Research Topics
| Paul JonesSummaryAffiliation: St George's Country: UK Publications
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Publications
Activity limitation and quality of life in COPDPaul W Jones
St George s, University of London, London, United Kingdom
COPD 4:273-8. 2007..This suggests that self-reported limitation of activity may form a reliable construct, and may also provide a good surrogate marker of health status in COPD...
Aclidinium bromide twice daily for the treatment of chronic obstructive pulmonary disease: a reviewPaul Jones
St George s University of London, Cranmer Terrace, London, SW17 0RE, UK
Adv Ther 30:354-68. 2013..i.d. is effective for the treatment of patients with COPD, offering improvements in lung function, breathlessness, and HRQoL, with a good safety profile and a low incidence of anticholinergic and cardiac AEs...
Beyond FEV₁ in COPD: a review of patient-reported outcomes and their measurementPaul Jones
Division of Clinical Science, University of London, London, UK
Int J Chron Obstruct Pulmon Dis 7:697-709. 2012..In turn, this will help us to understand better the patient's experience of the disease...- Efficacy and safety of twice-daily aclidinium bromide in COPD patients: the ATTAIN studyPaul W Jones
St George s, University of London, Cranmer Terrace, London, SW17 0RE, UK
Eur Respir J 40:830-6. 2012..Twice-daily aclidinium significantly improved bronchodilation, health status and dyspnoea, and was well tolerated in patients with COPD... - Tests of the responsiveness of the COPD assessment test following acute exacerbation and pulmonary rehabilitationPaul W Jones
Division of Clinical Science, St George s University of London, London, England
Chest 142:134-40. 2012..The COPD Assessment Test (CAT) is an eight-item questionnaire suitable for routine clinical use that shows reliability and validity in stable and exacerbating COPD... - Correlating changes in lung function with patient outcomes in chronic obstructive pulmonary disease: a pooled analysisPaul W Jones
Division of Clinical Science, St George s, University of London, London, UK
Respir Res 12:161. 2011..We examined whether changes in trough forced expiratory volume in 1 second (FEV(1)) are correlated with changes in patient-reported outcomes... - Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic reviewMarie Westwood
Kleijnen Systematic Reviews Ltd, York, UK
Respir Res 12:40. 2011..This systematic review and study-level analysis investigated the relationship between changes in FEV1 and changes in health status with bronchodilator therapy... - Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH studyChristine R Jenkins
Woolcock Institute of Medical Research, Sydney, Australia
Respir Res 10:59. 2009..However, there are only limited data about the influence of GOLD severity staging on the effectiveness of SFC, particularly in patients with milder disease... - Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trialSanjay Sethi
Division of Pulmonary, Critical Care and Sleep Medicine, University of Buffalo, State University of New York, Buffalo, NY, USA
Respir Res 11:10. 2010..This proof-of-concept study evaluates whether intermittent pulsed moxifloxacin treatment could reduce the frequency of these exacerbations... - Health status in the TORCH study of COPD: treatment efficacy and other determinants of changePaul W Jones
Department of Cardiac and Vascular Sciences, St George s Hospital, University of London, London, UK
Respir Res 12:71. 2011..Little is known about factors that determine health status decline in clinical trials of COPD... - Development and first validation of the COPD Assessment TestP W Jones
St George s University of London, UK
Eur Respir J 34:648-54. 2009..It has good measurement properties, is sensitive to differences in state and should provide a valid, reliable and standardised measure of COPD health status with worldwide relevance... - Health status and the spiral of declinePaul W Jones
St George s, University of London, Cranmer Terrace, London, UK
COPD 6:59-63. 2009..Inhaled corticosteroids have been shown to reduce the rate of decline of health status, possibly due to exacerbation prevention... - Improving the process and outcome of care in COPD: development of a standardised assessment toolPaul Jones
Department of Cardiac and Vascular Sciences, St George s Hospital, University of London, London, UK
Prim Care Respir J 18:208-15. 2009..This goal requires regular systematic assessment of the patient's COPD with clear and efficient communication between the patient and clinician... - Profiling the effects of indacaterol on dyspnoea and health status in patients with COPDPaul W Jones
Division of Clinical Science, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
Respir Med 105:892-9. 2011..The aim of this paper is to assess the effect of indacaterol on dyspnoea and health status, using pooled study data to evaluate the relative efficacy of indacaterol and existing bronchodilators... - Creating scenarios of the impact of COPD and their relationship to COPD Assessment Test (CAT™) scoresPaul W Jones
Division of Clinical Science, St, George s University of London, London, UK
BMC Pulm Med 11:42. 2011..New questionnaires require reference points so that users can understand the scores; descriptive scenarios are one way of doing this. A novel method of creating scenarios is described... - Role of clinical questionnaires in optimizing everyday care of chronic obstructive pulmonary diseasePaul W Jones
Cardiac and Vascular Medicine, St George s, University of London, UK
Int J Chron Obstruct Pulmon Dis 6:289-96. 2011..Such questionnaires provide important measurements that can assist primary care physicians to capture the impact of COPD on patients' daily lives and wellbeing, and improve long-term COPD management... - Quantifying of severity of exacerbations in chronic obstructive pulmonary disease: adaptations to the definition to allow quantificationPaul Jones
St George s, University of London, Cranmer Terrace, London, SW17 0RE, UK
Proc Am Thorac Soc 4:597-601. 2007..Methods for defining exacerbation onset and cessation are also proposed... - Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary diseasePaul W Jones
St George s, University of London, London, UK
Respir Res 12:55. 2011..The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD)... - Outcomes and markers in the assessment of chronic obstructive pulmonary diseaseP W Jones
Respiratory Medicine, St George s, University of London, Cranmer Terrace, London, SW17 0RE, UK, and Serviei de Pneumologia, Hospital Universitari Son Dureta, Fundació Caubet CIMERA, Palma de Mallorca, Spain
Eur Respir J 27:822-32. 2006..The process of marker selection and validation is reviewed and potential new biological, physiological and symptomatic markers for chronic obstructive pulmonary disease are assessed... - Health status: what does it mean for payers and patients?Paul W Jones
St George s, University of London, UK
Proc Am Thorac Soc 3:222-6. 2006..Improved health does not improve mortality or morbidity per se. It is also important to appreciate that the impact of any measured change in health may also be determined by the patient's baseline state... - Efficacy of indacaterol in the treatment of patients with COPDPaul W Jones
Division of Clinical Sciences, St George s University of London, London, UK
Prim Care Respir J 20:380-8. 2011..The safety profile was similar to placebo. Once-daily indacaterol is an effective and beneficial maintenance bronchodilator treatment for patients with moderate-to-severe COPD... - Measuring the effects of COPD on the patientPaul Jones
St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
Respir Med 99:S11-8. 2005..Future developments will include computerising these methodologies to permit faster and more individual patient-centred measurements... - Predicting EQ-5D values using the SGRQHelen J Starkie
National Institute for Health and Clinical Excellence, London, UK
Value Health 14:354-60. 2011..George's Respiratory Questionnaire (SGRQ) in subjects with chronic obstructive pulmonary disease and to examine the effect of using this algorithm in predicting quality-adjusted life-years (QALYs)... - Clinical effects of inhaled corticosteroids in chronic obstructive pulmonary diseasePaul W Jones
Respiratory Medicine, St George s Hospital Medical School, London SW 17 0RE, UK
Proc Am Thorac Soc 1:167-70. 2004..The effect of fluticasone on health appears to be due to a reduction in exacerbations coupled with its small effect on FEV(1)... - Utility estimation in chronic obstructive pulmonary disease: a preference for change?Jennifer Petrillo
Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK
Pharmacoeconomics 29:917-32. 2011..The trade-off allows relevant and sensitive matters most important to patients to be evaluated; however inevitable gaps such as those related to adverse events are not considered... - The effect of helium and oxygen on exercise performance in chronic obstructive pulmonary disease: a randomized crossover trialElizabeth A Laude
Respiratory Medicine, Royal Hallamshire Hospital, Department of General Practice and Primary Care, ScHARR, Biomedical Sciences, University of Sheffield, Sheffield, UK
Am J Respir Crit Care Med 173:865-70. 2006..Replacing nitrogen with helium reduces expiratory flow resistance and may improve lung emptying. Combining these treatments should be independently effective... - Development and Validation of an Improved, COPD-Specific Version of the St. George Respiratory QuestionnaireMakiko Meguro
Cardiac and Vascular Sciences, St George s, University of London, Cranmer Terrace, London, UK
Chest 132:456-63. 2007..To produce an improved, COPD-specific version of the St. George respiratory questionnaire (SGRQ-C)... - Adapting to asthma: are some asthma effects acceptable?Elizabeth A Barley
Department of Medicine, Respiratory Medicine, Cardiac and Vascular Sciences, St George s, University of London, London, United Kingdom
J Asthma 43:433-8. 2006..We conclude that patients accept some asthma effects but do not appear to discount them when using a detailed health status questionnaire... - Repeatability of a Rasch model of the AQ20 over five assessmentsElizabeth A Barley
Division of Physiological Medicine, Department of Medicine, St George s, University of London, Cranmer Terrace, SW17 0RE, London, UK
Qual Life Res 15:801-9. 2006..This is important as inclusion of 'time-dependent' items in a questionnaire may reduce the reliability of the instrument... - Short-term and long-term outcomes of moxifloxacin compared to standard antibiotic treatment in acute exacerbations of chronic bronchitisRobert Wilson
Royal Brompton Hospital, London, UK
Chest 125:953-64. 2004..To compare the effectiveness of oral moxifloxacin with standard antibiotic therapy in acute exacerbation of chronic bronchitis (AECB)... - St. George's Respiratory Questionnaire: MCIDPaul W Jones
St George s Hospital Medical School, London, UK
COPD 2:75-9. 2005.... - Evaluation of male COPD patients' health status by proxiesCarme Santiveri
Respiratory Department, Dos de Maig Hospital, Consorci Sanitari Integral, Barcelona 08025, Catalonia, Spain
Respir Med 101:439-45. 2007..The aim of this study was to analyse the reliability and validity of the St. George's Respiratory Questionnaire (SGRQ) answered by proxies and to determine their accuracy as raters... - The severity of airways obstruction as a determinant of treatment response in COPDPeter Calverley
Clinical Research Centre, University Hospital Aintree, Liverpool, UK
Int J Chron Obstruct Pulmon Dis 1:209-18. 2006.... - Brazilian version of airways questionnaire 20: a reproducibility study and correlations in patients with COPDAquiles Camelier
Pulmonary Division, Rehabilitation Center, Federal University of Sao Paulo, SP, Brazil
Respir Med 99:602-8. 2005..It can be concluded that AQ20 is reproducible, with an excellent correlation with SGRQ total score, and also having the advantage of taking just a few minutes to be applied and to have its score calculated... - Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH studyBartolome R Celli
Tufts University School of Medicine, Pulmonary and Critical Care Division, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
Am J Respir Crit Care Med 178:332-8. 2008..Chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline in lung function. No drug has been shown conclusively to reduce this decline... - It's about time--directing our attention toward modifying the course of COPDMario Cazzola
University of Rome Tor Vergata, Department of Internal Medicine, Unit of Respiratory Diseases, Rome, Italy
Respir Med 102:S37-48. 2008..In this review we have considered three approaches toward modifying the course of COPD: smoking cessation, reduction in lung hyperinflation through medical and surgical approaches, and long-term pharmacotherapy... - Health-related quality of life in patients with chronic respiratory failure after long-term mechanical ventilationSara Euteneuer
Krankenhaus Kloster Grafschaft, Schmallenberg, Germany
Respir Med 100:477-86. 2006..Despite severe physical handicaps due to CRF mental health is only mildly compromised... - Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary diseasePeter M A Calverley
University Hospital Aintree, Liverpool, United Kingdom
N Engl J Med 356:775-89. 2007..Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic obstructive pulmonary disease (COPD), but their effect on survival is unknown... - Symptom measurementPaul W Jones
Chest 134:226-7. 2008 - Corticosteroid therapy in pulmonary sarcoidosis: a systematic reviewShanthi Paramothayan
Division of Physiological Medicine, St George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, England
JAMA 287:1301-7. 2002..Trials of inhaled corticosteroids were small and results too inconsistent to make firm conclusions concerning their efficacy. There are no data to suggest that corticosteroid therapy alters long-term disease progression... - Withdrawal from treatment as an outcome in the ISOLDE study of COPDPeter M A Calverley
Department of Medicine, University Hospital Aintree, Liverpool, United Kingdom
Chest 124:1350-6. 2003..To investigate the determinants of patient withdrawal from our study, and the effect of these withdrawals on the outcome of treatment with inhaled corticosteroids in patients with COPD... - Measuring functional performance in patients with COPD: a discussion of patient-reported outcome measuresDonald E Stull
Center for Health Outcomes Research, United BioSource Corporation, Bethesda, MD, USA
Curr Med Res Opin 23:2655-65. 2007....