Paul T Heath

Summary

Affiliation: St George's
Country: UK

Publications

  1. doi request reprint Risk factors for late onset gram-negative infections: a case-control study
    Srabani Samanta
    Division of Child Health, St George s, University of London, Cranmer Terrace, Tooting, London, UK
    Arch Dis Child Fetal Neonatal Ed 96:F15-8. 2011
  2. pmc Haemophilus influenzae type b reemergence after combination immunization
    Nik G Johnson
    St George s University of London, London, United Kingdom
    Emerg Infect Dis 12:937-41. 2006
  3. pmc Group B streptococcal carriage, serotype distribution and antibiotic susceptibilities in pregnant women at the time of delivery in a refugee population on the Thai-Myanmar border
    Claudia Turner
    Shoklo Malaria Research Unit, Thailand
    BMC Infect Dis 12:34. 2012
  4. pmc Meropenem vs standard of care for treatment of late onset sepsis in children of less than 90 days of age: study protocol for a randomised controlled trial
    Irja Lutsar
    Institute of Microbiology, University of Tartu, Estonia
    Trials 12:215. 2011
  5. ncbi request reprint Group B streptococcal disease in infants: a case control study
    P T Heath
    Child Health and Vaccine Institute, St George s, University of London, UK
    Arch Dis Child 94:674-80. 2009
  6. doi request reprint An update on vaccination against group B streptococcus
    Paul T Heath
    Vaccine Institute and Division of Clinical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Expert Rev Vaccines 10:685-94. 2011
  7. ncbi request reprint Perinatal group B streptococcal disease
    Paul T Heath
    Vaccine Institute and Division of Child Health, St George s, University of London, London SW17 0RE, UK
    Best Pract Res Clin Obstet Gynaecol 21:411-24. 2007
  8. ncbi request reprint Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infants
    Jens U Ruggeberg
    Division of Child Health and Vaccine Institute, St George s University of London, London, UK, and Paediatric Infectious Diseases, Department of General Paediatrics, University Children s Hospital, Dusseldorf, Germany
    Vaccine 25:264-71. 2007
  9. ncbi request reprint Antibody responses to meningococcal (groups A, C, Y and W135) polysaccharide diphtheria toxoid conjugate vaccine in children who previously received meningococcal C conjugate vaccine
    Haitham El Bashir
    Research Centre for Child Health, St Bartholomew s and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Vaccine 24:2544-9. 2006
  10. doi request reprint Long-term immunological follow-up of children with haemophilus influenzae serotype b vaccine failure in the United Kingdom
    Shamez Ladhani
    Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, Centre for Infections, Health Protection Agency, St George s, University of London, London, United Kingdom
    Clin Infect Dis 49:372-80. 2009

Detail Information

Publications39

  1. doi request reprint Risk factors for late onset gram-negative infections: a case-control study
    Srabani Samanta
    Division of Child Health, St George s, University of London, Cranmer Terrace, Tooting, London, UK
    Arch Dis Child Fetal Neonatal Ed 96:F15-8. 2011
    ..To determine the incidence, mortality and risk factors for neonatal late onset gram-negative sepsis and meningitis (LOGNS)...
  2. pmc Haemophilus influenzae type b reemergence after combination immunization
    Nik G Johnson
    St George s University of London, London, United Kingdom
    Emerg Infect Dis 12:937-41. 2006
    ..001, respectively). Hib was found in 2.1% (95% CI 0.7%-6.0%) of study participants. Our data support an association between DTaP-Hib vaccine combinations and clinical Hib disease through an effect on antibody concentration and avidity...
  3. pmc Group B streptococcal carriage, serotype distribution and antibiotic susceptibilities in pregnant women at the time of delivery in a refugee population on the Thai-Myanmar border
    Claudia Turner
    Shoklo Malaria Research Unit, Thailand
    BMC Infect Dis 12:34. 2012
    ..Maternal carriage of GBS is a prerequisite for the development of early onset GBS neonatal sepsis but there is a paucity of carriage data published from the developing world, in particular South East Asia...
  4. pmc Meropenem vs standard of care for treatment of late onset sepsis in children of less than 90 days of age: study protocol for a randomised controlled trial
    Irja Lutsar
    Institute of Microbiology, University of Tartu, Estonia
    Trials 12:215. 2011
    ..Meropenem is an antibiotic with wide antibacterial coverage. The advantage of it over standard of care could be its wider antibacterial coverage and thus the use of mono-instead of combination therapy...
  5. ncbi request reprint Group B streptococcal disease in infants: a case control study
    P T Heath
    Child Health and Vaccine Institute, St George s, University of London, UK
    Arch Dis Child 94:674-80. 2009
    ..To describe and quantify the maternal and neonatal factors associated with Group B streptococcus (GBS) disease in infants <90 days of age...
  6. doi request reprint An update on vaccination against group B streptococcus
    Paul T Heath
    Vaccine Institute and Division of Clinical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Expert Rev Vaccines 10:685-94. 2011
    ..Issues yet to be resolved include the safety and acceptability of vaccination during pregnancy, the durability of vaccine-derived immunity and the regulatory issues required for licensure...
  7. ncbi request reprint Perinatal group B streptococcal disease
    Paul T Heath
    Vaccine Institute and Division of Child Health, St George s, University of London, London SW17 0RE, UK
    Best Pract Res Clin Obstet Gynaecol 21:411-24. 2007
    ..Decisions on which strategy to use will depend on a number of factors. A swab-based approach appears to have higher efficacy but is likely to lead to more antibiotic exposure...
  8. ncbi request reprint Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infants
    Jens U Ruggeberg
    Division of Child Health and Vaccine Institute, St George s University of London, London, UK, and Paediatric Infectious Diseases, Department of General Paediatrics, University Children s Hospital, Dusseldorf, Germany
    Vaccine 25:264-71. 2007
    ..Antibody concentrations wane over the first year of life in both preterm and term infants and booster vaccination is therefore likely to be important...
  9. ncbi request reprint Antibody responses to meningococcal (groups A, C, Y and W135) polysaccharide diphtheria toxoid conjugate vaccine in children who previously received meningococcal C conjugate vaccine
    Haitham El Bashir
    Research Centre for Child Health, St Bartholomew s and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Vaccine 24:2544-9. 2006
    ..No major between-group differences in solicited local and systemic reactions or adverse events (AEs)...
  10. doi request reprint Long-term immunological follow-up of children with haemophilus influenzae serotype b vaccine failure in the United Kingdom
    Shamez Ladhani
    Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, Centre for Infections, Health Protection Agency, St George s, University of London, London, United Kingdom
    Clin Infect Dis 49:372-80. 2009
    ..The objective of this study was to determine Hib antibody concentrations in children several years after infection and to identify risk factors for low antibody concentrations...
  11. doi request reprint Long-term complications and risk of other serious infections following invasive Haemophilus influenzae serotype b disease in vaccinated children
    Shamez Ladhani
    Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Vaccine 28:2195-200. 2010
    ..One in seven otherwise healthy children (14%) with Hib vaccine failure will go on to suffer another serious infection requiring hospital admission in childhood, which is higher than would be expected for the UK paediatric population...
  12. ncbi request reprint Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized children
    Shamez N Ladhani
    Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Clin Infect Dis 51:761-7. 2010
    ..The objective of this study was to investigate single-nucleotide polymorphisms (SNPs) known to affect function in biologically plausible genes in relation to the risk of Hib vaccine failure and its clinical manifestations...
  13. pmc Invasive Haemophilus influenzae Disease, Europe, 1996-2006
    Shamez Ladhani
    Health Protection Agency, London, UK
    Emerg Infect Dis 16:455-63. 2010
    ..Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality...
  14. ncbi request reprint Trends in bacterial, mycobacterial, and fungal meningitis in England and Wales 2004-11: an observational study
    Ifeanichukwu O Okike
    Paediatric Infectious Diseases Research Group and Vaccine Institute, St George s, University of London, London, UK Immunisation Department, Public Health England, London, UK
    Lancet Infect Dis 14:301-7. 2014
    ..Our aim was to do such a study using routinely reported data available in England and Wales...
  15. ncbi request reprint Characterization of group B streptococci recovered from infants with invasive disease in England and Wales
    Abbie M Weisner
    Streptococcus and Diphtheria Reference Unit, Respiratory and Systemic Infection Laboratory, Health Protection Agency, Colindale, London, United Kingdom
    Clin Infect Dis 38:1203-8. 2004
    ..A trivalent vaccine containing capsular polysaccharides III, Ia, and V could theoretically provide coverage against 85% of the cases of GBS disease among infants in England and Wales...
  16. doi request reprint Characteristics of Invasive Staphylococcus aureus in United Kingdom Neonatal Units
    Stefania Vergnano
    Division of Child Health, St George s, University of London, London, UK
    Pediatr Infect Dis J 30:850-4. 2011
    ..In industrialized countries, Staphylococcus aureus (SA) is a leading cause of late-onset neonatal sepsis...
  17. ncbi request reprint The immunogenicity of a novel A (H1N1) vaccine in HIV-infected children
    Ifeanyichukwu O Okike
    Vaccine Institute, St George s, University of London, London, United Kingdom
    Vaccine 29:6636-40. 2011
    ..There were no published data available regarding the immunogenicity of this vaccine in such children...
  18. doi request reprint Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis
    Karen M Edmond
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 379:547-56. 2012
    ..However, estimates of disease burden in many countries outside of these regions is not available. We aimed to examine the current global burden of invasive disease and the serotype distribution of group B streptococcus isolates...
  19. pmc Induction of protective serum meningococcal bactericidal and diphtheria-neutralizing antibodies and mucosal immunoglobulin A in volunteers by nasal insufflations of the Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with
    Zhiming Huo
    St George s Vaccine Institute, London, United Kingdom
    Infect Immun 73:8256-65. 2005
    ..Simple nasal insufflation of existing MCP-CRM197 conjugate vaccines in chitosan offers an inexpensive but effective needle-free prime and boost against serogroup C N. meningitidis and diphtheria...
  20. ncbi request reprint Group B streptococcal disease in UK and Irish infants younger than 90 days
    Paul T Heath
    Vaccine Institute, St George s Hospital, London, UK
    Lancet 363:292-4. 2004
    ..53 infants died (overall 9.7%). We have established the minimum current burden of group B streptococcal disease in UK and Irish infants. This information will assist in the formulation of guidelines for prevention of this disease...
  21. doi request reprint Trends in paediatric nosocomial bacteraemia in a London tertiary hospital
    Andrés Pérerz Lopéz
    Paediatric Infectious Disease Research Group, St George s Hospital NHS Trust, London, UK
    Acta Paediatr 102:1005-9. 2013
    ..To describe the incidence and microbiological characteristics of nosocomial bloodstream infections in childhood over a 9-year period at a South London tertiary hospital...
  22. ncbi request reprint PEPtalk: postexposure prophylaxis against varicella in children with cancer
    Jessica Bate
    Division of Clinical Sciences, St George s, University of London, London, UK
    Arch Dis Child 96:841-5. 2011
    ....
  23. doi request reprint Neonatal infections in England: the NeonIN surveillance network
    Stefania Vergnano
    Division of Child Health, St George s, University of London, Cranmer Terrace, London, UK
    Arch Dis Child Fetal Neonatal Ed 96:F9-F14. 2011
    ..Neonatal infection is an important cause of morbidity and mortality. Neonatal infection surveillance networks are necessary for defining the epidemiology of infections and monitoring changes over time...
  24. doi request reprint The contribution of infections to neonatal deaths in England and Wales
    Sarita J Depani
    St George s Hospital, London, UK
    Pediatr Infect Dis J 30:345-7. 2011
    ..Infection was recorded in 11% of deaths, with two-thirds occurring in premature neonates. Group B Streptococcus was indicated in 32% of death certificates that specified a bacterial infection and in 11% of all infection-related deaths...
  25. doi request reprint An overview of global GBS epidemiology
    Kirsty Le Doaré
    Paediatric Infectious Diseases Research Group, St Georges, University of London, London, UK
    Vaccine 31:D7-12. 2013
    ..Five serotypes (Ia, Ib, II, III, V) account for the majority of disease; conjugate vaccines including some or all of these serotypes therefore hold great promise for preventing this important disease. ..
  26. ncbi request reprint Estimating Haemophilus influenzae type b vaccine effectiveness in England and Wales by use of the screening method
    Mary E Ramsay
    Immunisation Division, Public Health Laboratory Service PHLS Communicable Disease Surveillance Centre, London, United Kingdom
    J Infect Dis 188:481-5. 2003
    ..Since 1999, however, low effectiveness in infants, declining effectiveness with age, and the use of lower-efficacy vaccines have contributed to increased rates of Hib infection. The potential role of boosters needs to be considered...
  27. ncbi request reprint Vaccination against group B streptococcus
    Paul T Heath
    Department of Child Health and Vaccine Institute, St George s Hospital Medical School, London, UK
    Expert Rev Vaccines 4:207-18. 2005
    ..However, unless the regulatory environment is changed specifically to allow the development of a Group B streptococcus vaccine, it is unlikely that one will ever reach the market...
  28. ncbi request reprint Immunogenicity and immunologic memory of meningococcal C conjugate vaccine in premature infants
    Clare L Collins
    St George s Hospital Medical School, London, United Kingdom
    Pediatr Infect Dis J 24:966-8. 2005
    ..K. routine immunization schedule in 1999. This study is the first to describe both persistence of antibody and evidence for induction of immune memory using meningococcal C conjugate (MCC) vaccine in preterm infants...
  29. ncbi request reprint Strategies for preventing group B streptococcal disease
    Esse Menson
    Pediatric Infectious Diseases Unit, St George s Hospital, London, United Kingdom
    Adv Exp Med Biol 549:231-6. 2004
  30. doi request reprint Improving the outcome of neonatal meningitis
    Eva P Galiza
    Vaccine Institute, London, UK
    Curr Opin Infect Dis 22:229-34. 2009
    ..This review focuses on recent advances in the management of neonatal meningitis and its implications for improved outcomes...
  31. ncbi request reprint Immunogenicity of pandemic (H1N1) 2009 vaccine in children with cancer in the United Kingdom
    Jessica Bate
    Dept of Child Health, St George s, University of London, London, England
    Clin Infect Dis 51:e95-104. 2010
    ..Children with cancer have an increased susceptibility to influenza infection. The objective of this study was to assess the immunogenicity of pandemic (H1N1) 2009 vaccine in children with cancer...
  32. doi request reprint The epidemiology of neonatal and pediatric candidemia in England and Wales, 2000-2009
    Clarissa Oeser
    Paediatric Infectious Diseases Research Group, Division of Clinical Sciences, St George s, University of London, London, United Kingdom
    Pediatr Infect Dis J 32:23-6. 2013
    ..This study aimed to describe the epidemiology of pediatric candidemia in England and Wales during a 10-year period as a means of quantifying the changing burden of infection and identifying emerging trends...
  33. ncbi request reprint Clinical trials in neonatal sepsis
    Clarissa Oeser
    Paediatric Infectious Diseases Research Group, St George s, University of London, London, UK
    J Antimicrob Chemother 68:2733-45. 2013
    ..The optimal design of future trials of new antibiotics will need to be based on pharmacokinetic/pharmacodynamic parameters, combined with adequately powered clinical studies to determine safety and efficacy. ..
  34. doi request reprint Aminoglycoside toxicity in neonates: something to worry about?
    Alison Kent
    Paediatric Infectious Diseases Research Group, Division of Clinical Sciences, St George s, University of London, London, UK
    Expert Rev Anti Infect Ther 12:319-31. 2014
    ..We discuss genetic susceptibility and the impact of other synergistic effects. ..
  35. doi request reprint Immunisation practices of paediatric oncology and shared care oncology consultants: a United Kingdom survey
    Jessica Bate
    Division of Child Health, St George s University of London, London, UK
    Pediatr Blood Cancer 54:941-6. 2010
    ..In March 2002, the Royal College of Paediatrics and Child Health (RCPCH) introduced guidelines for re-immunisation of children after completion of standard-dose chemotherapy and after haematopoietic stem cell transplant (HSCT)...
  36. pmc X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease
    Claire Booth
    Center of Immunodeficiency, Molecular Immunology Unit, Institute of Child Health, London, United Kingdom
    Blood 117:53-62. 2011
    ..The outcome of HSCT for other manifestations of XLP1 is very good, and if HSCT is not undertaken immediately, patients must be monitored closely for evidence of disease progression...
  37. ncbi request reprint Safety and efficacy of meningococcal group C conjugate vaccines
    Jens Rüggeberg
    Department of Child Health and Vaccine Institute, St George s Hospital Medical School, Cranmer Terrace, London SW17 0QT, UK
    Expert Opin Drug Saf 2:7-19. 2003
    ..The annual number of fatalities from confirmed meningococcal C disease in the same population has fallen from 67 to 5 cases within a 2-year period...
  38. ncbi request reprint Respiratory distress related to asymptomatic colonization with group B streptococci
    Benjamin J Stenson
    Pediatr Infect Dis J 26:765; author reply 765-6. 2007
  39. doi request reprint Changes in antibiotic resistance rates of invasive Haemophilus influenzae isolates in England and Wales over the last 20 years
    Shamez Ladhani
    Immunisation Department, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 62:776-9. 2008
    ..The aim of this study was to determine trends in antibiotic resistance profiles of invasive clinical Haemophilus influenzae isolates over the last 20 years...