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Species | Paul T HeathSummaryAffiliation: St George's Hospital Medical School Country: UK Publications
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Publications
The UK Hib vaccine experienceP T Heath
Department of Child Health and St George s Vaccine Institute, St George s Hospital Medical School, London, UK
Arch Dis Child 86:396-9. 2002..Cases continue to occur and complacency is ill advised, particularly as other vaccines and combinations are introduced. Surveillance of H influenzae disease in the UK remains important...- Haemophilus influenzae type b reemergence after combination immunizationNik G Johnson
St George's University of London, London, United Kingdom
Emerg Infect Dis 12:937-41. 2006..001, respectively). Hib was found in 2.1% (95% CI 0.7%-6.0%) of study participants. Our data support an association between DTaP-Hib vaccine combinations and clinical Hib disease through an effect on antibody concentration and avidity... 
Safety, immunogenicity, and induction of immunologic memory by a serogroup C meningococcal conjugate vaccine in infants: A randomized controlled trialJ M MacLennan
Department of Child Health, St George s Hospital Medical School, Cranmer Terrace, London, SW17 0RE, England
JAMA 283:2795-801. 2000..Neisseria meningitidis is a common cause of meningitis and septicemia in infants worldwide. Whether a meningococcal C conjugate vaccine protects infants against the serogroup C strain is unknown...- Group B streptococcal disease in UK and Irish infants younger than 90 daysPaul T Heath
Vaccine Institute, St George s Hospital, London, UK
Lancet 363:292-4. 2004..53 infants died (overall 9.7%). We have established the minimum current burden of group B streptococcal disease in UK and Irish infants. This information will assist in the formulation of guidelines for prevention of this disease... - Epidemiology and bacteriology of bacterial pneumoniasP T Heath
Department of Child Health and Vaccine Institute, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
Paediatr Respir Rev 1:4-7. 2000..The range of potential bacterial pathogens associated with nosocomial pneumonia and with pneumonia in the immunosuppressed child is wider with Gram-negative aerobic bacilli the most frequent isolate... - Vaccination against group B streptococcusPaul T Heath
Department of Child Health and Vaccine Institute, St George s Hospital Medical School, London, UK
Expert Rev Vaccines 4:207-18. 2005..However, unless the regulatory environment is changed specifically to allow the development of a Group B streptococcus vaccine, it is unlikely that one will ever reach the market... - Neonatal meningitisP T Heath
Paediatric Infectious Diseases Unit, St George s Hospital, Tooting, London SW17 0RE, UK
Arch Dis Child Fetal Neonatal Ed 88:F173-8. 2003..They noted the absence of clinical trials with third generation cephalosporins that showed an improvement in mortality or neurological outcome... - Hib vaccination in infants born prematurelyP T Heath
Department of Child Health and St George s Vaccine Institute, St George s Hospital Medical School, London, UK
Arch Dis Child 88:206-10. 2003.... - Antibody concentration and clinical protection after Hib conjugate vaccination in the United KingdomP T Heath
Department of Child Health and St George s Vaccine Institute, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, England
JAMA 284:2334-40. 2000..Few data are available to show that this fourth dose is actually necessary... - Clinical and immunological risk factors associated with Haemophilus influenzae type b conjugate vaccine failure in childhoodP T Heath
Oxford Vaccine Group, John Radcliffe Hospital, Oxford, United Kingdom
Clin Infect Dis 31:973-80. 2000..0 microg/mL) after disease, but the majority then responded to a further dose of Hib vaccine. Children who develop Hib disease despite vaccination deserve further clinical and immunological evaluation... 
Long-term complications and risk of other serious infections following invasive Haemophilus influenzae serotype b disease in vaccinated childrenShamez Ladhani
Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, London, United Kingdom
Vaccine 28:2195-200. 2010..One in seven otherwise healthy children (14%) with Hib vaccine failure will go on to suffer another serious infection requiring hospital admission in childhood, which is higher than would be expected for the UK paediatric population...- Haemophilus influenzae type b vaccine failure in children is associated with inadequate production of high-quality antibodyYeh Chen Lee
University Department of Paediatrics, University of Oxford, Oxford, UK
Clin Infect Dis 46:186-92. 2008.... - Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infantsJens U Ruggeberg
Division of Child Health and Vaccine Institute, St George s University of London, London, UK, and Paediatric Infectious Diseases, Department of General Paediatrics, University Children s Hospital, Dusseldorf, Germany
Vaccine 25:264-71. 2007..Antibody concentrations wane over the first year of life in both preterm and term infants and booster vaccination is therefore likely to be important... - Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized childrenShamez N Ladhani
Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, London, United Kingdom
Clin Infect Dis 51:761-7. 2010..The objective of this study was to investigate single-nucleotide polymorphisms (SNPs) known to affect function in biologically plausible genes in relation to the risk of Hib vaccine failure and its clinical manifestations... - Immunogenicity and immunologic memory of meningococcal C conjugate vaccine in premature infantsClare L Collins
St. George's Hospital Medical School, London, United Kingdom
Pediatr Infect Dis J 24:966-8. 2005..K. infants suggest a role for a routine booster dose of vaccine in all infants receiving MCC, especially those born preterm... - Long-term immunological follow-up of children with haemophilus influenzae serotype b vaccine failure in the United KingdomShamez Ladhani
Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, Centre for Infections, Health Protection Agency, St George s, University of London, London, United Kingdom
Clin Infect Dis 49:372-80. 2009..The objective of this study was to determine Hib antibody concentrations in children several years after infection and to identify risk factors for low antibody concentrations... - Invasive Haemophilus influenzae Disease, Europe, 1996-2006Shamez Ladhani
Health Protection Agency, London, UK
Emerg Infect Dis 16:455-63. 2010..Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality... - Antibody responses to meningococcal (groups A, C, Y and W135) polysaccharide diphtheria toxoid conjugate vaccine in children who previously received meningococcal C conjugate vaccineHaitham El Bashir
Research Centre for Child Health, St Bartholomew s and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Vaccine 24:2544-9. 2006..No major between-group differences in solicited local and systemic reactions or adverse events (AEs)... - Characterization of group B streptococci recovered from infants with invasive disease in England and WalesAbbie M Weisner
Streptococcus and Diphtheria Reference Unit, Respiratory and Systemic Infection Laboratory, Health Protection Agency, Colindale, London, United Kingdom
Clin Infect Dis 38:1203-8. 2004..A trivalent vaccine containing capsular polysaccharides III, Ia, and V could theoretically provide coverage against 85% of the cases of GBS disease among infants in England and Wales... - The immunogenicity of a novel A (H1N1) vaccine in HIV-infected childrenIfeanyichukwu O Okike
Vaccine Institute, St George s, University of London, London, United Kingdom
Vaccine 29:6636-40. 2011..There were no published data available regarding the immunogenicity of this vaccine in such children... - Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysisKaren M Edmond
London School of Hygiene and Tropical Medicine, London, UK
Lancet 379:547-56. 2012..However, estimates of disease burden in many countries outside of these regions is not available. We aimed to examine the current global burden of invasive disease and the serotype distribution of group B streptococcus isolates... - Induction of protective serum meningococcal bactericidal and diphtheria-neutralizing antibodies and mucosal immunoglobulin A in volunteers by nasal insufflations of the Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with Zhiming Huo
St. George's Vaccine Institute, London, United Kingdom
Infect Immun 73:8256-65. 2005..Simple nasal insufflation of existing MCP-CRM197 conjugate vaccines in chitosan offers an inexpensive but effective needle-free prime and boost against serogroup C N. meningitidis and diphtheria... - The contribution of infections to neonatal deaths in England and WalesSarita J Depani
St George s Hospital, London, UK
Pediatr Infect Dis J 30:345-7. 2011..Infection was recorded in 11% of deaths, with two-thirds occurring in premature neonates. Group B Streptococcus was indicated in 32% of death certificates that specified a bacterial infection and in 11% of all infection-related deaths... - Neonatal infections in England: the NeonIN surveillance networkStefania Vergnano
Division of Child Health, St George s, University of London, Cranmer Terrace, London, UK
Arch Dis Child Fetal Neonatal Ed 96:F9-F14. 2011..Neonatal infection is an important cause of morbidity and mortality. Neonatal infection surveillance networks are necessary for defining the epidemiology of infections and monitoring changes over time... - PEPtalk: postexposure prophylaxis against varicella in children with cancerJessica Bate
Division of Clinical Sciences, St George s, University of London, London, UK
Arch Dis Child 96:841-5. 2011.... - The economic costs of Group B Streptococcus (GBS) disease: prospective cohort study of infants with GBS disease in EnglandElizabeth Ann Schroeder
National Perinatal Epidemiology Unit, University of Oxford, Old Road Campus, Old Road, Headington, Oxford, OX3 7LF, UK
Eur J Health Econ 10:275-85. 2009..These data should be used to inform policy decisions regarding the cost-effectiveness of prevention and treatment strategies for GBS disease during early childhood... - Perinatal group B streptococcal diseasePaul T Heath
Vaccine Institute and Division of Child Health, St George s, University of London, London SW17 0RE, UK
Best Pract Res Clin Obstet Gynaecol 21:411-24. 2007..Decisions on which strategy to use will depend on a number of factors. A swab-based approach appears to have higher efficacy but is likely to lead to more antibiotic exposure... - An update on vaccination against group B streptococcusPaul T Heath
Vaccine Institute and Division of Clinical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
Expert Rev Vaccines 10:685-94. 2011..Issues yet to be resolved include the safety and acceptability of vaccination during pregnancy, the durability of vaccine-derived immunity and the regulatory issues required for licensure... - Strategies for preventing group B streptococcal diseaseEsse Menson
Pediatric Infectious Diseases Unit, St George's Hospital, London, United Kingdom
Adv Exp Med Biol 549:231-6. 2004 - Estimating Haemophilus influenzae type b vaccine effectiveness in England and Wales by use of the screening methodMary E Ramsay
Immunisation Division, Public Health Laboratory Service PHLS Communicable Disease Surveillance Centre, London, United Kingdom
J Infect Dis 188:481-5. 2003..Since 1999, however, low effectiveness in infants, declining effectiveness with age, and the use of lower-efficacy vaccines have contributed to increased rates of Hib infection. The potential role of boosters needs to be considered... - The epidemiology of neonatal and pediatric candidemia in England and Wales, 2000-2009Clarissa Oeser
Paediatric Infectious Diseases Research Group, Division of Clinical Sciences, St George s, University of London, London, United Kingdom
Pediatr Infect Dis J 32:23-6. 2013..This study aimed to describe the epidemiology of pediatric candidemia in England and Wales during a 10-year period as a means of quantifying the changing burden of infection and identifying emerging trends... - Immunogenicity of pandemic (H1N1) 2009 vaccine in children with cancer in the United KingdomJessica Bate
Dept of Child Health, St George s, University of London, London, England
Clin Infect Dis 51:e95-104. 2010..Children with cancer have an increased susceptibility to influenza infection. The objective of this study was to assess the immunogenicity of pandemic (H1N1) 2009 vaccine in children with cancer... - Safety and efficacy of meningococcal group C conjugate vaccinesJens Rüggeberg
Department of Child Health and Vaccine Institute, St George s Hospital Medical School, Cranmer Terrace, London SW17 0QT, UK
Expert Opin Drug Saf 2:7-19. 2003..The annual number of fatalities from confirmed meningococcal C disease in the same population has fallen from 67 to 5 cases within a 2-year period... - Immunisation practices of paediatric oncology and shared care oncology consultants: a United Kingdom surveyJessica Bate
Division of Child Health, St George s University of London, London, UK
Pediatr Blood Cancer 54:941-6. 2010..In March 2002, the Royal College of Paediatrics and Child Health (RCPCH) introduced guidelines for re-immunisation of children after completion of standard-dose chemotherapy and after haematopoietic stem cell transplant (HSCT)... - X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the diseaseClaire Booth
Center of Immunodeficiency, Molecular Immunology Unit, Institute of Child Health, London, United Kingdom
Blood 117:53-62. 2011..The outcome of HSCT for other manifestations of XLP1 is very good, and if HSCT is not undertaken immediately, patients must be monitored closely for evidence of disease progression... - Risk factors for late onset gram-negative infections: a case-control studySrabani Samanta
Division of Child Health, St George s, University of London, Cranmer Terrace, Tooting, London, UK
Arch Dis Child Fetal Neonatal Ed 96:F15-8. 2011..To determine the incidence, mortality and risk factors for neonatal late onset gram-negative sepsis and meningitis (LOGNS)... - Immunogenicity and reactogenicity of a 13-valent-pneumococcal conjugate vaccine administered at 2, 4, and 12 months of age: a double-blind randomized active-controlled trialMatthew D Snape
Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Headington, United Kingdom
Pediatr Infect Dis J 29:e80-90. 2010.... - Improving the outcome of neonatal meningitisEva P Galiza
Vaccine Institute, London, UK
Curr Opin Infect Dis 22:229-34. 2009..This review focuses on recent advances in the management of neonatal meningitis and its implications for improved outcomes... - Response of steroid-treated former preterm infants to a single dose of meningococcal C conjugate vaccinePaul Clarke
Neonatal Unit, Hope Hospital, Stott Lane, Salford M6 8HD, UK
Vaccine 24:3273-8. 2006..Previous neonatal dexamethasone treatment does not appear to attenuate immune response after infancy... - Haemophilus influenzae type b vaccine--booster campaignPaul T Heath
BMJ 326:1158-9. 2003 - Revaccination with measles, tetanus, poliovirus, Haemophilus influenzae type B, meningococcus C, and pneumococcus vaccines in children after hematopoietic stem cell transplantationSoonie R Patel
Pediatric Oncology Department, Royal Marsden Hospital, Sutton, United Kingdom
Clin Infect Dis 44:625-34. 2007..A simple and validated revaccination schedule is required. The aim of this study was to evaluate the immunogenicity of a revaccination schedule for pediatric HSCT recipients... - Effectiveness analyses may underestimate protection of infants after group C meningococcal immunizationDavid M Vu
Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA
J Infect Dis 194:231-7. 2006..On the basis of serum bactericidal activity and/or passive protection, 40%-50% of both age groups are protected at 2-3 years after immunization, which was significantly greater than in unimmunized historical controls (<5%)... - Revaccination of children after completion of standard chemotherapy for acute leukemiaSoonie R Patel
Pediatric Oncology Department, Royal Marsden Hospital, Sutton, United Kingdom
Clin Infect Dis 44:635-42. 2007..After the treatment of patients with acute leukemia, there is a decrease in vaccine-specific antibody and an increased susceptibility to certain vaccine-preventable diseases. A simple revaccination schedule is warranted... - Seroprotection against serogroup C meningococcal diseaseLucieni O Conterno
BMJ 336:1447-8. 2008 - Anaphylaxis as an adverse event following immunisationMichel Erlewyn-Lajeunesse
J Clin Pathol 60:737-9. 2007 - Prevalence of nasopharyngeal carriage of pneumococcus in preschool children attending day care in LondonAnita Roche
South West London Health Protection Unit, Springfield University Hospital, 61 Glenburnie Road, London SW17 7DB, UK
Arch Dis Child 92:1073-6. 2007..To estimate the prevalence of nasopharyngeal (NP) carriage of pneumococcus (Streptococcus pneumoniae) and describe the antibiotic resistance patterns and serotypes in young children attending group day care in London... - Respiratory distress related to asymptomatic colonization with group B streptococciBenjamin J Stenson
Pediatr Infect Dis J 26:765; author reply 765-6. 2007 - Vaccinations in children treated with standard-dose cancer therapy or hematopoietic stem cell transplantationSoonie R Patel
Paediatric Department, Mayday University Hospital, Croydon, UK
Pediatr Clin North Am 55:169-86, xi. 2008..It is important to protect these children against vaccine-preventable diseases by reimmunization... - Changes in antibiotic resistance rates of invasive Haemophilus influenzae isolates in England and Wales over the last 20 yearsShamez Ladhani
Immunisation Department, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
J Antimicrob Chemother 62:776-9. 2008..The aim of this study was to determine trends in antibiotic resistance profiles of invasive clinical Haemophilus influenzae isolates over the last 20 years...