David Tweats

Summary

Affiliation: Thames Valley University
Country: UK

Publications

  1. doi request reprint Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness)
    David Tweats
    Drugs for Neglected Diseases Initiative, 15 Chemin Louis Dunant, Geneva CH 1202, Switzerland
    Mutagenesis 27:523-32. 2012
  2. ncbi request reprint Determination of genetic toxicity and potential carcinogenicity in vitro--challenges post the Seventh Amendment to the European Cosmetics Directive
    D J Tweats
    The Medical School, University of Wales Swansea, Singleton Park, SA2 8PP, UK
    Mutagenesis 22:5-13. 2007
  3. pmc Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept(R), Roche): overview
    Anton Pozniak
    Pharmaceuticals Division, Hoffmann La Roche, Nutley, NJ, USA
    AIDS Res Ther 6:18. 2009
  4. doi request reprint 1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis
    Bernadette Bourdin Trunz
    Drugs for Neglected Diseases Initiative, 15 Chemin Louis Dunant, 1202 Geneva, Switzerland
    Eur J Med Chem 46:1524-35. 2011

Collaborators

Detail Information

Publications4

  1. doi request reprint Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness)
    David Tweats
    Drugs for Neglected Diseases Initiative, 15 Chemin Louis Dunant, Geneva CH 1202, Switzerland
    Mutagenesis 27:523-32. 2012
    ..Thus, fexinidazole does not pose a genotoxic hazard to patients and represents a promising drug candidate for HAT. Fexinidazole is expected to enter Phase II clinical trials in 2012...
  2. ncbi request reprint Determination of genetic toxicity and potential carcinogenicity in vitro--challenges post the Seventh Amendment to the European Cosmetics Directive
    D J Tweats
    The Medical School, University of Wales Swansea, Singleton Park, SA2 8PP, UK
    Mutagenesis 22:5-13. 2007
    ..This commentary brings together ideas and approaches from several international workshops and meetings to consider these issues...
  3. pmc Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept(R), Roche): overview
    Anton Pozniak
    Pharmaceuticals Division, Hoffmann La Roche, Nutley, NJ, USA
    AIDS Res Ther 6:18. 2009
    ..These findings are potentially relevant to >40 marketed drugs that are mesylate salts...
  4. doi request reprint 1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis
    Bernadette Bourdin Trunz
    Drugs for Neglected Diseases Initiative, 15 Chemin Louis Dunant, 1202 Geneva, Switzerland
    Eur J Med Chem 46:1524-35. 2011
    ..Both compounds are promising leads for the treatment of human African trypanosomiasis (HAT or sleeping sickness), including the fatal stage 2 of the disease, for which new treatments are urgently needed...