Affiliation: St Mary's Hospital
- Clinical risk assessment of GM foodsGideon Lack
Department of Paediatric Allergy and Immunology, Imperial College at St Mary s Hospital, Praed Street, London W2 1NY, UK
Toxicol Lett 127:337-40. 2002..We need to proceed cautiously in the future, assessing individual GM foods on the basis of their individual merits and risks prior to introducing them into the market...
- Report on the potential allergenicity of genetically modified organisms and their productsG Lack
Department of Paediatric Allergy and Immunology, St Mary s Hospital, London, UK
Clin Exp Allergy 32:1131-43. 2002
- Food allergy and asthma--what is the link?Graham Roberts
Paediatric Respiratory Medicine, Royal London Hospital, Whitechapel, E1 1BB, London, UK
Paediatr Respir Rev 4:205-12. 2003..The co-existence of food allergy should be considered in any child with asthma. Where food allergy is confirmed, steps should be taken to avoid these foods as this may considerably improve asthma control...
- Can food allergy be prevented? The current evidenceGeorge Du Toit
Division of Asthma, Allergy and Lung Biology, Guy s and St Thomas National Health Service Foundation Trust, Medical Research Council, London, UK
Pediatr Clin North Am 58:481-509, xii. 2011..Prevention strategies need to be tested using randomized controlled study designs that account for the numerous methodological challenges, safety concerns, and necessary ethical limitations...
- Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled studyGraham Roberts
Department of Paediatric Allergy and Clinical Immunology, St Mary s Hospital, London
J Allergy Clin Immunol 112:168-74. 2003..No objective clinical risk factors exist for pediatric life-threatening asthma...
- Early feeding practices and development of food allergiesGideon Lack
Children s Allergies Department, St Thomas Hospital, Kings College London, London, UK
Nestle Nutr Workshop Ser Pediatr Program 68:169-83; discussion 183-6. 2011..Novel interventional strategies to prevent the development of food allergies are also discussed...
- The concept of oral tolerance induction to foodsGideon Lack
Paediatric Unit, Department of Medicine, King s College London, Guys and St Thomas NHS Foundation Trust, St Thomas Hospital, Lambeth Palace Road, London, UK
Nestle Nutr Workshop Ser Pediatr Program 59:63-8; discussion 68-72. 2007..New strategies to prevent food allergy in infants need to be put to test in randomized controlled interventional studies...
- The predictive value of early life total immunoglobulin E measurement in identifying atopic children in a population-based birth cohort studyMichael R Perkin
Department of Child Health, St George s, University of London, London, UK
Pediatr Allergy Immunol 17:118-24. 2006..5% and a specificity of 95.8%. Although significant differences in early life IgE measurements were seen, the extent of overlap was great, such that the overall performance of IgE at 12 months as a screening test for atopy was poor...
- Diagnosing peanut allergy with skin prick and specific IgE testingGraham Roberts
Paediatric Allergy, Asthma and Immunology, Imperial College at St Mary s, St Mary s Hospital, Praed Street, London W2 1NY, UK
J Allergy Clin Immunol 115:1291-6. 2005..Food allergy is common in childhood. It has been suggested that the magnitude of a skin prick test or specific IgE result can improve diagnostic usefulness, but this has been addressed in only a few tertiary challenge-based studies...
- IgE-mediated facilitated antigen presentation underlies higher immune responses in peanut allergyV Turcanu
Department of Paediatric Allergy, Division of Asthma, Allergy and Lung Biology, MRC and Asthma UK Centre in the Allergic Mechanisms of Asthma, King s College London, London, UK
Allergy 65:1274-81. 2010..To explore the immunological mechanisms that underlie peanut allergy and tolerance, we compared the peanut-specific responses of peanut-allergic (PA) and nonallergic (NA) individuals...
- Is there an association between microbial exposure and food allergy? A systematic reviewTom Marrs
Department of Paediatric Allergy, Division of Asthma, Allergy and Lung Biology, King s College London, London, UK
Pediatr Allergy Immunol 24:311-320.e8. 2013..Factors influencing microbial exposure may be partly responsible for rising FA burden, but further prospective studies using double-blind placebo controlled food challenges as an outcome are required...
- Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infantsCarsten Flohr
1 St John s Institute of Dermatology, Guy s and St Thomas Hospital NHS Foundation Trust, London, UK 2 Children s Allergies Department, Division of Asthma, Allergy and Lung Biology, King s College London, Dundee, UK
J Invest Dermatol 134:345-50. 2014..76, P=0.05). AD is the main skin-related risk factor for food sensitization in young infants. In exclusively breastfed children, this suggests that allergic sensitization to foods can be mediated by cutaneous antigen-presenting cells. ..
- Why do few food-allergic adolescents treat anaphylaxis with adrenaline?--Reviewing a pressing issueTom Marrs
Department of Paediatric Allergy, Division of Asthma, Allergy and Lung Biology, King s College, London, UK
Pediatr Allergy Immunol 24:222-9. 2013..Further research is warranted to identify cognitive patterns associated with high-risk behaviour, and to design appropriate interventions for the augmentation of adolescent self-management skills...
- Clinical features and natural history of physical urticaria in childrenGulamabbas Khakoo
Department of Paediatric Allergy, Asthma and Immunology, St Mary s Hospital, London, UK
Pediatr Allergy Immunol 19:363-6. 2008..A history of allergic conditions and more frequent episodes of urticaria were associated with a poorer prognosis...
- Food allergy and anaphylaxis in pediatrics: update 2010-2012Alexandra F Santos
Department of Pediatric Allergy, Division of Asthma, Allergy and Lung Biology, King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK
Pediatr Allergy Immunol 23:698-706. 2012..Current research into the epidemiology and immunological mechanisms of FA and tolerance will enable us to devise strategies to both prevent and treat food allergies...
- Preventing food allergyAbbas Khakoo
Department of Paediatric Allergy, Asthma and Immunology, Imperial College London at St Mary s Hospital, Salton House, St Mary s Hospital, Praed Street, London W2 1NY, UK
Curr Allergy Asthma Rep 4:36-42. 2004..Additionally, we highlight the potential importance of different routes of allergic sensitization and the role of oral tolerance induction in the pathogenesis and prevention of food allergy...
- Factors associated with the development of peanut allergy in childhoodGideon Lack
Department of Paediatric Allergy and Immunology, St Mary s Hospital at Imperial College, London, United Kingdom
N Engl J Med 348:977-85. 2003..The prevalence of peanut allergy appears to have increased in recent decades. Other than a family history of peanut allergy and the presence of atopy, there are no known risk factors...
- Assessing Peanut Consumption in a Population of Mothers and Their Children in the UKAikaterini Sofianou-Katsoulis
Institute of Child Health, M Asias 76, GR 11527, Athens, Greece St Mary s Hospital, Paediatric Department, QEQM Building, Praed Street, W2 1NY, London, UK
World Allergy Organ J 4:38-44. 2011..The aim was to validate a 50-item FFQ for use in peanut protein sensitization studies...
- Relevance of inhalational exposure to food allergensGraham Roberts
Paediatric Respiratory Medicine, Royal London Hospital, Whitechapel, London
Curr Opin Allergy Clin Immunol 3:211-5. 2003..This review discusses the inhalational route as a clinically important route of exposure to food allergens...
- Food challenges: a review and auditTina Torr
Asthma and Immunology Department, St Mary s Hospital, London
Paediatr Nurs 14:30-4. 2002
- Commentary on 'glucocorticoids for the treatment of anaphylaxis'Alexandra F Santos
Department of Pediatric Allergy, Division of Asthma, Allergy and Lung Biology, King s College London MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK
Evid Based Child Health 8:1295-6. 2013..Glucocorticoids for the treatment of anaphylaxis. Cochrane Database of Systematic Reviews 2012, Issue 4. Art. No.: CD007596. DOI: 10.1002/14651858.CD007596.pub3. ..
- The link between otitis media with effusion and allergy: a potential role for intranasal corticosteroidsGideon Lack
Children s Allergy Department, King s College London, Guy s and St Thomas NHS Foundation Trust, London, UK
Pediatr Allergy Immunol 22:258-66. 2011..Benefits of considering medical treatment in patients with OME prior to surgery include both the potential reductions in allergic inflammation and the naturally occurring spontaneous resolution of OME in these patients...
- New visions for food allergy: an iPAC summary and future trendsPhilippe A Eigenmann
Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland
Pediatr Allergy Immunol 19:26-39. 2008....
- Grass pollen immunotherapy as an effective therapy for childhood seasonal allergic asthmaGraham Roberts
University Child Health, University of Southampton, Hants, UK
J Allergy Clin Immunol 117:263-8. 2006..Few studies have investigated the use of specific immunotherapy (SIT) for childhood seasonal allergic asthma...
- Epidemiologic risks for food allergyGideon Lack
Kings College London, St Thomas Hospital, Children s Allergies Department, London, United Kingdom
J Allergy Clin Immunol 121:1331-6. 2008..This hypothesis provides a possible explanation for the close link between eczema and the development of food allergies. It also suggests novel interventional strategies to prevent the development of food allergies...
- Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanutsVictor Turcanu
Department of Paediatrics, Imperial College Faculty of Medicine, London, United Kingdom
J Clin Invest 111:1065-72. 2003..In conclusion, food allergic status is characterized by a Th2 response whereas Th1-skewed responses underlie oral tolerance...
- New developments in food allergy: old questions remainGideon Lack
J Allergy Clin Immunol 114:127-30. 2004
- Reduced eosinophil pro-fibrogenic effect in severe childhood asthma compared to mild disease: an effect of corticosteroids?Ilaria Puxeddu
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem, Israel
Pediatr Pulmonol 38:222-8. 2004..Our data suggest that the pro-fibrogenic effect of eosinophils might be influenced by treatment with ICS in childhood asthma...
- Early nutrition and immunity - progress and perspectivesPhilip C Calder
Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 96:774-90. 2006..This report summarizes the content of the lectures and the subsequent discussions...
- Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxisPeter Vadas
Department of Medicine, Division of Allergy and Clinical Immunology, St Michael s Hospital, Toronto, ON, Canada
N Engl J Med 358:28-35. 2008..The roles of PAF and PAF acetylhydrolase, the enzyme that inactivates PAF, in anaphylaxis in humans have not been reported...
- Clinical practice. Food allergyGideon Lack
Department of Paediatric Allergy, King s College London, and the Children s Allergy Service, Guy s and St Thomas National Health Service Foundation Trust, London
N Engl J Med 359:1252-60. 2008
- Factors affecting the determination of threshold doses for allergenic foods: how much is too much?Steve L Taylor
University of Nebraska, Food Allergy Research and Resource Program, Lincoln 68583 0919, USA
J Allergy Clin Immunol 109:24-30. 2002..Are these very low, residual quantities hazardous to allergic consumers? How much of the offending food is too much? Very little quantitative information exists to allow any risk assessments to be conducted by the food industry...