P H Whincup

Summary

Affiliation: St George's
Country: UK

Publications

  1. pmc Interleukin 18 and coronary heart disease: prospective study and systematic review
    Barbara J M H Jefferis
    Department of Primary Care and Population Health, University College London, London NW3 2PF, UK
    Atherosclerosis 217:227-33. 2011
  2. ncbi request reprint Childhood obesity and cardiovascular disease: the challenge ahead
    Peter H Whincup
    Division of Community Health Sciences, St George s, University of London, UK
    Nat Clin Pract Cardiovasc Med 2:432-3. 2005
  3. ncbi request reprint Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors
    P H Whincup
    Division of Community Health Sciences, St George s, University of London, London SW17 0RE, United Kingdom
    Circulation 112:1789-97. 2005
  4. doi request reprint Birth weight and risk of type 2 diabetes: a systematic review
    Peter H Whincup
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, England
    JAMA 300:2886-97. 2008
  5. pmc Early emergence of ethnic differences in type 2 diabetes precursors in the UK: the Child Heart and Health Study in England (CHASE Study)
    Peter H Whincup
    Division of Community Health Sciences, St George s, University of London, London, United Kingdom
    PLoS Med 7:e1000263. 2010
  6. pmc Physical activity, obesity and cardiometabolic risk factors in 9- to 10-year-old UK children of white European, South Asian and black African-Caribbean origin: the Child Heart And health Study in England (CHASE)
    C G Owen
    Division of Community Health Sciences, St George s University of London, Cranmer Terrace, London SW17 ORE, UK
    Diabetologia 53:1620-30. 2010
  7. doi request reprint Prospective study of seasonal patterns in hemostatic factors in older men and their relation to excess winter coronary heart disease deaths
    M A Ghebre
    Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Thromb Haemost 10:352-8. 2012
  8. doi request reprint Prospective study of circulating soluble CD40 ligand concentrations and the incidence of cardiovascular disease in a nested prospective case-control study of older men and women
    B J Jefferis
    Department of Primary Care and Population Health, UCL Medical School, Rowland Hill Street, London, UK
    J Thromb Haemost 9:1452-9. 2011
  9. pmc Cotinine-assessed second-hand smoke exposure and risk of cardiovascular disease in older adults
    B J Jefferis
    UCL Department of Primary Care and Population Health, UCL Medical School, London, UK
    Heart 96:854-9. 2010
  10. doi request reprint Statin use after first myocardial infarction in UK men and women from 1997 to 2006: Who started and who continued treatment?
    I M Carey
    Division of Population Health Sciences and Education, St George s University of London, London SW17 0RE, United Kingdom
    Nutr Metab Cardiovasc Dis 22:400-8. 2012

Detail Information

Publications100

  1. pmc Interleukin 18 and coronary heart disease: prospective study and systematic review
    Barbara J M H Jefferis
    Department of Primary Care and Population Health, University College London, London NW3 2PF, UK
    Atherosclerosis 217:227-33. 2011
    ..We report new data from the largest prospective study to date, which are combined with data from all published prospective studies in a meta-analysis...
  2. ncbi request reprint Childhood obesity and cardiovascular disease: the challenge ahead
    Peter H Whincup
    Division of Community Health Sciences, St George s, University of London, UK
    Nat Clin Pract Cardiovasc Med 2:432-3. 2005
  3. ncbi request reprint Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors
    P H Whincup
    Division of Community Health Sciences, St George s, University of London, London SW17 0RE, United Kingdom
    Circulation 112:1789-97. 2005
    ....
  4. doi request reprint Birth weight and risk of type 2 diabetes: a systematic review
    Peter H Whincup
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, England
    JAMA 300:2886-97. 2008
    ..Low birth weight is implicated as a risk factor for type 2 diabetes. However, the strength, consistency, independence, and shape of the association have not been systematically examined...
  5. pmc Early emergence of ethnic differences in type 2 diabetes precursors in the UK: the Child Heart and Health Study in England (CHASE Study)
    Peter H Whincup
    Division of Community Health Sciences, St George s, University of London, London, United Kingdom
    PLoS Med 7:e1000263. 2010
    ..We examined whether corresponding ethnic differences were apparent in childhood...
  6. pmc Physical activity, obesity and cardiometabolic risk factors in 9- to 10-year-old UK children of white European, South Asian and black African-Caribbean origin: the Child Heart And health Study in England (CHASE)
    C G Owen
    Division of Community Health Sciences, St George s University of London, Cranmer Terrace, London SW17 ORE, UK
    Diabetologia 53:1620-30. 2010
    ..We examined these associations in UK children of South Asian, black African-Caribbean and white European origin...
  7. doi request reprint Prospective study of seasonal patterns in hemostatic factors in older men and their relation to excess winter coronary heart disease deaths
    M A Ghebre
    Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Thromb Haemost 10:352-8. 2012
    ..The potential contributions of these hemostatic activation measures to excess winter mortality are unknown...
  8. doi request reprint Prospective study of circulating soluble CD40 ligand concentrations and the incidence of cardiovascular disease in a nested prospective case-control study of older men and women
    B J Jefferis
    Department of Primary Care and Population Health, UCL Medical School, Rowland Hill Street, London, UK
    J Thromb Haemost 9:1452-9. 2011
    ..CD40 ligand(CD40L) is implicated in atherosclerotic plaque formation...
  9. pmc Cotinine-assessed second-hand smoke exposure and risk of cardiovascular disease in older adults
    B J Jefferis
    UCL Department of Primary Care and Population Health, UCL Medical School, London, UK
    Heart 96:854-9. 2010
    ..To examine whether second-hand smoke (SHS) exposure measured by serum cotinine is associated with increased coronary heart disease (CHD) and stroke risk among contemporary older British adults...
  10. doi request reprint Statin use after first myocardial infarction in UK men and women from 1997 to 2006: Who started and who continued treatment?
    I M Carey
    Division of Population Health Sciences and Education, St George s University of London, London SW17 0RE, United Kingdom
    Nutr Metab Cardiovasc Dis 22:400-8. 2012
    ..To examine trends in initiation and continuation of statin treatment after myocardial infarction (MI) and their determinants, during a period of increasing usage...
  11. doi request reprint Do women exhibit greater differences in established and novel risk factors between diabetes and non-diabetes than men? The British Regional Heart Study and British Women's Heart Health Study
    S G Wannamethee
    Department of Primary Care and Population Health, UCL Medical School, Hampstead Campus, Rowland Hill St, London, NW3 2PF, UK
    Diabetologia 55:80-7. 2012
    ....
  12. pmc Socioeconomic inequalities in coronary heart disease risk in older age: contribution of established and novel coronary risk factors
    S E Ramsay
    Division of Population Health, UCL, London, UK
    J Thromb Haemost 7:1779-86. 2009
    ..Little is also known about the contributions that novel coronary risk factors (particularly inflammatory/hemostatic markers) make to socioeconomic inequalities in CHD...
  13. ncbi request reprint C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors
    D G Cook
    Department of Public Health Sciences, St George s Hospital Medical School, Cranmer Terrace, London, UK
    Atherosclerosis 149:139-50. 2000
    ..Longitudinal studies are needed to determine whether these associations reflect long term elevations of these risk factors in some individuals, or short term fluctuations in different individuals...
  14. doi request reprint Sex differences in the relationship between inflammatory and hemostatic biomarkers and metabolic syndrome: British 1958 Birth Cohort
    A R Rudnicka
    Division of Population Health Sciences and Education, St George s, University of London, Cranmer Terrace, London Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Thromb Haemost 9:2337-44. 2011
    ..However, their associations with metabolic syndrome and its components in large populations of men and women have not been well defined...
  15. pmc Nutritional composition of the diets of South Asian, black African-Caribbean and white European children in the United Kingdom: the Child Heart and Health Study in England (CHASE)
    A S Donin
    Division of Community Health Sciences, St George s, University of London, London SW17 0RE, UK
    Br J Nutr 104:276-85. 2010
    ..Appreciable ethnic differences exist in the nutritional composition of children's diets, which may contribute to future differences in chronic disease risk...
  16. pmc Secondhand smoke (SHS) exposure is associated with circulating markers of inflammation and endothelial function in adult men and women
    B J Jefferis
    Department Primary Care and Population Health, UCL Medical School, Rowland Hill St, NW3 2PF, London, UK
    Atherosclerosis 208:550-6. 2010
    ..Therefore we investigate associations between SHS exposure and CHD risk factors, to clarify how SHS exposure may raise risk of CHD...
  17. ncbi request reprint Inter-relationships of interleukin-6, cardiovascular risk factors and the metabolic syndrome among older men
    S G Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    J Thromb Haemost 5:1637-43. 2007
    ..Interleukin-6 (IL-6) has been implicated in the development of cardiovascular disease. We have examined the relationship between plasma IL-6 and insulin resistance, and metabolic, inflammatory and hemostatic markers...
  18. pmc School dinners and markers of cardiovascular health and type 2 diabetes in 13-16 year olds: cross sectional study
    P H Whincup
    Division of Community Health Sciences, St George s, University of London, London SW17 0RE
    BMJ 331:1060-1. 2005
  19. ncbi request reprint British South Asians aged 13-16 years have higher fasting glucose and insulin levels than Europeans
    P H Whincup
    Department of Community Health Sciences, St George s Hospital Medical School, London, UK
    Diabet Med 22:1275-7. 2005
    ..To examine whether plasma glucose, insulin resistance and markers of adiposity differed between British adolescents of South Asian and European origin...
  20. ncbi request reprint Variability of angina symptoms and the risk of major ischemic heart disease events
    F C Lampe
    Cardiovascular Research Unit, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    Am J Epidemiol 153:1173-82. 2001
    ..In middle-aged men, exertional chest pain is a strong indicator of major coronary risk but frequently appears transient in the longer term. Persistently reported symptoms are associated with severe disease and a poor prognosis...
  21. doi request reprint Persistency with medical treatment for glaucoma and ocular hypertension in the United Kingdom: 1994-2005
    C G Owen
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London, UK
    Eye (Lond) 23:1098-110. 2009
    ..To examine trends and demographic factors affecting persistence with ocular hypotensive therapy, from a period before prostaglandins were available to when they were the most common therapy...
  22. pmc Are social inequalities in mortality in Britain narrowing? Time trends from 1978 to 2005 in a population-based study of older men
    S E Ramsay
    Department of Primary Care and Population Sciences, Royal Free Hospital and University College Medical School, London, UK
    J Epidemiol Community Health 62:75-80. 2008
    ..To examine whether social inequalities in all-cause and coronary heart disease (CHD) mortality in Britain have reduced between 1978 and 2005...
  23. doi request reprint Blood pressure recording bias during a period when the Quality and Outcomes Framework was introduced
    I M Carey
    Division of Community Health Sciences, St George s, University of London, London, UK
    J Hum Hypertens 23:764-70. 2009
    ..This fall has been exaggerated due to values being clustered just below the QOF target, but there is no evidence of adverse effects of this on clinical management...
  24. doi request reprint The potential for a two-stage diabetes risk algorithm combining non-laboratory-based scores with subsequent routine non-fasting blood tests: results from prospective studies in older men and women
    S G Wannamethee
    Department of Primary Care and Population Health, UCL Medical School, Glasgow, UK
    Diabet Med 28:23-30. 2011
    ..To develop strategies based on simple clinical assessment and blood markers to identify older individuals at high risk for Type 2 diabetes...
  25. ncbi request reprint Migration within Great Britain and cardiovascular disease: early life and adult environmental factors
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Int J Epidemiol 31:1054-60. 2002
    ..To examine the relative contributions of early life and adult life factors to risk of cardiovascular disease (CVD) in middle-aged men using migration within Great Britain (GB)...
  26. pmc Is body mass index before middle age related to coronary heart disease risk in later life? Evidence from observational studies
    C G Owen
    Division of Community Health Sciences, St George s, University of London, London, UK
    Int J Obes (Lond) 33:866-77. 2009
    ..We examined the relationship of body mass index (BMI) before 30 years of age to CHD risk in later life...
  27. ncbi request reprint Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    Am J Clin Nutr 83:567-74; quiz 726-7. 2006
    ..It has been suggested that a high dietary intake and high circulating concentrations of vitamin C may protect against ischemic heart disease...
  28. pmc The epidemiology of medical treatment for glaucoma and ocular hypertension in the United Kingdom: 1994 to 2003
    C G Owen
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Br J Ophthalmol 90:861-8. 2006
    ..To study trends in the prevalence of being treated for glaucoma and ocular hypertension from 1994 to 2003, and to examine factors determining treatment in 2002...
  29. ncbi request reprint Alcohol and adiposity: effects of quantity and type of drink and time relation with meals
    S G Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Int J Obes (Lond) 29:1436-44. 2005
    ..It has been suggested that the effects of alcohol on body weight and fat distribution may be influenced by the quantity and type of drink and may differ according to whether the alcohol is consumed with meals or not...
  30. ncbi request reprint Trends in secondary prevention of ischaemic heart disease in the UK 1994 2005: use of individual and combination treatment
    S DeWilde
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Heart 94:83-8. 2008
    ..Statins, antiplatelet drugs, beta-blockers and ACE inhibitors may produce marked benefits in secondary prevention of ischaemic heart disease (IHD), especially in combination...
  31. ncbi request reprint The relations of body composition and adiposity measures to ill health and physical disability in elderly men
    Sheena E Ramsay
    Department of Primary Care and Population Sciences, Royal Free Hospital and University College Medical School, London, United Kingdom
    Am J Epidemiol 164:459-69. 2006
    ..Prevention of weight gain with increasing age is likely to reduce morbidity and disability among older men...
  32. ncbi request reprint Age at puberty and adult blood pressure and body size in a British birth cohort study
    Rebecca Hardy
    Medical Research Council National Survey of Health and Development, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London, UK
    J Hypertens 24:59-66. 2006
    ..To investigate the association between age at puberty and blood pressure at age 53 years...
  33. pmc Are childhood socio-economic circumstances related to coronary heart disease risk? Findings from a population-based study of older men
    Sheena E Ramsay
    Department of Primary Care and Population Sciences, Royal Free Hospital and University College Medical School, Rowland Hill Street, London, UK
    Int J Epidemiol 36:560-6. 2007
    ..We examined the extent to which childhood socio-economic circumstances are related to the risk of coronary heart disease (CHD) in older British men, taking account of adult social class and behavioural risk factors...
  34. ncbi request reprint Prevalence of undiagnosed Type 2 diabetes and impaired fasting glucose in older British men and women
    M C Thomas
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Diabet Med 22:789-93. 2005
    ..To estimate the prevalence of undiagnosed diabetes and impaired fasting glucose in older British men and women, using the 1999 World Health Organization (WHO) thresholds based on fasting glucose measurements...
  35. ncbi request reprint Alcohol intake in middle age and risk of cardiovascular disease and mortality: accounting for intake variation over time
    J R Emberson
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Am J Epidemiol 161:856-63. 2005
    ..The findings suggest that considerable caution may be needed before any recommendations regarding acceptable limits of alcohol consumption are made...
  36. ncbi request reprint Insulin resistance, haemostatic and inflammatory markers and coronary heart disease risk factors in Type 2 diabetic men with and without coronary heart disease
    S G Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill St, London, NW3 2PF, UK
    Diabetologia 47:1557-65. 2004
    ..We have examined markers of haemostasis and inflammation in men with diabetes, coronary heart disease (CHD) or both, and assessed their associations with insulin resistance in men with Type 2 diabetes...
  37. ncbi request reprint Does breastfeeding influence risk of type 2 diabetes in later life? A quantitative analysis of published evidence
    Christopher G Owen
    Division of Community Health Sciences, St George s, University of London, London, United Kingdom
    Am J Clin Nutr 84:1043-54. 2006
    ..Observational evidence suggests that having been breastfed in infancy may reduce the prevalence of type 2 diabetes in later life...
  38. pmc Ethnic and gender differences in physical activity levels among 9-10-year-old children of white European, South Asian and African-Caribbean origin: the Child Heart Health Study in England (CHASE Study)
    Christopher G Owen
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London, UK
    Int J Epidemiol 38:1082-93. 2009
    ..We made objective measurements of physical activity in 9-10-year-old British children of South Asian, black African-Caribbean and white European origin...
  39. ncbi request reprint Modifiable lifestyle factors and the metabolic syndrome in older men: Effects of lifestyle changes
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    J Am Geriatr Soc 54:1909-14. 2006
    ..To examine the influence of lifestyle factors and changes in these factors on risk of the metabolic syndrome in elderly men...
  40. ncbi request reprint Birth weight and blood cholesterol level: a study in adolescents and systematic review
    Christopher G Owen
    Department of Public Health Sciences, St George s Hospital Medical School, London, United Kingdom
    Pediatrics 111:1081-9. 2003
    ..To examine the relationship between birth weight and blood total cholesterol (TC) and to compare its strength with that of the relationship between current body mass index and TC...
  41. doi request reprint Measuring retinal vessel tortuosity in 10-year-old children: validation of the Computer-Assisted Image Analysis of the Retina (CAIAR) program
    Christopher G Owen
    Division of Community Health Sciences, St George s, University of London, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:2004-10. 2009
    ..To examine the agreement of a novel computer program measuring retinal vessel tortuosity with subjective assessment of tortuosity in school-aged children...
  42. ncbi request reprint The relationship between physical activity, sedentary behaviour and psychological wellbeing among adolescents
    Michael H Ussher
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London, UK
    Soc Psychiatry Psychiatr Epidemiol 42:851-6. 2007
    ....
  43. doi request reprint Ethnic differences in blood lipids and dietary intake between UK children of black African, black Caribbean, South Asian, and white European origin: the Child Heart and Health Study in England (CHASE)
    Angela S Donin
    Division of Community Health Sciences, St George s, University of London, London, United Kingdom
    Am J Clin Nutr 92:776-83. 2010
    ..Ischemic heart disease (IHD) rates are lower in UK black Africans and black Caribbeans and higher in South Asians when compared with white Europeans. Ethnic differences in lipid concentrations may play a part in these differences...
  44. ncbi request reprint Effect of infant feeding on the risk of obesity across the life course: a quantitative review of published evidence
    Christopher G Owen
    Department of Community Health Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom
    Pediatrics 115:1367-77. 2005
    ..To examine the influence of initial infant feeding on obesity in later life...
  45. pmc Chronic exposure to outdoor air pollution and diagnosed cardiovascular disease: meta-analysis of three large cross-sectional surveys
    Lindsay J L Forbes
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Environ Health 8:30. 2009
    ..Our study aimed to estimate the size of the association between long term exposure to outdoor air pollution and prevalent cardiovascular disease...
  46. doi request reprint Chronic exposure to outdoor air pollution and markers of systemic inflammation
    Lindsay J L Forbes
    Division of Community Health Sciences, St George s, University of London, London, UK
    Epidemiology 20:245-53. 2009
    ....
  47. pmc Changes in environmental tobacco smoke (ETS) exposure over a 20-year period: cross-sectional and longitudinal analyses
    Barbara J Jefferis
    British Regional Heart Study, UCL Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Addiction 104:496-503. 2009
    ..To examine long-term changes in environmental tobacco smoke (ETS) exposure in British men between 1978 and 2000, using serum cotinine...
  48. ncbi request reprint Does initial breastfeeding lead to lower blood cholesterol in adult life? A quantitative review of the evidence
    Christopher G Owen
    Division of Community Health Sciences, St George s, University of London, London, United Kingdom
    Am J Clin Nutr 88:305-14. 2008
    ..Earlier studies have suggested that infant feeding may program long-term changes in cholesterol metabolism...
  49. ncbi request reprint Body fat distribution, body composition, and respiratory function in elderly men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    Am J Clin Nutr 82:996-1003. 2005
    ..Most population studies have reported weak or nonsignificant associations between body mass index (BMI; in kg/m2) and lung function...
  50. doi request reprint Hypotensive medication, statins, and the risk of glaucoma
    Christopher G Owen
    Division of Community Health Sciences, St George s, University of London, London, United Kingdom
    Invest Ophthalmol Vis Sci 51:3524-30. 2010
    ..Changes in prescribing oral beta-blockers for cardiovascular disorders may affect the number of those who eventually have glaucoma. There is no evidence to suggest that statins have a preventive role in glaucoma...
  51. ncbi request reprint The effect of breastfeeding on mean body mass index throughout life: a quantitative review of published and unpublished observational evidence
    Christopher G Owen
    Division of Community Health Sciences, St George s, University of London, London, United Kingdom
    Am J Clin Nutr 82:1298-307. 2005
    ..Evidence from observational studies has suggested that breastfeeding may reduce the prevalence of obesity in later life...
  52. pmc How much of the recent decline in the incidence of myocardial infarction in British men can be explained by changes in cardiovascular risk factors? Evidence from a prospective population-based study
    Sarah L Hardoon
    Department of Primary Care and Population Sciences, UCL, London, United Kingdom
    Circulation 117:598-604. 2008
    ..The incidence of myocardial infarction (MI) in Britain has fallen markedly in recent years. Few studies have investigated the extent to which this decline can be explained by concurrent changes in major cardiovascular risk factors...
  53. ncbi request reprint Infant feeding and blood cholesterol: a study in adolescents and a systematic review
    Christopher G Owen
    Department of Public Health Sciences, St George s Hospital Medical School, Cranmer Terrace, London, United Kingdom
    Pediatrics 110:597-608. 2002
    ..To examine the influence of infant feeding method on serum total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol...
  54. pmc Family dog ownership and levels of physical activity in childhood: findings from the Child Heart and Health Study in England
    Christopher G Owen
    Division of Community Health Sciences, St George s, University of London London, SW17 0RE, UK
    Am J Public Health 100:1669-71. 2010
    ....
  55. pmc Extent of social inequalities in disability in the elderly: results from a population-based study of British men
    Sheena E Ramsay
    Division of Population Health, University College London, St George s University of London, London, UK
    Ann Epidemiol 18:896-903. 2008
    ..Little is known about social inequalities in disability in the elderly. We examined the extent and determinants of socioeconomic inequalities in disability and functional limitation in elderly men in Britain...
  56. pmc Ethnic differences in the prevalence of myopia and ocular biometry in 10- and 11-year-old children: the Child Heart and Health Study in England (CHASE)
    Alicja R Rudnicka
    Division of Community Health Sciences, St George s, University of London, London, United Kingdom
    Invest Ophthalmol Vis Sci 51:6270-6. 2010
    ..In this study, ethnic differences in refractive status and ocular biometry were examined in a multiethnic sample of British children...
  57. pmc Is socioeconomic position related to the prevalence of metabolic syndrome?: influence of social class across the life course in a population-based study of older men
    Sheena E Ramsay
    Division of Population Health, University College London, London, UK
    Diabetes Care 31:2380-2. 2008
    ..To examine whether adult social class and childhood social class are related to metabolic syndrome in later life, independent of adult behavioral factors...
  58. ncbi request reprint Re-assessing the contribution of serum total cholesterol, blood pressure and cigarette smoking to the aetiology of coronary heart disease: impact of regression dilution bias
    Jonathan R Emberson
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Eur Heart J 24:1719-26. 2003
    ..To estimate the combined contribution of serum total cholesterol, blood pressure and cigarette smoking to coronary heart disease (CHD) risk after adjustment for regression dilution bias...
  59. ncbi request reprint Physical activity and hemostatic and inflammatory variables in elderly men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free Hospital School of Medicine, London, UK
    Circulation 105:1785-90. 2002
    ..Hemostatic and inflammatory markers have been linked with risk of cardiovascular disease. We therefore examined the relationship between physical activity and hemostatic and inflammatory variables...
  60. ncbi request reprint The metabolic syndrome and insulin resistance: relationship to haemostatic and inflammatory markers in older non-diabetic men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Atherosclerosis 181:101-8. 2005
    ..We have examined the cross-sectional relationship between insulin resistance, the metabolic syndrome and haemostatic and inflammatory markers...
  61. ncbi request reprint Measures of adiposity in the identification of metabolic abnormalities in elderly men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    Am J Clin Nutr 81:1313-21. 2005
    ..Body mass index (BMI; in kg/m(2)) is considered a poor indicator of overall and abdominal obesity in the elderly...
  62. ncbi request reprint The effects of different alcoholic drinks on lipids, insulin and haemostatic and inflammatory markers in older men
    Sasiwarang Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill St, London, NW3 2PF, UK
    Thromb Haemost 90:1080-7. 2003
    ..Wine has effects that may confer greater protection than other alcoholic beverages...
  63. ncbi request reprint Overweight and obesity and the burden of disease and disability in elderly men
    S Goya Wannamethee
    Department of Primary Care and Population Science, Royal Free and University College Medical School, London, UK
    Int J Obes Relat Metab Disord 28:1374-82. 2004
    ..To examine the prevalence of disease burden and disability associated with overweight and obesity in men aged 60-79 y and to assess whether the current WHO weight guidelines are appropriate in the elderly...
  64. doi request reprint Chronic exposure to outdoor air pollution and lung function in adults
    L J L Forbes
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London, UK
    Thorax 64:657-63. 2009
    ..The extent to which chronic exposure to outdoor air pollutants influences lung function in adults is unclear. The aim of this study was to measure the association between chronic exposure to outdoor air pollutants and adult lung function...
  65. ncbi request reprint Are early life factors responsible for international differences in adult blood pressure? An ecological study
    Christopher G Owen
    Department of Community Health Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Int J Epidemiol 34:649-54. 2005
    ..Although low birthweight has been related to higher mean blood pressure in individuals, there have been very few studies on the contribution of the 'fetal origins hypothesis' to international variations in mean blood pressure...
  66. pmc Is the recent rise in type 2 diabetes incidence from 1984 to 2007 explained by the trend in increasing BMI?: evidence from a prospective study of British men
    Sarah L Hardoon
    Division of Population Health, University College London, London, UK
    Diabetes Care 33:1494-6. 2010
    ..To estimate the extent to which increasing BMI may explain the rise in type 2 diabetes incidence in British men from 1984 to 2007...
  67. ncbi request reprint Extent of regression dilution for established and novel coronary risk factors: results from the British Regional Heart Study
    Jonathan R Emberson
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, NW3 2PF, UK
    Eur J Cardiovasc Prev Rehabil 11:125-34. 2004
    ..We examine the extent of this bias for established and novel risk factors for coronary heart disease (CHD) and consider the consequences for CHD prevention...
  68. ncbi request reprint Height loss in older men: associations with total mortality and incidence of cardiovascular disease
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, England
    Arch Intern Med 166:2546-52. 2006
    ..We examined the relationships between height loss over 20 years (starting at middle age) and subsequent total mortality and incidence of coronary heart disease and stroke in older men...
  69. pmc Associations between dietary fiber and inflammation, hepatic function, and risk of type 2 diabetes in older men: potential mechanisms for the benefits of fiber on diabetes risk
    S Goya Wannamethee
    Department of Primary Care and Population Health, University College Medical School, Hampstead Campus, University College London, London, UK
    Diabetes Care 32:1823-5. 2009
    ..To examine the relationship between dietary fiber and the risk of type 2 diabetes in older men and the role of hepatic and inflammatory markers...
  70. ncbi request reprint Social class differences in coronary heart disease in middle-aged British men: implications for prevention
    Jonathan R Emberson
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, NW3 2PF, UK
    Int J Epidemiol 33:289-96. 2004
    ....
  71. pmc Circulating TNFalpha levels in older men and women do not show independent prospective relations with MI or stroke
    Barbara J Jefferis
    UCL Department Primary Care and Population Health, Royal Free and University College Medical School, London, UK
    Atherosclerosis 205:302-8. 2009
    ....
  72. doi request reprint Do socioeconomic characteristics of neighbourhood of residence independently influence incidence of coronary heart disease and all-cause mortality in older British men?
    Richard W Morris
    Royal Free and University College Medical School, Hampstead Campus, Hampstead, London, UK
    Eur J Cardiovasc Prev Rehabil 15:19-25. 2008
    ..Our aim was to examine whether neighbourhood deprivation scores predict CHD and death in older men, independently of individual sociodemographic status...
  73. doi request reprint Hard drinking water does not protect against cardiovascular disease: new evidence from the British Regional Heart Study
    Richard W Morris
    Department of Primary Care and Population Sciences, University College London, London, UK
    Eur J Cardiovasc Prev Rehabil 15:185-9. 2008
    ..It has been previously suggested that hard drinking water in general, and in particular high calcium and magnesium intake from drinking water, protect against cardiovascular disease...
  74. ncbi request reprint Commentary: early life determinants of blood pressure in childhood--where do we go from here?
    Peter H Whincup
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Int J Epidemiol 35:877-9. 2006
  75. ncbi request reprint von Willebrand factor and coronary heart disease: prospective study and meta-analysis
    P H Whincup
    Department of Public Health Sciences, St George s Hospital Medical School, London, UK
    Eur Heart J 23:1764-70. 2002
    ..To determine whether circulating von Willebrand factor concentrations are prospectively related to risk of coronary heart disease in the general population...
  76. doi request reprint Length of the QT interval: determinants and prognostic implications in a population-based prospective study of older men
    Syed Mohammad Afzal Sohaib
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    J Electrocardiol 41:704-10. 2008
    ..We examined potential determinants and prognostic value of the corrected QT interval (QTc)...
  77. ncbi request reprint Decreased muscle mass and increased central adiposity are independently related to mortality in older men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    Am J Clin Nutr 86:1339-46. 2007
    ..Aging is associated with significant changes in body composition. Body mass index (BMI; in kg/m(2)) is not an accurate indicator of overweight and obesity in the elderly...
  78. pmc Secondary prevention of coronary heart disease in older British men: extent of inequalities before and after implementation of the National Service Framework
    Sheena E Ramsay
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    J Public Health (Oxf) 27:338-43. 2005
    ....
  79. ncbi request reprint Hepatic enzymes, the metabolic syndrome, and the risk of type 2 diabetes in older men
    Sasiwarang Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, U K
    Diabetes Care 28:2913-8. 2005
    ..We have examined the relationship between hepatic enzymes, the metabolic syndrome, insulin resistance, and type 2 diabetes and assessed the potential of hepatic enzyme measurements in determining diabetes risk...
  80. pmc Early evidence of ethnic differences in cardiovascular risk: cross sectional comparison of British South Asian and white children
    Peter H Whincup
    Department of Public Health Sciences, St George s Hospital Medical School, London SW17
    BMJ 324:635. 2002
    ..To examine whether British South Asian children differ in insulin resistance, adiposity, and cardiovascular risk profile from white children...
  81. doi request reprint Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies
    Naveed Sattar
    Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Lancet 371:1927-35. 2008
    ..We investigated to what extent metabolic syndrome and its individual components were related to risk for these two diseases in elderly populations...
  82. ncbi request reprint Adiponectin and coronary heart disease: a prospective study and meta-analysis
    Naveed Sattar
    University Department of Vascular Biochemistry, Glasgow, Scotland
    Circulation 114:623-9. 2006
    ..We report new data from a prospective study in the context of a meta-analysis of previously published prospective studies...
  83. pmc Effect of breast feeding in infancy on blood pressure in later life: systematic review and meta-analysis
    Christopher G Owen
    Department of Community Health Sciences, St George s Hospital Medical School, London SW17 ORE
    BMJ 327:1189-95. 2003
    ..To determine whether breast feeding in infancy compared with bottle feeding formula milk is associated with lower mean blood pressure at different ages...
  84. ncbi request reprint Relationships of inflammatory and haemostatic markers with social class: results from a population-based study of older men
    Sheena Ramsay
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Atherosclerosis 197:654-61. 2008
    ..The effect of socio-economic gradient on the factor VIII-vWF complex, APC resistance, plasma viscosity and platelet count merits further study...
  85. ncbi request reprint Lifestyle and cardiovascular disease in middle-aged British men: the effect of adjusting for within-person variation
    Jonathan Robert Emberson
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London NW3 2PF, UK
    Eur Heart J 26:1774-82. 2005
    ....
  86. doi request reprint Tissue plasminogen activator, von Willebrand factor, and risk of type 2 diabetes in older men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill St, London NW3 2PF, UK
    Diabetes Care 31:995-1000. 2008
    ....
  87. ncbi request reprint Sex differences in the association between birth weight and total cholesterol. A meta-analysis
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, United Kingdom
    Ann Epidemiol 16:19-25. 2006
    ..Determine whether a sex difference exists in the association between birth weight and total cholesterol later in life...
  88. ncbi request reprint Is the association between parity and coronary heart disease due to biological effects of pregnancy or adverse lifestyle risk factors associated with child-rearing? Findings from the British Women's Heart and Health Study and the British Regional Heart St
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    Circulation 107:1260-4. 2003
    ..Parity is associated with coronary heart disease (CHD) risk. In the present study, we assessed the associations between number of children and CHD in both women and men...
  89. ncbi request reprint Serum albumin and risk of stroke, coronary heart disease, and mortality: the role of cigarette smoking
    A Gerald Shaper
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowlands Hill Street, London NW3 2PF, UK
    J Clin Epidemiol 57:195-202. 2004
    ..These relationships have been examined with specific focus on the role of cigarette smoking...
  90. ncbi request reprint A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys
    Santiago Rodriguez
    Human Genetics Division, University of Southampton School of Medicine, Southampton General Hospital, Tremona Road, Southampton, UK
    Pharmacogenet Genomics 16:15-23. 2006
    ..We aimed here to study whether both TH01 and haplotypes of the wider IGF2-INS-TH region influence initiation of regular smoking in current smokers...
  91. pmc Secondary prevention of coronary heart disease in older patients after the national service framework: population based study
    Sheena E Ramsay
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London NW3 2PF
    BMJ 332:144-5. 2006
    ..To examine the extent of uptake of medication for secondary prevention of coronary heart disease in older British men and women before (1998-2001) and after (2003) the implementation of the national service framework...
  92. ncbi request reprint Renal function and cardiovascular mortality in elderly men: the role of inflammatory, procoagulant, and endothelial biomarkers
    Sasiwarang Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and, University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Eur Heart J 27:2975-81. 2006
    ..To assess the extent to which inflammatory, procoagulant, and endothelial biomarkers modify the relationship between diminished renal function and cardiovascular mortality...
  93. ncbi request reprint Hemostatic and rheological variables and risk of cardiovascular disease
    Gordon D O Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, United Kingdom
    Semin Vasc Med 2:429-39. 2002
    ....
  94. ncbi request reprint Adipokines and risk of type 2 diabetes in older men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Diabetes Care 30:1200-5. 2007
    ..The aim was to assess the relationship between adipokines, including interleukin (IL)-6, leptin, and adiponectin, with development of type 2 diabetes and assess the role of obesity and insulin resistance in these relationships...
  95. pmc Trends in rates of different forms of diagnosed coronary heart disease, 1978 to 2000: prospective, population based study of British men
    Fiona C Lampe
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London NW3 2PF
    BMJ 330:1046. 2005
    ..To examine trends over time in rates of different forms of diagnosed coronary heart disease among British men, during a period in which mortality due to coronary heart disease has been declining...
  96. ncbi request reprint Is birth weight a risk factor for ischemic heart disease in later life?
    Rachel Huxley
    George Institute, University of Sydney, Sydney, Australia
    Am J Clin Nutr 85:1244-50. 2007
    ..An inverse association between birth weight and ischemic heart disease (IHD) has been seen in observational studies...
  97. ncbi request reprint Circulating adiponectin levels and mortality in elderly men with and without cardiovascular disease and heart failure
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, England
    Arch Intern Med 167:1510-7. 2007
    ..We examined the relationship between adiponectin levels and mortality in older men with and without diagnosed cardiovascular disease (CVD) and heart failure...
  98. ncbi request reprint Associations between cigarette smoking, pipe/cigar smoking, and smoking cessation, and haemostatic and inflammatory markers for cardiovascular disease
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill St, London NW3 2PF, UK
    Eur Heart J 26:1765-73. 2005
    ..To examine the associations between cigarette smoking, pipe/cigar smoking, and years since quitting smoking, and inflammatory and haemostatic markers...
  99. ncbi request reprint Birth weight and subsequent cholesterol levels: exploration of the "fetal origins" hypothesis
    Rachel Huxley
    The George Institute, University of Sydney, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia
    JAMA 292:2755-64. 2004
    ..Inverse associations between birth weight and subsequent blood cholesterol levels have been used to support the "fetal origins" hypothesis of the relevance of fetal nutrition to adult disease...
  100. ncbi request reprint CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents
    Shuwen Huang
    Human Genetics Division, Duthie Building, Southampton General Hospital, UK
    Pharmacogenet Genomics 15:839-50. 2005
    ..Other genes are also implicated in smoking behaviour. We explored smoking behaviour and cotinine levels in relation to genotypes in adolescents...