Jonathan G Moggs

Summary

Affiliation: Syngenta Central Toxicology Laboratory
Country: UK

Publications

  1. pmc Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth
    Jonathan G Moggs
    Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, UK
    Environ Health Perspect 112:1589-606. 2004
  2. ncbi request reprint Molecular responses to xenoestrogens: mechanistic insights from toxicogenomics
    Jonathan G Moggs
    Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, UK
    Toxicology 213:177-93. 2005
  3. pmc Estrogen receptors: orchestrators of pleiotropic cellular responses
    J G Moggs
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield SK10 4TJ, UK
    EMBO Rep 2:775-81. 2001
  4. ncbi request reprint Sex steroids, ANGELS and osteoporosis
    Jonathan G Moggs
    Syngenta CTL, Alderley Park, Cheshire, United Kingdom
    Bioessays 25:195-9. 2003
  5. ncbi request reprint Anti-proliferative effect of estrogen in breast cancer cells that re-express ERalpha is mediated by aberrant regulation of cell cycle genes
    J G Moggs
    Syngenta CTL, Alderley Park, Cheshire SK10 4TJ, UK
    J Mol Endocrinol 34:535-51. 2005
  6. ncbi request reprint The role of chromatin in molecular mechanisms of toxicity
    Jonathan G Moggs
    Syngenta CTL, Cheshire SK10 4TJ, United Kingdom
    Toxicol Sci 80:218-24. 2004
  7. pmc The need to decide if all estrogens are intrinsically similar
    Jonathan G Moggs
    Syngenta CTL, Alderley Park, Cheshire SK10 4TJ, United Kingdom
    Environ Health Perspect 112:1137-42. 2004
  8. ncbi request reprint Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation
    Ruth Stuckey
    Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, UK
    Mol Cell Endocrinol 253:22-9. 2006
  9. ncbi request reprint Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate
    Richard A Currie
    Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, United Kingdom
    Toxicol Sci 86:453-69. 2005
  10. ncbi request reprint Mapping molecular responses to xenoestrogens through Gene Ontology and pathway analysis of toxicogenomic data
    Richard A Currie
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield SK10 4TJ, UK
    Reprod Toxicol 20:433-40. 2005

Detail Information

Publications22

  1. pmc Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth
    Jonathan G Moggs
    Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, UK
    Environ Health Perspect 112:1589-606. 2004
    ....
  2. ncbi request reprint Molecular responses to xenoestrogens: mechanistic insights from toxicogenomics
    Jonathan G Moggs
    Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, UK
    Toxicology 213:177-93. 2005
    ..This review illustrates how these toxicogenomic approaches are providing an unprecedented amount of mechanistic information on the molecular responses to xenoestrogens and how they are likely to impact on hazard and risk assessment...
  3. pmc Estrogen receptors: orchestrators of pleiotropic cellular responses
    J G Moggs
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield SK10 4TJ, UK
    EMBO Rep 2:775-81. 2001
    ..Analysis of the interrelationship between these distinct modes of ER action is likely to reveal novel aspects of estrogen signalling that will impact on nuclear receptor biology and human health...
  4. ncbi request reprint Sex steroids, ANGELS and osteoporosis
    Jonathan G Moggs
    Syngenta CTL, Alderley Park, Cheshire, United Kingdom
    Bioessays 25:195-9. 2003
    ..This compound acts via a novel extranuclear sex steroid receptor signaling mechanism that has important implications for nuclear receptor biology and human health...
  5. ncbi request reprint Anti-proliferative effect of estrogen in breast cancer cells that re-express ERalpha is mediated by aberrant regulation of cell cycle genes
    J G Moggs
    Syngenta CTL, Alderley Park, Cheshire SK10 4TJ, UK
    J Mol Endocrinol 34:535-51. 2005
    ..Together, these data suggest a mechanism for the E2-dependent suppression of proliferation in ER-negative breast cancer cells into which ERalpha has been reintroduced...
  6. ncbi request reprint The role of chromatin in molecular mechanisms of toxicity
    Jonathan G Moggs
    Syngenta CTL, Cheshire SK10 4TJ, United Kingdom
    Toxicol Sci 80:218-24. 2004
    ..We also review the evidence that chromatin itself is the direct target of certain toxicants and that toxicant-induced perturbations in chromatin structure may precipitate adverse effects...
  7. pmc The need to decide if all estrogens are intrinsically similar
    Jonathan G Moggs
    Syngenta CTL, Alderley Park, Cheshire SK10 4TJ, United Kingdom
    Environ Health Perspect 112:1137-42. 2004
    ..Key words: diethylstilbestrol, estrogen, gene expression, genistein, microarray, phytoestrogen, toxicogenomics, uterus...
  8. ncbi request reprint Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation
    Ruth Stuckey
    Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, UK
    Mol Cell Endocrinol 253:22-9. 2006
    ....
  9. ncbi request reprint Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate
    Richard A Currie
    Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, United Kingdom
    Toxicol Sci 86:453-69. 2005
    ....
  10. ncbi request reprint Mapping molecular responses to xenoestrogens through Gene Ontology and pathway analysis of toxicogenomic data
    Richard A Currie
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield SK10 4TJ, UK
    Reprod Toxicol 20:433-40. 2005
    ..The utility of this in mechanistic toxicology will be illustrated using examples in which GO mapping of toxicogenomic data has provided novel insights into the molecular mechanisms induced by exposure to xenoestrogens...
  11. ncbi request reprint Identification of early molecular pathways affected by paraquat in rat lung
    Guy Mainwaring
    Syngenta CTL, Alderley Park, Cheshire SK10 4TJ, United Kingdom
    Toxicology 225:157-72. 2006
    ..These data provide novel insights into the molecular pathways that lead to toxicity after exposure of the rat lung to paraquat...
  12. ncbi request reprint Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3
    Neil MacDonald
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, United Kingdom
    Mol Cell 20:199-211. 2005
    ..14-3-3 isoforms thus represent a class of proteins that mediate the effect of histone phosphorylation at inducible genes...
  13. ncbi request reprint Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor
    Richard C Peffer
    Syngenta Crop Protection, Inc, Greensboro, North Carolina 27419, USA
    Toxicol Sci 99:315-25. 2007
    ..These experiments demonstrate that short-term liver effects of cyproconazole in mice are CAR-dependent and similar to those of phenobarbital, a known nongenotoxic rodent liver carcinogen...
  14. ncbi request reprint Proteomic analysis of suction blister fluid isolated from human skin
    N Macdonald
    Syngenta CTL, Alderley Park, Macclesfield, UK
    Clin Exp Dermatol 31:445-8. 2006
    ....
  15. ncbi request reprint Emerging evidence for the interrelationship of xenobiotic exposure and circadian rhythms: a review
    F L Lim
    Syngenta CTL, Alderley Park, UK
    Xenobiotica 36:1140-51. 2006
    ..This review discusses the emerging evidence for the regulation of circadian rhythm genes having an important impact on molecular response to xenobiotics...
  16. ncbi request reprint Epigenetics and cancer: implications for drug discovery and safety assessment
    Jonathan G Moggs
    Syngenta CTL, Alderley Park, Cheshire SK10 4TJ, UK
    Toxicol Appl Pharmacol 196:422-30. 2004
    ..In this paper, we describe the potential for interplay between genetic alteration and epigenetic changes in cell growth regulation and discuss the implications for drug discovery and safety assessment...
  17. ncbi request reprint Perturbation of epigenetic status by toxicants
    Vincent Bombail
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Toxicol Lett 149:51-8. 2004
    ..We also address recent findings indicating that the availability of dietary methyl donors can modulate DNA methylation levels and precipitate adverse effects...
  18. ncbi request reprint Genomic analysis of stress response genes
    Jonathan G Moggs
    Syngenta Central Toxicology Laboratory, Alderley Park, SK10 4TJ, Cheshire, UK
    Toxicol Lett 140:149-53. 2003
    ..Together, these approaches reveal the molecular mechanisms used to finely tune alterations in gene expression, enabling cells to react in an appropriate manner to external stress-inducing stimuli...
  19. ncbi request reprint Assessment of glycosylation-dependent cell adhesion molecule 1 as a correlate of allergen-stimulated lymph node activation
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Toxicology 185:103-17. 2003
    ....
  20. ncbi request reprint Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain
    Ralph Andre
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Glia 53:477-83. 2006
    ..These results show that IL-1beta exclusively downregulates alpha-syntrophin expression independently of IL-1R1, and suggest the expression of additional functional IL-1 receptors in the CNS...
  21. ncbi request reprint Analysis of DNA repair and chromatin assembly in vitro using immobilized damaged DNA substrates
    Jill A Mello
    Research Section, Institut Curie, Paris, France
    Methods Mol Biol 314:477-87. 2006
    ....
  22. ncbi request reprint Analysis of DNA repair and chromatin assembly in vitro using immobilized damaged DNA substrates
    Jill A Mello
    Research Section, Institut Curie, UMR218 du Centre National de la Recherche Scientifique, Paris, France
    Methods Mol Biol 281:271-81. 2004
    ....