M Sharland

Summary

Affiliation: St George's Hospital
Country: UK

Publications

  1. ncbi request reprint The use of antibacterials in children: a report of the Specialist Advisory Committee on Antimicrobial Resistance (SACAR) Paediatric Subgroup
    Mike Sharland
    Paediatric Infectious Diseases Unit, 5th Floor Lanesborough Wing, St George s Hospital, Blackshaw Road, London SW17 0QT, UK
    J Antimicrob Chemother 60:i15-26. 2007
  2. doi request reprint Risk-benefit analysis of restricting antimicrobial prescribing in children: what do we really know?
    Tamara Keith
    Department of Primary Care and Social Medicine, Imperial College London, London, UK
    Curr Opin Infect Dis 23:242-8. 2010
  3. doi request reprint Antiviral therapy of CMV disease in children
    Mike Sharland
    Paediatric Infectious Diseases Unit, St George s Hospital, London, UK
    Adv Exp Med Biol 697:243-60. 2011
  4. ncbi request reprint PENTA guidelines for the use of antiretroviral therapy, 2004
    M Sharland
    Paediatric Infectious Diseases Unit, St George s Hospital, London, UK
    HIV Med 5:61-86. 2004
  5. ncbi request reprint PENTA guidelines for the use of antiretroviral therapy in paediatric HIV infection. Pediatric European Network for Treatment of AIDS
    M Sharland
    Paediatric Infectious Diseases Unit, St George s Hospital, London, UK
    HIV Med 3:215-26. 2002
  6. doi request reprint Tuberculosis in the United Kingdom and Republic of Ireland
    S S S Teo
    University of London, London, UK
    Arch Dis Child 94:263-7. 2009
  7. doi request reprint Has UK guidance affected general practitioner antibiotic prescribing for otitis media in children?
    P L Thompson
    Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London, BMA House, Tavistock Square, London, UK
    J Public Health (Oxf) 30:479-86. 2008
  8. doi request reprint Clinically targeted screening for congenital CMV - potential for integration into the National Hearing Screening Programme
    S Kadambari
    Paediatric Infectious Diseases Research Group, Jenner Wing, St George s University of London, London, UK
    Acta Paediatr 102:928-33. 2013
  9. doi request reprint Community-acquired, healthcare-associated and hospital-acquired bloodstream infection definitions inĀ children: a systematic review demonstrating inconsistent criteria
    K L Henderson
    Department of Healthcare Associated Infections and Antimicrobial Resistance, Public Health England, London, UK Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK Electronic address
    J Hosp Infect 85:94-105. 2013
  10. doi request reprint Evidence based management guidelines for the detection and treatment of congenital CMV
    S Kadambari
    Paediatric Infectious Diseases Unit, St George s University of London, Cranmer Terrace, London, United Kingdom
    Early Hum Dev 87:723-8. 2011

Detail Information

Publications43

  1. ncbi request reprint The use of antibacterials in children: a report of the Specialist Advisory Committee on Antimicrobial Resistance (SACAR) Paediatric Subgroup
    Mike Sharland
    Paediatric Infectious Diseases Unit, 5th Floor Lanesborough Wing, St George s Hospital, Blackshaw Road, London SW17 0QT, UK
    J Antimicrob Chemother 60:i15-26. 2007
    ..Adherence to national guidelines and clinical outcome data can then be monitored in turn to provide a continuous audit process aimed at improving prescribing advice and reducing antimicrobial resistance...
  2. doi request reprint Risk-benefit analysis of restricting antimicrobial prescribing in children: what do we really know?
    Tamara Keith
    Department of Primary Care and Social Medicine, Imperial College London, London, UK
    Curr Opin Infect Dis 23:242-8. 2010
    ..This review summarizes evidence for the role of antibiotics in preventing serious complications of URTIs in children...
  3. doi request reprint Antiviral therapy of CMV disease in children
    Mike Sharland
    Paediatric Infectious Diseases Unit, St George s Hospital, London, UK
    Adv Exp Med Biol 697:243-60. 2011
    ..It also discusses the antiviral studies currently being performed and those that need to be performed...
  4. ncbi request reprint PENTA guidelines for the use of antiretroviral therapy, 2004
    M Sharland
    Paediatric Infectious Diseases Unit, St George s Hospital, London, UK
    HIV Med 5:61-86. 2004
    ..Regular formal assessment of adherence is now the standard of care, and routine monitoring in the clinic for lipodystrophy syndrome (LDS) and other ART toxicities is increasingly important. These guidelines will be updated again in 2006...
  5. ncbi request reprint PENTA guidelines for the use of antiretroviral therapy in paediatric HIV infection. Pediatric European Network for Treatment of AIDS
    M Sharland
    Paediatric Infectious Diseases Unit, St George s Hospital, London, UK
    HIV Med 3:215-26. 2002
    ..To produce European Guidelines for the use of antiretroviral therapy (ART) in HIV-infected children...
  6. doi request reprint Tuberculosis in the United Kingdom and Republic of Ireland
    S S S Teo
    University of London, London, UK
    Arch Dis Child 94:263-7. 2009
    ..To describe the clinical features, diagnosis and management of children with tuberculosis in the United Kingdom and Republic of Ireland...
  7. doi request reprint Has UK guidance affected general practitioner antibiotic prescribing for otitis media in children?
    P L Thompson
    Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London, BMA House, Tavistock Square, London, UK
    J Public Health (Oxf) 30:479-86. 2008
    ..It is not known whether this has influenced general practitioner prescribing practice. Aims and objectives To investigate the trends in diagnoses and antibiotic prescribing for otitis media in children in relation to guidance...
  8. doi request reprint Clinically targeted screening for congenital CMV - potential for integration into the National Hearing Screening Programme
    S Kadambari
    Paediatric Infectious Diseases Research Group, Jenner Wing, St George s University of London, London, UK
    Acta Paediatr 102:928-33. 2013
    ..The potential of integrating screening for cCMV into the NHSP is discussed to consolidate the link between screening, early diagnosis and management...
  9. doi request reprint Community-acquired, healthcare-associated and hospital-acquired bloodstream infection definitions inĀ children: a systematic review demonstrating inconsistent criteria
    K L Henderson
    Department of Healthcare Associated Infections and Antimicrobial Resistance, Public Health England, London, UK Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK Electronic address
    J Hosp Infect 85:94-105. 2013
    ..Studies trying to define this evolving epidemiology often excluded children...
  10. doi request reprint Evidence based management guidelines for the detection and treatment of congenital CMV
    S Kadambari
    Paediatric Infectious Diseases Unit, St George s University of London, Cranmer Terrace, London, United Kingdom
    Early Hum Dev 87:723-8. 2011
    ..In the last three years there have been significant advances in the diagnosis and treatment of congenital CMV. We have developed practical evidence based guidelines for the management of congenital CMV...
  11. pmc Advances in the prevention and treatment of paediatric HIV infection in the United Kingdom
    M Sharland
    Paediatric Infectious Diseases Unit, St George s Hospital, Blackshaw Road, London SW17 0QT, UK
    Sex Transm Infect 79:53-5. 2003
  12. ncbi request reprint Cytomegalovirus treatment options in immunocompromised patients
    M D Khare
    Paediatric Infectious Diseases Unit, St George s Hospital, London, UK
    Expert Opin Pharmacother 2:1247-57. 2001
    ..The role of immunotherapy with either immunoglobulin prophylaxis or the novel adoptive immunotherapy needs further evaluation...
  13. doi request reprint Postnatal cytomegalovirus: innocent bystander or hidden problem?
    S Luck
    Department of Virology, Royal Free and University College Medical School, London, UK
    Arch Dis Child Fetal Neonatal Ed 94:F58-64. 2009
    ..The burden of postnatal CMV disease and the risk-benefit of screening and prevention strategies are all still unclear...
  14. doi request reprint Acute haematogenous osteomyelitis in children: is there any evidence for how long we should treat?
    Stefan Weichert
    Paediatric Infectious Diseases Unit, St George s Hospital, London, UK
    Curr Opin Infect Dis 21:258-62. 2008
    ..This review focuses on antibiotic treatment and length of antibiotic therapy...
  15. doi request reprint The Chennai Declaration: India's landmark national commitment to antibiotic stewardship demonstrates that 'truth alone triumphs'
    A H Holmes
    Centre for Infection Prevention and Management, Imperial College, London, UK
    J Antimicrob Chemother 68:1453-4. 2013
    ..The global importance of implementing such an antibiotic policy as a national strategy needs to be recognized and supported internationally...
  16. ncbi request reprint Congenital cytomegalovirus: association between dried blood spot viral load and hearing loss
    S Walter
    St George s Hospital, Blackshaw Road, Tooting, London SW17 0QT, UK
    Arch Dis Child Fetal Neonatal Ed 93:F280-5. 2008
    ..To investigate the relation between cytomegalovirus (CMV) viral load on dried blood spots (DBS) from newborn biochemical screening ("Guthrie") cards, and sensorineural hearing loss (SNHL) in congenital CMV...
  17. ncbi request reprint An evaluation of the completeness of reporting of childhood tuberculosis
    S S S Teo
    Centre for Child Health, University of London, London, UK
    Eur Respir J 34:176-9. 2009
    ..This should be taken into account when planning training and resource requirements for tuberculosis. Increased efforts are needed to ensure that all paediatric cases are reported to ETS...
  18. doi request reprint Empirical treatment of neonatal sepsis: are the current guidelines adequate?
    B Muller-Pebody
    Department of Healthcare Associated Infection and Antimicrobial Resistance, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London, UK
    Arch Dis Child Fetal Neonatal Ed 96:F4-8. 2011
    ..To use national laboratory surveillance data to determine whether pathogens responsible for neonatal bacteraemia were sensitive to nationally recommended antibiotic regimens...
  19. ncbi request reprint Current evidence for the use of paediatric antiretroviral therapy--a PENTA analysis. Paediatric European Network for the Treatment of AIDS Steering Committee
    M Sharland
    Paediatric Infectious Diseases Unit, St George s Hospital, London, UK
    Eur J Pediatr 159:649-56. 2000
    ..Suggestions for when to commence antiretroviral therapy, which drugs to start with and how to monitor and sequence drug regimens are given...
  20. ncbi request reprint Lone parent families are an independent risk factor for lower rates of childhood immunisation in London
    M Sharland
    Paediatric Infectious Diseases Unit, St George s Hospital, London
    Commun Dis Rep CDR Rev 7:R169-72. 1997
    ..The proportion of lone parent families explained 42% of the variation in coverage for D3 in November 1991. This study has identified lone parenthood as an important independent risk factor in London for failure to complete immunisation...
  21. ncbi request reprint Spinal malformations in the fetuses of HIV infected women receiving combination antiretroviral therapy and co-trimoxazole
    M P Richardson
    Paediatric Infectious Diseases Unit, St George s Hospital, London SW17 0QT, UK
    Eur J Obstet Gynecol Reprod Biol 93:215-7. 2000
    ..We report two cases of severe spinal malformations in the fetuses of women treated with combination antiretroviral therapy and co-trimoxazole...
  22. ncbi request reprint Current treatment options to prevent perinatal transmission of HIV
    Z Mitchla
    St George s Hospital, Blackshaw Road, London, SW17 0QT, UK
    Expert Opin Pharmacother 1:239-48. 2000
    ..There is limited safety data currently available on the use of other antiretrovirals in pregnancy. A cautious approach to the use of HAART in pregnancy is recommended at present...
  23. pmc Antibiotic prescribing in general practice and hospital admissions for peritonsillar abscess, mastoiditis, and rheumatic fever in children: time trend analysis
    M Sharland
    Paediatric Infectious Diseases Unit, St George s Hospital, London SW17 0QT
    BMJ 331:328-9. 2005
  24. doi request reprint Changes in clinical indications for community antibiotic prescribing for children in the UK from 1996 to 2006: will the new NICE prescribing guidance on upper respiratory tract infections just be ignored?
    P L Thompson
    Centre for Paediatric Pharmacy Research, School of Pharmacy, London, UK
    Arch Dis Child 94:337-40. 2009
    ..Study..
  25. doi request reprint HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004
    Rana Chakraborty
    Paediatric Infectious Diseases Unit, St George s Hospital, London
    Pediatr Infect Dis J 27:457-9. 2008
    ..Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance...
  26. doi request reprint Discordance between CD4 cell count and CD4 cell percentage: implications for when to start antiretroviral therapy in HIV-1 infected children
    K Boyd
    Medical Research Council Clinical Trials Unit, London, UK
    AIDS 24:1213-7. 2010
    ..This leads to clinical dilemma when one marker is below the threshold, whereas the other is above...
  27. pmc Advances in the prevention and treatment of paediatric HIV infection in the United Kingdom
    M Sharland
    Paediatric Infectious Diseases Unit, St George s Hospital, Blackshaw Road, London SW17 0QT, UK
    Arch Dis Child 87:178-80. 2002
  28. pmc Health protection and a new strategy for combating infection in children
    E G Davies
    Host Defence Unit, Great Ormond Street Hospital, London, UK
    Arch Dis Child 88:1-3. 2003
  29. pmc Syphilis in London circa 2004: new challenges from an old disease
    A Cross
    Department of Child Health, St George s Hospital, London, UK
    Arch Dis Child 90:1045-6. 2005
  30. ncbi request reprint Paediatric antiretroviral therapy audit in South London
    K Doerholt
    Paediatric Infectious Diseases Unit, St George s Hospital, London, UK
    HIV Med 3:44-8. 2002
    ..To audit clinical and surrogate marker outcome data following the introduction of combination antiretroviral therapy to HIV-infected children in South London...
  31. ncbi request reprint Nevirapine use in HIV-1-infected children
    Gwenda Verweel
    Imperial College, London, UK
    AIDS 17:1639-47. 2003
    ..To evaluate the safety, efficacy, and clinical, virological, and immunological responses in HIV-1-infected children receiving nevirapine as part of combination antiretroviral therapy (ART)...
  32. pmc Increasing skin infections and Staphylococcus aureus complications in children, England, 1997-2006
    Sonia Saxena
    Imperial College London, London, UK
    Emerg Infect Dis 16:530-3. 2010
    ..8 to 29.1/1,000 child-years. During the same time period, hospital admissions for Staphylococcus aureus infections rose 49% from 53.4 to 79.3/100,000 child-years...
  33. pmc Underdosing of antiretrovirals in UK and Irish children with HIV as an example of problems in prescribing medicines to children, 1997-2005: cohort study
    Esse N Menson
    MRC Clinical Trials Unit, London NW1 2DA
    BMJ 332:1183-7. 2006
    ..To measure the extent of underdosing of antiretroviral drugs in children...
  34. ncbi request reprint Outcomes for human immunodeficiency virus-1-infected infants in the United kingdom and Republic of Ireland in the era of effective antiretroviral therapy
    Katja Doerholt
    St Peter s Hospital, Chertsey
    Pediatr Infect Dis J 25:420-6. 2006
    ..There are few data about disease progression and response to antiretroviral therapy (ART) in vertically HIV-infected infants in the era of effective therapy...
  35. ncbi request reprint Morbidity, mortality, and response to treatment by children in the United Kingdom and Ireland with perinatally acquired HIV infection during 1996-2006: planning for teenage and adult care
    Ali Judd
    MRC Clinical Trials Unit, London, United Kingdom
    Clin Infect Dis 45:918-24. 2007
    ..We describe changes over time in these characteristics and in the response to treatment among children in the United Kingdom and Ireland with perinatally acquired HIV infection, many of whom are now adolescents...
  36. pmc Role of co-trimoxazole prophylaxis in reducing mortality in HIV infected adults being treated for tuberculosis: randomised clinical trial
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, London NW1 2DA
    BMJ 337:a257. 2008
    ..To assess the impact of prophylactic oral co-trimoxazole in reducing mortality in HIV positive Zambian adults being treated for pulmonary tuberculosis...
  37. doi request reprint Antibiotic prescribing for self limiting respiratory tract infections in primary care: summary of NICE guidance
    Toni Tan
    National Institute for Health and Clinical Excellence, Manchester M1 4BD
    BMJ 337:a437. 2008
  38. ncbi request reprint Haplotype mapping of the bronchiolitis susceptibility locus near IL8
    Jeremy Hull
    University Department of Paediatrics, Level 4, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Hum Genet 114:272-9. 2004
    ..In between these two genes there is only one structural feature of interest, a novel gene RASSF6, which is predicted to encode a Ras effector protein...
  39. ncbi request reprint Triple nucleoside reverse transcriptase inhibitor therapy in children
    Jennifer Handforth
    Paediatric Infectious Diseases Unit, St George s Hospital, Tooting, London, UK
    Paediatr Drugs 6:147-59. 2004
    ..The low pill burden of triple NRTI regimens (especially if combined in a single pill such as Trizivir), offers hope that regimen simplification may still be possible in the future...
  40. ncbi request reprint Early diagnosis of tuberculosis using an INF-gamma assay in a child with HIV-1 infection and a very low CD4 count
    Nikos Spyridis
    Paediatric Infectious Diseases Unit, St George s Hospital, London, UK
    Scand J Infect Dis 39:919-21. 2007
    ..Positive cultures for Mycobacterium tuberculosis followed 6 weeks later. INF-gamma assays should be considered as first line investigations in HIV-1 infected subjects when TB is a diagnostic possibility...
  41. ncbi request reprint Response to highly active antiretroviral therapy varies with age: the UK and Ireland Collaborative HIV Paediatric Study
    A Sarah Walker
    AIDS 18:1915-24. 2004
    ..To evaluate the effect of age, CD4 percentage (CD4%) and plasma HIV-1 RNA on response to highly active antiretroviral therapy (HAART) in previously untreated children...
  42. pmc Up-to-date findings show change in acute otitis media consultation trend
    Paula L Thompson
    Br J Gen Pract 56:379-80. 2006
  43. pmc Prevalence of nasopharyngeal carriage of pneumococcus in preschool children attending day care in London
    Anita Roche
    South West London Health Protection Unit, Springfield University Hospital, 61 Glenburnie Road, London SW17 7DB, UK
    Arch Dis Child 92:1073-6. 2007
    ..To estimate the prevalence of nasopharyngeal (NP) carriage of pneumococcus (Streptococcus pneumoniae) and describe the antibiotic resistance patterns and serotypes in young children attending group day care in London...