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Genomes and Genes
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Publications
Desktop software to identify patients eligible for recruitment into a clinical trial: using SARMA to recruit to the ROAD feasibility trialShaun Treweek
Clinical and Population Sciences and Education, University of Dundee, Dundee, UK
Inform Prim Care 18:51-8. 2010..For patients willing to learn more about the trial, the software allows practice staff to send the patient's contact details to the research team by text message...- Disorders of keratinisation: from rare to common genetic diseases of skin and other epithelial tissuesW H Irwin McLean
Epithelial Genetics Group, Human Genetics Unit, Division of Pathology andNeuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Ulster Med J 76:72-82. 2007 - The Objective Structured Clinical Examination (OSCE) as a determinant of veterinary clinical skillsMargery H Davis
Centre for Medical Education, University of Dundee, Scotland, UK
J Vet Med Educ 33:578-87. 2006..One key factor is that the examination can be structured to compare different students' abilities... - Integrating cell-signalling pathways with NF-kappaB and IKK functionNeil D Perkins
College of Life Sciences, Division of Gene Regulation and Expression, James Black Centre, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK
Nat Rev Mol Cell Biol 8:49-62. 2007..This crosstalk constitutes a decision-making process that determines the consequences of NF-kappaB and IKK activation and, ultimately, cell fate... - A comparison of health behaviours in lonely and non-lonely populationsWilliam Lauder
School of Nursing and Health, University of Dundee, Dundee, UK
Psychol Health Med 11:233-45. 2006..The findings provide support for an association between health behaviours, loneliness and excess morbidity reported in previous studies... - A feminist exploration of Traveller women's experiences of maternity care in the Republic of IrelandBernadette Reid
School of Nursing and Midwifery, University of Dundee, Tayside Campus, Ninewells, Dundee, Scotland, UK
Midwifery 23:248-59. 2007..to explore Traveller women's experiences of maternity care so that their needs might be identified and perceptions of helpful responses elicited... - Modulation of human jaw reflexes: heterotopic stimuli and stressSamuel W Cadden
Section of Clinical Dental Sciences, The Dental School, University of Dundee, Park Place, Dundee DD1 4HN, Scotland, United Kingdom
Arch Oral Biol 52:370-3. 2007.... - Respiratory symptoms, pulmonary function, and markers of inflammation among bar workers before and after a legislative ban on smoking in public placesDaniel Menzies
Asthma and Allergy Research Group, Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland
JAMA 296:1742-8. 2006..Scotland prohibited smoking in confined public places on March 26, 2006... - Sarcopenia--a potential target for Angiotensin-converting enzyme inhibition?Deepa Sumukadas
Department of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
Gerontology 52:237-42. 2006..We describe the literature to support our hypothesis that sarcopenia may be a potential therapeutic target for ACE inhibitors... - The impact of a school-based nutrition education intervention on dietary intake and cognitive and attitudinal variables relating to fruits and vegetablesA S Anderson
Centre for Public Health Nutrition Research, Ninewells Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
Public Health Nutr 8:650-6. 2005..To assess the impact of a school-based nutrition education intervention aimed at increasing the consumption of fruits and vegetables... - Reducing diazepam prescribing for illicit drug users: a randomised control studyLawrie Elliott
School of Nursing and Midwifery, University of Dundee, UK
Drug Alcohol Rev 24:25-31. 2005..The difficulties of working with this population necessitate a flexible and possibly long-term approach to reducing prescribed benzodiazepines... - Could sequential individual peer reviewed mortality audit data be used in appraisal?A M Thompson
Department of Surgery and Molecular Oncology, University of Dundee, Scotland, UK
Surgeon 3:288-92. 2005..Surgeons have traditionally monitored mortality as part of their surgical practice. The aim of this study was to determine whether peer review surgical mortality data might be useful in appraisal... - Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptomsGwen Kennedy
Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland DD1 9SY, UK
Free Radic Biol Med 39:584-9. 2005..002; postexertional malaise P=0.027, Pearson). This is the first time that raised levels of the gold standard measure of in vivo oxidative stress (isoprostanes) and their association with CFS symptoms have been reported... - Relationship between the role of the adenomatous polyposis coli protein in colon cancer and its contribution to cytoskeletal regulationI Nathke
Cell and Developmental Biology, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
Biochem Soc Trans 33:694-7. 2005..This review summarizes effects of APC on the cytoskeleton and discusses how these functions of APC may contribute to its role in cancer... - Development of therapeutic siRNAs for pachyonychia congenitaFrances J D Smith
Epithelial Genetics Group, Human Genetics Unit, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
J Invest Dermatol 128:50-8. 2008..These data suggest that siRNAs can specifically and very potently target mutated genes in the skin and support development of these inhibitors as potential therapeutics... - Leptin regulation of neuronal excitability and cognitive functionJenni Harvey
Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
Curr Opin Pharmacol 7:643-7. 2007..Characterisation of these novel actions of leptin is providing valuable insights into the role of this hormone in the regulation of diverse neuronal functions in health and disease... - Rehabilitative needs of individuals with spinal cord injury resulting from gun violence: the perspective of nursing and rehabilitation professionalsThilo Kroll
National Rehabilitation Hospital Center for Health and Disability Research, Washington, DC, USA
Appl Nurs Res 21:45-9. 2008..Achieving positive outcomes is hampered by a lack of information about resources, access to vocational rehabilitation, peer support, and accessible housing options after discharge... - FANCJ: solving problems in DNA replicationKevin Hiom
Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY, Scotland, UK
DNA Repair (Amst) 9:250-6. 2010..Here I will discuss the contribution of FANCJ to human disease, its role in maintenance of genome stability and some current thoughts on the mechanisms through which this is achieved... - Raised adolescent body mass index predicts the development of adiposity and a central distribution of body fat in adulthood: a longitudinal studyAngela M Craigie
Institute of Health and Society, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK
Obes Facts 2:150-6. 2009..To test the hypothesis that adolescent body mass index (BMI) tracks into adulthood and can be used as a predictor of obesity and/or central adiposity in adulthood... - Human miRNA precursors with box H/ACA snoRNA featuresMichelle S Scott
Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom
PLoS Comput Biol 5:e1000507. 2009..The detection of small RNA molecules that share features of miRNAs and snoRNAs suggest that these classes of RNA may have an evolutionary relationship... - Novel preventive treatment optionsC Longbottom
Dental Health Services and Research Unit, University of Dundee, Dundee, UK
Monogr Oral Sci 21:156-63. 2009..Implementation in practice should follow promptly as new techniques are shown to be clinically valuable for individual patients... - Bacterial attachment and removal properties of silicon- and nitrogen-doped diamond-like carbon coatingsQi Zhao
Department of Mechanical Engineering, University of Dundee, Dundee, UK
Biofouling 25:377-85. 2009..Bacterial adhesion strength on the DLC coatings is explained in terms of thermodynamic work of adhesion... - In vivo comparison of the relative systemic bioavailability of fluticasone propionate from three anti-static spacers and a metered dose inhalerArun Nair
Asthma and Allergy Research Group, Department of Medicine and Therapeutics, Ninewells Hospital and Medical School and Perth Royal Infirmary, University of Dundee, Dundee, Scotland, UK
Br J Clin Pharmacol 67:191-8. 2009.... - Standardization work on personalized eHealth systemsNick Hine
University of Dundee, DD1 4HN UK
Conf Proc IEEE Eng Med Biol Soc 2008:1518-20. 2008.... - Population reference intervals for minimal erythemal doses in monochromator phototestingHarry Moseley
The Photobiology Unit, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
Photodermatol Photoimmunol Photomed 25:8-11. 2009..It relies on access to reliable, up-to-date data on the MED in normal individuals. The purpose of this study was to determine MED in normal subjects at different wavebands and compare these with historical controls... - Development and validation of a clinical score to identify echocardiographic left ventricular hypertrophy in patients with cardiovascular diseaseDonald S C Ang
Division of Medicine and Therapeutics, Department of Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Am J Hypertens 21:1011-7. 2008..To help target echo screening for LVH in patient population, we developed and validated a simple clinical score to help identify those likely to have echo LVH... - Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 trafficKei Sakamoto
MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow St, Dundee, DD1 5EH, UK
Am J Physiol Endocrinol Metab 295:E29-37. 2008.... - A comparison of the aldosterone-blocking agents eplerenone and spironolactoneAllan Struthers
Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
Clin Cardiol 31:153-8. 2008..Choice of a specific agent should be based on individual patient issues, such as the nature of heart failure and patient concerns about adverse events... - Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient miceXu Huang
MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Biochem J 412:211-21. 2008.... - The effect of comparative context upon stereotype content: children's judgments of ingroup behaviorMark Bennett
University of Dundee, Scotland, UK
Scand J Psychol 49:141-6. 2008..Both types of judgment were found to differ as a function of comparative context in ways predicted by self-categorization theory. However, contrary to prediction, there was no effect of age on the extent of stereotype variability... - Decreased lung function in female but not male subjects with established cystic fibrosis-related diabetesErika J Sims
Division of Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
Diabetes Care 28:1581-7. 2005..This study examines the association between female subjects with CFRD and poor lung function relative to male subjects using the percent predicted forced expiratory volume in 1 s (FEV(1)) as a surrogate measure of morbidity... - Metformin and reduced risk of cancer in diabetic patientsJosie M M Evans
Division of Community Health Sciences, Section of Public Health, University of Dundee, Dundee DD2 4BF
BMJ 330:1304-5. 2005 - No sceptic me, but the long day's task is not yet done: the 2002 Gaston Labat lectureJohn A W Wildsmith
University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom
Reg Anesth Pain Med 27:503-8. 2002 - Voluntary and reflex control of the human temporalis muscleB J J Scott
Oral Physiology and Gerontology Research Group, Dundee Dental School, University of Dundee, Park Place, Dundee DD1 4HN, UK
J Oral Rehabil 29:634-43. 2002..Thus the results of the study suggest that there are similar neural control mechanisms for the anterior and posterior parts of the temporalis muscle despite the common view that these parts of the muscle have different functions... - Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndromeGopal P Sapkota
MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
Biochem J 362:481-90. 2002.... - Thyroid hormone metabolism and the developing human lungR Hume
Department of Obstetrics and Gynaecology, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK
Biol Neonate 80:18-21. 2001.... - Mechanisms for ATP-dependent chromatin remodellingA Flaus
The Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, DD1 5EH, Dundee, UK
Curr Opin Genet Dev 11:148-54. 2001.... - MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cellsJ S Arthur
MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dow Street, Dundee DD1 5EH, UK
FEBS Lett 482:44-8. 2000..Thus MSK1 is required for CREB and ATF1 phosphorylation after mitogenic stimulation of ES cells... - An overview of the cell cycle arrest protein, p21(WAF1)K Harada
Oral Diseases Group, Unit of Oral Surgery and Medicine, Dundee Dental Hospital and School, Park Place, DD1 4HN, UK
Oral Oncol 36:3-7. 2000..Greater understanding of its role may lead to therapeutic advances in the management of malignant disease... - Safety of inhaled and intranasal corticosteroids: lessons for the new millenniumB J Lipworth
Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland
Drug Saf 23:11-33. 2000..Prescribers of inhaled and intranasal corticosteroids should be aware of the potential for long term systemic effects. The safest way to use these drugs is to 'step-down' to achieve the lowest possible effective maintenance dosage... - Midfacial morphology of Koreans with class III malocclusions investigated with finite-element scaling analysisG D Singh
Dundee Dental Hospital and School, University of Dundee, United Kingdom
J Craniofac Genet Dev Biol 20:10-8. 2000..Moreover, perturbations in endochondral mechanisms of cranio-mandibular growth, and not maxillary intramembranous methods, may be implicated in the etiology of Class III malocclusions in South East Asians... - Validity of ultrasound estimation of fetal weightP F Chien
Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, Dunde, United Kingdom
Obstet Gynecol 95:856-60. 2000..To assess the validity of ultrasound estimation of fetal weight at term... - The rhetoric vs. the reality in child care and protection: ideology and practice in working with fathersJ Taylor
School of Nursing, University of Dundee, Dundee, Scotland, UK
J Adv Nurs 31:12-9. 2000..The working context for this paper is Scotland, although we believe that the ideas may be extrapolated to other geographical areas... - Bronchodilator response to albuterol after regular formoterol and effects of acute corticosteroid administrationB J Lipworth
Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
Chest 117:156-62. 2000..There is controversy about the development of bronchodilator subsensitivity after regular administration of long-acting beta(2)-agonists... - Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acidP Cohen
MRC Protein Phosphorylation Unit Department of Biochemistry University of Dundee MSI WTB Complex Dow Street, Dundee, DD1 5EH, UK
Chem Biol 5:R161-4. 1998..The task might be simplified by the discovery that the mutation of a single amino acid dramatically alters the nucleotide specificity of protein kinases and their inhibition by a particular class of anti-inflammatory drug... - The patient's role in the spread and control of bacterial resistance to antibioticsPeter Davey
MEMO, University of Dundee, Dundee, UK, Tayside Center for General Practice, Dundee, UK
Clin Microbiol Infect 8:43-68. 2002..This, in turn, may help to control the development and spread of resistance to antibiotics... - Developing the teaching instinct, 3: facilitating learningE A Hesketh
Educational Development Unit (SCPMDE, Tay Park House, Dundee, Scotland, UK
Med Teach 24:479-82. 2002 - Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signallingPaul R Crocker
The Wellcome Trust Biocentre at Dundee, Division of Cell Biology and Immunology, School of Life Sciences, Dundee University, Dow Street, Dundee DD1 5EH, Scotland, UK
Curr Opin Struct Biol 12:609-15. 2002..These "CD33-related" siglecs have molecular features of inhibitory receptors and may be important in regulating leucocyte activation during immune and inflammatory responses... - Methotrexate toxicity induced by acute renal failureA Strang
Rheumatic Diseases Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
J R Soc Med 97:536-7. 2004 - Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICARKei Sakamoto
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Scotland, UK
Am J Physiol Endocrinol Metab 287:E310-7. 2004..They also suggest that the effects of excercise, phenformin, and AICAR on metabolic processes in muscle may be mediated through activation of AMPK rather than activation of LKB1 or the AMPK-related kinases... - Human antibody-Fc receptor interactions illuminated by crystal structuresJenny M Woof
Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
Nat Rev Immunol 4:89-99. 2004..The results might also open up new possibilities for the design of therapeutic antibodies... - Do the British Guidelines for Asthma Management facilitate concordance?Karen Steven
Tayside Centre for General Practice, University of Dundee, Dundee, UK
Health Expect 7:74-84. 2004..Asthma is an example of a common, chronic illness in which clinicians are encouraged to promote concordance and adhere to guidelines. Some existing research suggests that these aims may be incompatible... - Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cellsIan H Batty
The Division of Cell Signalling, School of Life Sciences, MSI WTB complex, University of Dundee, Dow St, Dundee DD1 5EH, Scotland, UK
Biochem J 379:641-51. 2004..However, the proportion of IRS-1 molecules phosphorylated at a particular site or the phosphorylation of additional IRS-1 serine residues other than those noted above must be important... - New doctors' perceptions of their educational development during their first year of postgraduate trainingE A Hesketh
Education Development Unit, Tay Park House, Dundee, Scotland, UK
Med Teach 25:67-76. 2003..This study helps to define the benefits and opportunities of the PRHO year, as currently perceived by the trainees, and should be of interest to those involved in the planning and delivery of postgraduate training... - A microarray-based high throughput molecular marker genotyping method: the tagged microarray marker (TAM) approachAndrew J Flavell
Plant Research Unit, University of Dundee at Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
Nucleic Acids Res 31:e115. 2003..Two tagged primer oligonucleotides are used per locus and each tag is detected by hybridisation to a concatameric DNA probe labelled with multiple fluorochromes... - The role of protein phosphorylation in alpha2,6(N)-sialyltransferase activityKieran C Breen
Department of Psychiatry, University of Dundee Medical School, Ninewells Hospital, UK
Biochem Biophys Res Commun 309:32-5. 2003..These results provide further evidence for the role of second messenger-associated kinase enzymes in the modulation of the cell glycosylation potential... - Tackling children's road safety through edutainment: an evaluation of effectivenessM S Zeedyk
Department of Psychology, University of Dundee, Dundee DD1 4HN, UK
Health Educ Res 18:493-505. 2003..Crucially, however, parents strongly believed that it had. The discussion explores the implications of such a mismatch and highlights similarities with outcomes of other health education interventions... - Management of cellular energy by the AMP-activated protein kinase systemD Grahame Hardie
Division of Molecular Physiology, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, UK
FEBS Lett 546:113-20. 2003..A survey of the range of downstream targets for this important signalling pathway is presented... - Early experience as a determinant of adult behavioural responses to reward: the effects of repeated maternal separation in the ratKeith Matthews
Department of Psychiatry, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Neurosci Biobehav Rev 27:45-55. 2003..These data further support the hypothesis that it is possible to model vulnerability to anhedonia in the adult rat by manipulation of early experience... - Radiation measurement for plant ecophysiologyHamlyn G Jones
Plant Research Unit, Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee at SCRI, Invergowrie, Dundee DD2 5DA, UK
J Exp Bot 54:879-89. 2003.... - Genetic variation of human UDP-glucuronosyltransferase: implications in disease and drug glucuronidationBrian Burchell
Department of Molecular and Cellular Pathology, Ninewells Medical School, University of Dundee, Dundee, Scotland
Am J Pharmacogenomics 3:37-52. 2003..Additional novel polymorphisms in this gene family are yet to be revealed and studied, but will have a profound effect on the development of new drugs and therapies... - Drug glucuronidation by human renal UDP-glucuronosyltransferasesK A McGurk
Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Scotland, UK
Biochem Pharmacol 55:1005-12. 1998..The human kidney was capable of conjugating various structurally diverse drugs and xenobiotics...
Research Grants
- ROLE OF MSF IN ETIOLOGY & TREATMENT OF FOOT ULCERSSETH SCHOR; Fiscal Year: 2003..d. Assess the effect of rhMSF and selected IGD analogues in animal models of normal and diabetic wound healing. ..