Research Topics
| Catherine J BettsSummaryAffiliation: Syngenta Central Toxicology Laboratory Country: UK Publications
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Detail Information
Publications
Temporal changes in cytokine gene expression profiles induced in mice by trimellitic anhydrideCatherine J Betts
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
Toxicol Lett 136:121-32. 2002..These data show that as the immune response to TMA develops, the cytokine gene expression profile of allergen-activated lymph node cells evolves from a mixed Th1/Th2 phenotype to a more polarized Th2 profile...- The use of ethanol:diethylphthalate as a vehicle for the local lymph node assayCatherine J Betts
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
Contact Dermatitis 56:70-5. 2007..The conclusion drawn is that EtOH:DEP provides a suitable vehicle for use in the LLNA and that the approach described provides a basis for future evaluation of novel vehicles... - Skin sensitization potency of methyl methacrylate in the local lymph node assay: comparisons with guinea-pig data and human experienceCatherine J Betts
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK1 4TJ, UK
Contact Dermatitis 55:140-7. 2006..Results of LLNA studies have been interpreted in the context of historical clinical data on occupational allergic contact dermatitis associated with exposure to MMA... - Potency and risk assessment of a skin-sensitizing disperse dye using the local lymph node assayCatherine J Betts
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK1 4TJ, UK
Contact Dermatitis 52:268-72. 2005.... - Intradermal exposure of BALB/c strain mice to peanut protein elicits a type 2 cytokine responseCatherine J Betts
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
Food Chem Toxicol 42:1589-99. 2004..These data demonstrate that exposure of mice to peanut allergen results in the selective stimulation of a Th2-type response... - Assessment of glycosylation-dependent cell adhesion molecule 1 as a correlate of allergen-stimulated lymph node activationCatherine J Betts
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
Toxicology 185:103-17. 2003.... - B220 analysis with the local lymph node assay: proposal for a more flexible prediction modelCatherine J Betts
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
J Appl Toxicol 27:506-10. 2007..As a result a new prediction model is proposed in which reliance on the use of absolute thresholds is reduced, and in which small changes in control values can be better accommodated... - Comparative analysis of skin sensitization potency of acrylates (methyl acrylate, ethyl acrylate, butyl acrylate, and ethylhexyl acrylate) using the local lymph node assayRebecca J Dearman
Immunology, Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK1 4TJ, UK
Contact Dermatitis 57:242-7. 2007..7% is on the borderline between moderate (<10%) and weak (>10%) categories. Thus, the judicious view is that all 4 chemicals possess relatively weak skin sensitizing potential... - The local lymph node assay and skin sensitization: a cut-down screen to reduce animal requirements?Ian Kimber
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
Contact Dermatitis 54:181-5. 2006..However, a detailed evaluation will be necessary to provide reassurance that a reduction in group size would provide adequate sensitivity across a range of skin sensitization potencies... - Chemical allergy: considerations for the practical application of cytokine profilingRebecca J Dearman
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, United Kingdom
Toxicol Sci 71:137-45. 2003..The purpose of this brief review article is to consider the approaches available and to highlight key procedural issues... - Assessment of the allergenic potential of proteinsIan Kimber
Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, Macclesfield, UK
Toxicol Lett 140:297-302. 2003..Experience to date is encouraging and the data available reveal that this method is able to distinguish between proteins of different allergenic potential... - Interactions of contact allergens with dendritic cells: opportunities and challenges for the development of novel approaches to hazard assessmentCindy A Ryan
Miami Valley Innovation Center, Central Product Safety Department, The Procter and Gamble Company, Cincinnati, Ohio 45253 8707, USA
Toxicol Sci 88:4-11. 2005.... - The reduced local lymph node assay: the impact of group sizeCindy A Ryan
The Procter and Gamble Company, Cincinnati, OH 45253 8707, USA
J Appl Toxicol 28:518-23. 2008..It is concluded that a rLLNA with two mice/group would display decreased sensitivity and is inappropriate for use in hazard identification...