G A Sagnella

Summary

Affiliation: St George's
Country: UK

Publications

  1. ncbi request reprint The renal epithelial sodium channel: genetic heterogeneity and implications for the treatment of high blood pressure
    G A Sagnella
    Blood Pressure Unit, Cardiac and Vascular Sciences, St George s, University of London, Cranmer Terrace, London, SW17 0RE, UK
    Curr Pharm Des 12:2221-34. 2006
  2. ncbi request reprint Association of hypertension with T594M mutation in beta subunit of epithelial sodium channels in black people resident in London
    E H Baker
    Department of Pharmacology, St George s Hospital Medical School, London, UK
    Lancet 351:1388-92. 1998
  3. ncbi request reprint Platelet sodium/hydrogen exchanger activity in normotensives and hypertensives
    G A Sagnella
    Blood Pressure Unit, St George s Hospital Medical School, London, UK
    Clin Chim Acta 283:105-18. 1999
  4. ncbi request reprint Urinary calcium excretion, sodium intake and blood pressure in a multi-ethnic population: results of the Wandsworth Heart and Stroke Study
    A M Blackwood
    Department of Medicine, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Hum Hypertens 15:229-37. 2001
  5. ncbi request reprint Platelet sodium-hydrogen exchanger activity and left ventricular mass
    T K Khong
    Blood Pressure Unit, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Hum Hypertens 15:523-7. 2001
  6. ncbi request reprint Ethnic differences in erythrocyte membrane fluidity and the association with serum triacylglycerols
    M A Miller
    Blood Pressure Unit, Department of Medicine, Division of Physiological Medicine, St George s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 ORE, UK
    Clin Sci (Lond) 100:653-8. 2001
  7. ncbi request reprint Angiotensin converting enzyme insertion/deletion polymorphism: association with ethnic origin
    J Barley
    Medical Genetics Unit, St George s Hospital Medical School, London, UK
    J Hypertens 12:955-7. 1994
  8. ncbi request reprint In-vivo intracellular pH at rest and during exercise in patients with essential hypertension
    T K Khong
    Blood Pressure Unit, St George s Hospital Medical School, London, UK
    J Hypertens 19:1595-600. 2001
  9. ncbi request reprint T594M and G442V polymorphisms of the sodium channel beta subunit and hypertension in a black population
    Y B Dong
    Department of Physiological Medicine, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Hum Hypertens 15:425-30. 2001
  10. ncbi request reprint Why is plasma renin activity lower in populations of African origin?
    G A Sagnella
    Blood Pressure Unit, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    J Hum Hypertens 15:17-25. 2001

Collaborators

Detail Information

Publications17

  1. ncbi request reprint The renal epithelial sodium channel: genetic heterogeneity and implications for the treatment of high blood pressure
    G A Sagnella
    Blood Pressure Unit, Cardiac and Vascular Sciences, St George s, University of London, Cranmer Terrace, London, SW17 0RE, UK
    Curr Pharm Des 12:2221-34. 2006
    ..Lastly, we also examine the potential value of pharmacological targeting of the renal epithelial sodium channel with the sodium channel inhibitor amiloride for the treatment of hypertension...
  2. ncbi request reprint Association of hypertension with T594M mutation in beta subunit of epithelial sodium channels in black people resident in London
    E H Baker
    Department of Pharmacology, St George s Hospital Medical School, London, UK
    Lancet 351:1388-92. 1998
    ..Essential hypertension in black patients also shows clinical features of sodium retention so we screened black people for the T594M mutation, the most commonly identified sodium-channel mutation...
  3. ncbi request reprint Platelet sodium/hydrogen exchanger activity in normotensives and hypertensives
    G A Sagnella
    Blood Pressure Unit, St George s Hospital Medical School, London, UK
    Clin Chim Acta 283:105-18. 1999
    ....
  4. ncbi request reprint Urinary calcium excretion, sodium intake and blood pressure in a multi-ethnic population: results of the Wandsworth Heart and Stroke Study
    A M Blackwood
    Department of Medicine, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Hum Hypertens 15:229-37. 2001
    ..The estimated effects of either BP or sodium intake on UCa, sustained over many years, may be associated with significant effects on bone calcium content...
  5. ncbi request reprint Platelet sodium-hydrogen exchanger activity and left ventricular mass
    T K Khong
    Blood Pressure Unit, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Hum Hypertens 15:523-7. 2001
    ..The aim of this study was to examine the relationship between platelet sodium-hydrogen exchanger activity and left ventricular mass index (LVMI)...
  6. ncbi request reprint Ethnic differences in erythrocyte membrane fluidity and the association with serum triacylglycerols
    M A Miller
    Blood Pressure Unit, Department of Medicine, Division of Physiological Medicine, St George s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 ORE, UK
    Clin Sci (Lond) 100:653-8. 2001
    ..In conclusion, ethnic differences in erythrocyte membrane fluidity, as determined by the use of TMA-DPH anisotropy, appear to be the result of ethnic differences in the level of serum triacylglycerols...
  7. ncbi request reprint Angiotensin converting enzyme insertion/deletion polymorphism: association with ethnic origin
    J Barley
    Medical Genetics Unit, St George s Hospital Medical School, London, UK
    J Hypertens 12:955-7. 1994
    ....
  8. ncbi request reprint In-vivo intracellular pH at rest and during exercise in patients with essential hypertension
    T K Khong
    Blood Pressure Unit, St George s Hospital Medical School, London, UK
    J Hypertens 19:1595-600. 2001
    ..Such an abnormality of pHi in hypertension would be consistent with enhanced sodium-hydrogen exchanger activity and may provide potential mechanisms by which hypertension and its complications could develop...
  9. ncbi request reprint T594M and G442V polymorphisms of the sodium channel beta subunit and hypertension in a black population
    Y B Dong
    Department of Physiological Medicine, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Hum Hypertens 15:425-30. 2001
    ..These results suggest that the 594M variant may contribute to high blood pressure in black people of African origin whereas the G442V polymorphism is unlikely to influence blood pressure in this population...
  10. ncbi request reprint Why is plasma renin activity lower in populations of African origin?
    G A Sagnella
    Blood Pressure Unit, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    J Hum Hypertens 15:17-25. 2001
    ..Journal of Human Hypertension (2001) 15, 17-25..
  11. ncbi request reprint Effect of salt intake on renal excretion of water in humans
    F J He
    Blood Pressure Unit, St George's Hospital Medical School, London, United Kingdom
    Hypertension 38:317-20. 2001
    ..This would reduce fluid intake in the population by approximately 350 mL/d per person. This would have a large impact on the sales of soft drinks, mineral water, and beer...
  12. ncbi request reprint Lack of association of ACE/angiotensinogen genotype with renal function in autosomal dominant polycystic kidney disease
    A K Saggar-Malik
    Medical Genetics Unit, St George s Hospital Medical School, London, United Kingdom
    Genet Test 4:299-303. 2000
    ..These findings do not support the proposition that ACE genotype or angiotensinogen polymorphisms are associated with a worse prognosis in patients with ADPKD...
  13. ncbi request reprint Determinants of platelet intracellular free calcium in essential hypertension and effect of stimulation by arginine vasopressin
    M A Miller
    Department of Physiological Medicine, St. George's Hospital Medical School, London, England
    Am J Hypertens 6:209-16. 1993
    ..34, p = .02; n = 46).(abstract truncated at 250 words)..
  14. ncbi request reprint Plasma atrial natriuretic peptide in essential hypertension. Comparison with normotensive subjects and effects of changes in dietary sodium intake
    G A Sagnella
    Department of Medicine, Charing Cross and Westminister Medical School, London, England
    Am J Hypertens 1:112-8. 1988
    ..005). However, there was no significant difference between the blood pressure levels on their usual and high sodium intake (118.3 +/- 3.0 mmHg).(ABSTRACT TRUNCATED AT 250 WORDS)..
  15. ncbi request reprint N-terminal pro atrial natriuretic peptide in human plasma
    M G Buckley
    Department of Medicine, Charing Cross and Westminister Medical School, London, England
    Am J Hypertens 3:933-5. 1990
    ....
  16. ncbi request reprint Plasma atrial natriuretic peptide, aldosterone, and plasma renin activity responses to gradual changes in dietary sodium intake
    G A Sagnella
    Department of Medicine, St. George's Hospital Medical School, London, England
    Am J Hypertens 3:863-5. 1990
    ....
  17. ncbi request reprint A double-blind crossover study of the effect of concomitant diuretic therapy in hypertensive patients treated with amlodipine
    F P Cappuccio
    Department of Medicine, St. George's Hospital Medical School, London, England
    Am J Hypertens 4:297-302. 1991
    ..The results of this study suggest that a thiazide diuretic has little additive effect on blood pressure in patients already on the long-acting dihydropyridine amlodipine, and may cause hypokalemia...