Jecko Thachil

Summary

Country: UK

Publications

  1. ncbi request reprint Heparin induced thrombocytopenia with thrombosis: a two step process?
    Jecko Thachil
    Department of Haematology, Royal Liverpool University Hospital, Prescot Road, Liverpool L7 8XP, UK
    Hematology 13:181-2. 2008
  2. doi request reprint Should low molecular weight heparin dosing be based on anti-Xa assays in antiphospholipid syndrome?
    Jecko Thachil
    Department of Haematology, Manchester Royal Infirmary, Oxford Road, Manchester, UK
    Blood Coagul Fibrinolysis 24:82-4. 2013
  3. doi request reprint Inappropriateness of fresh frozen plasma for abnormal coagulation tests
    S Pybus
    School of Medicine, University of Liverpool, Liverpool, UK
    J R Coll Physicians Edinb 42:294-300. 2012
  4. doi request reprint Clotting screen requests in pediatrics
    Jecko Thachil
    Department of Hematology, Royal Liverpool University Hospital, Prescot Street, Liverpool, UK, L7 8XP
    Indian J Pediatr 79:1233-5. 2012
  5. ncbi request reprint Current concepts in the management of disseminated intravascular coagulation
    Jecko Thachil
    Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Prescot Road, Liverpool, United Kingdom
    Thromb Res 129:S54-9. 2012
  6. doi request reprint Recurrent venous thromboembolism while on anticoagulant therapy
    Jecko Thachil
    Department of Haematology, Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Liverpool L7 8XP, United Kingdom
    Blood Rev 26:175-81. 2012
  7. doi request reprint Lessons from acute pancreatitis-induced thrombotic thrombocytopenic purpura
    Jecko Thachil
    University of Liverpool, Prescot Road, Liverpool, UK
    Eur J Intern Med 20:739-43. 2009
  8. ncbi request reprint Appropriate use of D-dimer in hospital patients
    Jecko Thachil
    Department of Haematology, University of Liverpool, UK
    Am J Med 123:17-9. 2010
  9. doi request reprint The prothrombotic potential of platelet factor 4
    Jecko Thachil
    University of Liverpool, UK
    Eur J Intern Med 21:79-83. 2010
  10. doi request reprint Nitric oxide and adverse events of vascular endothelial growth factor inhibitors
    Jecko Thachil
    Department of Haematology, University of Liverpool, Liverpool, UK
    Curr Med Res Opin 27:1503-7. 2011

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Heparin induced thrombocytopenia with thrombosis: a two step process?
    Jecko Thachil
    Department of Haematology, Royal Liverpool University Hospital, Prescot Road, Liverpool L7 8XP, UK
    Hematology 13:181-2. 2008
    ..The article describes a two-step process, where a quantitative role for platelet factor 4 in activating monocytes at the tissue injury sites may play a role in the pathogenesis of heparin induced thrombocytopenia with thrombosis...
  2. doi request reprint Should low molecular weight heparin dosing be based on anti-Xa assays in antiphospholipid syndrome?
    Jecko Thachil
    Department of Haematology, Manchester Royal Infirmary, Oxford Road, Manchester, UK
    Blood Coagul Fibrinolysis 24:82-4. 2013
    ..It is however not entirely clear, whether the dose should be altered on the basis of anti-Xa results in asymptomatic individuals...
  3. doi request reprint Inappropriateness of fresh frozen plasma for abnormal coagulation tests
    S Pybus
    School of Medicine, University of Liverpool, Liverpool, UK
    J R Coll Physicians Edinb 42:294-300. 2012
    ..The aim of the study was to assess compliance with current prophylactic FFP guidelines at a large tertiary centre...
  4. doi request reprint Clotting screen requests in pediatrics
    Jecko Thachil
    Department of Hematology, Royal Liverpool University Hospital, Prescot Street, Liverpool, UK, L7 8XP
    Indian J Pediatr 79:1233-5. 2012
    ....
  5. ncbi request reprint Current concepts in the management of disseminated intravascular coagulation
    Jecko Thachil
    Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Prescot Road, Liverpool, United Kingdom
    Thromb Res 129:S54-9. 2012
    ..Newer therapeutic modalities have been recently tried with success although the management of DIC still remains a major challenge...
  6. doi request reprint Recurrent venous thromboembolism while on anticoagulant therapy
    Jecko Thachil
    Department of Haematology, Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Liverpool L7 8XP, United Kingdom
    Blood Rev 26:175-81. 2012
    ..The clinical approach and management of these patients are complex, and require understanding of the differences in thrombus development in the different clinical circumstances...
  7. doi request reprint Lessons from acute pancreatitis-induced thrombotic thrombocytopenic purpura
    Jecko Thachil
    University of Liverpool, Prescot Road, Liverpool, UK
    Eur J Intern Med 20:739-43. 2009
    ..This review focuses on the association of these two conditions which have given insights into the role players and the pathogenic mechanisms leading to the development of either of these conditions...
  8. ncbi request reprint Appropriate use of D-dimer in hospital patients
    Jecko Thachil
    Department of Haematology, University of Liverpool, UK
    Am J Med 123:17-9. 2010
    ..This article focuses on the available evidence to guide the appropriate use of D-dimer in patients admitted to a hospital...
  9. doi request reprint The prothrombotic potential of platelet factor 4
    Jecko Thachil
    University of Liverpool, UK
    Eur J Intern Med 21:79-83. 2010
    ..This article explains the important role of PF4 released during platelet activation with the administration of heparin in the pathogenesis of thrombocytopenia and thrombosis in HIT...
  10. doi request reprint Nitric oxide and adverse events of vascular endothelial growth factor inhibitors
    Jecko Thachil
    Department of Haematology, University of Liverpool, Liverpool, UK
    Curr Med Res Opin 27:1503-7. 2011
    ..With their increased use, adverse events, some common and certain rare but characteristic complications, are being recognized. The exact mechanisms for the development of at least some of these side effects are not entirely clear...
  11. ncbi request reprint Myelodysplastic syndrome with trisomy 8 associated with Behçet syndrome: an immunologic link to a karyotypic abnormality
    Jecko V Thachil
    Department of Haematology, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Pediatr Blood Cancer 50:649-51. 2008
    ..We present a female with a similar association and explain the importance of identifying the coexisting conditions. The immunological abnormalities, which may be observed in MDS and their possible mechanisms, are also discussed...
  12. doi request reprint The enigma of pulmonary hypertension after splenectomy--does the megakaryocyte provide a clue?
    J Thachil
    University of Liverpool, Prescot Road, Liverpool, L7 8XP, UK
    QJM 102:743-5. 2009
    ..The manuscript explains the role of the less recognized 'lung megakaryocytes' in the development of this complication...
  13. doi request reprint Nitric oxide in immune thrombocytopenic purpura
    Jecko Thachil
    Department of Haematology, University of Liverpool, Prescot Road, Liverpool L78XP, UK
    Hematology 14:59-62. 2009
    ..At the same time, some of the treatment modalities for ITP may be exerting their beneficial effects by increasing the levels of NO and thus improving platelet production...
  14. ncbi request reprint A mystery unravels
    Jecko V Thachil
    Department of Haematology, Stoke Mandeville Hospital, Aylesbury, Buckinghamshire, UK
    Am J Med 120:669-70. 2007
  15. doi request reprint Nitric oxide and the clinical manifestations of acute porphyria
    J Thachil
    Hematology Department, Royal Liverpool University Hospital, Liverpool, UK
    Intern Med J 38:732-5. 2008
    ..The article describes the possibility of nitric oxide depletion in porphyria contributing to its clinical manifestations...
  16. doi request reprint The lung megakaryocytes and pulmonary fibrosis in systemic sclerosis
    Jecko Thachil
    University of Liverpool, Prescot Street, Liverpool L7 8XP, United Kingdom
    Med Hypotheses 72:291-3. 2009
    ..The article describes available evidence for the presence of lung megakaryocytes and hypothesizes that these cells are responsible for the development of pulmonary fibrosis in SSc based on the myelofibrosis model...
  17. doi request reprint Management of surgical patients receiving anticoagulation and antiplatelet agents
    J Thachil
    Department of Haematology, University of Liverpool, Royal Free Hospital, London, UK
    Br J Surg 95:1437-48. 2008
    ..Continuation of these agents, however, is associated with an increased risk of bleeding. Managing anticoagulation can be a particular challenge in the emergency setting...
  18. ncbi request reprint Extreme thrombocytosis--an unusual presentation of inflammatory bowel disease
    Jecko Thachil
    Royal Liverpool University Hospital, Liverpool, United Kingdom
    Intern Med 47:1255-7. 2008
    ..The report details a case of extreme thrombocytosis which masked an underlying diagnosis of inflammatory bowel disease...
  19. pmc Granulocytic sarcoma - a rare presentation of a breast lump
    Jecko Thachil
    Haematology Department, Royal Liverpool University Hospital, Liverpool, UK
    Ann R Coll Surg Engl 89:W7-9. 2007
    ..This report describes a woman who presented with a breast lump, which was initially misdiagnosed as lymphoma, but later turned out to be granulocytic sarcoma of the breast...
  20. doi request reprint The possible role of reticulocytes in sickle cell disease associated thromboembolism
    Jecko Thachil
    Haematology Department, Royal, Liverpool University Hospital, UK
    Hematology 13:68-70. 2008
    ..This article discusses the possible role of reticulocytes in promoting thrombus formation in individuals with SCD and suggests a similar pathogenetic mechanism in thromboembolism associated with other hemolytic states...
  21. doi request reprint Relevance of clotting tests in liver disease
    J Thachil
    University of Liverpool, Prescot Road, Liverpool L7 8XP, UK
    Postgrad Med J 84:177-81. 2008
    ..Most importantly, it stresses the need for more trials to help us guide the management of bleeding in patients with liver impairment...
  22. ncbi request reprint Dispelling myths about coagulation abnormalities in internal medicine
    Jecko Thachil
    Department of Haematology, Manchester Royal Infirmary, Manchester, UK
    Clin Med 14:239-44. 2014
    ..Some of these are discussed with considerations of appropriate management in those situations. ..
  23. ncbi request reprint The newer direct oral anticoagulants: a practical guide
    Jecko Thachil
    Department of Haematology, Manchester Royal Infirmary
    Clin Med 14:165-75. 2014
    ..Being relatively newer drugs, physicians need to be familiar with the various practical issues that may be encountered with the prescription of these drugs, which are summarised in this review. ..
  24. doi request reprint Providing accurate information to patients who develop deep vein thrombosis
    Jecko Thachil
    Department of Haematology, Manchester Royal Infirmary, UK
    Clin Med 13:449-51. 2013
    ..Some of these issues are discussed in this paper, with considerations for changes in management. ..
  25. pmc The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis
    Margarita Pérez-Casal
    Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    Crit Care 15:R195. 2011
    ..We hypothesised that APC on these circulating MPs activate endothelial protease-activated receptor 1 (PAR1) to induce anti-apoptotic and anti-inflammatory properties that can improve patient outcome...
  26. doi request reprint Disseminated intravascular coagulation in obstetric disorders and its acute haematological management
    Jecko Thachil
    School of Clinical Sciences, University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK
    Blood Rev 23:167-76. 2009
    ..It also discusses the latest developments in our understanding of haemostatic mechanisms within the placenta and how these may have relevance to new diagnostic approaches as well as novel therapeutic modalities...
  27. doi request reprint Human CRP defends against the toxicity of circulating histones
    Simon T Abrams
    Department of Blood Sciences, Royal Liverpool and Broadgreen University Hospitals National Health Service Trust, Liverpool L7 8XP, United Kingdom
    J Immunol 191:2495-502. 2013
    ..Because histone elevation occurs in the acute phase of numerous critical illnesses associated with extensive cell death, CRP detoxification of circulating histones would be a generic host defense mechanism in humans. ..
  28. doi request reprint Prognostic implications of leg ulcers from hydroxycarbamide therapy in patients with essential thrombocythaemia
    Sebastian Francis
    Department of Haematology, Russells Hall Hospital, Dudley, UK
    Leuk Res 36:488-90. 2012
    ....
  29. doi request reprint Phenotypic implications of a co-existent haemorrhagic and thrombotic genotype
    Jecko Thachil
    Department of Haematology, Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, UK
    Blood Coagul Fibrinolysis 23:232-4. 2012
    ..Genetic mutations have been noted in persons with haemophilia to be contributing to a milder bleeding phenotype. This report describes the clinical implications of a similar mixed haemorrhagic-thrombotic genotype...
  30. ncbi request reprint Is this immune thrombocytopenic purpura?
    Jecko Thachil
    Haematology Department, Royal Liverpool Children s Hospital, Liverpool, UK
    Arch Dis Child 93:76-81. 2008