Jonathan D G Jones

Summary

Affiliation: The Sainsbury Laboratory
Country: UK

Publications

  1. pmc Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens
    Paul R Muskett
    The Sainsbury Laboratory, John Innes Centre, Colney, Norwich NR4 7UH, United Kingdom
    Plant Cell 14:979-92. 2002
  2. ncbi request reprint The plant immune system
    Jonathan D G Jones
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Nature 444:323-9. 2006
  3. doi request reprint Why genetically modified crops?
    Jonathan D G Jones
    The Sainsury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK
    Philos Trans A Math Phys Eng Sci 369:1807-16. 2011
  4. pmc A downy mildew effector attenuates salicylic Acid-triggered immunity in Arabidopsis by interacting with the host mediator complex
    Marie Cécile Caillaud
    The Sainsbury Laboratory, John Innes Centre, Norwich, United Kingdom
    PLoS Biol 11:e1001732. 2013
  5. pmc EXPRSS: an Illumina based high-throughput expression-profiling method to reveal transcriptional dynamics
    Ghanasyam Rallapalli
    The Sainsbury Laboratory, Norwich Research Park, Colney, Norwich, UK NR4 7UH
    BMC Genomics 15:341. 2014
  6. pmc Gene gain and loss during evolution of obligate parasitism in the white rust pathogen of Arabidopsis thaliana
    Eric Kemen
    The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom
    PLoS Biol 9:e1001094. 2011
  7. pmc The F-box protein ACRE189/ACIF1 regulates cell death and defense responses activated during pathogen recognition in tobacco and tomato
    Harrold A van den Burg
    Sainsbury Laboratory, John Ines Centre, Norwich NR4 7UH, United Kingdom
    Plant Cell 20:697-719. 2008
  8. ncbi request reprint Characterization of Arabidopsis mur3 mutations that result in constitutive activation of defence in petioles, but not leaves
    Jennifer D Tedman-Jones
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich, Norfolk NR47UH, UK
    Plant J 56:691-703. 2008
  9. pmc CITRX thioredoxin interacts with the tomato Cf-9 resistance protein and negatively regulates defence
    Susana Rivas
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Norwich, UK
    EMBO J 23:2156-65. 2004
  10. doi request reprint In planta effector competition assays detect Hyaloperonospora arabidopsidis effectors that contribute to virulence and localize to different plant subcellular compartments
    Jorge Luis Badel
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK
    Mol Plant Microbe Interact 26:745-57. 2013

Collaborators

Detail Information

Publications86

  1. pmc Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens
    Paul R Muskett
    The Sainsbury Laboratory, John Innes Centre, Colney, Norwich NR4 7UH, United Kingdom
    Plant Cell 14:979-92. 2002
    ..An absence of obvious developmental defects in null Arabidopsis rar1 mutants favors the notion that, in contrast, RAR1 does not play a fundamental role in plant development...
  2. ncbi request reprint The plant immune system
    Jonathan D G Jones
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Nature 444:323-9. 2006
    ..A detailed understanding of plant immune function will underpin crop improvement for food, fibre and biofuels production...
  3. doi request reprint Why genetically modified crops?
    Jonathan D G Jones
    The Sainsury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK
    Philos Trans A Math Phys Eng Sci 369:1807-16. 2011
    ..It would be perverse to spurn this approach at a time when we need every tool in the toolbox to ensure adequate food production in the short, medium and long term...
  4. pmc A downy mildew effector attenuates salicylic Acid-triggered immunity in Arabidopsis by interacting with the host mediator complex
    Marie Cécile Caillaud
    The Sainsbury Laboratory, John Innes Centre, Norwich, United Kingdom
    PLoS Biol 11:e1001732. 2013
    ....
  5. pmc EXPRSS: an Illumina based high-throughput expression-profiling method to reveal transcriptional dynamics
    Ghanasyam Rallapalli
    The Sainsbury Laboratory, Norwich Research Park, Colney, Norwich, UK NR4 7UH
    BMC Genomics 15:341. 2014
    ..Most existing Tag-seq methods either have biases or not high throughput due to use of restriction enzymes or enzymatic manipulation of 5' ends of mRNA or use of RNA ligations...
  6. pmc Gene gain and loss during evolution of obligate parasitism in the white rust pathogen of Arabidopsis thaliana
    Eric Kemen
    The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom
    PLoS Biol 9:e1001094. 2011
    ..These mechanisms are not only relevant to plant pathogenic oomycetes but also to human pathogens within the Chromalveolata...
  7. pmc The F-box protein ACRE189/ACIF1 regulates cell death and defense responses activated during pathogen recognition in tobacco and tomato
    Harrold A van den Burg
    Sainsbury Laboratory, John Ines Centre, Norwich NR4 7UH, United Kingdom
    Plant Cell 20:697-719. 2008
    ..Together, these findings support a role of ACIF1/VFBs in plant defense responses...
  8. ncbi request reprint Characterization of Arabidopsis mur3 mutations that result in constitutive activation of defence in petioles, but not leaves
    Jennifer D Tedman-Jones
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich, Norfolk NR47UH, UK
    Plant J 56:691-703. 2008
    ..We propose that perturbed cell wall biosynthesis may activate plant defence and provide a rationale for the cie1 and the mur3 knockout phenotypes...
  9. pmc CITRX thioredoxin interacts with the tomato Cf-9 resistance protein and negatively regulates defence
    Susana Rivas
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Norwich, UK
    EMBO J 23:2156-65. 2004
    ..Recognition of the Cf-9 C-terminus by CITRX is necessary and sufficient for this negative regulation. This is the first study that implicates thioredoxin activity in the regulation of plant disease resistance...
  10. doi request reprint In planta effector competition assays detect Hyaloperonospora arabidopsidis effectors that contribute to virulence and localize to different plant subcellular compartments
    Jorge Luis Badel
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK
    Mol Plant Microbe Interact 26:745-57. 2013
    ....
  11. ncbi request reprint Gene shuffling-generated and natural variants of the tomato resistance gene Cf-9 exhibit different auto-necrosis-inducing activities in Nicotiana species
    Brande B H Wulff
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney Lane, Norwich NR4 7UH, UK
    Plant J 40:942-56. 2004
    ....
  12. pmc The downy mildew effector proteins ATR1 and ATR13 promote disease susceptibility in Arabidopsis thaliana
    Kee Hoon Sohn
    Sainsbury Laboratory, John Ines Centre, Norwich NR4 7UH, United Kingdom
    Plant Cell 19:4077-90. 2007
    ..parasitica isolate Emco5, ATR13Emco5 when delivered by Pst DC3000 triggered localized immunity, including HR, on Ws-0. We suggest that an additional H. parasitica Emco5 effector might suppress ATR13-triggered immunity...
  13. ncbi request reprint Subcellular localization of the Hpa RxLR effector repertoire identifies a tonoplast-associated protein HaRxL17 that confers enhanced plant susceptibility
    Marie Cécile Caillaud
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Plant J 69:252-65. 2012
    ..The roles of subcellular changes and effector localization, with specific reference to the potential role of HaRxL17 in plant cell membrane trafficking, are discussed with respect to Hpa virulence...
  14. ncbi request reprint Expression of RPS4 in tobacco induces an AvrRps4-independent HR that requires EDS1, SGT1 and HSP90
    Yan Zhang
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich, NR4 7UH, UK
    Plant J 40:213-24. 2004
    ..All these data suggest that heterologous expression of an R gene can result in activation of cell death even in the absence of its cognate avirulence product, and provides a system for studying the RPS4 domains required for HR...
  15. doi request reprint The major specificity-determining amino acids of the tomato Cf-9 disease resistance protein are at hypervariable solvent-exposed positions in the central leucine-rich repeats
    Brande B H Wulff
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney Lane, Norwich NR4 7UH, UK
    Mol Plant Microbe Interact 22:1203-13. 2009
    ..Interestingly, there is an overlap between the Cf-4 and Cf-9 specificity-determining residues, precluding a protein with dual specificity...
  16. ncbi request reprint An approximately 400 kDa membrane-associated complex that contains one molecule of the resistance protein Cf-4
    Susana Rivas
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, UK
    Plant J 29:783-96. 2002
    ..However, extensive characterization of the Cf-4 complex revealed essentially identical characteristics to the Cf-9 complex and significant differences from the CLV2 complex...
  17. pmc Functional analysis of Avr9/Cf-9 rapidly elicited genes identifies a protein kinase, ACIK1, that is essential for full Cf-9-dependent disease resistance in tomato
    Owen Rowland
    Sainsbury Laboratory, John Ines Centre, Norwich NR4 7UH, United Kingdom
    Plant Cell 17:295-310. 2005
    ..Moreover, VIGS of LeACIK1 in tomato decreased Cf-9-mediated resistance to C. fulvum, showing the importance of ACIK1 in disease resistance...
  18. doi request reprint The microRNA miR393 re-directs secondary metabolite biosynthesis away from camalexin and towards glucosinolates
    Alexandre Robert-Seilaniantz
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich, UK
    Plant J 67:218-31. 2011
    ..We propose that miR393 levels can fine-tune plant defences and prioritize resources...
  19. ncbi request reprint CITRX thioredoxin is a putative adaptor protein connecting Cf-9 and the ACIK1 protein kinase during the Cf-9/Avr9- induced defence response
    Vladimir Nekrasov
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    FEBS Lett 580:4236-41. 2006
    ..Interestingly, the catalytic activities of both CITRX and ACIK1 are not required for their interaction...
  20. ncbi request reprint Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance
    Henrietta C E Rooney
    Sainsbury Laboratory, John Innes Centre, Norwich NR4 7UH, UK
    Science 308:1783-6. 2005
    ..We show here that Avr2 binds and inhibits Rcr3 and propose that the Rcr3-Avr2 complex enables the Cf-2 protein to activate an HR...
  21. doi request reprint Rpi-vnt1.1, a Tm-2(2) homolog from Solanum venturii, confers resistance to potato late blight
    Simon J Foster
    The Sainsbury Laboratory, John Innes Centre, Norwich, UK
    Mol Plant Microbe Interact 22:589-600. 2009
    ..1, suggesting either that this strong resistance gene has been maintained since a common ancestor, due to selection pressure for blight resistance, or that genetic exchange between S. venturii and S. phureja has occurred at some time...
  22. pmc Specific ER quality control components required for biogenesis of the plant innate immune receptor EFR
    Jing Li
    The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 106:15973-8. 2009
    ..These data reveal a previously unsuspected role of a specific subset of ER-QC machinery components for PRR accumulation in plant innate immunity...
  23. ncbi request reprint A plant miRNA contributes to antibacterial resistance by repressing auxin signaling
    Lionel Navarro
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Science 312:436-9. 2006
    ..Repression of auxin signaling restricts P. syringae growth, implicating auxin in disease susceptibility and miRNA-mediated suppression of auxin signaling in resistance...
  24. doi request reprint The Pseudomonas syringae effector protein, AvrRPS4, requires in planta processing and the KRVY domain to function
    Kee Hoon Sohn
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich, UK
    Plant J 57:1079-91. 2009
    ..XopO is also processed into a smaller form in N. benthamiana, similar to AvrRPS4, suggesting that a common mechanism is involved in activation of the virulence activities of both AvrRPS4 and XopO...
  25. ncbi request reprint Regulatory role of SGT1 in early R gene-mediated plant defenses
    Mark J Austin
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Science 295:2077-80. 2002
    ..Moreover, SGT1b and RAR1 contribute additively to RPP5-mediated pathogen recognition. These data imply both operationally distinct and cooperative functions of SGT1 and RAR1 in plant disease resistance...
  26. doi request reprint The TIR domain of TIR-NB-LRR resistance proteins is a signaling domain involved in cell death induction
    Michal R Swiderski
    Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Norwich, UK
    Mol Plant Microbe Interact 22:157-65. 2009
    ..This is consistent with previous observations that the TIR domain itself is insufficient to induce cell death upon transient expression...
  27. pmc The U-box protein CMPG1 is required for efficient activation of defense mechanisms triggered by multiple resistance genes in tobacco and tomato
    Rocio Gonzalez-Lamothe
    Sainsbury Laboratory, John Ines Centre, Norwich NR4 7UH, UK
    Plant Cell 18:1067-83. 2006
    ..We also show that Nt CMPG1 is involved in the Pto/AvrPto and Inf1 responses. In summary, we show that the E3 ligase Nt CMPG1 is essential for plant defense and disease resistance...
  28. ncbi request reprint A tomato cysteine protease required for Cf-2-dependent disease resistance and suppression of autonecrosis
    Julia Krüger
    The Sainsbury Laboratory, John Innes Centre, Norwich NR4 7UH, UK
    Science 296:744-7. 2002
    ..esculentum allele, ne (necrosis). Rcr3 alleles from these two species encode proteins that differ by only seven amino acids. Possible roles of Rcr3 in Cf-2-dependent defense and autonecrosis are discussed...
  29. ncbi request reprint Induction of phenotypic variation by activation of genes harbouring a maize Spm element in their promoter regions using a TnpA-VP16 fusion protein
    Alexander P Sorokin
    Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, UK
    Plant J 53:587-94. 2008
    ..It also provides a proof-of-principle demonstration that the method could be used to generate new variation in elite lines of maize...
  30. pmc Multiple avirulence paralogues in cereal powdery mildew fungi may contribute to parasite fitness and defeat of plant resistance
    Christopher J Ridout
    Department of Disease and Stress Biology, John Ines Centre, Colney, Norwich, NR4 7UH, United Kingdom
    Plant Cell 18:2402-14. 2006
    ..Multiple copies of related but distinct AVR effector paralogues might enable populations of Bgh to rapidly overcome host R genes while maintaining virulence...
  31. pmc Multiple candidate effectors from the oomycete pathogen Hyaloperonospora arabidopsidis suppress host plant immunity
    Georgina Fabro
    The Sainsbury Laboratory, John Innes Centre, Norwich, United Kingdom
    PLoS Pathog 7:e1002348. 2011
    ....
  32. pmc Distinct regions of the Pseudomonas syringae coiled-coil effector AvrRps4 are required for activation of immunity
    Kee Hoon Sohn
    The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 109:16371-6. 2012
    ..The structure of AvrRps4(C), and identification of functionally important residues for its activation of plant immunity, advances our understanding of these processes in a well-defined model pathosystem...
  33. pmc Control of the pattern-recognition receptor EFR by an ER protein complex in plant immunity
    Vladimir Nekrasov
    The Sainsbury Laboratory, Norwich Research Park, Norwich, UK
    EMBO J 28:3428-38. 2009
    ..They also provide an unexpected differential requirement for ER-QC and N-glycosylation components by two closely related receptors...
  34. doi request reprint DELLAs control plant immune responses by modulating the balance of jasmonic acid and salicylic acid signaling
    Lionel Navarro
    The Sainsbury Laboratory, John Innes Centre, Norwich, UK
    Curr Biol 18:650-5. 2008
    ..These findings suggest an explanation for why the necrotrophic fungus Gibberella fujikuroi, causal agent of the foolish-seedling disease of rice, makes gibberellin...
  35. ncbi request reprint p-Coumaroylnoradrenaline, a novel plant metabolite implicated in tomato defense against pathogens
    Edda von Roepenack-Lahaye
    Sainsbury Laboratory, Norwich Research Park, Colney Lane, Norwich, NR4 7UH, United Kingdom
    J Biol Chem 278:43373-83. 2003
    ..The fourth cDNA, tomTHT1-4, directed synthesis of a truncated enzymatically inactive protein due to the presence of a premature stop codon...
  36. doi request reprint HopAS1 recognition significantly contributes to Arabidopsis nonhost resistance to Pseudomonas syringae pathogens
    Kee Hoon Sohn
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    New Phytol 193:58-66. 2012
    ..syringae strains that are pathogenic in Arabidopsis carry truncated hopAS1 variants of forms, demonstrating that HopAS1-triggered immunity plays an important role in Arabidopsis NHR to a broad-range of P. syringae strains...
  37. doi request reprint Role of plant hormones in plant defence responses
    Rajendra Bari
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Plant Mol Biol 69:473-88. 2009
    ..Here, we review recent advances made in understanding the role of these hormones in modulating plant defence responses against various diseases and pests...
  38. pmc The transcriptional innate immune response to flg22. Interplay and overlap with Avr gene-dependent defense responses and bacterial pathogenesis
    Lionel Navarro
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, United Kingdom
    Plant Physiol 135:1113-28. 2004
    ..We also compared FLARE gene sets and genes induced in basal or gene-for-gene interactions upon different Pseudomonas syringae treatments, and infer that Pseudomonas syringae pv tomato represses the flagellin-initiated defense response...
  39. doi request reprint De novo assembly of the Pseudomonas syringae pv. syringae B728a genome using Illumina/Solexa short sequence reads
    Rhys A Farrer
    The Sainsbury Laboratory, Colney Lane, Norwich, UK
    FEMS Microbiol Lett 291:103-11. 2009
    ..These draft assemblies are useful for exploring an organism's proteomic potential, at a very economic low cost...
  40. pmc Genome-wide survey of Arabidopsis natural variation in downy mildew resistance using combined association and linkage mapping
    Adnane Nemri
    Sainsbury Laboratory, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 107:10302-7. 2010
    ..Our results suggest that combining association and linkage mapping could accelerate resistance gene discovery in plants...
  41. pmc Genetic variation at the tomato Cf-4/Cf-9 locus induced by EMS mutagenesis and intralocus recombination
    Brande B H Wulff
    Sainsbury Laboratory, John Innes Centre, Norwich, NR4 7UH, United Kingdom
    Genetics 167:459-70. 2004
    ..Most mutations result in single-amino-acid substitutions in their C terminus at residues that are conserved in other Cf proteins...
  42. pmc Ethylene-mediated cross-talk between calcium-dependent protein kinase and MAPK signaling controls stress responses in plants
    Andrea A Ludwig
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 102:10736-41. 2005
    ..These data indicate that CDPK and MAPK pathways do not function independently and that a concerted activation of both pathways controls response specificity to biotic and abiotic stress...
  43. pmc Resistance gene enrichment sequencing (RenSeq) enables reannotation of the NB-LRR gene family from sequenced plant genomes and rapid mapping of resistance loci in segregating populations
    Florian Jupe
    The Sainsbury Laboratory, Norwich Research Park, NR4 7UH, Norwich, UK
    Plant J 76:530-44. 2013
    ..These SNP identification workflows were designed as easy-to-adapt Galaxy pipelines...
  44. ncbi request reprint Marker development for the genetic study of natural variation in Arabidopsis thaliana
    Adnane Nemri
    Sainsbury Laboratory, Norwich NR4 7UH, UK
    Bioinformatics 23:3108-9. 2007
    ..We show that AtPRIMER accurately found specific polymorphic markers for our linkage mapping project. AtPRIMER will therefore be useful for efficient marker development with high density and specificity...
  45. ncbi request reprint Pathological hormone imbalances
    Alexandre Robert-Seilaniantz
    The Sainsbury Lab, Colney Lane, Norwich, UK
    Curr Opin Plant Biol 10:372-9. 2007
    ..We propose that these hormones may influence disease outcomes through their effect on SA or JA signalling...
  46. doi request reprint Obligate biotroph parasitism: can we link genomes to lifestyles?
    Eric Kemen
    The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK
    Trends Plant Sci 17:448-57. 2012
    ..In this opinion article we combine classical knowledge with recently sequenced pathogen genomes and present new hypotheses about the convergent evolution that led to these two distinct phenotypes in obligate biotrophs...
  47. pmc Characterization of the membrane-associated HaRxL17 Hpa effector candidate
    Marie Cécile Caillaud
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Norwich, UK
    Plant Signal Behav 7:145-9. 2012
    ..Thus, HaRxL17 that increases plant susceptibility to Hpa during both compatible and incompatible interactions, localizes around oomycete haustoria when stably expressed in Arabidopsis...
  48. pmc The Cf-9 disease resistance protein is present in an approximately 420-kilodalton heteromultimeric membrane-associated complex at one molecule per complex
    Susana Rivas
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney Lane, Norwich NR4 7UH, United Kingdom
    Plant Cell 14:689-702. 2002
    ..Thus, Cf-9-dependent defense signaling and CLV2-dependent regulation of meristem development seem to be accomplished via distinct mechanisms, despite the structural similarity of their key components Cf-9 and CLV2...
  49. ncbi request reprint The Arabidopsis thaliana TIR-NB-LRR R-protein, RPP1A; protein localization and constitutive activation of defence by truncated alleles in tobacco and Arabidopsis
    L Michael Weaver
    Sainsbury Laboratory, John Innes Centre, Norwich Research Park Colney Lane, Norwich NR4 7UH, UK
    Plant J 47:829-40. 2006
    ..Two-phase partitioning and sucrose density gradient sedimentation established that RPP1A resides in the endoplasmic reticulum and/or Golgi apparatus...
  50. pmc Identifying and classifying trait linked polymorphisms in non-reference species by walking coloured de bruijn graphs
    Richard M Leggett
    The Sainsbury Laboratory, Norwich Research Park, Colney, Norwich, United Kingdom
    PLoS ONE 8:e60058. 2013
    ....
  51. pmc Anthocyanins double the shelf life of tomatoes by delaying overripening and reducing susceptibility to gray mold
    Yang Zhang
    John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK
    Curr Biol 23:1094-100. 2013
    ..Enhancing the levels of natural antioxidants in tomato provides a novel strategy for extending shelf life by genetic engineering or conventional breeding. ..
  52. doi request reprint Application of 'next-generation' sequencing technologies to microbial genetics
    Daniel Maclean
    The Sainsbury Laboratory, Norwich NR4 7UH, United Kingdom
    Nat Rev Microbiol 7:287-96. 2009
    ..In this article, we review the capabilities of high-throughput sequencing technologies and discuss the many options for getting useful information from the data...
  53. pmc Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants
    Jack R Peart
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 99:10865-9. 2002
    ..Our findings show that silencing SGT1 affects diverse types of disease resistance in plants and support the idea that R protein-mediated and nonhost resistance may involve similar mechanisms...
  54. ncbi request reprint Hormone crosstalk in plant disease and defense: more than just jasmonate-salicylate antagonism
    Alexandre Robert-Seilaniantz
    The Sainsbury Laboratory, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Annu Rev Phytopathol 49:317-43. 2011
    ..We highlight an emerging theme that positive and negative regulators of these disparate hormone signaling pathways are crucial regulatory targets of hormonal crosstalk in disease and defense...
  55. pmc Rapid phosphorylation of a syntaxin during the Avr9/Cf-9-race-specific signaling pathway
    Antje Heese
    Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom
    Plant Physiol 138:2406-16. 2005
    ....
  56. pmc Elevating crop disease resistance with cloned genes
    Jonathan D G Jones
    The Sainsbury Laboratory, Norwich Research Park, Colney Lane, Norwich NR4 7UH, UK
    Philos Trans R Soc Lond B Biol Sci 369:20130087. 2014
    ..1 gene isolated from a wild relative of potato, Solanum venturii, and introduced by GM methods into the potato variety Desiree...
  57. ncbi request reprint Molecular analysis of Agrobacterium T-DNA integration in tomato reveals a role for left border sequence homology in most integration events
    Colwyn M Thomas
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Mol Genet Genomics 278:411-20. 2007
    ..We propose that most T-DNA integrations in tomato require sequence homology between the ssT-DNA LB and plant target DNA which results in the generation of DSBs in plant chromosomal DNA...
  58. ncbi request reprint Virus-induced gene silencing in Solanum species
    Gianinna Brigneti
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney Lane, Norwich NR4 7UH, UK
    Plant J 39:264-72. 2004
    ..Thus, the VIGS system is an effective method of rapidly assessing gene function in potato...
  59. pmc Draft genome sequence of Pseudomonas syringae pathovar syringae strain FF5, causal agent of stem tip dieback disease on ornamental pear
    Kee Hoon Sohn
    The Sainsbury Laboratory, John Innes Centre, Norwich, United Kingdom
    J Bacteriol 194:3733-4. 2012
    ..Lacking detectable homologues of other T3SS effectors, it may encode novel, undiscovered effectors...
  60. ncbi request reprint Reactive oxygen species produced by NADPH oxidase regulate plant cell growth
    Julia Foreman
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK
    Nature 422:442-6. 2003
    ..This indicates that NADPH oxidases control development by making ROS that regulate plant cell expansion through the activation of Ca2+ channels...
  61. ncbi request reprint CDPK-mediated signalling pathways: specificity and cross-talk
    Andrea A Ludwig
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    J Exp Bot 55:181-8. 2004
    ..Furthermore, loss-of-function and gain-of-function studies revealed that signalling pathways leading to cold, salt, drought or pathogen resistance are mediated by specific CDPK isoforms..
  62. doi request reprint Plant pathogen effectors: getting mixed messages
    David L Greenshields
    The Sainsbury Laboratory, John Innes Centre, Norwich NR4 7BU, UK
    Curr Biol 18:R128-30. 2008
    ..Plant pathogen effectors have now been shown to mimic plant transcription factors and turn on genes that help the pathogen. Some plants, however, have evolved to use these pathogen-derived transcription factors to turn on defence...
  63. ncbi request reprint Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mildew resistance through multiple signalling components
    Erik A van der Biezen
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Plant J 29:439-51. 2002
    ..Our results suggest that RPP4-mediated resistance is developmentally regulated and that in cotyledons there is cross-talk between EDS1 and NDR1 signalling and processes regulating systemic acquired resistance...
  64. ncbi request reprint Bacterial disease resistance in Arabidopsis through flagellin perception
    Cyril Zipfel
    Friedrich Miescher Institute for Biomedical Research, PO Box 2543, CH 4002 Basel, Switzerland
    Nature 428:764-7. 2004
    ..tomato DC3000 when it is sprayed on the leaf surface. Thus, flagellin perception restricts bacterial invasion, probably at an early step, and contributes to the plant's disease resistance...
  65. ncbi request reprint Inducible cell death in plant immunity
    Daniel Hofius
    Department of Molecular Biology, University of Copenhagen, Øster Farimagsgade 2A, 1353 Copenhagen K, Denmark
    Semin Cancer Biol 17:166-87. 2007
    ..Recent research aiming to understand these pathways and their molecular components in plants are reviewed here...
  66. pmc The E3 ubiquitin ligase activity of arabidopsis PLANT U-BOX17 and its functional tobacco homolog ACRE276 are required for cell death and defense
    Cheng Wei Yang
    Plant Science Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Plant Cell 18:1084-98. 2006
    ..We identify a conserved class of U-box ARMADILLO repeat E3 ligases that are positive regulators of cell death and defense across the Solanaceae and Brassicaceae...
  67. pmc Arabidopsis downy mildew resistance gene RPP27 encodes a receptor-like protein similar to CLAVATA2 and tomato Cf-9
    Mahmut Tör
    Horticulture Research International, Wellesbourne, Warwick CV35 9EF, United Kingdom
    Plant Physiol 135:1100-12. 2004
    ..A combination of sequence and phylogenetic analysis of these predicted RLPs reveals conserved structural features of the family...
  68. ncbi request reprint The plant proteolytic machinery and its role in defence
    Renier A L van der Hoorn
    Laboratory of Phytopathology, Wageningen University, 6709 PD, Wageningen, The Netherlands
    Curr Opin Plant Biol 7:400-7. 2004
    ..These exciting recent reports are probably just the first examples of what lies beneath. More roles for plant proteases in defence, as well as the regulation and substrates of these enzymes, are waiting to be discovered...
  69. pmc Arabidopsis gp91phox homologues AtrbohD and AtrbohF are required for accumulation of reactive oxygen intermediates in the plant defense response
    Miguel Angel Torres
    Department of Biology and Curriculum in Genetics and Molecular Biology, CB 3280, 108 Coker Hall, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Proc Natl Acad Sci U S A 99:517-22. 2002
    ..parasitica. Paradoxically, although atrbohD mutation eliminated the majority of total ROI production, atrbohF mutation exhibited the strongest effect on cell death...
  70. pmc Nicotiana benthamiana gp91phox homologs NbrbohA and NbrbohB participate in H2O2 accumulation and resistance to Phytophthora infestans
    Hirofumi Yoshioka
    Plant Pathology Laboratory, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, 464 8601 Japan
    Plant Cell 15:706-18. 2003
    ....
  71. ncbi request reprint Trehalose-6-phosphate synthase 1, which catalyses the first step in trehalose synthesis, is essential for Arabidopsis embryo maturation
    Peter J Eastmond
    Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, York, YO10 5DD, UK
    Plant J 29:225-35. 2002
    ..Our data establish for the first time that an enzyme of trehalose metabolism is essential in plants and is implicated in the regulation of sugar metabolism/embryo development via a different mechanism to that reported in S. cerevisiae...
  72. ncbi request reprint Rapid migration in gel filtration of the Cf-4 and Cf-9 resistance proteins is an intrinsic property of Cf proteins and not because of their association with high-molecular-weight proteins
    Renier A L van der Hoorn
    Wageningen University, Laboratory of Phytopathology, Binnenhaven 5, 6709 PD, Wageningen, The Netherlands
    Plant J 35:305-15. 2003
    ..Taken together, these results suggest that caution should be taken when interpreting data obtained from gel filtration of LRR-containing proteins...
  73. pmc NADPH oxidase AtrbohD and AtrbohF genes function in ROS-dependent ABA signaling in Arabidopsis
    June M Kwak
    Cell and Developmental Biology Section, Division of Biological Sciences and Center for Molecular Genetics, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0116, USA
    EMBO J 22:2623-33. 2003
    ..These data provide direct molecular genetic and cell biological evidence that ROS are rate-limiting second messengers in ABA signaling, and that the AtrbohD and AtrbohF NADPH oxidases function in guard cell ABA signal transduction...
  74. pmc Phylogenomic analysis of the receptor-like proteins of rice and Arabidopsis
    Lillian K Fritz-Laylin
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Plant Physiol 138:611-23. 2005
    ..Due to the synteny between rice and other Gramineae, this analysis should provide valuable tools for experimental studies in rice and other cereals...
  75. ncbi request reprint Pathogen-induced, NADPH oxidase-derived reactive oxygen intermediates suppress spread of cell death in Arabidopsis thaliana
    Miguel Angel Torres
    Department of Biology, University of North Carolina, CB 3280, Coker Hall, Room 108, Chapel Hill, North Carolina 27599 3280, USA
    Nat Genet 37:1130-4. 2005
    ..These results have implications for understanding how salicylic acid activates defense signaling in cells spatially removed from infection sites without causing cell death...
  76. pmc A genome-wide functional investigation into the roles of receptor-like proteins in Arabidopsis
    Guodong Wang
    Plant Research International, B V, Business Unit of Bioscience, 6700 AA Wageningen, The Netherlands
    Plant Physiol 147:503-17. 2008
    ..This genome-wide collection of Arabidopsis RLP gene T-DNA insertion mutants provides a tool for future investigations into the biological roles of RLPs...
  77. ncbi request reprint Nuclear accumulation of the Arabidopsis immune receptor RPS4 is necessary for triggering EDS1-dependent defense
    Lennart Wirthmueller
    Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, Carl von Linne Weg 10, 50829 Cologne, Germany
    Curr Biol 17:2023-9. 2007
    ..We find that EDS1 is an indispensable component of RPS4 signaling and that it functions downstream of RPS4 activation but upstream of RPS4-mediated transcriptional reprogramming in the nucleus...
  78. pmc Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana
    Justin O Borevitz
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:12057-62. 2007
    ..SFPs identified with the gene expression array also provide an empirical hybridization polymorphism background for studies of gene expression polymorphism and are available through the genome browser http://signal.salk.edu/cgi-bin/AtSFP...
  79. ncbi request reprint A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence
    Delphine Chinchilla
    Zurich Basel Plant Science Center, Botanical Institute, University of Basel, Hebelstrasse 1, 4056 Basel, Switzerland
    Nature 448:497-500. 2007
    ..Thus, BAK1 is not only associated with developmental regulation through the plant hormone receptor BRI1 (refs 6,7), but also has a functional role in PRR-dependent signalling, which initiates innate immunity...
  80. pmc Reactive oxygen species signaling in response to pathogens
    Miguel Angel Torres
    Department of Biology, University of North Carolina, Chapel Hill, 27599 3280, USA
    Plant Physiol 141:373-8. 2006
  81. ncbi request reprint Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation
    Cyril Zipfel
    Botanical Institute, Zurich Basel Plant Science Centre, University of Basel, Hebelstrasse 1, CH 4056 Basel, Switzerland
    Cell 125:749-60. 2006
    ..These results demonstrate that EFR is the EF-Tu receptor and that plant defense responses induced by PAMPs such as EF-Tu reduce transformation by Agrobacterium...
  82. ncbi request reprint Dominant-negative interference with defence signalling by truncation mutations of the tomato Cf-9 disease resistance gene
    Claire L Barker
    Plant Cell Biology Group, Research School of Biological Sciences, The Australian National University, Canberra ACT 0200, Australia
    Plant J 46:385-99. 2006
    ....
  83. ncbi request reprint A tomato mutant that shows stunting, wilting, progressive necrosis and constitutive expression of defence genes contains a recombinant Hcr9 gene encoding an autoactive protein
    Claire L Barker
    Plant Cell Biology Group, Research School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia
    Plant J 46:369-84. 2006
    ..Agrobacterium tumefaciens-mediated transient expression of Hcr9-M205 in Nicotiana tabacum caused chlorosis and the accumulation of defence gene transcripts, indicating that the protein encoded by this novel Hcr9 gene is autoactive...
  84. pmc Rewiring mitogen-activated protein kinase cascade by positive feedback confers potato blight resistance
    Chihiro Yamamizo
    Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464 8601, Japan
    Plant Physiol 140:681-92. 2006
    ..We propose that enhancing disease resistance through altered regulation of plant defense mechanisms should be more durable and publicly acceptable than engineering overexpression of antimicrobial proteins...
  85. pmc Involvement of PPS3 phosphorylated by elicitor-responsive mitogen-activated protein kinases in the regulation of plant cell death
    Shinpei Katou
    Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464 8601, Japan
    Plant Physiol 139:1914-26. 2005
    ..This work strongly supports the idea that PPS3 is a physiological substrate of StMPK1 and is involved in cell death activated by a MAPK cascade...
  86. doi request reprint The auxin influx carrier LAX3 promotes lateral root emergence
    Kamal Swarup
    School of Biosciences and Centre for Plant Integrative Biology, University of Nottingham, LE12 5RD, UK
    Nat Cell Biol 10:946-54. 2008
    ..Increased LAX3 activity reinforces the auxin-dependent induction of a selection of cell-wall-remodelling enzymes, which are likely to promote cell separation in advance of developing lateral root primordia...