Linda J Stephen

Summary

Country: UK

Publications

  1. doi request reprint Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer's disease
    Eduardo Cumbo
    Alzheimer Unit, Neuroscience Department, ASP Caltanissetta, Caltanissetta, Italy
    Epilepsy Behav 17:461-6. 2010
  2. doi request reprint A prospective audit of adjunctive zonisamide in an everyday clinical setting
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Behav 17:455-60. 2010
  3. doi request reprint Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit
    L J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, UK
    Acta Neurol Scand 124:142-5. 2011
  4. doi request reprint Levetiracetam monotherapy--outcomes from an epilepsy clinic
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Seizure 20:554-7. 2011
  5. doi request reprint Adjunctive lacosamide in clinical practice: sodium blockade with a difference?
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Behav 22:499-504. 2011
  6. ncbi request reprint Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy
    Linda J Stephen
    Epilepsy Unit, University Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Res 75:122-9. 2007
  7. ncbi request reprint Levetiracetam for people with mental retardation and refractory epilepsy
    Kevin Kelly
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Behav 5:878-83. 2004
  8. doi request reprint Binasal visual field defects are not specific to vigabatrin
    Pedro Gonzalez
    Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, Scotland, UK
    Epilepsy Behav 16:521-6. 2009
  9. ncbi request reprint Pharmacological outcomes in people with mental retardation and epilepsy
    Kevin Kelly
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Behav 5:67-71. 2004
  10. ncbi request reprint Pharmacological outcomes in older people with newly diagnosed epilepsy
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Behav 8:434-7. 2006

Collaborators

Detail Information

Publications23

  1. doi request reprint Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer's disease
    Eduardo Cumbo
    Alzheimer Unit, Neuroscience Department, ASP Caltanissetta, Caltanissetta, Italy
    Epilepsy Behav 17:461-6. 2010
    ..LTG had a better effect on mood. LEV had a benign neuropsychological side effect profile, making it a cognitively safe drug to use for controlling established seizures in elderly patients with Alzheimer's disease...
  2. doi request reprint A prospective audit of adjunctive zonisamide in an everyday clinical setting
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Behav 17:455-60. 2010
    ..Around 80% of patients who became seizure free on ZNS or had the drug withdrawn did so on a dose 200mg. ZNS is an effective broad-spectrum AED that can also produce a range of dose-dependent and idiosyncratic side effects...
  3. doi request reprint Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit
    L J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, UK
    Acta Neurol Scand 124:142-5. 2011
    ..Pregabalin (PGB) was licensed in Europe as an add-on antiepileptic drug (AED) for the treatment of partial-onset seizures in 2004. This audit assessed the response to adjunctive PGB in patients with uncontrolled seizures...
  4. doi request reprint Levetiracetam monotherapy--outcomes from an epilepsy clinic
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Seizure 20:554-7. 2011
    ..This retrospective audit explores outcomes in patients commenced on LEV monotherapy at the Epilepsy Unit at the Western Infirmary, Glasgow, Scotland from 1st January 2001 until 30th June 2009...
  5. doi request reprint Adjunctive lacosamide in clinical practice: sodium blockade with a difference?
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Behav 22:499-504. 2011
    ..These data suggest that the pharmacological effect of LCM differs importantly from that of AEDs that influence fast inactivation of the sodium channel...
  6. ncbi request reprint Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy
    Linda J Stephen
    Epilepsy Unit, University Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Res 75:122-9. 2007
    ..No difference in efficacy was found between VPA and LTG in our patients with newly diagnosed epilepsy. LTG appeared to be better tolerated. Neither drug appeared to alter the circulating levels of androgenic hormones...
  7. ncbi request reprint Levetiracetam for people with mental retardation and refractory epilepsy
    Kevin Kelly
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Behav 5:878-83. 2004
    ..001). LEV improved seizure control in the majority of patients with mental retardation and may also have enhanced their quality of life...
  8. doi request reprint Binasal visual field defects are not specific to vigabatrin
    Pedro Gonzalez
    Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, Scotland, UK
    Epilepsy Behav 16:521-6. 2009
    ..Assessment by conventional static perimetry may neither be sufficiently sensitive nor specific to reliably identify retinal toxicity associated with VGB...
  9. ncbi request reprint Pharmacological outcomes in people with mental retardation and epilepsy
    Kevin Kelly
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Behav 5:67-71. 2004
    ..These findings suggest that AED therapy can result in seizure freedom in more than 40% of mentally retarded people with epilepsy without producing unacceptable toxicity...
  10. ncbi request reprint Pharmacological outcomes in older people with newly diagnosed epilepsy
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Behav 8:434-7. 2006
    ..Old age is the most common time in life to develop epilepsy. Despite this, there are few published data exploring pharmacological outcomes in this population...
  11. ncbi request reprint Sudden unexpected death in epilepsy: a search for risk factors
    Nikolas Hitiris
    Epilepsy Unit, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Behav 10:138-41. 2007
    ..There is an urgent need for a large-scale, prospective, international, community-based study of SUDEP to explore more closely the risk factors to plan preventive strategies...
  12. doi request reprint Antiepileptic drug combinations--have newer agents altered clinical outcomes?
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Res 98:194-8. 2012
    ..An alternative approach to AED development may be required to change this disappointing scenario...
  13. ncbi request reprint Levetiracetam in refractory epilepsy: a prospective observational study
    Rajiv Mohanraj
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Seizure 14:23-7. 2005
    ..LEV is an effective adjunctive treatment for refractory idiopathic and localisation-related epilepsies. Many patients who responded optimally to LEV did so at 1000 mg per day or less...
  14. doi request reprint Management of a first seizure. Special problems: adults and elderly
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, United Kingdom
    Epilepsia 49:45-9. 2008
    ..Treatment following a first seizure should balance risk factors for recurrence with the informed opinion of the patients and their family...
  15. doi request reprint Antiepileptic drug monotherapy versus polytherapy: pursuing seizure freedom and tolerability in adults
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Curr Opin Neurol 25:164-72. 2012
    ..This article explores treatment options and issues influencing whether AEDs should be substituted or combined in the remainder of the patient population...
  16. ncbi request reprint Seizure freedom with more than one antiepileptic drug
    Linda J Stephen
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Seizure 11:349-51. 2002
    ..Treatment with two or three but not four AEDs may be a useful therapeutic option for patients not responding to monotherapy. Further explorations of the best regimens for individual seizure types and epilepsy syndromes is required...
  17. doi request reprint Pharmacotherapy of epilepsy: newly approved and developmental agents
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland
    CNS Drugs 25:89-107. 2011
    ....
  18. ncbi request reprint Drug treatment of epilepsy in elderly people: focus on valproic Acid
    Linda J Stephen
    Epilepsy Unit, University Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Drugs Aging 20:141-52. 2003
    ..To accurately establish the place of this and other AEDs in treating elderly patients with epilepsy, well designed clinical trials are urgently required in this vulnerable population...
  19. doi request reprint Selection of antiepileptic drugs in adults
    Linda J Stephen
    Division of Cardiovascular and Medical Sciences, Epilepsy Unit, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Neurol Clin 27:967-92. 2009
    ..In the past 20 years, the explosion of 13 new agents into the marketplace has greatly increased the potential for therapeutic intervention. This article explores the rationale for treatment selection in adults with epilepsy...
  20. ncbi request reprint Topiramate in patients with learning disability and refractory epilepsy
    Kevin Kelly
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsia 43:399-402. 2002
    ..This prospective study explored the efficacy and tolerability of adjunctive topiramate (TPM) in patients with learning disability and refractory epilepsy attending a single centre...
  21. ncbi request reprint Outcomes in elderly patients with newly diagnosed and treated epilepsy
    Martin J Brodie
    Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, UK
    Int Rev Neurobiol 81:253-63. 2007
    ..Choice of drug may depend on comorbidity and comedication, among other factors. Initial dosing should be low with a slow titration schedule. A holistic approach to care helps optimize the outcome for elderly people with epilepsy...
  22. doi request reprint Prospective audits with newer antiepileptic drugs in focal epilepsy: Insights into population responses?
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Behav 31:73-6. 2014
    ..These data support the suggestion that the introduction of modern agents has not importantly impacted the outcomes in refractory epilepsy. ..
  23. ncbi request reprint Outcomes from a nurse-led clinic for adolescents with epilepsy
    Linda J Stephen
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Seizure 12:539-44. 2003
    ..We established a nurse-led clinic for young people with suspected or diagnosed epilepsy. Outcomes in all patients referred during the first 4 years after its inception are reported...