Simon J Waddell

Summary

Affiliation: St George's
Country: UK

Publications

  1. pmc Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages
    Ludovic Tailleux
    Institut Pasteur, Unit of Mycobacterial Genetics, Paris, France
    PLoS ONE 3:e1403. 2008
  2. doi request reprint Use of DNA arrays to study transcriptional responses to antimycobacterial compounds
    Simon J Waddell
    Medical Microbiology, Division of Cellular and Molecular Medicine, Centre for Infection, St George s University of London, London, UK
    Methods Mol Biol 642:75-91. 2010
  3. pmc Dissecting interferon-induced transcriptional programs in human peripheral blood cells
    Simon J Waddell
    Department of Medicine, Stanford University, Stanford, California, United States of America
    PLoS ONE 5:e9753. 2010
  4. pmc Microarray analysis of whole genome expression of intracellular Mycobacterium tuberculosis
    Simon J Waddell
    Medical Microbiology, Division of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Curr Mol Med 7:287-96. 2007
  5. doi request reprint Whole genome analysis using microarrays
    S J Waddell
    Medical Microbiology, Division of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Methods Mol Biol 465:83-93. 2009
  6. pmc Microarray analysis of defined Mycobacterium tuberculosis populations using RNA amplification strategies
    Simon J Waddell
    Medical Microbiology, Centre for Infection, Division of Cellular and Molecular Medicine, St, George s University of London, Cranmer Terrace, Tooting, London, UK
    BMC Genomics 9:94. 2008
  7. doi request reprint Examining the basis of isoniazid tolerance in nonreplicating Mycobacterium tuberculosis using transcriptional profiling
    Griselda Tudó
    Medical Microbiology, Centre for Infection, Division of Cellular and Molecular Medicine, St George s University of London, London, SW17 0RE, UK
    Future Med Chem 2:1371-83. 2010
  8. ncbi request reprint The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds
    Simon J Waddell
    Department of Cellular and Molecular Medicine, St George s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Tuberculosis (Edinb) 84:263-74. 2004
  9. doi request reprint Distance-based differential analysis of gene curves
    Christopher Minas
    Statistics Section, Department of Mathematics, Imperial College London, London, UK
    Bioinformatics 27:3135-41. 2011
  10. pmc Quantification of global transcription patterns in prokaryotes using spotted microarrays
    Ben Sidders
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK
    Genome Biol 8:R265. 2007

Collaborators

Detail Information

Publications15

  1. pmc Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages
    Ludovic Tailleux
    Institut Pasteur, Unit of Mycobacterial Genetics, Paris, France
    PLoS ONE 3:e1403. 2008
    ..Here, for the first time, we have been able to investigate gene expression changes in both Mycobacterium tuberculosis, a major human pathogen, and its human host cells, macrophages and dendritic cells...
  2. doi request reprint Use of DNA arrays to study transcriptional responses to antimycobacterial compounds
    Simon J Waddell
    Medical Microbiology, Division of Cellular and Molecular Medicine, Centre for Infection, St George s University of London, London, UK
    Methods Mol Biol 642:75-91. 2010
    ..tuberculosis complex microarray, and the analysis strategies employed to interpret the transcriptional data generated...
  3. pmc Dissecting interferon-induced transcriptional programs in human peripheral blood cells
    Simon J Waddell
    Department of Medicine, Stanford University, Stanford, California, United States of America
    PLoS ONE 5:e9753. 2010
    ..This information provides a detailed view of cellular activation by immune mediators, and contributes an interpretive framework for the definition of host immune responses in a variety of disease settings...
  4. pmc Microarray analysis of whole genome expression of intracellular Mycobacterium tuberculosis
    Simon J Waddell
    Medical Microbiology, Division of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Curr Mol Med 7:287-96. 2007
    ..tuberculosis physiology and host microenvironments during natural infection...
  5. doi request reprint Whole genome analysis using microarrays
    S J Waddell
    Medical Microbiology, Division of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Methods Mol Biol 465:83-93. 2009
    ..Further developments in microarray design and methodology promise to ensure that microarrays remain an important resource for comparative genomic studies in the future...
  6. pmc Microarray analysis of defined Mycobacterium tuberculosis populations using RNA amplification strategies
    Simon J Waddell
    Medical Microbiology, Centre for Infection, Division of Cellular and Molecular Medicine, St, George s University of London, Cranmer Terrace, Tooting, London, UK
    BMC Genomics 9:94. 2008
    ..The first using oligo-dT primers after polyadenylation of the bacterial RNA, the second using a set of mycobacterial amplification-directed primers both linked to T7 polymerase in vitro run off transcription...
  7. doi request reprint Examining the basis of isoniazid tolerance in nonreplicating Mycobacterium tuberculosis using transcriptional profiling
    Griselda Tudó
    Medical Microbiology, Centre for Infection, Division of Cellular and Molecular Medicine, St George s University of London, London, SW17 0RE, UK
    Future Med Chem 2:1371-83. 2010
    ..In this article, we describe the transcriptional programs mediated by isoniazid (INH) during the transition from log-phase to nonreplicating bacilli, from INH-sensitive to INH-tolerant bacilli respectively, using the Wayne model...
  8. ncbi request reprint The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds
    Simon J Waddell
    Department of Cellular and Molecular Medicine, St George s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Tuberculosis (Edinb) 84:263-74. 2004
    ..tuberculosis to anti-microbial compounds. Further investigation into these mechanisms may elucidate novel pathways contributing to mycobacterial drug resistance and influence anti-mycobacterial drug development strategies...
  9. doi request reprint Distance-based differential analysis of gene curves
    Christopher Minas
    Statistics Section, Department of Mathematics, Imperial College London, London, UK
    Bioinformatics 27:3135-41. 2011
    ..We have assessed the comparative performance of the test on realistically simulated datasets and applied it to human immune cell responses to bacterial infection over time...
  10. pmc Quantification of global transcription patterns in prokaryotes using spotted microarrays
    Ben Sidders
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK
    Genome Biol 8:R265. 2007
    ....
  11. pmc RNA profiling in host-pathogen interactions
    Simon J Waddell
    Medical Microbiology, Division of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Curr Opin Microbiol 10:297-302. 2007
    ..Global expression profiling using microarray technologies can help to describe and define the mechanisms required by bacterial pathogens to cause disease and the host responses required to defeat bacterial infection...
  12. ncbi request reprint Increased transcription of a potential sigma factor regulatory gene Rv1364c in Mycobacterium bovis BCG while residing in macrophages indicates use of alternative promoters
    Ming Shi Li
    Department of Cellular and Molecular Medicine Medical Microbiology, St George s Hospital Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK
    FEMS Microbiol Lett 233:333-9. 2004
    ....
  13. doi request reprint Effects of low incubation temperatures on the bactericidal activity of anti-tuberculosis drugs
    David Coleman
    Centre for Infection, St George s, University of London, London SW17 0RE, UK
    J Antimicrob Chemother 66:146-50. 2011
    ..to explore the effect of low incubation temperatures and the consequent slowing of bacterial metabolism on the bactericidal action of anti-tuberculosis drugs against Mycobacterium tuberculosis...
  14. doi request reprint Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase
    Nazima Pathan
    Department of Paediatrics, Imperial College London, London, UK
    Crit Care Med 39:1692-711. 2011
    ..In the current study, we aimed to investigate the mechanisms by which interleukin 6 induces myocardial failure in meningococcal sepsis and to identify potential novel therapeutic targets...
  15. pmc Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum
    Natalie J Garton
    Department of Infection, Immunity and Inflammation, University of Leicester Medical School, Leicester, United Kingdom
    PLoS Med 5:e75. 2008
    ..A preliminary observation that Mycobacterium tuberculosis cells contain triacylglycerol lipid bodies in sputum, but not when growing in vitro, led us to investigate the extent of this phenomenon and its physiological basis...