further value to evaluators outside transport...

..We discuss important factors to be considered for interactive two-dimensional display of large three-dimensional datasets, including the use of intuitive input devices and level of detail aspects...

..This study investigates the views and experiences of medical tutors and students of involving patients in undergraduate curricula...

..Here, we demonstrate two new programs that facilitate the identification of autozygous regions within a heterogeneous SNP dataset derived from familial and sporadic affected individuals...

..These results suggest that full physical movement plays a critical role in navigational search, but only moderate visual detail is required...

..A second missense mutation, D170G, was found in a single RP patient. The putative RP9 gene appears to be expressed in a wide range of tissues, but its function is unknown and a pathogenic mechanism remains to be determined...

..These data suggest that the involvement of excitatory spinal lamina I projection neurones in the transmission of peripheral chemical nociceptive inputs to the NTS may be restricted to information of visceral origin...

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..Some of the practical problems experienced in the development and application of these models are described, and examples are given...

..The checklist is a useful tool for highlighting problems. As a tool for screening for social problems it has some limitations...

..In this article, we look at the background to the development of BPD, primarily for its use in AMD, but also in other applications...

..This study investigated how energy expenditure may contribute to energy balance in lean male individuals consuming a diet either high or low in fat...

..These data indicate that expression of ragAB may be modulated in response to changes in temperature and that this may suggest a mechanism of evading the host response in the inflamed periodontal pocket...

..The mechanism whereby NSAIDs inhibit granulation tissue angiogenesis is unknown but may involve inhibition of either or both COX isoforms (COX-1 and COX-2)...

..In a double blind cross over study sucrose reduced the pain response of preterm infants exposed to heel prick blood samples only when it was administered into the mouth. It was ineffective when administered intragastrically...

..Digital image processing is central to the efficiency with which it achieves this...

..All introns have the conserved GT and AG dinucleotides present at their donor and acceptor sites, respectively. We have localized KIF3C to chromosome band 2p23 by fluorescence in situ hybridization...

..This study sought to investigate FVII:C levels and factor VII (FVII) gene polymorphisms in relation to stroke and disease outcome...

..e., finding and ingesting food without oneself becoming a meal for someone else...

..We report a case where a young patient with undiagnosed breast cancer with axillary and liver metastases underwent liver transplantation and is effectively leading a normal life 33 months after transplant...

..For the statics, the filaments have a length-scale-dependent rigidity. Dynamically, we find strongly enhanced anomalous diffusion...

..A rethink of health sector reforms and macro-economic development policies is called for, to focus on equity and strengthening the role of the state...

..New juxta-articular bone cysts were observed to appear in five cases between the ages of 10 years 10 months and 15 years 0 months. No island or cyst changed in size during the review period...

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..It is argued that research in poorer countries is essential both to ensure that an existing academic imbalance is addressed and to underpin more informed policy making in complex medically pluralistic (poorer) countries...

..It is argued that we need a much more complex and less linear notion of how families change across generations and in time...

..In all, we see a development of a vulnerable sense of professionalism alongside a frustration of losing out potentially on wider aspects of personal development due to the high work demands...

..Our data identify Cx43 as a potential therapeutic target for quashing the age-related deterioration of the cardiac pacemaker...

..The theme of this essay was inspired by Gerry Smith's conceptual and experimental work on both homeostatic and hedonic mechanisms implicated in the control of food intake...

..Many general practitioners have insufficient time to review patients' medications in a consultation. Pharmacist review has been offered as an alternative and this will be a new experience for many patients...

..The diversity and breadth of antimicrobial cover and immunomodulatory function provided by AMPs is central to the ability of a host to respond to the diverse and highly adaptable organisms colonising oral and respiratory mucosa...

..Apart from sequestering nuclear proteins for a role in replication, such viruses may also target the nucleus to disrupt nuclear functions and to inhibit antiviral responses...

..Together these maps provide a valuable resource for fine structure mapping and DNA sequencing across the region as well as for the identification of disease gene loci and the isolation of novel coding sequences...