Hugh Markus

Summary

Affiliation: St George's Hospital Medical School
Country: UK

Publications

  1. ncbi request reprint Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness
    Christine Armstrong
    Centre for Clinical Neuroscience, St George s University of London, Cranmer Terrace, Tooting, London, UK
    Stroke 38:2895-9. 2007
  2. pmc Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI
    H S Markus
    Department of Clinical Neurosciences, Guy s, King s, and St Thomas Hospital School of Medicine and the Institute of Psychiatry, London, UK
    J Neurol Neurosurg Psychiatry 69:48-53. 2000
  3. pmc Cerebral perfusion and stroke
    H S Markus
    Clinical Neuroscience, St George s Hospital Medical School, London, UK
    J Neurol Neurosurg Psychiatry 75:353-61. 2004
  4. ncbi request reprint Acute stroke
    Hugh Markus
    Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Int Psychogeriatr 15:161-6. 2003
  5. ncbi request reprint Current treatments in neurology: stroke
    Hugh S Markus
    Clinical Neuroscience, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Neurol 252:260-7. 2005
  6. ncbi request reprint Asymptomatic embolization detected by Doppler ultrasound predicts stroke risk in symptomatic carotid artery stenosis
    Hugh S Markus
    Clinical Neuroscience, Department of Cardiac and Vascular Sciences, London, UK
    Stroke 36:971-5. 2005
  7. ncbi request reprint Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial
    Hugh S Markus
    Department of Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Circulation 111:2233-40. 2005
  8. ncbi request reprint Markers of endothelial and hemostatic activation and progression of cerebral white matter hyperintensities: longitudinal results of the Austrian Stroke Prevention Study
    Hugh S Markus
    Clinical Neuroscience, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Stroke 36:1410-4. 2005
  9. pmc Asymptomatic embolisation for prediction of stroke in the Asymptomatic Carotid Emboli Study (ACES): a prospective observational study
    Hugh S Markus
    Clinical Neuroscience, St George s University of London, London, UK
    Lancet Neurol 9:663-71. 2010
  10. ncbi request reprint Evaluation of a 1 MHz transducer for transcranial Doppler ultrasound including embolic signal detection
    M Cullinane
    Department of Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Ultrasound Med Biol 27:795-800. 2001

Detail Information

Publications75

  1. ncbi request reprint Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness
    Christine Armstrong
    Centre for Clinical Neuroscience, St George s University of London, Cranmer Terrace, Tooting, London, UK
    Stroke 38:2895-9. 2007
    ..We have therefore sought to address this issue in a large, well-phenotyped community population to assess the effect of a number of polymorphisms in both MMP and TIMP genes on carotid artery intima-media thickness (IMT)...
  2. pmc Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI
    H S Markus
    Department of Clinical Neurosciences, Guy s, King s, and St Thomas Hospital School of Medicine and the Institute of Psychiatry, London, UK
    J Neurol Neurosurg Psychiatry 69:48-53. 2000
    ..This technique was applied to patients with ischaemic leukoaraiosis to determine whether reduced white matter CBF in this patient group could be demonstrated...
  3. pmc Cerebral perfusion and stroke
    H S Markus
    Clinical Neuroscience, St George s Hospital Medical School, London, UK
    J Neurol Neurosurg Psychiatry 75:353-61. 2004
    ..A central concept in treating patients with acute ischaemic stroke is the existence of an ischaemic penumbra of potentially salvageable tissue, and the evidence for its existence in humans is reviewed...
  4. ncbi request reprint Acute stroke
    Hugh Markus
    Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Int Psychogeriatr 15:161-6. 2003
    ..The evidence for each of these approaches is reviewed. Organization of stroke services, and particularly the use of stroke units, have been shown to significantly improve stroke outcome and these data are presented...
  5. ncbi request reprint Current treatments in neurology: stroke
    Hugh S Markus
    Clinical Neuroscience, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Neurol 252:260-7. 2005
    ....
  6. ncbi request reprint Asymptomatic embolization detected by Doppler ultrasound predicts stroke risk in symptomatic carotid artery stenosis
    Hugh S Markus
    Clinical Neuroscience, Department of Cardiac and Vascular Sciences, London, UK
    Stroke 36:971-5. 2005
    ..Small studies have demonstrated that they predict the combined endpoint of stroke and transient ischemic attack (TIA), but no studies have shown that they predict the more important endpoint of stroke alone...
  7. ncbi request reprint Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial
    Hugh S Markus
    Department of Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Circulation 111:2233-40. 2005
    ..They offer a surrogate marker to evaluate antiplatelet therapy, but no multicenter study has evaluated the feasibility of this approach...
  8. ncbi request reprint Markers of endothelial and hemostatic activation and progression of cerebral white matter hyperintensities: longitudinal results of the Austrian Stroke Prevention Study
    Hugh S Markus
    Clinical Neuroscience, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Stroke 36:1410-4. 2005
    ..In a prospective study, we determined whether circulating markers of endothelial activation predicted progression of WMH...
  9. pmc Asymptomatic embolisation for prediction of stroke in the Asymptomatic Carotid Emboli Study (ACES): a prospective observational study
    Hugh S Markus
    Clinical Neuroscience, St George s University of London, London, UK
    Lancet Neurol 9:663-71. 2010
    ..We aimed to investigate whether detection of asymptomatic embolic signals by use of transcranial doppler (TCD) could predict stroke risk in patients with asymptomatic carotid stenosis...
  10. ncbi request reprint Evaluation of a 1 MHz transducer for transcranial Doppler ultrasound including embolic signal detection
    M Cullinane
    Department of Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Ultrasound Med Biol 27:795-800. 2001
    ..A lower frequency transducer of 1 MHz or possibly 1.5 MHz with transcranial Doppler ultrasound may improve the application of embolic signal detection but may not improve the signal for routine measurement of flow velocities...
  11. ncbi request reprint Severely impaired cerebrovascular reactivity predicts stroke and TIA risk in patients with carotid artery stenosis and occlusion
    H Markus
    Clinical Neuroscience, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Brain 124:457-67. 2001
    ..Particularly in the former group, a study is required to determine whether revascularization reduces the risk of stroke in patients with exhausted reactivity...
  12. ncbi request reprint Increased common carotid intima-media thickness in UK African Caribbeans and its relation to chronic inflammation and vascular candidate gene polymorphisms
    H Markus
    Department of Clinical Neuroscience, St George s Hospital Medical School, Guy s, King s and St Thomas School of Medicine, London, UK
    Stroke 32:2465-71. 2001
    ....
  13. doi request reprint Optimizing protocols for risk prediction in asymptomatic carotid stenosis using embolic signal detection: the Asymptomatic Carotid Emboli Study
    Alice King
    Stroke and Dementia Research Centre, St George s University of London, Cranmer Terrace, London SW17 0RE, United Kingdom
    Stroke 42:2819-24. 2011
    ..ES detection is time-consuming, and whether similar predictive information could be obtained from simpler recording protocols is unknown...
  14. doi request reprint Ultrasonic plaque echolucency and emboli signals predict stroke in asymptomatic carotid stenosis
    R Topakian
    Clinical Neuroscience, St Georges University of London, London, UK
    Neurology 77:751-8. 2011
    ..We explored the predictive value of a score based on these 2 measures in the prospective, observational, international multicenter Asymptomatic Carotid Emboli Study...
  15. doi request reprint The effect of medical treatments on stroke risk in asymptomatic carotid stenosis
    Alice King
    Stroke and Dementia Research Center, St Georges University of London, London, SW17ORE, UK
    Stroke 44:542-6. 2013
    ..Using Asymptomatic Carotid Emboli Study (ACES) prospective data, the effect of current treatment and risk factors on future stroke and transient ischemic attack risk were determined...
  16. doi request reprint Ethnic differences in the cerebrovascular impact of hypertension
    Jonathan Birns
    Department of Stroke Medicine, King s College London School of Medicine, London, UK
    Cerebrovasc Dis 25:408-16. 2008
    ....
  17. ncbi request reprint Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease
    A Hassan
    Department of Clinical Neurosciences, St George s Hospital Medical School, London, UK
    Stroke 35:654-9. 2004
    ....
  18. doi request reprint Clopidogrel versus dipyridamole in addition to aspirin in reducing embolization detected with ambulatory transcranial Doppler: a randomized trial
    Alice King
    Clinical Neuroscience, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    Stroke 42:650-5. 2011
    ..In a randomized trial (ISRCTN68019845) with blinded end point evaluation, we determined whether treatment with dipyridamole or clopidogrel, in addition to aspirin, was more effective at reducing embolization...
  19. pmc Long-term risk of carotid restenosis in patients randomly assigned to endovascular treatment or endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial
    Leo H Bonati
    Stroke Research Group, UCL Institute of Neurology, University College London, Queen Square, London, UK
    Lancet Neurol 8:908-17. 2009
    ..We aimed to investigate the long-term risks of restenosis in patients included in CAVATAS...
  20. doi request reprint Long-term outcome of endovascular treatment versus medical care for carotid artery stenosis in patients not suitable for surgery and randomised in the Carotid and Vertebral Artery Transluminal Angioplasty study (CAVATAS)
    Jörg Ederle
    Stroke Research Group, UCL Institute of Neurology, London, UK
    Cerebrovasc Dis 28:1-7. 2009
    ..The Carotid and Vertebral Artery Transluminal Angioplasty study contained a trial comparing medical and endovascular treatment in patients not suitable for surgery...
  21. pmc Endovascular treatment with angioplasty or stenting versus endarterectomy in patients with carotid artery stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial
    Jörg Ederle
    Stroke Research Group, UCL Institute of Neurology, University College London, Queen Square, London, UK
    Lancet Neurol 8:898-907. 2009
    ..We therefore report the long-term results of the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS)...
  22. ncbi request reprint Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS)
    Matthias W Lorenz
    Department of Neurology, Johann Wofgang Goethe University, Frankfurt am Main, Germany
    Stroke 37:87-92. 2006
    ..Carotid intima-media thickness (IMT) is an independent predictor of vascular events in age groups >45 years. However, there is little information about the predictive value of IMT in younger individuals...
  23. ncbi request reprint Tissue plasminogen activator -7351C/T polymorphism and lacunar stroke
    Christine A Armstrong
    Stroke 37:329; author reply 329-30. 2006
  24. ncbi request reprint The use of embolic signal detection in multicenter trials to evaluate antiplatelet efficacy: signal analysis and quality control mechanisms in the CARESS (Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic carotid Stenosis) trial
    Ralf Dittrich
    Department of Neurology, University Hospital of Munster, Germany
    Stroke 37:1065-9. 2006
    ..The present study aimed at installing primary and secondary quality control measures in CARESS because MES evaluation relies on subjective judgment by human experts...
  25. ncbi request reprint Genetic and acquired inflammatory conditions are synergistically associated with early carotid atherosclerosis
    Hugh S Markus
    Centre for Clinical Neuroscience, Department of Cardiac and Vascular Sciences, St George s University of London, UK
    Stroke 37:2253-9. 2006
    ..We replicated this finding in a second large population and extended the analysis by inclusion of other inflammatory conditions (chronic infection and obesity/abnormal glucose tolerance)...
  26. pmc The role of genetic variants of matrix metalloproteinases in coronary and carotid atherosclerosis
    Sonia Abilleira
    Department of Clinical Neuroscience, St George s University of London, London, UK
    J Med Genet 43:897-901. 2006
    ....
  27. pmc Risk factor profile of cerebral small vessel disease and its subtypes
    Usman Khan
    Centre for Clinical Neuroscience, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    J Neurol Neurosurg Psychiatry 78:702-6. 2007
    ..If atherosclerosis were important in SVD as a whole or in one particular subtype, one would expect the risk factor profile to be similar to that of cerebral large vessel disease (LVD)...
  28. ncbi request reprint Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis
    Matthias W Lorenz
    Johann Wolfgang Goethe University, Department for Neurology, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    Circulation 115:459-67. 2007
    ..Its use relies on its ability to predict future clinical cardiovascular end points. We performed a systematic review and meta-analysis of data to examine this association...
  29. doi request reprint Homocysteine and its relationship to stroke subtypes in a UK black population: the south London ethnicity and stroke study
    Usman Khan
    Centre for Clinical Neuroscience, St George s University of London, London, UK
    Stroke 39:2943-9. 2008
    ..We determined the association between homocysteine and stroke subtypes, especially SVD, in a well-phenotyped UK cohort of black stroke patients compared to community controls...
  30. ncbi request reprint NADPH oxidase polymorphisms in cerebral small vessel disease
    Usman Khan
    Centre for Clinical Neuroscience, St George s University of London, London, UK
    Cerebrovasc Dis 24:135-8. 2007
  31. doi request reprint Variation in the PDE4D gene and ischemic stroke risk: a systematic review and meta-analysis on 5200 cases and 6600 controls
    Steve Bevan
    Centre for Clinical Neuroscience, St George s, University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Stroke 39:1966-71. 2008
    ..Meta-analysis provides a method to combine this data and determine in a larger sample size whether the association with PDE4D can be replicated...
  32. doi request reprint Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations
    Steve Bevan
    Centre for Clinical Neuroscience, St Georges University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Stroke 39:1109-14. 2008
    ..Using a case control replication methodology, all members of the leukotriene synthesis pathway and their receptors were examined for genetic variants, which may act as risk factors for all ischemic stroke and stroke subtypes...
  33. doi request reprint Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease
    Arani Nitkunan
    Centre for Clinical Neurosciences, St George s, University of London, London, United Kingdom
    Magn Reson Med 59:528-34. 2008
    ..457, controls -0.317). NAA is a marker of axonal loss/dysfunction. These findings are consistent with axonal loss/dysfunction being the principal process causing the DTI changes found in cerebral SVD and ageing...
  34. ncbi request reprint Differences in stroke subtypes between black and white patients with stroke: the South London Ethnicity and Stroke Study
    Hugh S Markus
    Centre for Clinical Neuroscience, St George s University of London, London, SW17 ORE, UK
    Circulation 116:2157-64. 2007
    ..Determining whether the distribution of stroke subtypes differs between ethnic groups is important in understanding the mechanisms of the increased stroke incidence in black patients...
  35. ncbi request reprint High-sensitivity C-reactive protein is not associated with carotid intima-media progression: the carotid atherosclerosis progression study
    Matthias W Lorenz
    Department of Neurology, J W Goethe University, Frankfurt am Main, Germany
    Stroke 38:1774-9. 2007
    ..It is unclear whether elevated serum C-reactive protein (CRP) is causal to the initiation and progression of atherosclerosis. We undertook a prospective longitudinal cohort study to address this question...
  36. ncbi request reprint Toll receptor polymorphisms and carotid artery intima-media thickness
    Robyn Labrum
    Centre for Clinical Neuroscience, St George s University of London, London, UK
    Stroke 38:1179-84. 2007
    ....
  37. ncbi request reprint Genetic association studies in stroke: methodological issues and proposed standard criteria
    Martin Dichgans
    Department of Neurology, Klinikum Grosshadern, Munich, Germany
    Stroke 36:2027-31. 2005
    ..A large number of candidate gene association studies have attempted to identify genes implicated in stroke, but there have been few replicable and robust associations reported...
  38. ncbi request reprint Can transcranial Doppler discriminate between solid and gaseous microemboli? Assessment of a dual-frequency transducer system
    Hugh S Markus
    Clinical Neuroscience, Department of Cardiac and Vascular Sciences, St George s Hospital Medical School, Cranmer Terr, London, SW17 0RE, UK
    Stroke 36:1731-4. 2005
    ..An initial study with a small sample size suggested it provided excellent discrimination. We performed a validation study in subjects with embolic signals of known nature...
  39. ncbi request reprint Frequency of subclinical lacunar infarcts in ischemic leukoaraiosis and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Michael O'Sullivan
    Division of Clinical Neuroscience, St George s Hospital Medical School, London, England
    AJNR Am J Neuroradiol 24:1348-54. 2003
    ..In this study, the frequency of asymptomatic new lesions in ischemic leukoaraiosis and CADASIL was determined as a step toward assessing the potential of this technique as a surrogate marker of disease activity...
  40. ncbi request reprint Online automated detection of cerebral embolic signals from a variety of embolic sources
    Marisa Cullinane
    Department of Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Ultrasound Med Biol 28:1271-7. 2002
    ..Refinement of the algorithm is required to improve its sensitivity for AF data...
  41. ncbi request reprint S-nitrosoglutathione reduces asymptomatic embolization after carotid angioplasty
    Zoltan Kaposzta
    Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Circulation 106:3057-62. 2002
    ..S-nitrosoglutathione (GSNO) is a nitric oxide donor that appears to have relative platelet specificity. We evaluated its effectiveness in reducing embolization after carotid angioplasty...
  42. ncbi request reprint Long-term ambulatory monitoring for cerebral emboli using transcranial Doppler ultrasound
    Andrew D Mackinnon
    Department of Clinical Neurosciences, St George s Hospital Medical School, Cranmer Terr, Tooting, London SW17 0RE, UK
    Stroke 35:73-8. 2004
    ..We have developed a first ambulatory TCD system, evaluated it in at-risk patient groups, and used it to study the pattern of embolization in patients with symptomatic carotid stenosis...
  43. ncbi request reprint Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction
    Ahamad Hassan
    Department of Clinical Neurosciences, St George s Hospital Medical School, London SW17 ORE, UK
    Brain 127:212-9. 2004
    ..Homocysteine-lowering therapy may be particularly effective in this subgroup...
  44. ncbi request reprint Yield of screening for CADASIL mutations in lacunar stroke and leukoaraiosis
    Yanbin Dong
    Department of Clinical Neurosciences, St George s Hospital Medical School, London, United Kingdom
    Stroke 34:203-5. 2003
    ..Atypical phenotypes have been recognized, and the disease is probably underdiagnosed in the wider stroke population. Therefore, we determined the yield of screening for Notch3 mutations in lacunar stroke with or without leukoaraiosis...
  45. ncbi request reprint Ethnic differences in markers of thrombophilia: implications for the investigation of ischemic stroke in multiethnic populations: the South London Ethnicity and Stroke Study
    Paula Jerrard-Dunne
    Department of Clinical Neurosciences, St George s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Stroke 34:1821-6. 2003
    ..This study estimated ethnic-specific reference ranges in a community population to determine the prevalence of thrombophilic states in a multiethnic stroke population...
  46. ncbi request reprint Evaluating the genetic component of ischemic stroke subtypes: a family history study
    Paula Jerrard-Dunne
    Department of Clinical Neurosciences, St George s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Stroke 34:1364-9. 2003
    ..We determined the familial aggregation of stroke risk in different stroke phenotypes and used the results to model estimated sample size requirements for case-control studies...
  47. ncbi request reprint Internal carotid artery angle of origin: a novel risk factor for early carotid atherosclerosis
    Matthias Sitzer
    Department of Neurology, J W Goethe University Frankfurt am Main, Schleusenweg 2 16, 60528 Frankfurt Main, Germany
    Stroke 34:950-5. 2003
    ..Local anatomic and hemodynamic factors may also influence the initiation of the atherosclerotic process. We determined whether the angle of internal carotid artery (ICA) origin is a risk factor for early atherosclerosis...
  48. ncbi request reprint Promoter polymorphism in the endotoxin receptor (CD14) is associated with increased carotid atherosclerosis only in smokers: the Carotid Atherosclerosis Progression Study (CAPS)
    Paul Risley
    Department of Clinical Neurosciences, St George s Hospital Medical School, Cranmer Terr, Tooting, London SW17 0RE, UK
    Stroke 34:600-4. 2003
    ....
  49. ncbi request reprint Early carotid atherosclerosis and family history of vascular disease: specific effects on arterial sites have implications for genetic studies
    Paula Jerrard-Dunne
    Department of Clinical Neurosciences, St Georges Hospital Medical School, London, UK
    Arterioscler Thromb Vasc Biol 23:302-6. 2003
    ..In a community population (n=5400), we determined whether a parental history of myocardial infarction (MI) or stroke is associated with increased IMT and whether associations differ at specific sites in the carotid arterial tree...
  50. ncbi request reprint Interleukin-6 promoter polymorphism modulates the effects of heavy alcohol consumption on early carotid artery atherosclerosis: the Carotid Atherosclerosis Progression Study (CAPS)
    Paula Jerrard-Dunne
    Department of Clinical Neurosciences, St Georges Hospital Medical School, Tooting, London, UK
    Stroke 34:402-7. 2003
    ..If inflammation were on the intermediate causal pathway between alcohol intake and atherosclerosis, then genetic determinants of enhanced inflammation would be expected to modify this relationship...
  51. ncbi request reprint Effect of rosiglitazone on common carotid intima-media thickness progression in coronary artery disease patients without diabetes mellitus
    Jagdip S Sidhu
    Coronary Artery Disease Research Unit, St George s Hospital Medical School, London, UK
    Arterioscler Thromb Vasc Biol 24:930-4. 2004
    ..In this study, we assessed the effect of rosiglitazone on common carotid intima-media thickness (IMT) progression in nondiabetic coronary artery disease (CAD) patients...
  52. ncbi request reprint Online automated detection of cerebral embolic signals using a wavelet-based system
    Salman Marvasti
    Visual Information Processing, Department of Computing, Imperial College London, London, UK
    Ultrasound Med Biol 30:647-53. 2004
    ..It may be particularly good for detecting short-duration low-energy signals, although a frequency filtering-based approach currently offers a higher sensitivity on an unselected data set...
  53. ncbi request reprint Polymorphisms in genes of the endothelin system and cerebral small-vessel disease
    Kelly Gormley
    Department of Clinical Neuroscience, St George s Hospital Medical School, St George s Hospital, London, England
    Stroke 36:1656-60. 2005
    ..We determined whether genetic variants in components of the ET system are a risk factor for cerebral SVD...
  54. ncbi request reprint Switching off embolization from symptomatic carotid plaque using S-nitrosoglutathione
    Zoltan Kaposzta
    Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Circulation 105:1480-4. 2002
    ..We evaluated its effectiveness in reducing embolization in patients with symptomatic carotid stenosis who already were taking aspirin...
  55. ncbi request reprint Helicobacter pylori infection, the cytotoxin gene A strain, and carotid artery intima-media thickness
    Hugh S Markus
    Department of Clinical Neuroscience, St George s Hospital Medical School, London, UK
    J Cardiovasc Risk 9:1-6. 2002
    ..We determined whether H. pylori infection, and particularly the CagA strain, is associated with increased IMT...
  56. ncbi request reprint The potential for utilizing the "mirror neurone system" to enhance recovery of the severely affected upper limb early after stroke: a review and hypothesis
    Valerie M Pomeroy
    Geriatric Medicine, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Neurorehabil Neural Repair 19:4-13. 2005
    ..The information from such studies should aid identification of those stroke patients who might be most likely to benefit from observation to imitate and therefore guide phase I clinical studies...
  57. ncbi request reprint Inflammatory gene load is associated with enhanced inflammation and early carotid atherosclerosis in smokers
    Paula Jerrard-Dunne
    Department of Clinical Neurosciences, St George s Hospital Medical School, Cranmer Terrace, London SW170RE
    Stroke 35:2438-43. 2004
    ..This study examined the impact of inflammatory gene polymorphisms and gene-smoking interactions on common carotid artery intima-media thickness (IMT), a measure of early atherosclerosis...
  58. ncbi request reprint C-reactive protein and carotid intimal medial thickness in a community population
    Matthias Sitzer
    Department of Neurology, J W Goethe University Frankfurt am Main, Germany, St George s Hospital Medical School, London, UK
    J Cardiovasc Risk 9:97-103. 2002
    ..Nevertheless, the question whether serum CRP itself is an independent indicator of the atherosclerotic process remains unanswered...
  59. ncbi request reprint Planning genetic studies in human stroke: sample size estimates based on family history data
    Ahamad Hassan
    Department of Clinical Neurosciences, St George s Hospital Medical School, London, United Kingdom
    Neurology 58:1483-8. 2002
    ..Alternative approaches include linkage analysis using affected sibling pairs, transmission disequilibrium testing (TDT), and sibling TDT (S-TDT). Despite theoretical benefits, the feasibility of these methods in stroke remains unknown...
  60. ncbi request reprint Practicalities of genetic studies in human stroke
    Ahamad Hassan
    Clinical Neurosciences, St George s Hospital Medical School, London, United Kingdom
    Methods Mol Med 104:223-40. 2005
    ..Linkage-based approaches have been used less although current studies are implementing the affected-sibling-pair method. In the future genome-wide association studies are likely to become more widely used...
  61. ncbi request reprint Asymptomatic embolisation in non-valvular atrial fibrillation and its relationship to anticoagulation therapy
    Kerry Tinkler
    Department of Surgery, Royal Free Hampstead NHS Trust, London, UK
    Eur J Ultrasound 15:21-7. 2002
    ..A prospective study to determine the prevalence of embolic signals (ES) detected with transcranial Doppler ultrasound (TCD) in subjects with non-valvular atrial fibrillation (NVAF) who were and were not taking anticoagulants...
  62. ncbi request reprint Rates and determinants of site-specific progression of carotid artery intima-media thickness: the carotid atherosclerosis progression study
    Andrew D Mackinnon
    Department of Clinical Neurosciences, St George s Hospital Medical School, Cranmer Terrace, Tooting, London, United Kingdom
    Stroke 35:2150-4. 2004
    ..The study aim was to evaluate site-specific IMT progression rates and their relationships to vascular risk factors compared with baseline IMT measurements...
  63. ncbi request reprint The influence of genetic and cardiovascular risk factors on the CADASIL phenotype
    Sumeet Singhal
    Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Brain 127:2031-8. 2004
    ..This implies that modulating factors influence phenotype. Smoking appears to increase the risk of stroke, while high homocysteine levels are associated with an increased risk of migraine...
  64. ncbi request reprint Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis
    Ahamad Hassan
    Department of Clinical Neurosciences, St George s Hospital Medical School, London, UK
    Brain 126:424-32. 2003
    ..Therapies which help to stabilize the endothelium may have a role in this group of patients...
  65. doi request reprint Multimodal MRI in cerebral small vessel disease: its relationship with cognition and sensitivity to change over time
    Arani Nitkunan
    Centre for Clinical Neuroscience, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Stroke 39:1999-2005. 2008
    ..In patients with symptomatic sporadic small vessel disease, we determined which MRI parameters best correlated with cognitive function on cross-sectional analysis and which changed over a period of 1 year...
  66. ncbi request reprint Cerebrovascular reactivity and dynamic autoregulation in nondemented patients with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)
    Sumeet Singhal
    Department of Clinical Neuroscience, St George s Hospital Medical School, London, UK
    J Neurol 252:163-7. 2005
    ..TCD is unlikely to be useful for disease monitoring in patients without advanced disease...
  67. ncbi request reprint The spatial distribution of MR imaging abnormalities in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and their relationship to age and clinical features
    Sumeet Singhal
    Department of Clinical Neuroscience, St George s Hospital Medical School, St George s Hospital, London, United Kingdom
    AJNR Am J Neuroradiol 26:2481-7. 2005
    ....
  68. ncbi request reprint Does the white matter matter in Alzheimer disease and cerebral amyloid angiopathy?
    Jin Moo Lee
    Neurology 66:6-7. 2006
  69. ncbi request reprint Update on genetics of stroke and cerebrovascular disease 2005
    Hugh S Markus
    The Clinical Neuroscience, St Georges, University of London, London, UK
    Stroke 37:288-90. 2006
  70. ncbi request reprint Correlations between MRS and DTI in cerebral small vessel disease
    Arani Nitkunan
    Centre of Clinical Neurosciences, St George s, University of London, London, UK
    NMR Biomed 19:610-6. 2006
    ..It provides evidence that DTI identifies axonal disruption in white matter tracts...
  71. ncbi request reprint Neurocognitive function and cerebral emboli: randomized study of on-pump versus off-pump coronary artery bypass surgery
    Reza Motallebzadeh
    Department of Cardiac Surgery, St George s Hospital Medical School, London, United Kingdom
    Ann Thorac Surg 83:475-82. 2007
    ..Cardiopulmonary bypass, in particular, cerebral emboli, has been implicated. We compared neurocognitive function and cerebral emboli in patients undergoing on-pump and off-pump CABG...
  72. ncbi request reprint Mild cognitive impairment after lacunar infarction: voxel-based morphometry and neuropsychological assessment
    Hugh S Markus
    Cerebrovasc Dis 23:323-4. 2007
  73. ncbi request reprint Ambulatory transcranial Doppler cerebral embolic signal detection in symptomatic and asymptomatic carotid stenosis
    Andrew D Mackinnon
    Department of Clinical Neurosciences, St Georges Hospital Medical School, London SW17 0RE, United Kingdom
    Stroke 36:1726-30. 2005
    ..A novel ambulatory TCD system allows prolonged recording. We applied this to patients with symptomatic and asymptomatic carotid stenosis to determine patterns of embolization in the 2 conditions and optimal recording protocols...
  74. ncbi request reprint Genetics: What is relevant for the stroke physician?
    Hugh S Markus
    Centre for Clinical Neuroscience, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Int J Stroke 2:114-7. 2007