X Lu

Summary

Affiliation: Thrombosis Research Institute
Country: UK

Publications

  1. ncbi Arg-Tyr-Asp (RYD) and Arg-Cys-Asp (RCD) motifs in dendroaspin promote selective inhibition of beta1 and beta3 integrins
    B Wattam
    Thrombosis Research Institute, Manresa Road, London SW3 6LR, UK
    Biochem J 356:11-7. 2001
  2. ncbi Can neutrophils be manipulated in vivo?
    M D Morgan
    Renal Immunobiology, Division of Immunity and Infection, The School of Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Rheumatology (Oxford) 44:597-601. 2005
  3. ncbi Snake venom metalloproteinase containing a disintegrin-like domain, its structure-activity relationships at interacting with integrins
    X Lu
    Thrombosis Research Institute, London, UK
    Curr Med Chem Cardiovasc Hematol Agents 3:249-60. 2005
  4. ncbi Inhibition of DLX4 promotes apoptosis in choriocarcinoma cell lines
    Y Sun
    Hospital of Obstetrics and Gynecology, Fudan University, 419 Fangxie Road, Shanghai 200011, China
    Placenta 27:375-83. 2006
  5. ncbi The effect of the single substitution of arginine within the RGD tripeptide motif of a modified neurotoxin dendroaspin on its activity of platelet aggregation and cell adhesion
    Xinjie Lu
    Thrombosis Research Institute, London, UK
    Cell Commun Adhes 13:171-83. 2006
  6. ncbi ADAM-15 disintegrin-like domain structure and function
    Dong Lu
    Thrombosis Research Institute, Manresa Road, London, SW3 6LR, UK
    Toxins (Basel) 2:2411-27. 2010
  7. ncbi Impact of multiple antigenic epitopes from ApoB100, hHSP60 and Chlamydophila pneumoniae on atherosclerotic lesion development in Apob(tm2Sgy)Ldlr(tm1Her)J mice
    Xinjie Lu
    The Mary and Garry Weston Molecular Immunology Laboratory, Thrombosis Research Institute, London, United Kingdom
    Atherosclerosis 225:56-68. 2012
  8. ncbi Immunization with a combination of 2 peptides derived from the C5a receptor significantly reduces early atherosclerotic lesion in Ldlr(tm1Her) Apob(tm2Sgy) J mice
    Xinjie Lu
    Thrombosis Research Institute, Emmanuel Kaye Bldg, Manresa Rd, London SW3 6LR, UK
    Arterioscler Thromb Vasc Biol 32:2358-71. 2012
  9. ncbi Integrins in drug targeting-RGD templates in toxins
    X Lu
    Thrombosis Research Institute, Manresa Road, London, SW3 6LR UK
    Curr Pharm Des 12:2749-69. 2006
  10. ncbi Structure-activity relationship studies on ADAM protein-integrin interactions
    X Lu
    Thrombosis Research Institute, Manresa Road, London, SW3 6LR, UK
    Cardiovasc Hematol Agents Med Chem 5:29-42. 2007

Collaborators

  • V V Kakkar
  • Ildiko Faludi
  • Andrea Szabo
  • S Mittnacht
  • S Rahman
  • Y Sun
  • T Bartfai
  • Yuguang Wang
  • Gang Cheng
  • W C Shakespeare
  • S Tao
  • Tomi K Sawyer
  • Ying E Zhang
  • Lili Wang
  • Dong Lu
  • A K Dillon
  • H Badie-Mahdavi
  • M D Morgan
  • J K Hsieh
  • J Rutherford
  • B Wattam
  • P B Stathopulos
  • B Wlodarczyk
  • N Kawahata
  • Y Samuels-Lev
  • O T Fackler
  • Mike Scully
  • S Zhong
  • D J O'Connor
  • K Barnouin
  • M Tessier-Lavigne
  • Z Kaprielian
  • A R Jevince
  • S L Ackerman
  • L Hinck
  • J Williams
  • L Harper
  • M M Behrens
  • G Nash
  • C O S Savage
  • C E Hörnquist
  • D M Barnes
  • R S Camplejohn
  • P M Duddy
  • P Chumas
  • G R Taylor
  • L Howard
  • R S Charlton
  • C E Chu
  • S Egglezou
  • M Scully
  • J A Scott
  • D Johnson
  • D C Dalgarno
  • M G Yang
  • T Merry
  • D Bergamaschi
  • G P Luke
  • S Violette
  • R Sundaramoorthi
  • R H Finnell
  • G Trigiante
  • J Smith
  • M Hatada
  • Q Feng
  • J Gelineau-van Waes
  • J R Hammond
  • T Crook
  • W Guan
  • J Shen
  • D Shang
  • I Campargue
  • O Spiegelstein
  • L Naumovski
  • C J Eyermann
  • C Bartlett
  • R S Bohacek
  • C X Le
  • D G McCormack
  • R L Vorce
  • J M Arnold
  • B Jiang
  • M Geyer
  • A S Alberts
  • J A Frost
  • B M Peterlin
  • A Abo
  • W Luo
  • M Q Du
  • F S Chan

Detail Information

Publications36

  1. ncbi Arg-Tyr-Asp (RYD) and Arg-Cys-Asp (RCD) motifs in dendroaspin promote selective inhibition of beta1 and beta3 integrins
    B Wattam
    Thrombosis Research Institute, Manresa Road, London SW3 6LR, UK
    Biochem J 356:11-7. 2001
    ..2-6-fold less potent compared with either RGD or RYD. These findings show that the selectivity of dendroaspin binding to beta(1) and beta(3) integrins can be modulated by the introduction of alternative cell recognition sequences...
  2. ncbi Can neutrophils be manipulated in vivo?
    M D Morgan
    Renal Immunobiology, Division of Immunity and Infection, The School of Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Rheumatology (Oxford) 44:597-601. 2005
  3. ncbi Snake venom metalloproteinase containing a disintegrin-like domain, its structure-activity relationships at interacting with integrins
    X Lu
    Thrombosis Research Institute, London, UK
    Curr Med Chem Cardiovasc Hematol Agents 3:249-60. 2005
    ..The review is intended to provide insights in which may assist the development of new therapeutic approaches...
  4. ncbi Inhibition of DLX4 promotes apoptosis in choriocarcinoma cell lines
    Y Sun
    Hospital of Obstetrics and Gynecology, Fudan University, 419 Fangxie Road, Shanghai 200011, China
    Placenta 27:375-83. 2006
    ..In conclusion, this study suggests that DLX4 may be involved in the survival of human choriocarcinoma cells, which may be mediated by the inhibition of apoptosis. The detailed mechanism needs further investigation...
  5. ncbi The effect of the single substitution of arginine within the RGD tripeptide motif of a modified neurotoxin dendroaspin on its activity of platelet aggregation and cell adhesion
    Xinjie Lu
    Thrombosis Research Institute, London, UK
    Cell Commun Adhes 13:171-83. 2006
    ..These findings show that the presence of the arginine within the RGD motif of dendroaspin is not obligatory and substitution of this residue can modulate inhibitory potency and integrin binding selectivity...
  6. ncbi ADAM-15 disintegrin-like domain structure and function
    Dong Lu
    Thrombosis Research Institute, Manresa Road, London, SW3 6LR, UK
    Toxins (Basel) 2:2411-27. 2010
    ..This manuscript will present a review of the RGD-containing disintegrin-like domain structures and the structural features responsible for their activity as antagonists of integrin function in relation to the canonical RGD template...
  7. ncbi Impact of multiple antigenic epitopes from ApoB100, hHSP60 and Chlamydophila pneumoniae on atherosclerotic lesion development in Apob(tm2Sgy)Ldlr(tm1Her)J mice
    Xinjie Lu
    The Mary and Garry Weston Molecular Immunology Laboratory, Thrombosis Research Institute, London, United Kingdom
    Atherosclerosis 225:56-68. 2012
    ..To assess whether immunizing Apob(tm2Sgy)Ldlr(tm1Her)J mice simultaneously with different atherosclerosis-related epitopes engineered in a single recombinant protein is effective in reducing atherosclerotic lesions...
  8. ncbi Immunization with a combination of 2 peptides derived from the C5a receptor significantly reduces early atherosclerotic lesion in Ldlr(tm1Her) Apob(tm2Sgy) J mice
    Xinjie Lu
    Thrombosis Research Institute, Emmanuel Kaye Bldg, Manresa Rd, London SW3 6LR, UK
    Arterioscler Thromb Vasc Biol 32:2358-71. 2012
    ....
  9. ncbi Integrins in drug targeting-RGD templates in toxins
    X Lu
    Thrombosis Research Institute, Manresa Road, London, SW3 6LR UK
    Curr Pharm Des 12:2749-69. 2006
    ..The use of integrins in drug targeting and integrins as targets for drug delivery by using the RGD as a template structure will also be discussed...
  10. ncbi Structure-activity relationship studies on ADAM protein-integrin interactions
    X Lu
    Thrombosis Research Institute, Manresa Road, London, SW3 6LR, UK
    Cardiovasc Hematol Agents Med Chem 5:29-42. 2007
    ..Lastly, it describes progress in understanding the structural features and functional roles of the ADAMs in normal and pathological conditions and how this insight may assist the development of new therapeutic approaches...
  11. ncbi The role of integrin-mediated cell adhesion in atherosclerosis: pathophysiology and clinical opportunities
    X Lu
    Thrombosis Research Institute, Manresa Road, London, SW3 6LR, UK
    Curr Pharm Des 14:2140-58. 2008
    ..It discusses the properties of the integrin-based chemotherapeutic agents currently under consideration clinically and endeavours to provide insights into development of cardiovascular drugs using integrins as targets...
  12. ncbi ADAM proteins - therapeutic potential in cancer
    Xinjie Lu
    Thrombosis Research Institute, London, UK
    Curr Cancer Drug Targets 8:720-32. 2008
    ..It is the intention of the review to provide insights which may assist in the development of ADAM-based approaches for the treatment of human cancers...
  13. ncbi Modulation of integrin-binding selectivity by mutation within the RGD-loop of snake venom proteins: a novel drug development approach
    X Lu
    Thrombosis Research Institute, Manresa Road, London, SW3 6LR UK
    Curr Med Chem Cardiovasc Hematol Agents 1:189-96. 2003
    ..The review is intended to provide insight into the development of novel inhibitors as drugs...
  14. ncbi Evaluation of the role of proline residues flanking the RGD motif of dendroaspin, an inhibitior of platelet aggregation and cell adhesion
    X Lu
    Thrombosis Research Institute, Manresa Road, London, SW3 6LR, UK
    Biochem J 355:633-8. 2001
    ..g. disintegrins, may contribute to maintaining a favourable conformation for the solvent-exposed RGD site for its recognition by integrin receptors...
  15. ncbi The role of heat shock protein (HSP) in atherosclerosis: Pathophysiology and clinical opportunities
    X Lu
    Thrombosis Research Institute, London, UK
    Curr Med Chem 17:957-73. 2010
    ..The role of these HSPs, their protective vs. immunogenic properties with special emphasis on their potential as targets to develop therapeutic agent against atherosclerosis will be discussed...
  16. ncbi Immunization with a combination of ApoB and HSP60 epitopes significantly reduces early atherosclerotic lesion in Apobtm2SgyLdlrtm1Her/J mice
    Xinjie Lu
    Thrombosis Research Institute, London, United Kingdom
    Atherosclerosis 212:472-80. 2010
    ....
  17. ncbi The role of T-helper cells in atherosclerosis
    X Lu
    Thrombosis Research Institute, Manresa Road, London, SW3 6LR UK
    Cardiovasc Hematol Agents Med Chem 9:25-41. 2011
    ..We further examine the diverse roles of T helper cells for regulating the progression of atherosclerosis...
  18. ncbi Antiproliferative function of p27kip1 is frequently inhibited in highly malignant Burkitt's lymphoma cells
    K Barnouin
    Ludwig Institute for Cancer Research, Imperial College School of Medicine at St Mary s, London, UK
    Oncogene 18:6388-97. 1999
    ..They also suggest a novel role for the overexpression of D-type cyclins as one pathway allowing tumour cells to overcome the antiproliferative function of p27kip1...
  19. ncbi RB regulates the stability and the apoptotic function of p53 via MDM2
    J K Hsieh
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, London, United Kingdom
    Mol Cell 3:181-93. 1999
    ..However, an RB-MDM2-p53 trimeric complex is active in p53-mediated transrepression. These data link directly the function of two tumor suppressor proteins and demonstrate a novel role of RB in regulating the apoptotic function of p53...
  20. ncbi Regulation of Hsp70 function by a eukaryotic DnaJ homolog
    D M Cyr
    Department of Biochemistry and Biophysics, University of North Carolina Medical School, Chapel Hill 27599 7260
    J Biol Chem 267:20927-31. 1992
    ..Thus, Hsp70SSA1 and YDJ1p interact functionally in the execution of Hsp70SSA1 chaperone activities in the eukaryotic cell...
  21. ncbi Thyrotropin-releasing hormone receptors -- similarities and differences
    Y Sun
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892-1818, USA
    J Mol Endocrinol 30:87-97. 2003
    ..These differences in signaling and internalization properties are probably important in the distinct parts that TRH-R1 and TRH-R2 may play in mammalian physiology...
  22. ncbi Identification of two N-terminal non-alpha-helical domain motifs important in the assembly of glial fibrillary acidic protein
    J E Ralton
    Department of Biochemistry, The University, Dundee, UK
    J Cell Sci 107:1935-48. 1994
    ..Like GFAP, these include phosphorylation and proteolysis sites and are adjacent to the start of the central alpha-helical rod domain, suggesting that this motif of general importance to type III intermediate filament protein assembly...
  23. ncbi Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types
    L Howard
    Medical Research Council Toxicology Unit, University of Leicester, U K
    Biochem J 317:45-50. 1996
    ..MADM appears to be a rather distantly related member of the reprolysin protein family, which includes both the snake venom disintegrin-metalloproteases and a number of predicted cell-surface disintegrin-containing mammalian proteins...
  24. ncbi G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines
    C E Hörnquist
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 158:1068-77. 1997
    ..This was shown by ELISPOT analysis to result from local production within the lamina propria...
  25. ncbi p21-activated kinase 1 plays a critical role in cellular activation by Nef
    O T Fackler
    Howard Hughes Medical Institute, Departments of Medicine, Microbiology, and Immunology, San Francisco, California 94143 0703, USA
    Mol Cell Biol 20:2619-27. 2000
    ..These results identify NAK as PAK1 and emphasize the central role its kinase activity plays in cytoskeletal rearrangements and cellular signaling by Nef...
  26. ncbi Increased L-arginine uptake and inducible nitric oxide synthase activity in aortas of rats with heart failure
    P B Stathopulos
    Cardiology Research Laboratory, Departments of Medicine, Pharmacology, and Toxicology, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada N6A 4G5
    Am J Physiol Heart Circ Physiol 280:H859-67. 2001
    ..05). Our data demonstrate that NO production is dependent on iNOS activity and L-arginine uptake and suggest that L-arginine transport plays an important role in enhanced NO production in heart failure...
  27. ncbi A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain
    N Kawahata
    ARIAD Pharmaceuticals, Inc, Cambridge, MA 02139-4234, USA
    Bioorg Med Chem Lett 11:2319-23. 2001
    ..A 2.2 A X-ray crystal structure of 1a bound to a mutant form of Lck SH2 domain provides insight regarding the structure-activity relationships and supports the design concept of this new pTyr mimetic...
  28. ncbi A comparison of the fragment constant and molecular connectivity indices models for normalized sorption coefficient estimation
    S Tao
    Department of Urban and Environmental Sciences, Peiking University, Beijing, PR China
    Water Environ Res 73:307-13. 2001
    ....
  29. ncbi UNC5C is required for spinal accessory motor neuron development
    A K Dillon
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Cell Neurosci 35:482-9. 2007
    ..These results support an important role for UNC5C in SACMN development...
  30. ncbi Relationship between endothelial dysfunction, oxidant stress and aspirin resistance in patients with stable coronary heart disease
    G Cheng
    Department of Cardiology, The Second Affiliated Hospital, Zhejiang University, Medical School, Hangzhou Zhejiang, China
    J Clin Pharm Ther 32:287-92. 2007
    ..Additionally, aspirin resistance occurs in some individuals, but the mechanism for aspirin resistance is still unknown. The aim of the present study was to examine the role of endothelial dysfunction in aspirin resistance...
  31. ncbi ASPP proteins specifically stimulate the apoptotic function of p53
    Y Samuels-Lev
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, United Kingdom
    Mol Cell 8:781-94. 2001
    ..The expression of ASPP is frequently downregulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP regulate the tumor suppression function of p53 in vivo...
  32. ncbi Identification of the critical role of Tyr-194 in the catalytic activity of a novel N-acyl-homoserine lactonase from marine Bacillus cereus strain Y2
    X Lu
    Department of Biochemistry, College of Life Science, SunYat-sen University, Guangzhou, 510275, China
    Curr Microbiol 53:346-50. 2006
    ..These results suggested that the conserved residue Tyr-194 is critical for catalytic function of the novel AHL-lactonase...
  33. ncbi Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice
    B Wlodarczyk
    Center for Human Molecular Genetics, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Toxicol Appl Pharmacol 177:238-46. 2001
    ....
  34. ncbi Localization, genomic organization, and alternative transcription of a novel human SAM-dependent methyltransferase gene on chromosome 2p22-->p21
    Y Zhang
    Center for Craniofacial and Dental Genetics, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA 15261, USA
    Cytogenet Cell Genet 95:146-52. 2001
    ..Sequence analyses of C2orf8 excluded coding region mutations as causative of GINGF...
  35. ncbi Investigations on a clinically and functionally unusual and novel germline p53 mutation
    J Rutherford
    Richard Dimbleby Department Cancer Research, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London SE1 7EH, UK
    Br J Cancer 86:1592-6. 2002
    ..However, surprisingly, data from irradiated peripheral blood lymphocytes and transfected Saos-2 cells, suggested that this truncated, mutant protein retains significant ability to induce apoptosis...
  36. ncbi Role of galanin receptor 1 and galanin receptor 2 activation in synaptic plasticity associated with 3',5'-cyclic AMP response element-binding protein phosphorylation in the dentate gyrus: studies with a galanin receptor 2 agonist and galanin receptor 1 kn
    H Badie-Mahdavi
    The Scripps Research Institute, Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, La Jolla, CA 92037, USA
    Neuroscience 133:591-604. 2005
    ....