Jecko Thachil

..The article describes a two-step process, where a quantitative role for platelet factor 4 in activating monocytes at the tissue injury sites may play a role in the pathogenesis of heparin induced thrombocytopenia with thrombosis...

..It is however not entirely clear, whether the dose should be altered on the basis of anti-Xa results in asymptomatic individuals...

..The aim of the study was to assess compliance with current prophylactic FFP guidelines at a large tertiary centre...

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..Newer therapeutic modalities have been recently tried with success although the management of DIC still remains a major challenge...

..The clinical approach and management of these patients are complex, and require understanding of the differences in thrombus development in the different clinical circumstances...

..The manuscript explains the role of the less recognized 'lung megakaryocytes' in the development of this complication...

..This review focuses on the association of these two conditions which have given insights into the role players and the pathogenic mechanisms leading to the development of either of these conditions...

..This article focuses on the available evidence to guide the appropriate use of D-dimer in patients admitted to a hospital...

..This article explains the important role of PF4 released during platelet activation with the administration of heparin in the pathogenesis of thrombocytopenia and thrombosis in HIT...

..With their increased use, adverse events, some common and certain rare but characteristic complications, are being recognized. The exact mechanisms for the development of at least some of these side effects are not entirely clear...

..We present a female with a similar association and explain the importance of identifying the coexisting conditions. The immunological abnormalities, which may be observed in MDS and their possible mechanisms, are also discussed...

..At the same time, some of the treatment modalities for ITP may be exerting their beneficial effects by increasing the levels of NO and thus improving platelet production...

..The article describes the possibility of nitric oxide depletion in porphyria contributing to its clinical manifestations...

..The article describes available evidence for the presence of lung megakaryocytes and hypothesizes that these cells are responsible for the development of pulmonary fibrosis in SSc based on the myelofibrosis model...

..Continuation of these agents, however, is associated with an increased risk of bleeding. Managing anticoagulation can be a particular challenge in the emergency setting...

..The report details a case of extreme thrombocytosis which masked an underlying diagnosis of inflammatory bowel disease...

..This article discusses the possible role of reticulocytes in promoting thrombus formation in individuals with SCD and suggests a similar pathogenetic mechanism in thromboembolism associated with other hemolytic states...

..Most importantly, it stresses the need for more trials to help us guide the management of bleeding in patients with liver impairment...

..This report describes a woman who presented with a breast lump, which was initially misdiagnosed as lymphoma, but later turned out to be granulocytic sarcoma of the breast...

..We hypothesised that APC on these circulating MPs activate endothelial protease-activated receptor 1 (PAR1) to induce anti-apoptotic and anti-inflammatory properties that can improve patient outcome...

..It also discusses the latest developments in our understanding of haemostatic mechanisms within the placenta and how these may have relevance to new diagnostic approaches as well as novel therapeutic modalities...

..Genetic mutations have been noted in persons with haemophilia to be contributing to a milder bleeding phenotype. This report describes the clinical implications of a similar mixed haemorrhagic-thrombotic genotype...