Genomes and Genes
University of Leeds
Organization: University of Leeds
- Undulation instability in a bilayer lipid membrane due to electric field interaction with lipid dipolesRichard J Bingham
Polymers and Complex Fluids Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom
Phys Rev E Stat Nonlin Soft Matter Phys 81:051909. 2010..The instability is found to depend strongly on the strength of the coupling between the dipolar headgroups and the membrane tilt as well as the degree of dipolar ordering in the membrane...
- The coordination of upper and lower arm rotationAli Alazmani
School of Mechanical Engineering, University of Leeds, Leeds, UK
Exp Brain Res 192:635-49. 2009..The results support the idea that functional coupling can occur between upper and lower arm rotations and thus provides further evidence for a higher order control system which is responsible for coordination of arm segment movement...
- El NiÃ±o-Southern Oscillation, Pliocene climate and equifinalitySarah G Bonham
School of Earth and Environment, University of Leeds, Leeds LS2 9JT, UK
Philos Transact A Math Phys Eng Sci 367:127-56. 2009..Our experiments highlight the possibility that the same outcome may be achieved through different initial conditions (equifinality); an important consideration for reconstructed patterns of regional Mid-Pliocene climate...
- Help-seeking behaviour for sexual-health concerns: a qualitative study of men in ZimbabweStephen Pearson
Nuffield Centre for International Health and Development, University of Leeds, Leeds, UK
Cult Health Sex 10:361-76. 2008..Understanding and taking account of these issues in research, health promotion and healthcare services should benefit the sexual health of both men and women...
- Cyanobacteria-bryophyte symbiosesDavid G Adams
Institute of Integrative and Comparative Biology, Faculty of Biological Sciences, Garstang Building, University of Leeds, Leeds LS2 9JT, UK
J Exp Bot 59:1047-58. 2008..This short review summarizes knowledge of the cyanobacterial symbioses with liverworts and hornworts, with particular emphasis on the importance of pili and gliding motility for the symbiotic competence of hormogonia...
- Lack of interleukin-4 receptor alpha chain-dependent signalling promotes azoxymethane-induced colorectal aberrant crypt focus formation in Balb/c miceC W S Ko
Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, University of Leeds, Wellcome Trust Brenner Building, St James s University Hospital, Leeds LS9 7TF, UK
J Pathol 214:603-9. 2008....
- Difficulties in tracking the long-term global trend in tropical forest areaAlan Grainger
School of Geography, University of Leeds, Leeds LS2 9JT, United Kingdom
Proc Natl Acad Sci U S A 105:818-23. 2008..A better monitoring program is needed to give a more reliable trend. Scientists who use FRA data should check how the accuracy of their findings depends on errors in the data...
- Assessing UK specialists' knowledge of the diagnostic criteria for painful bladder syndrome/interstitial cystitisFiona Marsh
Department of Obstetrics and Gynaecology, St James s University Hospital, Leeds, LS9 7TF, UK
Int Urogynecol J Pelvic Floor Dysfunct 19:615-20. 2008..The findings suggest misdiagnosis of PBS/IC may be widespread in the UK. The NIDDK criteria are complex and appear to be of little relevance in clinical practice highlighting the need for more clearly defined diagnostic criteria...
- Mapping the phase diagram of the writhe of DNA nanocircles using atomistic molecular dynamics simulationsSarah A Harris
School of Physics and Astronomy, University of Leeds, Leeds, LS2 9JT, UK
Nucleic Acids Res 36:21-9. 2008..The changes in DNA structure that accompany supercoiling suggest a number of mechanisms whereby changes in DNA topology in vivo might be used to influence gene expression...
- Dietary wheat reduction decreases the level of urinary deoxynivalenol in UK adultsPaul C Turner
Molecular Epidemiology Unit and Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
J Expo Sci Environ Epidemiol 18:392-9. 2008..On the basis of urinary biomarker levels some individuals are predicted to exceed current recommended daily intakes of DON, and thus the health consequences of these exposures merit further investigation...
- The use of bone markers in a 6-week study to assess the efficacy of oral clodronate in patients with metastatic bone diseaseJ E Brown
Academic Unit of Clinical Oncology, Weston Park Hospital University of Sheffield, Sheffield S10 2SJ, UK
Calcif Tissue Int 81:341-51. 2007..It has confirmed that the 1,600 mg dose is safe and effective for breast cancer patients but may be suboptimal for the other tumors studied...
- A primer on learning in Bayesian networks for computational biologyChris J Needham
School of Computing, University of Leeds, Leeds, United Kingdom
PLoS Comput Biol 3:e129. 2007
- Improving sputum microscopy services for the diagnosis of tuberculosis in Peru and BoliviaK Siddiqi
Nuffield Centre for International Health and Development, Institute of Health Sciences and Public Health Research, Faculty of Medicine and Health, University of Leeds, Leeds, UK
Int J Tuberc Lung Dis 11:665-70. 2007..Sixteen primary care health centres in Peru and Bolivia...
- Induction of decision trees using genetic programming for modelling ecotoxicity data: adaptive discretization of real-valued endpointsX Z Wang
Institute of Particle Science and Engineering, School of Process, Environmental and Materials Engineering, LS2 9JT, UK
SAR QSAR Environ Res 17:451-71. 2006....
- Help-seeking before and after episodes of self-harm: a descriptive study in school pupils in EnglandSarah Fortune
University of Oxford Centre for Suicide Research, Department of Psychiatry, Warneford Hospital, Oxford, OX3 7JX, UK
BMC Public Health 8:369. 2008..The vast majority of episodes of self-harm do not result in presentation to hospital and relatively little is known about to whom or where adolescents who harm themselves go for help...
- Preferences of older patients and choice of treatment location in the UK: a binary choice experimentJennifer N W Lim
Leeds Institute of Health Sciences, University of Leeds, United Kingdom
Health Policy 91:252-7. 2009..Here, the closest treatment location may simply be the one that best reflects their preferences...
- Replication of the recessive STBMS1 locus but with dominant inheritanceAine Rice
Section of Ophthalmology and Neuroscience, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
Invest Ophthalmol Vis Sci 50:3210-7. 2009..The purpose of this study was to determine the frequency of STBMS1 as a cause of primary nonsyndromic comitant esotropia (PNCE)...
- IL-7 and lymphopeniaFrederique Ponchel
Leeds Institute of Molecular Medicine, Section of Musculoskeletal Disease, The University of Leeds, Leeds, UK
Clin Chim Acta 412:7-16. 2011..Anti- IL-7 is on the other hand proposed to treat conditions where IL-7 may play a more direct role in pathogenesis such as autoimmune disease like Rheumatoid Arthritis, Multiple Sclerosis or Inflammatory Bowel disease...
- Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patientsLydia R Coulthard
NIHR Leeds Musculoskeletal Biomedical Research Unit NIHR LMBRU, University of Leeds, Leeds, UK
Ann Rheum Dis 70:98-103. 2011..A study was undertaken to investigate whether genetic variation within genes, encoding proteins in the p38 signalling network, contributes to the variable response to TNF antagonists...
- Improvements in measuring the health-related quality of life of cancer patientsAdam B Smith
Senior Scientific Officer, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
Expert Rev Pharmacoecon Outcomes Res 6:97-105. 2006....
- Use of prognostic markers in early rheumatoid arthritis to identify patients at risk of destructive diseaseSally Cox
Rheumatology Research Fellow, Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
Expert Rev Clin Immunol 2:853-7. 2006..This article reviews laboratory markers and imaging currently used in recognizing those patients at risk of nonreversible, destructive disease...
- Evaluation of five search strategies in retrieving qualitative patient-reported electronic data on the impact of pressure ulcers on quality of lifeClaudia A Gorecki
Clinical Trials Research Unit, University of Leeds, Leeds, UK
J Adv Nurs 66:645-52. 2010....
- Feature bindings are maintained in visual short-term memory without sustained focused attentionJean Francois Delvenne
University of Leeds, England
Exp Psychol 57:108-16. 2010..Therefore, this finding does not support the view that the sustained focused attention is needed to properly maintain feature bindings in VSTM...
- The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapyS P R Romaine
Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
Pharmacogenomics J 10:1-11. 2010..We discuss their potential to predict the efficacy of statin therapy and the likelihood that patients will experience adverse effects...
- Patient experiences of continuity of cancer care: development of a new medical care questionnaire (MCQ) for oncology outpatientsClare Harley
Cancer Research UK Clinical Centre Leeds, Cancer Medicine Research Unit, St James s University Hospital, Beckett Street, Leeds, UK
Value Health 12:1180-6. 2009..To adapt the Components of Primary Care Index (CPCI) to be applicable to oncology outpatients and to assess the reliability and validity of the adapted instrument (renamed the Medical Care Questionnaire [MCQ])...
- Hydrology and hydraulics expertise in participatory processes for climate change adaptation in the Dutch MeuseAnna Wesselink
School of Earth and Environment, University of Leeds, Leeds LS2 9JT, West Yorkshire, UK corrected
Water Sci Technol 60:583-95. 2009..In this case, political arguments clearly prevail over policy objectives, with hydraulic expertise providing decisive arbitration between the two...
- Incorporating equity considerations in transport infrastructure evaluation: Current practice and a proposed methodologyN Thomopoulos
Institute for Transport Studies, University of Leeds, 36 40 University Road ITS, LS2 9JT Leeds, UK
Eval Program Plann 32:351-9. 2009..This framework may also be of further value to evaluators outside transport...
- Using high-resolution displays for high-resolution cardiac dataChristopher Goodyer
School of Computing, University of Leeds, Leeds LS2 9JT, UK
Philos Transact A Math Phys Eng Sci 367:2667-77. 2009..We discuss important factors to be considered for interactive two-dimensional display of large three-dimensional datasets, including the use of intuitive input devices and level of detail aspects...
- What educators and students really think about using patients as teachers in medical education: a qualitative studyVikram Jha
Leeds Institute of Medical Education, University of Leeds, Leeds, UK
Med Educ 43:449-56. 2009..This study investigates the views and experiences of medical tutors and students of involving patients in undergraduate curricula...
- IBDfinder and SNPsetter: tools for pedigree-independent identification of autozygous regions in individuals with recessive inherited diseaseIan M Carr
Centre for Autozygosity Mapping and Section of Genetics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
Hum Mutat 30:960-7. 2009..Here, we demonstrate two new programs that facilitate the identification of autozygous regions within a heterogeneous SNP dataset derived from familial and sporadic affected individuals...
- A proposed classification of the immunological diseasesDennis McGonagle
Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom
PLoS Med 3:e297. 2006
- For efficient navigational search, humans require full physical movement, but not a rich visual sceneRoy A Ruddle
School of Computing, University of Leeds, Leeds, United Kingdom
Psychol Sci 17:460-5. 2006..These results suggest that full physical movement plays a critical role in navigational search, but only moderate visual detail is required...
- Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosaT Jeffrey Keen
Molecular Medicine Unit, University of Leeds, UK
Eur J Hum Genet 10:245-9. 2002..A second missense mutation, D170G, was found in a single RP patient. The putative RP9 gene appears to be expressed in a wide range of tissues, but its function is unknown and a pathogenic mechanism remains to be determined...
- Neurochemistry of superficial spinal neurones projecting to nucleus of the solitary tract that express c-fos on chemical somatic and visceral nociceptive input in the ratF O Gamboa-Esteves
Institute for Cardiovascular Research, School of Medicine, University of Leeds, United Kingdom
Metab Brain Dis 16:151-64. 2001..These data suggest that the involvement of excitatory spinal lamina I projection neurones in the transmission of peripheral chemical nociceptive inputs to the NTS may be restricted to information of visceral origin...
- Chromatin remodellingP Meyer
Leeds Institute for Plant Biotechnology and Agriculture LIBA, Centre for Plant Sciences, University of Leeds, LS2 9JT, Leeds, UK
Curr Opin Plant Biol 4:457-62. 2001....
- Computational models of normal and abnormal action potential propagation in cardiac tissue: linking experimental and clinical cardiologyR H Clayton
School of Biomedical Sciences, University of Leeds, UK
Physiol Meas 22:R15-34. 2001..Some of the practical problems experienced in the development and application of these models are described, and examples are given...
- Detecting social problems in cancer patientsE P Wright
Imperial Cancer Research Fund, Cancer Medicine Research Unit, St James s University Hospital, Beckett St, Leeds LS9 7TF, UK
Psychooncology 10:242-50. 2001..The checklist is a useful tool for highlighting problems. As a tool for screening for social problems it has some limitations...
- Verteporfin: a milestone in opthalmology and photodynamic therapyS B Brown
Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
Expert Opin Pharmacother 2:351-61. 2001..In this article, we look at the background to the development of BPD, primarily for its use in AMD, but also in other applications...
- Lean male high- and low-fat phenotypes--different routes for achieving energy balanceJ Cooling
BioPyschology Group, School of Psychology, University of Leeds, UK
Int J Obes Relat Metab Disord 24:1561-6. 2000..This study investigated how energy expenditure may contribute to energy balance in lean male individuals consuming a diet either high or low in fat...
- Identification of ragAB as a temperature-regulated operon of Porphyromonas gingivalis W50 using differential display of randomly primed RNAW A Bonass
Oral Microbiology Group, Division of Oral Biology, Leeds Dental Institute, University of Leeds, LS2 9LU, United Kingdom
Infect Immun 68:4012-7. 2000..These data indicate that expression of ragAB may be modulated in response to changes in temperature and that this may suggest a mechanism of evading the host response in the inflamed periodontal pocket...
- Expression of cyclooxygenase 1 and 2 by human gastric endothelial cellsM A Hull
Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, UK
Gut 45:529-36. 1999..The mechanism whereby NSAIDs inhibit granulation tissue angiogenesis is unknown but may involve inhibition of either or both COX isoforms (COX-1 and COX-2)...
- "Sucrose analgesia": absorptive mechanism or taste perception?L A Ramenghi
Growth and Development, Paediatric Department, General Infirmary at Leeds
Arch Dis Child Fetal Neonatal Ed 80:F146-7. 1999..In a double blind cross over study sucrose reduced the pain response of preterm infants exposed to heel prick blood samples only when it was administered into the mouth. It was ineffective when administered intragastrically...
- A comprehensive physical image quality evaluation of a selenium based digital x-ray imaging system for thorax radiographyJ H Launders
FAXIL, Department of Medical Physics, General Infirmary, Leeds, West Yorkshire, United Kingdom
Med Phys 25:986-97. 1998..Digital image processing is central to the efficiency with which it achieves this...
- cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3CE A Telford
Molecular Medicine Unit, St James s University Hospital, University of Leeds, United Kingdom
Biochem Biophys Res Commun 242:407-12. 1998..All introns have the conserved GT and AG dinucleotides present at their donor and acceptor sites, respectively. We have localized KIF3C to chromosome band 2p23 by fluorescence in situ hybridization...
- Polymorphisms of the factor VII gene and circulating FVII:C levels in relation to acute cerebrovascular disease and poststroke mortalityD M Heywood
Division of Medicine, School of Medicine, University of Leeds, UK
Stroke 28:816-21. 1997..This study sought to investigate FVII:C levels and factor VII (FVII) gene polymorphisms in relation to stroke and disease outcome...
- Orexins and appetite regulationR J Rodgers
School of Psychology, University of Leeds, Leeds, UK
Neuropeptides 36:303-25. 2002..e., finding and ingesting food without oneself becoming a meal for someone else...
- Treatment of metastatic breast cancer with liver transplantationJ M Wilson
Academic Unit of Surgery, St James s University Teaching Hospital, Leeds, West Yorkshire, United Kingdom
Breast J 9:126-8. 2003..We report a case where a young patient with undiagnosed breast cancer with axillary and liver metastases underwent liver transplantation and is effectively leading a normal life 33 months after transplant...
- Anomalous fluctuations of active polar filamentsTanniemola B Liverpool
Condensed Matter Theory Group, Blackett Laboratory, Imperial College, London SW7 2BZ, United Kingdom
Phys Rev E Stat Nonlin Soft Matter Phys 67:031909. 2003..For the statics, the filaments have a length-scale-dependent rigidity. Dynamically, we find strongly enhanced anomalous diffusion...
- The implications of shortages of health professionals for maternal health in sub-saharan AfricaNancy Gerein
Nuffield Centre for International Health and Development, Institute of Health Sciences and Public Health Research, University of Leeds, Leeds, UK
Reprod Health Matters 14:40-50. 2006..A rethink of health sector reforms and macro-economic development policies is called for, to focus on equity and strengthening the role of the state...
- Prevalence, duration and indications for prescribing of antidepressants in primary careDuncan Robert Petty
School of Healthcare, University of Leeds, Leeds, West Yorkshire, UK
Age Ageing 35:523-6. 2006
- The distribution of bone islands and juxta-articular bone cysts in the growing handD Limb
Department of Trauma and Orthopaedics, St James s University Hospital, Leeds, UK
J Hand Surg Br 31:441-4. 2006..New juxta-articular bone cysts were observed to appear in five cases between the ages of 10 years 10 months and 15 years 0 months. No island or cyst changed in size during the review period...
- Molecularly imprinted polymers for the enantioseparation of chiral drugsRichard J Ansell
School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
Adv Drug Deliv Rev 57:1809-35. 2005....
- Toward an understanding of decision making on complementary and alternative medicine use in poorer countries: the case of cancer care in PakistanPhilip Tovey
School of Healthcare, Baines Wing, University of Leeds, UK
Integr Cancer Ther 4:236-41. 2005..It is argued that research in poorer countries is essential both to ensure that an existing academic imbalance is addressed and to underpin more informed policy making in complex medically pluralistic (poorer) countries...
- Physiology. Walking made simpleR McNeill Alexander
School of Biology, University of Leeds, Leeds LS2 9JT, UK
Science 308:58-9. 2005
- Visions in monochrome: families, marriage and the individualization thesisCarol Smart
ESRC Research Group on Care, Values and the Future of Welfare, University of Leeds
Br J Sociol 55:491-509. 2004..It is argued that we need a much more complex and less linear notion of how families change across generations and in time...
- Identity change and the human dissection experience over the first year of medical trainingAnna Madill
Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
Soc Sci Med 60:1637-47. 2005..In all, we see a development of a vulnerable sense of professionalism alongside a frustration of losing out potentially on wider aspects of personal development due to the high work demands...
- Ageing-related changes of connexins and conduction within the sinoatrial nodeSandra A Jones
School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
J Physiol 560:429-37. 2004..Our data identify Cx43 as a potential therapeutic target for quashing the age-related deterioration of the cardiac pacemaker...
- Is susceptibility to weight gain characterized by homeostatic or hedonic risk factors for overconsumption?John E Blundell
Psychobiology Group, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
Physiol Behav 82:21-5. 2004..The theme of this essay was inspired by Gerry Smith's conceptual and experimental work on both homeostatic and hedonic mechanisms implicated in the control of food intake...
- Patients' views of a pharmacist-run medication review clinic in general practiceDuncan R Petty
Pharmacy Practice and Medicines Management Group, School of Healthcare Studies, Baines Wing, University of Leeds, PO Box 214, Leeds LS2 9UT
Br J Gen Pract 53:607-13. 2003..Many general practitioners have insufficient time to review patients' medications in a consultation. Pharmacist review has been offered as an alternative and this will be a new experience for many patients...
- Antimicrobial peptides in defence of the oral and respiratory tractsDeirdre A Devine
Division of Oral Biology, Leeds Dental Institute, University of Leeds, Leeds LS2 9LU, UK
Mol Immunol 40:431-43. 2003..The diversity and breadth of antimicrobial cover and immunomodulatory function provided by AMPs is central to the ability of a host to respond to the diverse and highly adaptable organisms colonising oral and respiratory mucosa...
- The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replicationJulian A Hiscox
School of Biochemistry and Molecular Biology, University of Leeds, LS2 9JT Leeds, UK
Virus Res 95:13-22. 2003..Apart from sequestering nuclear proteins for a role in replication, such viruses may also target the nucleus to disrupt nuclear functions and to inhibit antiviral responses...
- An EST and STS-based YAC contig map of human chromosome 9q22.3N J Lench
Molecular Medicine Unit, University of Leeds, St James s University Hospital, West Yorkshire, United Kingdom
Genomics 38:199-205. 1996..Together these maps provide a valuable resource for fine structure mapping and DNA sequencing across the region as well as for the identification of disease gene loci and the isolation of novel coding sequences...