Paul T Heath
Affiliation: St George's
- Risk factors for late onset gram-negative infections: a case-control studySrabani Samanta
Division of Child Health, St George s, University of London, Cranmer Terrace, Tooting, London, UK
Arch Dis Child Fetal Neonatal Ed 96:F15-8. 2011..To determine the incidence, mortality and risk factors for neonatal late onset gram-negative sepsis and meningitis (LOGNS)...
- Haemophilus influenzae type b reemergence after combination immunizationNik G Johnson
St George s University of London, London, United Kingdom
Emerg Infect Dis 12:937-41. 2006..001, respectively). Hib was found in 2.1% (95% CI 0.7%-6.0%) of study participants. Our data support an association between DTaP-Hib vaccine combinations and clinical Hib disease through an effect on antibody concentration and avidity...
- Group B streptococcal carriage, serotype distribution and antibiotic susceptibilities in pregnant women at the time of delivery in a refugee population on the Thai-Myanmar borderClaudia Turner
Shoklo Malaria Research Unit, Thailand
BMC Infect Dis 12:34. 2012..Maternal carriage of GBS is a prerequisite for the development of early onset GBS neonatal sepsis but there is a paucity of carriage data published from the developing world, in particular South East Asia...
- Meropenem vs standard of care for treatment of late onset sepsis in children of less than 90 days of age: study protocol for a randomised controlled trialIrja Lutsar
Institute of Microbiology, University of Tartu, Estonia
Trials 12:215. 2011..Meropenem is an antibiotic with wide antibacterial coverage. The advantage of it over standard of care could be its wider antibacterial coverage and thus the use of mono-instead of combination therapy...
- Group B streptococcal disease in infants: a case control studyP T Heath
Child Health and Vaccine Institute, St George s, University of London, UK
Arch Dis Child 94:674-80. 2009..To describe and quantify the maternal and neonatal factors associated with Group B streptococcus (GBS) disease in infants <90 days of age...
- An update on vaccination against group B streptococcusPaul T Heath
Vaccine Institute and Division of Clinical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
Expert Rev Vaccines 10:685-94. 2011..Issues yet to be resolved include the safety and acceptability of vaccination during pregnancy, the durability of vaccine-derived immunity and the regulatory issues required for licensure...
- Perinatal group B streptococcal diseasePaul T Heath
Vaccine Institute and Division of Child Health, St George s, University of London, London SW17 0RE, UK
Best Pract Res Clin Obstet Gynaecol 21:411-24. 2007..Decisions on which strategy to use will depend on a number of factors. A swab-based approach appears to have higher efficacy but is likely to lead to more antibiotic exposure...
- Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infantsJens U Ruggeberg
Division of Child Health and Vaccine Institute, St George s University of London, London, UK, and Paediatric Infectious Diseases, Department of General Paediatrics, University Children s Hospital, Dusseldorf, Germany
Vaccine 25:264-71. 2007..Antibody concentrations wane over the first year of life in both preterm and term infants and booster vaccination is therefore likely to be important...
- Antibody responses to meningococcal (groups A, C, Y and W135) polysaccharide diphtheria toxoid conjugate vaccine in children who previously received meningococcal C conjugate vaccineHaitham El Bashir
Research Centre for Child Health, St Bartholomew s and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Vaccine 24:2544-9. 2006..No major between-group differences in solicited local and systemic reactions or adverse events (AEs)...
- Long-term immunological follow-up of children with haemophilus influenzae serotype b vaccine failure in the United KingdomShamez Ladhani
Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, Centre for Infections, Health Protection Agency, St George s, University of London, London, United Kingdom
Clin Infect Dis 49:372-80. 2009..The objective of this study was to determine Hib antibody concentrations in children several years after infection and to identify risk factors for low antibody concentrations...
- Long-term complications and risk of other serious infections following invasive Haemophilus influenzae serotype b disease in vaccinated childrenShamez Ladhani
Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, London, United Kingdom
Vaccine 28:2195-200. 2010..One in seven otherwise healthy children (14%) with Hib vaccine failure will go on to suffer another serious infection requiring hospital admission in childhood, which is higher than would be expected for the UK paediatric population...
- Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized childrenShamez N Ladhani
Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, London, United Kingdom
Clin Infect Dis 51:761-7. 2010..The objective of this study was to investigate single-nucleotide polymorphisms (SNPs) known to affect function in biologically plausible genes in relation to the risk of Hib vaccine failure and its clinical manifestations...
- Invasive Haemophilus influenzae Disease, Europe, 1996-2006Shamez Ladhani
Health Protection Agency, London, UK
Emerg Infect Dis 16:455-63. 2010..Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality...
- Trends in bacterial, mycobacterial, and fungal meningitis in England and Wales 2004-11: an observational studyIfeanichukwu O Okike
Paediatric Infectious Diseases Research Group and Vaccine Institute, St George s, University of London, London, UK Immunisation Department, Public Health England, London, UK
Lancet Infect Dis 14:301-7. 2014..Our aim was to do such a study using routinely reported data available in England and Wales...
- Characterization of group B streptococci recovered from infants with invasive disease in England and WalesAbbie M Weisner
Streptococcus and Diphtheria Reference Unit, Respiratory and Systemic Infection Laboratory, Health Protection Agency, Colindale, London, United Kingdom
Clin Infect Dis 38:1203-8. 2004..A trivalent vaccine containing capsular polysaccharides III, Ia, and V could theoretically provide coverage against 85% of the cases of GBS disease among infants in England and Wales...
- Characteristics of Invasive Staphylococcus aureus in United Kingdom Neonatal UnitsStefania Vergnano
Division of Child Health, St George s, University of London, London, UK
Pediatr Infect Dis J 30:850-4. 2011..In industrialized countries, Staphylococcus aureus (SA) is a leading cause of late-onset neonatal sepsis...
- The immunogenicity of a novel A (H1N1) vaccine in HIV-infected childrenIfeanyichukwu O Okike
Vaccine Institute, St George s, University of London, London, United Kingdom
Vaccine 29:6636-40. 2011..There were no published data available regarding the immunogenicity of this vaccine in such children...
- Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysisKaren M Edmond
London School of Hygiene and Tropical Medicine, London, UK
Lancet 379:547-56. 2012..However, estimates of disease burden in many countries outside of these regions is not available. We aimed to examine the current global burden of invasive disease and the serotype distribution of group B streptococcus isolates...
- Induction of protective serum meningococcal bactericidal and diphtheria-neutralizing antibodies and mucosal immunoglobulin A in volunteers by nasal insufflations of the Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with Zhiming Huo
St George s Vaccine Institute, London, United Kingdom
Infect Immun 73:8256-65. 2005..Simple nasal insufflation of existing MCP-CRM197 conjugate vaccines in chitosan offers an inexpensive but effective needle-free prime and boost against serogroup C N. meningitidis and diphtheria...
- Group B streptococcal disease in UK and Irish infants younger than 90 daysPaul T Heath
Vaccine Institute, St George s Hospital, London, UK
Lancet 363:292-4. 2004..53 infants died (overall 9.7%). We have established the minimum current burden of group B streptococcal disease in UK and Irish infants. This information will assist in the formulation of guidelines for prevention of this disease...
- Trends in paediatric nosocomial bacteraemia in a London tertiary hospitalAndrés Pérerz Lopéz
Paediatric Infectious Disease Research Group, St George s Hospital NHS Trust, London, UK
Acta Paediatr 102:1005-9. 2013..To describe the incidence and microbiological characteristics of nosocomial bloodstream infections in childhood over a 9-year period at a South London tertiary hospital...
- PEPtalk: postexposure prophylaxis against varicella in children with cancerJessica Bate
Division of Clinical Sciences, St George s, University of London, London, UK
Arch Dis Child 96:841-5. 2011....
- Neonatal infections in England: the NeonIN surveillance networkStefania Vergnano
Division of Child Health, St George s, University of London, Cranmer Terrace, London, UK
Arch Dis Child Fetal Neonatal Ed 96:F9-F14. 2011..Neonatal infection is an important cause of morbidity and mortality. Neonatal infection surveillance networks are necessary for defining the epidemiology of infections and monitoring changes over time...
- The contribution of infections to neonatal deaths in England and WalesSarita J Depani
St George s Hospital, London, UK
Pediatr Infect Dis J 30:345-7. 2011..Infection was recorded in 11% of deaths, with two-thirds occurring in premature neonates. Group B Streptococcus was indicated in 32% of death certificates that specified a bacterial infection and in 11% of all infection-related deaths...
- An overview of global GBS epidemiologyKirsty Le Doaré
Paediatric Infectious Diseases Research Group, St Georges, University of London, London, UK
Vaccine 31:D7-12. 2013..Five serotypes (Ia, Ib, II, III, V) account for the majority of disease; conjugate vaccines including some or all of these serotypes therefore hold great promise for preventing this important disease. ..
- Estimating Haemophilus influenzae type b vaccine effectiveness in England and Wales by use of the screening methodMary E Ramsay
Immunisation Division, Public Health Laboratory Service PHLS Communicable Disease Surveillance Centre, London, United Kingdom
J Infect Dis 188:481-5. 2003..Since 1999, however, low effectiveness in infants, declining effectiveness with age, and the use of lower-efficacy vaccines have contributed to increased rates of Hib infection. The potential role of boosters needs to be considered...
- Vaccination against group B streptococcusPaul T Heath
Department of Child Health and Vaccine Institute, St George s Hospital Medical School, London, UK
Expert Rev Vaccines 4:207-18. 2005..However, unless the regulatory environment is changed specifically to allow the development of a Group B streptococcus vaccine, it is unlikely that one will ever reach the market...
- Immunogenicity and immunologic memory of meningococcal C conjugate vaccine in premature infantsClare L Collins
St George s Hospital Medical School, London, United Kingdom
Pediatr Infect Dis J 24:966-8. 2005..K. routine immunization schedule in 1999. This study is the first to describe both persistence of antibody and evidence for induction of immune memory using meningococcal C conjugate (MCC) vaccine in preterm infants...
- Strategies for preventing group B streptococcal diseaseEsse Menson
Pediatric Infectious Diseases Unit, St George s Hospital, London, United Kingdom
Adv Exp Med Biol 549:231-6. 2004
- Improving the outcome of neonatal meningitisEva P Galiza
Vaccine Institute, London, UK
Curr Opin Infect Dis 22:229-34. 2009..This review focuses on recent advances in the management of neonatal meningitis and its implications for improved outcomes...
- Immunogenicity of pandemic (H1N1) 2009 vaccine in children with cancer in the United KingdomJessica Bate
Dept of Child Health, St George s, University of London, London, England
Clin Infect Dis 51:e95-104. 2010..Children with cancer have an increased susceptibility to influenza infection. The objective of this study was to assess the immunogenicity of pandemic (H1N1) 2009 vaccine in children with cancer...
- The epidemiology of neonatal and pediatric candidemia in England and Wales, 2000-2009Clarissa Oeser
Paediatric Infectious Diseases Research Group, Division of Clinical Sciences, St George s, University of London, London, United Kingdom
Pediatr Infect Dis J 32:23-6. 2013..This study aimed to describe the epidemiology of pediatric candidemia in England and Wales during a 10-year period as a means of quantifying the changing burden of infection and identifying emerging trends...
- Clinical trials in neonatal sepsisClarissa Oeser
Paediatric Infectious Diseases Research Group, St George s, University of London, London, UK
J Antimicrob Chemother 68:2733-45. 2013..The optimal design of future trials of new antibiotics will need to be based on pharmacokinetic/pharmacodynamic parameters, combined with adequately powered clinical studies to determine safety and efficacy. ..
- Aminoglycoside toxicity in neonates: something to worry about?Alison Kent
Paediatric Infectious Diseases Research Group, Division of Clinical Sciences, St George s, University of London, London, UK
Expert Rev Anti Infect Ther 12:319-31. 2014..We discuss genetic susceptibility and the impact of other synergistic effects. ..
- Immunisation practices of paediatric oncology and shared care oncology consultants: a United Kingdom surveyJessica Bate
Division of Child Health, St George s University of London, London, UK
Pediatr Blood Cancer 54:941-6. 2010..In March 2002, the Royal College of Paediatrics and Child Health (RCPCH) introduced guidelines for re-immunisation of children after completion of standard-dose chemotherapy and after haematopoietic stem cell transplant (HSCT)...
- X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the diseaseClaire Booth
Center of Immunodeficiency, Molecular Immunology Unit, Institute of Child Health, London, United Kingdom
Blood 117:53-62. 2011..The outcome of HSCT for other manifestations of XLP1 is very good, and if HSCT is not undertaken immediately, patients must be monitored closely for evidence of disease progression...
- Safety and efficacy of meningococcal group C conjugate vaccinesJens Rüggeberg
Department of Child Health and Vaccine Institute, St George s Hospital Medical School, Cranmer Terrace, London SW17 0QT, UK
Expert Opin Drug Saf 2:7-19. 2003..The annual number of fatalities from confirmed meningococcal C disease in the same population has fallen from 67 to 5 cases within a 2-year period...
- Respiratory distress related to asymptomatic colonization with group B streptococciBenjamin J Stenson
Pediatr Infect Dis J 26:765; author reply 765-6. 2007
- Changes in antibiotic resistance rates of invasive Haemophilus influenzae isolates in England and Wales over the last 20 yearsShamez Ladhani
Immunisation Department, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
J Antimicrob Chemother 62:776-9. 2008..The aim of this study was to determine trends in antibiotic resistance profiles of invasive clinical Haemophilus influenzae isolates over the last 20 years...