M Stubbs

Summary

Affiliation: St George's Hospital Medical School
Country: UK

Publications

  1. ncbi request reprint Causes and consequences of tumour acidity and implications for treatment
    M Stubbs
    Department of Biochemistry, St George s Hospital Medical School, London, UK
    Mol Med Today 6:15-9. 2000
  2. ncbi request reprint Application of magnetic resonance techniques for imaging tumour physiology
    M Stubbs
    Cancer Research Campaign Biomedical Magnetic Resonance Research Group, Department of Biochemistry, St George s Hospital Medical School, London, UK
    Acta Oncol 38:845-53. 1999
  3. ncbi request reprint Understanding the tumor metabolic phenotype in the genomic era
    M Stubbs
    Cancer Research UK Biomedical Magnetic Resonance Research Group, St George s Hospital Medical School, London SW17 ORE, UK
    Curr Mol Med 3:49-59. 2003
  4. ncbi request reprint Effects of different levels of hypercapnic hyperoxia on tumour R(2)* and arterial blood gases
    S P Robinson
    CRC Biomedical Magnetic Resonance Research Group, Division of Biochemistry and Immunology, St George s Hospital Medical School, London, UK
    Magn Reson Imaging 19:161-6. 2001
  5. pmc In vivo detection of ifosfamide by 31P-MRS in rat tumours: increased uptake and cytotoxicity induced by carbogen breathing in GH3 prolactinomas
    L M Rodrigues
    CRC Biomedical Magnetic Resonance Research Group, St George s Hospital Medical School, London, UK
    Br J Cancer 75:62-8. 1997
  6. pmc The effects of host carbogen (95% oxygen/5% carbon dioxide) breathing on metabolic characteristics of Morris hepatoma 9618a
    M Stubbs
    Cancer Research Campaign Biomedical Magnetic Resonance Research Group, Division of Biochemistry, St George s Hospital Medical School, London, UK
    Br J Cancer 78:1449-56. 1998
  7. pmc Influence of pH on the uptake of 5-fluorouracil into isolated tumour cells
    A S Ojugo
    Division of Biochemistry, St George s Hospital Medical School, London, UK
    Br J Cancer 77:873-9. 1998
  8. ncbi request reprint Issues in flow and oxygenation dependent contrast (FLOOD) imaging of tumours
    F A Howe
    CRC Biomedical Magnetic Resonance Research Group, Department of Biochemistry and Immunology, St George s Hospital Medical School, London SW17 ORE, UK
    NMR Biomed 14:497-506. 2001
  9. pmc Response of hepatoma 9618a and normal liver to host carbogen and carbon monoxide breathing
    S P Robinson
    CRC Biomedical Magnetic Resonance Research Group, Division of Biochemistry, St George s Hospital Medical School, London, United Kingdom
    Neoplasia 1:537-43. 1999
  10. pmc Growth studies of subcutaneous rat tumours: comparison of 31P-NMR spectroscopy, acid extracts and histology
    M Stubbs
    CRC Biomedical Magnetic Resonance Research Group, St George s Hospital Medical School, London, UK
    Br J Cancer 60:701-7. 1989

Detail Information

Publications22

  1. ncbi request reprint Causes and consequences of tumour acidity and implications for treatment
    M Stubbs
    Department of Biochemistry, St George s Hospital Medical School, London, UK
    Mol Med Today 6:15-9. 2000
    ..Understanding tumour acidity opens up new opportunities for therapy...
  2. ncbi request reprint Application of magnetic resonance techniques for imaging tumour physiology
    M Stubbs
    Cancer Research Campaign Biomedical Magnetic Resonance Research Group, Department of Biochemistry, St George s Hospital Medical School, London, UK
    Acta Oncol 38:845-53. 1999
    ..g. 5FU, ifosfamide) and their metabolites at their sites of action. The role of these state-of-the-art MR methods in imaging tumour physiology and their potential role in the clinic are discussed...
  3. ncbi request reprint Understanding the tumor metabolic phenotype in the genomic era
    M Stubbs
    Cancer Research UK Biomedical Magnetic Resonance Research Group, St George s Hospital Medical School, London SW17 ORE, UK
    Curr Mol Med 3:49-59. 2003
    ....
  4. ncbi request reprint Effects of different levels of hypercapnic hyperoxia on tumour R(2)* and arterial blood gases
    S P Robinson
    CRC Biomedical Magnetic Resonance Research Group, Division of Biochemistry and Immunology, St George s Hospital Medical School, London, UK
    Magn Reson Imaging 19:161-6. 2001
    ..The data support the concept that levels of hypercapnia can be reduced without loss of enhanced oxygenation and hence potential radiotherapeutic benefit...
  5. pmc In vivo detection of ifosfamide by 31P-MRS in rat tumours: increased uptake and cytotoxicity induced by carbogen breathing in GH3 prolactinomas
    L M Rodrigues
    CRC Biomedical Magnetic Resonance Research Group, St George s Hospital Medical School, London, UK
    Br J Cancer 75:62-8. 1997
    ..Isolated GH3 cells were sensitive to the parent drug (IF) in vitro (IC50 = 1.3 +/- 0.2 mM) suggesting that the GH3 cells may be either expressing P450 enzymes or are sensitive to the parent drug per se...
  6. pmc The effects of host carbogen (95% oxygen/5% carbon dioxide) breathing on metabolic characteristics of Morris hepatoma 9618a
    M Stubbs
    Cancer Research Campaign Biomedical Magnetic Resonance Research Group, Division of Biochemistry, St George s Hospital Medical School, London, UK
    Br J Cancer 78:1449-56. 1998
    ....
  7. pmc Influence of pH on the uptake of 5-fluorouracil into isolated tumour cells
    A S Ojugo
    Division of Biochemistry, St George s Hospital Medical School, London, UK
    Br J Cancer 77:873-9. 1998
    ..Incubation with a drug that made plasma membranes permeable to H+ significantly decreased 5FU uptake in Lettre cells. The co-transport of 5FU may occur on a proton symport using the proton motive force of the deltapH...
  8. ncbi request reprint Issues in flow and oxygenation dependent contrast (FLOOD) imaging of tumours
    F A Howe
    CRC Biomedical Magnetic Resonance Research Group, Department of Biochemistry and Immunology, St George s Hospital Medical School, London SW17 ORE, UK
    NMR Biomed 14:497-506. 2001
    ..This can lead to R(2)* changes that are smaller or the reverse of those expected. To properly interpret FLOOD contrast changes these effects must be accounted for...
  9. pmc Response of hepatoma 9618a and normal liver to host carbogen and carbon monoxide breathing
    S P Robinson
    CRC Biomedical Magnetic Resonance Research Group, Division of Biochemistry, St George s Hospital Medical School, London, United Kingdom
    Neoplasia 1:537-43. 1999
    ..This tumor type and the liver are unaffected by CO breathing at 660 ppm, which implies an adequate oxygen supply...
  10. pmc Growth studies of subcutaneous rat tumours: comparison of 31P-NMR spectroscopy, acid extracts and histology
    M Stubbs
    CRC Biomedical Magnetic Resonance Research Group, St George s Hospital Medical School, London, UK
    Br J Cancer 60:701-7. 1989
    ..We conclude that increasing numbers of hypoxic tumour cells, rather than large areas of necrotic tissue, contribute largely to the NMR spectrum...
  11. ncbi request reprint Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours
    P M J McSheehy
    Department of Biochemistry, Cancer Research UK Biomedical Magnetic Resonance Research Group, St George s Hospital Medical School, London, UK
    Cancer Chemother Pharmacol 55:117-28. 2005
    ..5FU pharmacokinetics in tumour and plasma and physiological effects on the tumour by carbogen were investigated to determine the locus of carbogen action on augmenting tumour uptake of 5FU...
  12. pmc Effects of nicotinamide and carbogen on tumour oxygenation, blood flow, energetics and blood glucose levels
    S P Robinson
    CRC Biomedical Magnetic Resonance Research Group, Division of Biochemistry, St George s Hospital Medical School, London, UK
    Br J Cancer 82:2007-14. 2000
    ..The most striking observation was the marked increase in blood glucose (twofold) induced by both nicotinamide and carbogen. Whether this may play a role in tumour radiosensitivity has yet to be determined...
  13. ncbi request reprint Why are cancers acidic? A carrier-mediated diffusion model for H+ transport in the interstitial fluid
    J R Griffiths
    CRC Biomedical Magnetic Resonance Research Group, Department of Biochemistry and Immunology, St George s Hospital Medical School, London, UK
    Novartis Found Symp 240:46-62; discussion 62-7, 152-3. 2001
    ..We have developed a mathematical model of this carrier-mediated system that predicts pHe values as low as those observed in some tumours...
  14. pmc Monitoring therapeutic response to tamoxifen in NMU-induced rat mammary tumours by 31P MRS
    S Baluch
    CRC Biomedical Magnetic Resonance Research Group, St George s Hospital Medical School, London, UK
    Br J Cancer 63:901-4. 1991
    ..The significance of these findings and the possible mechanisms underlying the changes are discussed...
  15. pmc The effect of blood flow modification on intra- and extracellular pH measured by 31P magnetic resonance spectroscopy in murine tumours
    C L McCoy
    CRC Biomedical Magnetic Resonance Research Group, St George s Hospital Medical School, London, UK
    Br J Cancer 72:905-11. 1995
    ..These results indicate that the intracellular uptake of chemotherapeutic drugs which are dependent on the transmembrane pH gradient will not be enhanced in cells made ischaemic as a result of vascular shutdown...
  16. pmc 31P-NMR spectroscopy and histological studies of the response of rat mammary tumours to endocrine therapy
    M Stubbs
    CRC Biomedical Magnetic Resonance Research Group, St George s Hospital Medical School, London, UK
    Br J Cancer 61:258-62. 1990
    ..The changes detected by NMR must reflect early metabolic events, perhaps related to the histological changes observed at 14 days after ovariectomy. 31P-NMR spectroscopy may permit early monitoring of endocrine therapy for mammary cancer...
  17. ncbi request reprint The C-neu mammary carcinoma in Oncomice; characterization and monitoring response to treatment with herceptin by magnetic resonance methods
    L M Rodrigues
    CR UK Biomedical Magnetic Resonance Research Group, Department of Basic Medical Sciences, St George s Hospital Medical School, London, SW17 0RE, UK
    MAGMA 17:260-70. 2004
    ....
  18. ncbi request reprint Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy
    F A Howe
    Cancer Research UK Biomedical Magnetic Resonance Research Group, Department of Biochemistry and Immunology, St George s Hospital Medical School, Cramner Terrace, London, UK
    Magn Reson Med 49:223-32. 2003
    ..3 lipid signals vs. mI/Cho provided a simple way to separate most tumors by type and grade...
  19. ncbi request reprint Issues of normal tissue toxicity in patient and animal studies--effect of carbogen breathing in rats after 5-fluorouracil treatment
    J R Griffiths
    Department of Biochemistry and Immunology, St George s Hospital Medical School, London, UK
    Acta Oncol 40:609-14. 2001
    ..This study demonstrates that there were no significant effects of carbogen breathing on the levels of 5-FU and its metabolites in normal rat tissues, or on the histology of the tissues assessed after treatment...
  20. ncbi request reprint Magnetic Resonance Spectroscopy of cancer-practicalities of multi-centre trials and early results in non-Hodgkin's lymphoma
    J R Griffiths
    Cancer Research Campaign Biomedical Magnetic Resonance Research Group, Department of Biochemistry and Immunology, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Eur J Cancer 38:2085-93. 2002
    ....
  21. ncbi request reprint In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial
    F Arias-Mendoza
    Hatch Center for MR Research, Radiology Department, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    NMR Biomed 19:504-12. 2006
    ....
  22. ncbi request reprint Analysis of the acidic microenvironment in murine tumours by high-performance ion chromatography
    M R Stratford
    Cancer Research Campaign Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK
    J Chromatogr A 706:459-62. 1995
    ..After complete vascular occlusion induced by a clamp, lactate levels increased in the extracellular compartment...