J R Kerr

Summary

Affiliation: St George's
Country: UK

Publications

  1. ncbi Chronic fatigue syndrome and arthralgia following parvovirus B19 infection
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    J Rheumatol 29:595-602. 2002
  2. ncbi Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes
    J R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London, UK
    J Clin Pathol 61:730-9. 2008
  3. doi Preexisting psychological stress predicts acute and chronic fatigue and arthritis following symptomatic parvovirus B19 infection
    Jonathan R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, United Kingdom
    Clin Infect Dis 46:e83-7. 2008
  4. doi Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis
    Jonathan R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London
    J Infect Dis 197:1171-84. 2008
  5. ncbi Gene profiling of patients with chronic fatigue syndrome/myalgic encephalomyelitis
    Jonathan R Kerr
    St George s University of London, Cranmer Terrace, London SW17 0RE, United Kingdom
    Curr Rheumatol Rep 10:482-91. 2008
  6. pmc Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis
    Lihan Zhang
    Department of Cellular and Molecular Medicine, St George s University of London, London, UK
    J Clin Pathol 63:156-64. 2010
  7. pmc Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome
    Harriet C T Groom
    Division of Virology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Retrovirology 7:10. 2010
  8. ncbi Short regions of sequence identity between the genomes of human and rodent parvoviruses and their respective hosts occur within host genes for the cytoskeleton, cell adhesion and Wnt signalling
    Jonathan R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    J Gen Virol 87:3567-75. 2006
  9. pmc Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments
    J R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London, UK
    J Clin Pathol 60:113-6. 2007
  10. ncbi Pathogenesis of parvovirus B19 infection: host gene variability, and possible means and effects of virus persistence
    J R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    J Vet Med B Infect Dis Vet Public Health 52:335-9. 2005

Collaborators

Detail Information

Publications22

  1. ncbi Chronic fatigue syndrome and arthralgia following parvovirus B19 infection
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    J Rheumatol 29:595-602. 2002
    ..To determine the incidence of arthralgia and fatigue complicating B19 infection, along with associated B19 markers and autoantibodies...
  2. ncbi Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes
    J R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London, UK
    J Clin Pathol 61:730-9. 2008
    ..Clustering of quantitative PCR (qPCR) data from patients with CFS/ME revealed seven distinct subtypes with distinct differences in Medical Outcomes Survey Short Form-36 scores, clinical phenotypes and severity...
  3. doi Preexisting psychological stress predicts acute and chronic fatigue and arthritis following symptomatic parvovirus B19 infection
    Jonathan R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, United Kingdom
    Clin Infect Dis 46:e83-7. 2008
    ..Psychological stress is thought to be an important factor in the pathogenesis of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Therefore, we sought to examine this relationship in the context of parvovirus B19 infection...
  4. doi Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis
    Jonathan R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London
    J Infect Dis 197:1171-84. 2008
    ..Clustering of quantitative polymerase chain reaction data from patients with CFS/ME revealed 7 subtypes with distinct differences in Medical Outcomes Survey Short Form-36 scores, clinical phenotypes, and severity...
  5. ncbi Gene profiling of patients with chronic fatigue syndrome/myalgic encephalomyelitis
    Jonathan R Kerr
    St George s University of London, Cranmer Terrace, London SW17 0RE, United Kingdom
    Curr Rheumatol Rep 10:482-91. 2008
    ..The possibility that these subtypes represent individual host responses to particular microbial infections is being investigated and may provide another route to specific therapies for CFS patients...
  6. pmc Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis
    Lihan Zhang
    Department of Cellular and Molecular Medicine, St George s University of London, London, UK
    J Clin Pathol 63:156-64. 2010
    ..The authors have previously reported genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) based on expression of 88 human genes...
  7. pmc Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome
    Harriet C T Groom
    Division of Virology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Retrovirology 7:10. 2010
    ....
  8. ncbi Short regions of sequence identity between the genomes of human and rodent parvoviruses and their respective hosts occur within host genes for the cytoskeleton, cell adhesion and Wnt signalling
    Jonathan R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    J Gen Virol 87:3567-75. 2006
    ..All of these aspects suggest a particular advantage to the viruses of the presence of these sequences...
  9. pmc Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments
    J R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London, UK
    J Clin Pathol 60:113-6. 2007
    ..Finally, clinical trials are being planned; novel treatments that we believe are important to trial in patients with CFS are interferon-beta and one of the anti-tumour necrosis factor-alpha drugs...
  10. ncbi Pathogenesis of parvovirus B19 infection: host gene variability, and possible means and effects of virus persistence
    J R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    J Vet Med B Infect Dis Vet Public Health 52:335-9. 2005
    ..In conclusion, these disparate findings contribute to our understanding of the pathogenesis of B19 disease. We are using these studies as a starting point to study the phenomenon of chronic immune activation following B19 infection...
  11. doi Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis
    Jonathan R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London, UK
    J Gen Virol 91:893-7. 2010
    ....
  12. doi Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder
    L Zhan
    Clinical Developmental Sciences, St George s University of London, Cranmer Terrace, London
    Neuropathol Appl Neurobiol 37:206-19. 2011
    ..signalling through dopamine receptors is of critical importance in the brain and is implicated in schizophrenia and bipolar disorder, but its underlying molecular mechanisms remain poorly understood...
  13. ncbi Circulating cytokines and chemokines in acute symptomatic parvovirus B19 infection: negative association between levels of pro-inflammatory cytokines and development of B19-associated arthritis
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Med Virol 74:147-55. 2004
    ..The profile of circulating mediators may provide insights into the possible pathogenesis of particular clinical manifestations of this infection...
  14. ncbi Single-nucleotide polymorphisms associated with symptomatic infection and differential human gene expression in healthy seropositive persons each implicate the cytoskeleton, integrin signaling, and oncosuppression in the pathogenesis of human parvovirus B
    Jonathan R Kerr
    Department of Paediatric Infectious Diseases, St Mary s Campus, Imperial College, London, United Kingdom
    J Infect Dis 192:276-86. 2005
    ..Genes identified in both studies play a functional role in the cytoskeleton, integrin signaling, and oncosuppression, themes that have been shown to be important in parvovirus infections...
  15. ncbi David Arthur John Tyrrell CBE: 19 June 1925 - 2 May 2005
    J R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London
    Biogr Mem Fellows R Soc 53:349-63. 2007
    ..He also had a warmth and a mischievous sense of humour that was frequently directed at bureaucracy, which he thoroughly disliked...
  16. ncbi Chronic fatigue syndrome
    L D Devanur
    Chronic Fatigue Syndrome CFS Group, Department of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, London SW17 0RE, United Kingdom
    J Clin Virol 37:139-50. 2006
    ..Current priorities are to understand the molecular pathogenesis of disease in terms of human and virus gene expression, to develop a diagnostic test based on protein biomarkers, and to develop specific curative treatments...
  17. pmc Evidence for the role of demyelination, HLA-DR alleles, and cytokines in the pathogenesis of parvovirus B19 meningoencephalitis and its sequelae
    J R Kerr
    Department of Microbiology, Royal Brompton and Harefield NHS Trust, Imperial College School of Medicine, London, UK
    J Neurol Neurosurg Psychiatry 73:739-46. 2002
    ..To review the clinical and pathological features of parvovirus B19 meningoencephalitis and its sequelae in 12 previously published cases, and to perform additional tests to determine the pathogenesis of the disease...
  18. ncbi Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College London, UK
    Curr Pain Headache Rep 7:333-41. 2003
    ....
  19. ncbi Neurological manifestations of human parvovirus B19 infection
    Faraj Barah
    Laboratory Medicine Academic Group, University of Manchester, Clinical Sciences Building 3rd Floor, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Rev Med Virol 13:185-99. 2003
    ..The outcome of the review supports an aetiological role of the virus in neurological disease. However, the pathogenesis remains unknown and elucidating this is a priority...
  20. ncbi Association of symptomatic acute human parvovirus B19 infection with human leukocyte antigen class I and II alleles
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College of Science, Technology, and Medicine, SW3 6NP London, United Kingdom
    J Infect Dis 186:447-52. 2002
    ..HLA-B49 was associated with parvovirus infection independently of HLA-DRB1*01, DRB1*04, and DRB1*07...
  21. ncbi A case of persistent parvovirus B19 infection with bilateral cartilaginous and ligamentous damage to the wrists
    Susan M Lowry
    Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, DE 19713, USA
    Clin Infect Dis 41:e42-4. 2005
    ..Nineteen months after presentation, intravenous immunoglobulin therapy resulted in clearance of parvovirus B19 viremia and a significant improvement in the symptoms of fatigue and arthritis...
  22. ncbi Enterovirus infection of the stomach in chronic fatigue syndrome/myalgic encephalomyelitis
    Jonathan R Kerr
    J Clin Pathol 61:1-2. 2008