W M Liu

Summary

Affiliation: St George's
Country: UK

Publications

  1. ncbi request reprint Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules
    Katherine Ann Scott
    Dept of Oncology, Division of Clinical Sciences, St George s, University of London, 2nd Floor, Jenner Wing, London, SW17 0RE, U K
    Anticancer Res 33:4373-80. 2013
  2. ncbi request reprint Dendritic cell phenotype can be improved by certain chemotherapies and is associated with alterations to p21(waf1/cip1.)
    Wai Man Liu
    Division of Clinical Sciences, Department of Oncology, St George s, University of London, 2nd Floor, Jenner Wing, London, SW17 0RE, UK
    Cancer Immunol Immunother 62:1553-61. 2013
  3. pmc Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis
    W M Liu
    Department of Oncology, Division of Clinical Sciences, St George s, University of London, London SW17 0RE, UK
    Br J Cancer 106:896-903. 2012
  4. ncbi request reprint Cannabis-derived substances in cancer therapy--an emerging anti-inflammatory role for the cannabinoids
    Wai M Liu
    Division of Cellular and Molecular Medicine Oncology, St George s University of London, London, UK
    Curr Clin Pharmacol 5:281-7. 2010
  5. doi request reprint The antimalarial agent artesunate possesses anticancer properties that can be enhanced by combination strategies
    Wai M Liu
    Department of Oncology, Division of Clinical Sciences, St George s, University of London, Jenner Wing, London SW17, United Kingdom
    Int J Cancer 128:1471-80. 2011
  6. pmc Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses
    W M Liu
    Section of Oncology, Division of Cellular and Molecular Medicine, St George s University of London, London, UK
    Br J Cancer 102:115-23. 2010
  7. pmc Supernatants from lymphocytes stimulated with Bacillus Calmette-Guerin can modify the antigenicity of tumours and stimulate allogeneic T-cell responses
    W M Liu
    Department of Oncology, Division of Clinical Sciences, St George s, University of London, 2nd Floor, Jenner Wing, London SW17 0RE, UK
    Br J Cancer 105:687-93. 2011
  8. pmc Inhibition of metastatic potential in colorectal carcinoma in vivo and in vitro using immunomodulatory drugs (IMiDs)
    W M Liu
    Division of Cellular and Molecular Medicine, Department of Oncology, St George s, University of London, London SW17 0RE, UK
    Br J Cancer 101:803-12. 2009
  9. doi request reprint A microarray study of altered gene expression in colorectal cancer cells after treatment with immunomodulatory drugs: differences in action in vivo and in vitro
    Wai M Liu
    Department of Oncology, Division of Cellular and Molecular Medicine, St George s University of London, 2nd Floor, Jenner Wing, London, SW17 0RE, UK
    Mol Biol Rep 37:1801-14. 2010
  10. doi request reprint Gemcitabine and lenalidomide combination in a patient with metastatic pancreatic cancer: a case study
    Wai M Liu
    Department of Oncology, Division of Cellular and Molecular Medicine, St George s University of London, 2nd Floor, Jenner Wing, London SW17 0RE, UK
    Med Oncol 27:430-3. 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules
    Katherine Ann Scott
    Dept of Oncology, Division of Clinical Sciences, St George s, University of London, 2nd Floor, Jenner Wing, London, SW17 0RE, U K
    Anticancer Res 33:4373-80. 2013
    ..We suggest that the activities of some cannabinoids are influenced by treatment schedules; therefore, it is important to carefully select the most appropriate strategy in order to maximise their efficacy. ..
  2. ncbi request reprint Dendritic cell phenotype can be improved by certain chemotherapies and is associated with alterations to p21(waf1/cip1.)
    Wai Man Liu
    Division of Clinical Sciences, Department of Oncology, St George s, University of London, 2nd Floor, Jenner Wing, London, SW17 0RE, UK
    Cancer Immunol Immunother 62:1553-61. 2013
    ..However, a lack of an appreciation of the quality of the DC that is used and/or the monocyte from which it is derived has limited their successful incorporation into treatment strategies...
  3. pmc Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis
    W M Liu
    Department of Oncology, Division of Clinical Sciences, St George s, University of London, London SW17 0RE, UK
    Br J Cancer 106:896-903. 2012
    ..Furthermore, chemotherapy has also been shown to modify these exudates and in doing so, neutralise their tumourigenic influence...
  4. ncbi request reprint Cannabis-derived substances in cancer therapy--an emerging anti-inflammatory role for the cannabinoids
    Wai M Liu
    Division of Cellular and Molecular Medicine Oncology, St George s University of London, London, UK
    Curr Clin Pharmacol 5:281-7. 2010
    ..Furthermore, the relationship between chronic inflammation and cancer, and how cannabinoids can impact this relationship will be described...
  5. doi request reprint The antimalarial agent artesunate possesses anticancer properties that can be enhanced by combination strategies
    Wai M Liu
    Department of Oncology, Division of Clinical Sciences, St George s, University of London, Jenner Wing, London SW17, United Kingdom
    Int J Cancer 128:1471-80. 2011
    ..Therefore, it is important to carefully select the most appropriate schedule to maximise ART efficacy...
  6. pmc Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses
    W M Liu
    Section of Oncology, Division of Cellular and Molecular Medicine, St George s University of London, London, UK
    Br J Cancer 102:115-23. 2010
    ..However, increasing evidence suggests that standard chemotherapy drugs may stimulate beneficial changes in both the immune system and tumour...
  7. pmc Supernatants from lymphocytes stimulated with Bacillus Calmette-Guerin can modify the antigenicity of tumours and stimulate allogeneic T-cell responses
    W M Liu
    Department of Oncology, Division of Clinical Sciences, St George s, University of London, 2nd Floor, Jenner Wing, London SW17 0RE, UK
    Br J Cancer 105:687-93. 2011
    ..This is often associated with an immune function that is unable to mount appropriate responses against disease, which can result in a state that favours carcinogenesis...
  8. pmc Inhibition of metastatic potential in colorectal carcinoma in vivo and in vitro using immunomodulatory drugs (IMiDs)
    W M Liu
    Division of Cellular and Molecular Medicine, Department of Oncology, St George s, University of London, London SW17 0RE, UK
    Br J Cancer 101:803-12. 2009
    ..Although these agents display immunomodulatory, anti-angiogenic and anti-apoptotic effects, little is known about their primary mode of therapeutic action in patients with cancer...
  9. doi request reprint A microarray study of altered gene expression in colorectal cancer cells after treatment with immunomodulatory drugs: differences in action in vivo and in vitro
    Wai M Liu
    Department of Oncology, Division of Cellular and Molecular Medicine, St George s University of London, 2nd Floor, Jenner Wing, London, SW17 0RE, UK
    Mol Biol Rep 37:1801-14. 2010
    ..Overall, these microarray studies highlighted the diversity of this class of drug, which have effects ranging from cell signalling to translation initiation...
  10. doi request reprint Gemcitabine and lenalidomide combination in a patient with metastatic pancreatic cancer: a case study
    Wai M Liu
    Department of Oncology, Division of Cellular and Molecular Medicine, St George s University of London, 2nd Floor, Jenner Wing, London SW17 0RE, UK
    Med Oncol 27:430-3. 2010
    ..We also present in vitro data that highlight a hyper-additive effect of the two drugs when used in combination. To date, 33 months after diagnosis, the patient remains well and continues in full-time employment...
  11. ncbi request reprint Enhancing the cytotoxic activity of novel targeted therapies--is there a role for a combinatorial approach?
    Wai Man Liu
    Department of Oncology, Division of Cellular and Molecular Medicine, St George s, University of London, London, UK
    Curr Clin Pharmacol 3:108-17. 2008
    ....
  12. doi request reprint Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach
    Wai M Liu
    Department of Oncology, St George s University of London, Jenner Wing, London, UK
    Leuk Lymphoma 49:1800-9. 2008
    ..Overall, these results demonstrate for the first time that a combination approach with THC and established cytotoxic agents may enhance cell death in vitro. Additionally the MAPK/ERK pathway appears responsible in part for these effects...
  13. doi request reprint The gene expression profile of unstimulated dendritic cells can be used as a predictor of function
    Wai M Liu
    Department of Oncology, Division of Clinical Sciences, St George s University of London, London, United Kingdom
    Int J Cancer 130:979-90. 2012
    ..Overall, these studies have highlighted a gene-based screen that predicts DC function, which could be used to guide DC-vaccine trials...
  14. ncbi request reprint How immunotherapy can enhance the response to other modalities and improve outcome and quality of life
    W M Liu
    Department of Oncology, Division of Cellular and Molecular Medicine, St George s, University of London, UK
    J BUON 14:S103-9. 2009
    ..A number of regularly used chemotherapy regimens have marked activity in modulating the immune response. These maybe of benefit and the regimens will be reviewed, which include gemcitabine, cyclophosphamide and the IMiDs...
  15. ncbi request reprint Exposure to low concentrations of etoposide reduces the apoptotic capability of leukaemic cell lines
    W M Liu
    Barry Reed Oncology Laboratory, St Bartholomew s Hospital, London, UK
    Leukemia 16:1705-12. 2002
    ..The persistence of these alterations in cellular processes following an initial exposure to topo II inhibitors suggests a DNA-based mechanism, and highlights the existence of drug/target interactions even at very low drug concentrations...
  16. ncbi request reprint Effect of haemopoietic growth factors on cancer cell lines and their role in chemosensitivity
    Wai Man Liu
    New Drug Study Group, Barry Reed Oncology Laboratory, St Bartholomew s Hospital, London, UK
    Oncogene 23:981-90. 2004
    ..Conversely, our results also suggest that GFs are safe to use in chemotherapeutic regimens if the cancer cells do not overexpress the particular receptor...
  17. ncbi request reprint Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway
    Thomas Powles
    New Drug Study Group, St Bartholomew s Hospital, London, United Kingdom
    Blood 105:1214-21. 2005
    ..Both apoptosis and gene expression changes were altered independent of p53 and the CB-Rs...