Catherine J Betts

Summary

Affiliation: Syngenta Central Toxicology Laboratory
Country: UK

Publications

  1. ncbi Temporal changes in cytokine gene expression profiles induced in mice by trimellitic anhydride
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
    Toxicol Lett 136:121-32. 2002
  2. ncbi Assessment of glycosylation-dependent cell adhesion molecule 1 as a correlate of allergen-stimulated lymph node activation
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Toxicology 185:103-17. 2003
  3. ncbi B220 analysis with the local lymph node assay: proposal for a more flexible prediction model
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    J Appl Toxicol 27:506-10. 2007
  4. ncbi Intradermal exposure of BALB/c strain mice to peanut protein elicits a type 2 cytokine response
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Food Chem Toxicol 42:1589-99. 2004
  5. ncbi Potency and risk assessment of a skin-sensitizing disperse dye using the local lymph node assay
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK1 4TJ, UK
    Contact Dermatitis 52:268-72. 2005
  6. ncbi The use of ethanol:diethylphthalate as a vehicle for the local lymph node assay
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
    Contact Dermatitis 56:70-5. 2007
  7. ncbi Skin sensitization potency of methyl methacrylate in the local lymph node assay: comparisons with guinea-pig data and human experience
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK1 4TJ, UK
    Contact Dermatitis 55:140-7. 2006
  8. ncbi Comparative analysis of skin sensitization potency of acrylates (methyl acrylate, ethyl acrylate, butyl acrylate, and ethylhexyl acrylate) using the local lymph node assay
    Rebecca J Dearman
    Immunology, Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK1 4TJ, UK
    Contact Dermatitis 57:242-7. 2007
  9. ncbi The local lymph node assay and skin sensitization: a cut-down screen to reduce animal requirements?
    Ian Kimber
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
    Contact Dermatitis 54:181-5. 2006
  10. ncbi Chemical allergy: considerations for the practical application of cytokine profiling
    Rebecca J Dearman
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, United Kingdom
    Toxicol Sci 71:137-45. 2003

Collaborators

Detail Information

Publications14

  1. ncbi Temporal changes in cytokine gene expression profiles induced in mice by trimellitic anhydride
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
    Toxicol Lett 136:121-32. 2002
    ..These data show that as the immune response to TMA develops, the cytokine gene expression profile of allergen-activated lymph node cells evolves from a mixed Th1/Th2 phenotype to a more polarized Th2 profile...
  2. ncbi Assessment of glycosylation-dependent cell adhesion molecule 1 as a correlate of allergen-stimulated lymph node activation
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Toxicology 185:103-17. 2003
    ....
  3. ncbi B220 analysis with the local lymph node assay: proposal for a more flexible prediction model
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    J Appl Toxicol 27:506-10. 2007
    ..As a result a new prediction model is proposed in which reliance on the use of absolute thresholds is reduced, and in which small changes in control values can be better accommodated...
  4. ncbi Intradermal exposure of BALB/c strain mice to peanut protein elicits a type 2 cytokine response
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Food Chem Toxicol 42:1589-99. 2004
    ..These data demonstrate that exposure of mice to peanut allergen results in the selective stimulation of a Th2-type response...
  5. ncbi Potency and risk assessment of a skin-sensitizing disperse dye using the local lymph node assay
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK1 4TJ, UK
    Contact Dermatitis 52:268-72. 2005
    ....
  6. ncbi The use of ethanol:diethylphthalate as a vehicle for the local lymph node assay
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
    Contact Dermatitis 56:70-5. 2007
    ..The conclusion drawn is that EtOH:DEP provides a suitable vehicle for use in the LLNA and that the approach described provides a basis for future evaluation of novel vehicles...
  7. ncbi Skin sensitization potency of methyl methacrylate in the local lymph node assay: comparisons with guinea-pig data and human experience
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK1 4TJ, UK
    Contact Dermatitis 55:140-7. 2006
    ..Results of LLNA studies have been interpreted in the context of historical clinical data on occupational allergic contact dermatitis associated with exposure to MMA...
  8. ncbi Comparative analysis of skin sensitization potency of acrylates (methyl acrylate, ethyl acrylate, butyl acrylate, and ethylhexyl acrylate) using the local lymph node assay
    Rebecca J Dearman
    Immunology, Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK1 4TJ, UK
    Contact Dermatitis 57:242-7. 2007
    ..7% is on the borderline between moderate (<10%) and weak (>10%) categories. Thus, the judicious view is that all 4 chemicals possess relatively weak skin sensitizing potential...
  9. ncbi The local lymph node assay and skin sensitization: a cut-down screen to reduce animal requirements?
    Ian Kimber
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
    Contact Dermatitis 54:181-5. 2006
    ..However, a detailed evaluation will be necessary to provide reassurance that a reduction in group size would provide adequate sensitivity across a range of skin sensitization potencies...
  10. ncbi Chemical allergy: considerations for the practical application of cytokine profiling
    Rebecca J Dearman
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, United Kingdom
    Toxicol Sci 71:137-45. 2003
    ..The purpose of this brief review article is to consider the approaches available and to highlight key procedural issues...
  11. ncbi Assessment of the allergenic potential of proteins
    Ian Kimber
    Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, Macclesfield, UK
    Toxicol Lett 140:297-302. 2003
    ..Experience to date is encouraging and the data available reveal that this method is able to distinguish between proteins of different allergenic potential...
  12. doi Islets of Langerhans from prohormone convertase-2 knockout mice show α-cell hyperplasia and tumorigenesis with elevated α-cell neogenesis
    Huw B Jones
    Department of Pathological Sciences, AstraZeneca Pharmaceuticals, Macclesfield, Cheshire, UK
    Int J Exp Pathol 95:29-48. 2014
    ..We conclude that absolute blockade of the glucagon signal results in tumorigenesis and that the PC2-ko mouse represents a valuable model for investigation of islet tumours and pancreatic ductal neogenesis. ..
  13. ncbi Interactions of contact allergens with dendritic cells: opportunities and challenges for the development of novel approaches to hazard assessment
    Cindy A Ryan
    Miami Valley Innovation Center, Central Product Safety Department, The Procter and Gamble Company, Cincinnati, Ohio 45253 8707, USA
    Toxicol Sci 88:4-11. 2005
    ....
  14. ncbi The reduced local lymph node assay: the impact of group size
    Cindy A Ryan
    The Procter and Gamble Company, Cincinnati, OH 45253 8707, USA
    J Appl Toxicol 28:518-23. 2008
    ..It is concluded that a rLLNA with two mice/group would display decreased sensitivity and is inappropriate for use in hazard identification...