Guy Thwaites

Summary

Country: UK

Publications

  1. ncbi request reprint The clinical benefit of adjunctive dexamethasone in tuberculous meningitis is not associated with measurable attenuation of peripheral or local immune responses
    Cameron P Simmons
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Immunol 175:579-90. 2005
  2. ncbi request reprint Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study
    Guy E Thwaites
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Lancet Neurol 6:230-6. 2007
  3. doi request reprint Clinical management of Staphylococcus aureus bacteraemia
    Guy E Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, London, UK
    Lancet Infect Dis 11:208-22. 2011
  4. pmc Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles
    Nitya Krishnan
    Centre for Molecular Microbiology and Infection, Imperial College London, London, United Kingdom
    PLoS ONE 6:e23870. 2011
  5. doi request reprint Tuberculous meningitis: more questions, still too few answers
    Guy E Thwaites
    Centre for Clinical Infection and Diagnostics Research, Guy s and St Thomas Hospital, London, UK Department of Infectious Diseases, King s College London, London, UK Electronic address
    Lancet Neurol 12:999-1010. 2013
  6. doi request reprint Advances in the diagnosis and treatment of tuberculous meningitis
    Guy E Thwaites
    Department of Infectious Diseases, Centre for Clinical Infection and Diagnostics Research, Guy s and St Thomas Hospitals NHS Foundation Trust, King s College London, London, UK
    Curr Opin Neurol 26:295-300. 2013
  7. pmc Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia (ARREST): study protocol for a randomised controlled trial
    Guy Thwaites
    Department of Infectious Diseases Centre for Clinical Infection and Diagnostics Research, Kings College London Guy s and St, Thomas Hospitals NHS Foundation Trust, London, England, United Kingdom
    Trials 13:241. 2012
  8. doi request reprint British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children
    Guy Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Road, South Kensington, London, UK
    J Infect 59:167-87. 2009
  9. doi request reprint Update on tuberculosis of the central nervous system: pathogenesis, diagnosis, and treatment
    Guy E Thwaites
    Department of Microbiology, Imperial College, South Kensington, London, SW7 2AZ UK
    Clin Chest Med 30:745-54, ix. 2009
  10. pmc The management of Staphylococcus aureus bacteremia in the United Kingdom and Vietnam: a multi-centre evaluation
    Guy E Thwaites
    Imperial College, London, United Kingdom
    PLoS ONE 5:e14170. 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint The clinical benefit of adjunctive dexamethasone in tuberculous meningitis is not associated with measurable attenuation of peripheral or local immune responses
    Cameron P Simmons
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Immunol 175:579-90. 2005
    ..These findings challenge previously held theories of corticosteroid action in this disease. An understanding of how dexamethasone acts in TBM may suggest novel and more effective treatment strategies...
  2. ncbi request reprint Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study
    Guy E Thwaites
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Lancet Neurol 6:230-6. 2007
    ..We aimed to determine the effect of dexamethasone on cerebral MRI changes and their association with intracerebral inflammatory responses and clinical outcome in adults treated for tuberculous meningitis...
  3. doi request reprint Clinical management of Staphylococcus aureus bacteraemia
    Guy E Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, London, UK
    Lancet Infect Dis 11:208-22. 2011
    ..We discuss the consequences on clinical practice, and how these findings define the agenda for future clinical research...
  4. pmc Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles
    Nitya Krishnan
    Centre for Molecular Microbiology and Infection, Imperial College London, London, United Kingdom
    PLoS ONE 6:e23870. 2011
    ..tuberculosis and host are determined by the lineage of the infecting strain; but we were unable to show these differences are driven by lineage-specific cell-surface expressed lipids...
  5. doi request reprint Tuberculous meningitis: more questions, still too few answers
    Guy E Thwaites
    Centre for Clinical Infection and Diagnostics Research, Guy s and St Thomas Hospital, London, UK Department of Infectious Diseases, King s College London, London, UK Electronic address
    Lancet Neurol 12:999-1010. 2013
    ..Many questions remain about the best approaches to prevent, diagnose, and treat tuberculous meningitis, and there are still too few answers. ..
  6. doi request reprint Advances in the diagnosis and treatment of tuberculous meningitis
    Guy E Thwaites
    Department of Infectious Diseases, Centre for Clinical Infection and Diagnostics Research, Guy s and St Thomas Hospitals NHS Foundation Trust, King s College London, London, UK
    Curr Opin Neurol 26:295-300. 2013
    ..This article reviews the advances towards better TBM diagnosis and treatments made over the last 2 years...
  7. pmc Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia (ARREST): study protocol for a randomised controlled trial
    Guy Thwaites
    Department of Infectious Diseases Centre for Clinical Infection and Diagnostics Research, Kings College London Guy s and St, Thomas Hospitals NHS Foundation Trust, London, England, United Kingdom
    Trials 13:241. 2012
    ..Our aim is to determine whether adjunctive rifampicin reduces all-cause mortality within 14 days and bacteriological failure or death within 12 weeks from randomisation...
  8. doi request reprint British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children
    Guy Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Road, South Kensington, London, UK
    J Infect 59:167-87. 2009
    ..The co-administration of anti-retroviral and anti-tuberculosis drugs should follow guidance issued by the British HIV association (www.bhiva.org)...
  9. doi request reprint Update on tuberculosis of the central nervous system: pathogenesis, diagnosis, and treatment
    Guy E Thwaites
    Department of Microbiology, Imperial College, South Kensington, London, SW7 2AZ UK
    Clin Chest Med 30:745-54, ix. 2009
    ..First, how does Mycobacterium tuberculosis reach the brain? Second, what is the best way of identifying patients who require early empiric antituberculosis therapy? Third, what is the best way of managing tuberculous hydrocephalus?..
  10. pmc The management of Staphylococcus aureus bacteremia in the United Kingdom and Vietnam: a multi-centre evaluation
    Guy E Thwaites
    Imperial College, London, United Kingdom
    PLoS ONE 5:e14170. 2010
    ..In this study we assessed the variation in management and adherence to treatment guidelines of S. aureus bacteremia...
  11. doi request reprint Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?
    Guy E Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Nat Rev Microbiol 9:215-22. 2011
    ..Furthermore, we suggest how this can be experimentally confirmed and how it may prompt a change in the current paradigm of S. aureus bacteraemia and identify better treatment options for improved clinical outcomes...
  12. pmc Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis
    Guy E Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Road, London, United Kingdom
    Antimicrob Agents Chemother 55:3244-53. 2011
    ..Fluoroquinolones add antituberculosis activity to the standard treatment regimen, but to improve outcomes of TBM, they must be started early, before the onset of coma...
  13. ncbi request reprint The influence of HIV infection on clinical presentation, response to treatment, and outcome in adults with Tuberculous meningitis
    Guy E Thwaites
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Infect Dis 192:2134-41. 2005
    ..Tuberculous meningitis occurs more commonly in human immunodeficiency virus (HIV)-infected individuals than in HIV-uninfected individuals, but whether HIV infection alters the presentation and outcome of tuberculous meningitis is unknown...
  14. ncbi request reprint Effect of antituberculosis drug resistance on response to treatment and outcome in adults with tuberculous meningitis
    Guy E Thwaites
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Infect Dis 192:79-88. 2005
    ..Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to 1 or more antituberculosis drugs is an increasingly common clinical problem, although the impact on outcome is uncertain...
  15. ncbi request reprint Tuberculous meningitis: many questions, too few answers
    Guy E Thwaites
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, UK
    Lancet Neurol 4:160-70. 2005
    ..There are many important unanswered questions about the pathophysiology, diagnosis, and treatment of TM. Here we review the available evidence to answer some of these questions, particularly those on the diagnosis and treatment of TM...
  16. ncbi request reprint Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults
    Guy E Thwaites
    Oxford University Clinical Research Unit at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 351:1741-51. 2004
    ....
  17. pmc Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis
    Guy Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Rd, South Kensington, London, United Kingdom
    J Clin Microbiol 46:1363-8. 2008
    ..In addition, increased drug resistance among bacteria of the East Asian/Beijing lineage might influence the response to treatment. This study suggests the genetic diversity of M. tuberculosis has important clinical consequences...
  18. pmc The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis
    Maxine Caws
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
    PLoS Pathog 4:e1000034. 2008
    ..The study provides evidence that M. tuberculosis genotype influences clinical disease phenotype and demonstrates, for the first time, a significant interaction between host and bacterial genotypes and the development of tuberculosis...
  19. ncbi request reprint Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis
    Thi Hoang Mai Nguyen
    Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 357:2431-40. 2007
    ..It is uncertain whether all adults with bacterial meningitis benefit from treatment with adjunctive dexamethasone...
  20. pmc Pathways of IL-1╬▓ secretion by macrophages infected with clinical Mycobacterium tuberculosis strains
    Nitya Krishnan
    MRC Centre for Molecular Bacteriology and Infection, Department of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Tuberculosis (Edinb) 93:538-47. 2013
    ..Taken together, these findings demonstrate that clinical strains of M. tuberculosis employ a unique caspase-1 independent pathway to stimulate IL-1β secretion from macrophages. ..
  21. pmc Beijing genotype of Mycobacterium tuberculosis is significantly associated with human immunodeficiency virus infection and multidrug resistance in cases of tuberculous meningitis
    Maxine Caws
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam
    J Clin Microbiol 44:3934-9. 2006
    ..001). The association of the Beijing genotype with drug resistance was independent of HIV status. This is the first report of Beijing genotype association with HIV status, which may be an association unique to tuberculous meningitis...
  22. doi request reprint The mechanisms and consequences of the extra-pulmonary dissemination of Mycobacterium tuberculosis
    Nitya Krishnan
    Centre for Molecular Microbiology and Infection, Division of Infectious Diseases, Faculty of Medicine, Imperial College, London SW7 2AZ, United Kingdom
    Tuberculosis (Edinb) 90:361-6. 2010
    ..Further understanding of the pathways, mechanisms and consequences of M. tuberculosis dissemination could have a major impact in designing novel vaccines and therapeutic strategies...
  23. pmc Comparison of conventional bacteriology with nucleic acid amplification (amplified mycobacterium direct test) for diagnosis of tuberculous meningitis before and after inception of antituberculosis chemotherapy
    Guy E Thwaites
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Clin Microbiol 42:996-1002. 2004
    ..However, the combination of these methods on serial samples detects more cases. Alternative tests are still urgently required...
  24. ncbi request reprint Pathophysiology and prognosis in vietnamese adults with tuberculous meningitis
    Guy E Thwaites
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Infect Dis 188:1105-15. 2003
    ..Death was associated with high initial CSF concentrations of lactate, low numbers of white blood cells, in particular neutrophils, and low CSF glucose levels...
  25. pmc Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations and clinical outcomes in tuberculous meningitis
    Justin A Green
    Department of Infectious Diseases and Immunity, Imperial College London, London, United Kingdom
    PLoS ONE 4:e7277. 2009
    ..Matrix metalloproteinases (MMPs) are important in the immunopathology of many inflammatory CNS diseases thus we hypothesized that that their secretion is important in TBM and might be influenced by dexamethasone...
  26. ncbi request reprint Pretreatment intracerebral and peripheral blood immune responses in Vietnamese adults with tuberculous meningitis: diagnostic value and relationship to disease severity and outcome
    Cameron P Simmons
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Immunol 176:2007-14. 2006
    ....
  27. pmc Improving the bacteriological diagnosis of tuberculous meningitis
    Guy E Thwaites
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Clin Microbiol 42:378-9. 2004
    ..Volume of cerebrospinal fluid, duration of symptoms, cerebrospinal fluid neutrophils, lactate, and glucose were all independently associated with bacteriological confirmation...
  28. pmc Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles
    Nguyen Thuy Thuong Thuong
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS Pathog 4:e1000229. 2008
    ....
  29. ncbi request reprint Validation of a diagnostic algorithm for adult tuberculous meningitis
    M Estee Torok
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    Am J Trop Med Hyg 77:555-9. 2007
    ..Validation in an HIV-endemic setting is required...
  30. ncbi request reprint A common human TLR1 polymorphism regulates the innate immune response to lipopeptides
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA, and Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Eur J Immunol 37:2280-9. 2007
    ....
  31. ncbi request reprint A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle WA 98195, USA
    J Infect Dis 194:1127-34. 2006
    ....
  32. ncbi request reprint Emerging trends in enteric fever in Nepal: 9124 cases confirmed by blood culture 1993-2003
    Ashish P Maskey
    Patan Hospital, GPO Box 252, Kathmandu, Nepal
    Trans R Soc Trop Med Hyg 102:91-5. 2008
    ..Salmonella paratyphi A contributes an increasingly large proportion of cases, and ciprofloxacin resistance is also emerging more rapidly in S. paratyphi A...
  33. ncbi request reprint Salmonella enterica serovar Paratyphi A and S. enterica serovar Typhi cause indistinguishable clinical syndromes in Kathmandu, Nepal
    Ashish P Maskey
    Patan Hospital, Lagankhel, Lalitpur, Bagmati, Kathmandu, Nepal
    Clin Infect Dis 42:1247-53. 2006
    ..enterica serovar Typhi. There are few data on which to base this assumption, little is known of the serovar's antibacterial susceptibilities, and there is no readily available tolerable vaccination...