Doris M Jacobs

Summary

Affiliation: Unilever Research
Country: UK

Publications

  1. doi request reprint The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics
    Ferdinand A van Dorsten
    Unilever R and D Vlaardingen, NL 3130 AC Vlaardingen, The Netherlands
    Mol Nutr Food Res 54:897-908. 2010
  2. ncbi request reprint Kinetics and active site dynamics of Staphylococcus aureus arsenate reductase
    Joris Messens
    Dienst Ultrastructuur, Vlaams Interuniversitair Instituut voor Biotechnologie VIB, Vrije Universiteit Brussel, Paardenstraat 65, 1640 Sint Genesius Rode, Belgium
    J Biol Inorg Chem 7:146-56. 2002
  3. ncbi request reprint (1)H NMR metabolite profiling of feces as a tool to assess the impact of nutrition on the human microbiome
    Doris M Jacobs
    Unilever R and D, Vlaardingen, The Netherlands
    NMR Biomed 21:615-26. 2008
  4. ncbi request reprint Non-digestible food ingredients, colonic microbiota and the impact on gut health and immunity: a role for metabolomics
    Doris M Jacobs
    Unilever Food and Health Research Institute UFHRI, Unilever R and D, Olivier van Noortlaan 120, 3130 AC Vlaardingen, The Netherlands
    Curr Drug Metab 10:41-54. 2009
  5. ncbi request reprint Assessment of inflammatory resilience in healthy subjects using dietary lipid and glucose challenges
    Suzan Wopereis
    Unilever R and D, Olivier van Noortlaan 120, Vlaardingen 3130 AC, The Netherlands
    BMC Med Genomics 6:44. 2013
  6. doi request reprint SPE-NMR metabolite sub-profiling of urine
    Doris M Jacobs
    Unilever R and D, Olivier van Noortlaan 120, 3130 AC, Vlaardingen, The Netherlands
    Anal Bioanal Chem 404:2349-61. 2012
  7. doi request reprint Impact of short-term intake of red wine and grape polyphenol extract on the human metabolome
    Doris M Jacobs
    Unilever R and D, Olivier van Noortlaan 120, 3130AC Vlaardingen, The Netherlands
    J Agric Food Chem 60:3078-85. 2012
  8. ncbi request reprint GC-MS methods for metabolic profiling of microbial fermentation products of dietary polyphenols in human and in vitro intervention studies
    Christian H Grün
    Unilever Food and Health Research Institute, Olivier van Noortlaan 120, 3133 AT, Vlaardingen, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 871:212-9. 2008
  9. pmc Metabolic fate of polyphenols in the human superorganism
    John van Duynhoven
    Unilever R and D, Olivier van Noortlaan 120, 3133 AT, Vlaardingen, The Netherlands
    Proc Natl Acad Sci U S A 108:4531-8. 2011
  10. doi request reprint Multilevel data analysis of a crossover designed human nutritional intervention study
    Ewoud J J van Velzen
    Biosystems Data Analysis, Swammerdam Institute for Life Sciences, Universiteit van Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    J Proteome Res 7:4483-91. 2008

Collaborators

  • Richard Draijer
  • Bas Kremer
  • Ben van Ommen
  • Suzan Wopereis
  • Esther Boelsma
  • Sonja Peters
  • Tom Van de Wiele
  • Sam Possemiers
  • Hans Gerd Janssen
  • H Matter
  • Ewoud J J van Velzen
  • John P M Van Duynhoven
  • Christian H Grün
  • John van Duynhoven
  • Ferdinand A van Dorsten
  • Bettina Elshorst
  • Age K Smilde
  • Johan A Westerhuis
  • Ferdi A van Dorsten
  • Sunil Kochhar
  • Pau Bernado
  • Klaus Fiebig
  • Martin Vogtherr
  • Joris Messens
  • Elaine E Vaughan
  • Robèr A Kemperman
  • Laure C Roger
  • Joel Dore
  • Gabriele Gross
  • Christine I Kroner
  • Suzanne Smit
  • Marie Le Belleguic
  • Huub C J Hoefsloot
  • Max O Bingham
  • France Berruex
  • Andreas Fuerholz
  • Laurent B Fay
  • Ziad Ramadan
  • Miguel X Fernandes
  • Miquel Pons
  • Jose Garcia de la Torre
  • Thomas Langer
  • Ralph Zahn
  • Harald Schwalbe
  • Christian Griesinger
  • Susanne Grimme
  • José C Martins
  • Lode Wyns
  • Rudolph Willem
  • Elke Brosens
  • Karolien Van Belle

Detail Information

Publications16

  1. doi request reprint The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics
    Ferdinand A van Dorsten
    Unilever R and D Vlaardingen, NL 3130 AC Vlaardingen, The Netherlands
    Mol Nutr Food Res 54:897-908. 2010
    ..MIX and GJX consumption had a slightly different effect on the excreted phenolic acid profile and on endogenous metabolite excretion, possibly reflecting their different polyphenol composition...
  2. ncbi request reprint Kinetics and active site dynamics of Staphylococcus aureus arsenate reductase
    Joris Messens
    Dienst Ultrastructuur, Vlaams Interuniversitair Instituut voor Biotechnologie VIB, Vrije Universiteit Brussel, Paardenstraat 65, 1640 Sint Genesius Rode, Belgium
    J Biol Inorg Chem 7:146-56. 2002
    ..2 x 10(4 )M-1s-1), while its product, arsenite, was identified as a mixed inhibitor ( K*iu=534 microM, K*ic=377 microM)...
  3. ncbi request reprint (1)H NMR metabolite profiling of feces as a tool to assess the impact of nutrition on the human microbiome
    Doris M Jacobs
    Unilever R and D, Vlaardingen, The Netherlands
    NMR Biomed 21:615-26. 2008
    ....
  4. ncbi request reprint Non-digestible food ingredients, colonic microbiota and the impact on gut health and immunity: a role for metabolomics
    Doris M Jacobs
    Unilever Food and Health Research Institute UFHRI, Unilever R and D, Olivier van Noortlaan 120, 3130 AC Vlaardingen, The Netherlands
    Curr Drug Metab 10:41-54. 2009
    ....
  5. ncbi request reprint Assessment of inflammatory resilience in healthy subjects using dietary lipid and glucose challenges
    Suzan Wopereis
    Unilever R and D, Olivier van Noortlaan 120, Vlaardingen 3130 AC, The Netherlands
    BMC Med Genomics 6:44. 2013
    ..Meals are a challenge to metabolic homeostasis and are suggested to affect inflammatory pathways, yet data in literature are limited and inconsistent...
  6. doi request reprint SPE-NMR metabolite sub-profiling of urine
    Doris M Jacobs
    Unilever R and D, Olivier van Noortlaan 120, 3130 AC, Vlaardingen, The Netherlands
    Anal Bioanal Chem 404:2349-61. 2012
    ..In conclusion, SPE-NMR metabolite sub-profiling is a reliable and improved method for quantification and identification of metabolites in urine to discover dietary effects and markers of phytochemical exposure...
  7. doi request reprint Impact of short-term intake of red wine and grape polyphenol extract on the human metabolome
    Doris M Jacobs
    Unilever R and D, Olivier van Noortlaan 120, 3130AC Vlaardingen, The Netherlands
    J Agric Food Chem 60:3078-85. 2012
    ..In plasma, tyrosine was reduced. The results suggest that short-term intake of WGM altered microbial protein fermentation and/or amino acid metabolism...
  8. ncbi request reprint GC-MS methods for metabolic profiling of microbial fermentation products of dietary polyphenols in human and in vitro intervention studies
    Christian H Grün
    Unilever Food and Health Research Institute, Olivier van Noortlaan 120, 3133 AT, Vlaardingen, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 871:212-9. 2008
    ..In conclusion, the methods presented are robust and generally applicable to diverse biological fluids. Its profiling character is useful to investigate on a large scale the gut microbiome-mediated bioavailability of flavonoids...
  9. pmc Metabolic fate of polyphenols in the human superorganism
    John van Duynhoven
    Unilever R and D, Olivier van Noortlaan 120, 3133 AT, Vlaardingen, The Netherlands
    Proc Natl Acad Sci U S A 108:4531-8. 2011
    ..This approach will pave the way for personalization of nutrition based on gut microbial functionality of individuals or populations...
  10. doi request reprint Multilevel data analysis of a crossover designed human nutritional intervention study
    Ewoud J J van Velzen
    Biosystems Data Analysis, Swammerdam Institute for Life Sciences, Universiteit van Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    J Proteome Res 7:4483-91. 2008
    ..0002) is a major improvement compared to a ordinary PLS-DA model ( p = 0.058) without variation splitting. Finally, rank products are used to determine which NMR signals are most important in the multilevel classification model...
  11. ncbi request reprint Peptide binding induces large scale changes in inter-domain mobility in human Pin1
    Doris M Jacobs
    Institut für Organische Chemie und Chemische Biologie, Johann Wolfgang Goethe Universitat Frankfurt, Marie Curie Strasse 11, 60439 Frankfurt, Germany
    J Biol Chem 278:26174-82. 2003
    ..The functional importance of the modulation of relative domain flexibility in light of the multitude of interaction partners of Pin1 is discussed...
  12. ncbi request reprint Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein
    Martin Vogtherr
    Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    J Med Chem 46:3563-4. 2003
    ..The millimolar dissociation constant of the complex suggests that in vivo inhibition of prion propagation occurs after 10000-fold concentration of quinacrine within endolysosomes...
  13. ncbi request reprint Probing gender-specific metabolism differences in humans by nuclear magnetic resonance-based metabonomics
    Sunil Kochhar
    BioAnalytical Science Department, Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Anal Biochem 352:274-81. 2006
    ..Estrogen most likely plays an essential role in the regulation of, and communication between, protein and lipid biosynthesis by controlling pH in mitochondria and the cytoplasm and hence the observed altered citrate levels...
  14. ncbi request reprint 1H, 13C and 15N backbone resonance assignment of the integrin alpha2 I-domain
    Bettina Elshorst
    Johann Wolfgang Goethe University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Marie Curie Strasse 11, D 60439 Frankfurt am Main, Germany
    J Biomol NMR 27:191-2. 2003
  15. ncbi request reprint Interpretation of NMR relaxation properties of Pin1, a two-domain protein, based on Brownian dynamic simulations
    Pau Bernado
    Departament de Quimica Organica, Universitat de Barcelona, Marti i Franques 1 11, 08028 Barcelona, Spain
    J Biomol NMR 29:21-35. 2004
    ....
  16. ncbi request reprint QSAR-by-NMR: quantitative insights into structural determinants for binding affinity by analysis of 1H/15N chemical shift differences in MMP-3 ligands
    Hans Matter
    Aventis Pharma Deutschland GmbH, DI and A Chemistry, Building G 878, D 65926 Frankfurt am Main, Germany
    Bioorg Med Chem Lett 15:1779-83. 2005
    ....