Affiliation: UK Cochrane Centre
- Systematic review of reviews of risk factors for intracranial aneurysmsMike Clarke
UK Cochrane Centre, National Institute for Health Research, Middle Way, Oxford, OX2 7LG, UK
Neuroradiology 50:653-64. 2008..The following factors appear to be associated with a lower risk of subarachnoid haemorrhage: high cholesterol, diabetes and use of hormone replacement therapy...
- Methodology in conducting a systematic review of systematic reviews of healthcare interventionsValerie Smith
School of Nursing and Midwifery, University of Dublin, Trinity College Dublin, 24 D Olier Street, Dublin 2, Ireland
BMC Med Res Methodol 11:15. 2011..Systematic reviews (or overviews) of reviews are a logical and appropriate next step, allowing the findings of separate reviews to be compared and contrasted, providing clinical decision makers with the evidence they need...
- Chlorpromazine for schizophrenia: a Cochrane systematic review of 50 years of randomised controlled trialsClive Elliott Adams
Cochrane Schizophrenia Group, Academic Department of Psychiatry and Behavioural Sciences, University of Leeds, Leeds, LS2 9LT, UK
BMC Med 3:15. 2005..Quantitative reviews are rare; this one evaluates the effects of chlorpromazine in the treatment of schizophrenia in comparison with placebo...
- Reports of clinical trials should begin and end with up-to-date systematic reviews of other relevant evidence: a status reportMike Clarke
UK Cochrane Centre, NHS R and D Programme, Summertown Pavilion, Middle Way, Oxford OX2 7LG, UK
J R Soc Med 100:187-90. 2007..In the current study, we assess whether there had been progress in this respect in 2005 and also investigate the extent to which reports begin by referring to systematic reviews providing the justification for the new research reported...
- Individual patient data meta-analysesMichael J Clarke
Clinical Trial Service Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK
Best Pract Res Clin Obstet Gynaecol 19:47-55. 2005..This chapter discusses the rationale for individual patient data reviews and describes some of their features...
- Doing new research? Don't forget the oldMike Clarke
United Kingdom Cochrane Centre, Oxford, United Kingdom
PLoS Med 1:e35. 2004
- The Cochrane Collaboration and the Cochrane LibraryMike Clarke
UK Cochrane Centre, NHS R and D Programme, Oxford, England
Otolaryngol Head Neck Surg 137:S52-4. 2007..I review the origins, development, and structure of the organization and describe the important components of its output, The Cochrane Library...
- The Cochrane Collaboration and systematic reviewsM Clarke
The UK Cochrane Centre, NHS R and D Programme, Summertown Pavilion, Middle Way, Oxford, Oxfordshire OX2 7LG, UK
Br J Surg 94:391-2. 2007
- Commentary: Good, but not perfectMike Clarke
UK Cochrane Centre, Oxford OX2 7LG
BMJ 336:549. 2008
- Interpreting the results of systematic reviewsMike Clarke
School of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland
Semin Hematol 45:176-80. 2008....
- Yes Sir, no Sir, not much difference SirMike Clarke
School of Nursing and Midwifery, Trinity College Dublin, 24 D Olier Street, Dublin 2, Ireland
J R Soc Med 100:571-2. 2007..To assess whether making the sender's knighthood explicit in a series of letters would have any detectable effect on the response...
- Discussion sections in reports of controlled trials published in general medical journalsMike Clarke
UK Cochrane Centre, National Health Service Research and Development Programme, Summertown Pavilion, Middle Way, Oxford OX2 7LG, England
JAMA 287:2799-801. 2002..We assessed the extent to which reports of controlled trials published in the same 5 journals discussed new results in light of the totality of evidence from other controlled trials...
- Can you believe what you read in the papers?Mike Clarke
School of Nursing and Midwifery, Trinity College Dublin, Dublin 2, Ireland
Trials 10:55. 2009..It's not that you can't believe anything that you read in the papers, just that you cannot believe everything...
- Commentary: searching for trials for systematic reviews: what difference does it make?Mike Clarke
UK Cochrane Centre, NHS R and D Programme, Summertown Pavilion, Middle Way Oxford OX2 7LG, UK
Int J Epidemiol 31:123-4. 2002
- The 1944 patulin trial of the British Medical Research CouncilMike Clarke
The UK Cochrane Centre, NHS R and D Programme, Oxford OX2 7LG, UK
J R Soc Med 99:478-80. 2006
- Commentary: the 1944 patulin trial: the first properly controlled multicentre trial conducted under the aegis of the British Medical Research CouncilIain Chalmers
James Lind Library, James Lind Initiative, Summertown Pavilion, Middle Way, Oxford OX2 7LG, UK
Int J Epidemiol 33:253-60. 2004..This status is reflected in the International Journal of Epidemiology's reproduction of the full text of the trial report in this issue of the journal...
- The sensitivity and precision of search terms in Phases I, II and III of the Cochrane Highly Sensitive Search Strategy for identifying reports of randomized trials in medline in a specific area of health care--HIV/AIDS prevention and treatment interventioAnne Eisinga
UK Cochrane Centre, Summertown Pavilion, Middle Way, Oxford, UK
Health Info Libr J 24:103-9. 2007..To detect term(s) in the Cochrane Highly Sensitive Search Strategy (HSSS) that retain high sensitivity but improve precision in retrieving reports of trials in the PubMed version of medline...
- CONSORT for reporting randomized controlled trials in journal and conference abstracts: explanation and elaborationSally Hopewell
UK Cochrane Centre, Oxford, United Kingdom
PLoS Med 5:e20. 2008..Here, we extend the CONSORT (Consolidated Standards of Reporting Trials) Statement to develop a minimum list of essential items, which authors should consider when reporting the results of a RCT in any journal or conference abstract...
- CONSORT for reporting randomised trials in journal and conference abstractsSally Hopewell
UK Cochrane Centre, Summertown Pavilion, Oxford OX2 7LG, UK
Lancet 371:281-3. 2008
- Reporting of adverse events in systematic reviews can be improved: survey resultsSally Hopewell
UK Cochrane Centre, Oxford OX2 7LG, UK
J Clin Epidemiol 61:597-602. 2008..To assess how information about adverse events is included in systematic reviews...
- Reporting of trials presented in conference abstracts needs to be improvedSally Hopewell
UK Cochrane Centre, Summertown Pavilion, Middle Way, Oxford OX2 7LB, UK
J Clin Epidemiol 59:681-4. 2006..To assess how trial information reported in conference abstracts differs to their subsequent full publication...
- Randomised controlled trials in Africa of HIV and AIDS: descriptive study and spatial distributionNandi Siegfried
UK Cochrane Centre, Oxford OX2 7LG
BMJ 331:742. 2005..To identify and describe randomised controlled trials on HIV and AIDS conducted in Africa and to map their spatial distribution using exact geographic coordinates...
- Abstracts presented at the American Society of Clinical Oncology conference: how completely are trials reported?Sally Hopewell
UK Cochrane Centre, Oxford, UK
Clin Trials 2:265-8. 2005..To assess how completely trials published in conference proceedings are reported and whether this has changed over time...
- Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trialsM Clarke
Clinical Trial Service Unit, Oxford, UK
Lancet 366:2087-106. 2005....
- International activity in the Cochrane Collaboration with particular reference to IndiaClaire Allen
The Cochrane Collaboration Secretariat, Oxford, United Kingdom
Natl Med J India 20:250-5. 2007..The continued growth of contributors from India and South Asia will help ensure that decisions regarding healthcare in the region are informed by reliable and relevant evidence...
- How useful are Cochrane reviews in identifying research needs?Lorcan Clarke
UK Cochrane Centre, NHS R and D Programme, Oxford, UK
J Health Serv Res Policy 12:101-3. 2007..To determine the extent to which reports of Cochrane reviews recommend the need for further research and, if so, the extent to which they make suggestions regarding that research...
- Systematic reviews of surgical interventionsMartin Burton
Department of Otolaryngology Head and Neck Surgery, University of Oxford, The Radcliffe Infirmary, Oxford OX2 6HE, England, UK
Surg Clin North Am 86:101-14, ix. 2006..They should be a prerequisite of any new research, a key component in decision making, and an opportunity for all surgical practitioners to get involved in the conduct and interpretation of research...
- Number and size of randomized trials reported in general health care journals from 1948 to 1997Steve McDonald
UK Cochrane Centre, NHS Research and Development Programme, Oxford OX2 7LG, UK
Int J Epidemiol 31:125-7. 2002..Randomized trials are important for controlling selection biases, and where sufficient numbers of participants are involved, have the potential to yield reliable estimates of treatment effects...
- How many do I need? Basic principles of sample size estimationDeclan Devane
School of Nursing and Midwifery Studies, University of Dublin Trinity College, Dublin, Ireland
J Adv Nurs 47:297-302. 2004..Nevertheless, this aspect of research design often causes confusion for the novice researcher...
- How important is the size of a reprint order?Sally Hopewell
The UK Cochrane Centre, Middle Way, Oxford, UK
Int J Technol Assess Health Care 19:711-4. 2003..Further research is needed to explore other aspects of the relative importance and impact of high-reprint articles...
- A comparison of handsearching versus MEDLINE searching to identify reports of randomized controlled trialsS Hopewell
The U K Cochrane Centre, Oxford, UK
Stat Med 21:1625-34. 2002..The results of this study suggest that a combination of MEDLINE and handsearching is required to identify adequately reports of randomized trials...
- CNS-directed therapy for childhood acute lymphoblastic leukemia: Childhood ALL Collaborative Group overview of 43 randomized trialsM Clarke
Clinical Trial Service Unit, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
J Clin Oncol 21:1798-809. 2003..A collaborative meta-analysis was performed to clarify the relative effects on relapse and survival of different types of therapies directed at the CNS in childhood acute lymphoblastic leukemia...
- Discussion sections in reports of controlled trials published in general medical journals: islands in search of continents?M Clarke
Clinical Trial Service Unit, Oxford University, United Kingdom Cochrane Centre, England
JAMA 280:280-2. 1998..One of these recommendations is that the trial's results be discussed in light of the totality of the available evidence...
- 'Breaking up is hard to do': perspectives of general practitioners and patients towards removals from GP listsM Clarke
Department of Family Medicine and General Practice, Royal College of Surgeons in Ireland, Dublin, Ireland
Ir J Med Sci 176:221-4. 2007..The numbers of removals of patients from General Practitioner lists in Ireland is increasing and is a cause for some concern...
- Meta-analyses of adjuvant therapies for women with early breast cancer: the Early Breast Cancer Trialists' Collaborative Group overviewM Clarke
Clinical Trial Service Unit, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford, UK
Ann Oncol 17:x59-62. 2006
- DICE 2: a further investigation of the effects of chance in life, death and subgroup analysesM Clarke
Clinical Trial Service Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK
Int J Clin Pract 55:240-2. 2001..This should be borne in mind both by trialists when reporting their results and by readers and reviewers of those reports...
- Methodology of neuropsychological research in multicentre randomized clinical trials: a model derived from the International Subarachnoid Aneurysm TrialRichard B Scott
Russell Cairns Unit, The Radcliffe Infirmary, Oxford Radcliffe Hospitals NHS Trust, Oxford, Oxfordshire, UK
Clin Trials 1:31-9. 2004..Extrapolations from the observations and calculations reported here can be employed as an evidence base to inform the design of neuropsychological outcome studies in large multicentre trials...
- Can we systematically review studies that evaluate complex interventions?Sasha Shepperd
Department of Public Health, University of Oxford, Oxford, United Kingdom
PLoS Med 6:e1000086. 2009..This PLoS Medicine Debate considers the challenges facing systematic reviewers and suggests several ways of addressing them...
- How many Cochrane reviews are needed to cover existing evidence on the effects of health care interventions?Susan Mallett
UK Cochrane Centre, Oxford, England, UK
ACP J Club 139:A11. 2003
- International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and Andrew J Molyneux
Neurovascular Research Unit, Nuffield Department of Surgery, University of Oxford and Oxford Radcliffe Hospitals NHS Trust, Radcliffe Infirmary, Oxford, UK
Lancet 366:809-17. 2005..Here we present clinical outcomes 1 year after treatment...
- International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trialAndrew Molyneux
ISAT, Neurovascular Research Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK
Lancet 360:1267-74. 2002..We undertook a randomised, multicentre trial to compare the safety and efficacy of endovascular coiling with standard neurosurgical clipping for such aneurysms judged to be suitable for both treatments...
- A descriptive study of randomized trials of treatments for childhood acute lymphoblastic leukaemiaJulie A Burrett
Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford, UK
Br J Haematol 118:986-90. 2002..However trials remained relatively small, with more than half of all randomizations accruing less than 200 patients and only five having more than 1000. Most trials were published more than once...