Claudia Eder

Summary

Affiliation: St George's
Country: UK

Publications

  1. pmc A mysterious channel: new insights into proton channel functioning raise new questions
    Claudia Eder
    St George s, University of London, Division of Basic Medical Sciences, London SW17 0RE, UK
    J Physiol 586:2419-20. 2008
  2. ncbi request reprint Ion channels in monocytes and microglia/brain macrophages: promising therapeutic targets for neurological diseases
    Claudia Eder
    Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom
    J Neuroimmunol 224:51-5. 2010
  3. ncbi request reprint Mechanisms of interleukin-1beta release
    Claudia Eder
    Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Immunobiology 214:543-53. 2009
  4. ncbi request reprint Importance of lipid rafts for lysophosphatidylcholine-induced caspase-1 activation and reactive oxygen species generation
    Tom Schilling
    Division of Biomedical Sciences, St George s University of London, Cranmer Terrace, London SW17 0RE, United Kingdom
    Cell Immunol 265:87-90. 2010
  5. ncbi request reprint Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generation
    Tom Schilling
    Division of Basic Medical Sciences, St George s, University of London, London, UK
    J Neuroimmunol 216:118-21. 2009
  6. ncbi request reprint Stimulus-dependent requirement of ion channels for microglial NADPH oxidase-mediated production of reactive oxygen species
    Tom Schilling
    Division of Basic Medical Sciences, St George s, University of London, London, United Kingdom
    J Neuroimmunol 225:190-4. 2010
  7. ncbi request reprint Sodium dependence of lysophosphatidylcholine-induced caspase-1 activity and reactive oxygen species generation
    Tom Schilling
    Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Immunobiology 216:118-25. 2011
  8. ncbi request reprint Fluorescence imaging of intracellular Ca2+, Na+, and H+ in cultured microglia
    Tom Schilling
    St George s, University of London, London, UK
    Methods Mol Biol 1041:147-61. 2013
  9. ncbi request reprint Patch clamp protocols to study ion channel activity in microglia
    Tom Schilling
    St George s, University of London, London, UK
    Methods Mol Biol 1041:163-82. 2013
  10. ncbi request reprint Lysophosphatidylcholine- and MCP-1-induced chemotaxis of monocytes requires potassium channel activity
    Tom Schilling
    Division of Basic Medical Sciences, St George s University of London, Cranmer Terrace, London, SW17 0RE, UK
    Pflugers Arch 459:71-7. 2009

Collaborators

Detail Information

Publications18

  1. pmc A mysterious channel: new insights into proton channel functioning raise new questions
    Claudia Eder
    St George s, University of London, Division of Basic Medical Sciences, London SW17 0RE, UK
    J Physiol 586:2419-20. 2008
  2. ncbi request reprint Ion channels in monocytes and microglia/brain macrophages: promising therapeutic targets for neurological diseases
    Claudia Eder
    Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom
    J Neuroimmunol 224:51-5. 2010
    ..Thus, ion channels of monocytes and microglia/brain macrophages could represent good candidates for therapeutic interventions in neurological diseases...
  3. ncbi request reprint Mechanisms of interleukin-1beta release
    Claudia Eder
    Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Immunobiology 214:543-53. 2009
    ..A better understanding of IL-1beta release mechanisms is of great therapeutic relevance and may help in the development of strategies aimed at reducing the severity of inflammatory and autoimmune diseases...
  4. ncbi request reprint Importance of lipid rafts for lysophosphatidylcholine-induced caspase-1 activation and reactive oxygen species generation
    Tom Schilling
    Division of Biomedical Sciences, St George s University of London, Cranmer Terrace, London SW17 0RE, United Kingdom
    Cell Immunol 265:87-90. 2010
    ..Since ROS regulate caspase-1 activity in LPC-stimulated microglia, the effects of lipid raft-disrupting agents on caspase-1 activation can be related to their inhibition of NADPH oxidase-mediated ROS production...
  5. ncbi request reprint Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generation
    Tom Schilling
    Division of Basic Medical Sciences, St George s, University of London, London, UK
    J Neuroimmunol 216:118-21. 2009
    ..Together, our data suggest that TRPV1 channels are involved in regulating NADPH oxidase-mediated ROS generation in microglia...
  6. ncbi request reprint Stimulus-dependent requirement of ion channels for microglial NADPH oxidase-mediated production of reactive oxygen species
    Tom Schilling
    Division of Basic Medical Sciences, St George s, University of London, London, United Kingdom
    J Neuroimmunol 225:190-4. 2010
    ..In contrast, activity of all four ion channel types was required for PMA-induced NADPH oxidase-mediated ROS generation, suggesting a differential, stimulus-dependent regulation of microglial ROS production by ion channel activity...
  7. ncbi request reprint Sodium dependence of lysophosphatidylcholine-induced caspase-1 activity and reactive oxygen species generation
    Tom Schilling
    Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Immunobiology 216:118-25. 2011
    ..In summary, it is suggested that in LPC-activated microglia, Na(+) influx is required for the production of NADPH oxidase-mediated ROS, which subsequently stimulate caspase-1 activity...
  8. ncbi request reprint Fluorescence imaging of intracellular Ca2+, Na+, and H+ in cultured microglia
    Tom Schilling
    St George s, University of London, London, UK
    Methods Mol Biol 1041:147-61. 2013
    ..This chapter summarizes protocols of loading of microglial cells with small-molecule ion indicators as well as protocols optimal for measurement and analysis of intracellular Ca(2+), Na(+), and H(+) concentrations in microglia in vitro. ..
  9. ncbi request reprint Patch clamp protocols to study ion channel activity in microglia
    Tom Schilling
    St George s, University of London, London, UK
    Methods Mol Biol 1041:163-82. 2013
    ..This chapter summarizes patch clamp protocols optimal for recording and analysis of microglial ion channel activity in vitro and in situ...
  10. ncbi request reprint Lysophosphatidylcholine- and MCP-1-induced chemotaxis of monocytes requires potassium channel activity
    Tom Schilling
    Division of Basic Medical Sciences, St George s University of London, Cranmer Terrace, London, SW17 0RE, UK
    Pflugers Arch 459:71-7. 2009
    ..Thus, K+ channel inhibition may represent a novel powerful strategy to reduce monocyte infiltration and subsequent inflammation in atherosclerosis...
  11. ncbi request reprint Non-selective cation channel activity is required for lysophosphatidylcholine-induced monocyte migration
    Tom Schilling
    Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London, UK
    J Cell Physiol 221:325-34. 2009
    ..Thus, ion channel inhibition may represent a powerful strategy to attenuate the progression of atherosclerosis by reducing monocyte infiltration...
  12. ncbi request reprint TRPM7 regulates proliferation and polarisation of macrophages
    Tom Schilling
    Infection and Immunity Research Institute, St George s, University of London, London SW17 0RE, UK
    J Cell Sci 127:4561-6. 2014
    ..In summary, our data suggest a main role of TRPM7 in the regulation of macrophage proliferation and polarisation. ..
  13. ncbi request reprint TRAM-34 inhibits nonselective cation channels
    Tom Schilling
    Institute of Physiology, Medical Faculty Charité, Tucholskystrasse 2, 10117 Berlin, Germany
    Pflugers Arch 454:559-63. 2007
    ..These data indicate that TRAM-34 may cause additional effects on immune cells that are unrelated to the well-described inhibition of Ca(2+)-activated K(+) channels...
  14. ncbi request reprint Lysophosphatidylcholine stimulates IL-1beta release from microglia via a P2X7 receptor-independent mechanism
    Christian Stock
    Institute of Physiology II, University of Muenster, Muenster, Germany
    J Immunol 177:8560-8. 2006
    ..In summary, these data indicate that the activity of nonselective cation channels and Ca(2+)-activated K(+) channels is required for optimal IL-1beta release from LPC-stimulated microglia...
  15. ncbi request reprint Regulation of microglial behavior by ion channel activity
    Claudia Eder
    Institute of Physiology, Humboldt University, Berlin, Germany
    J Neurosci Res 81:314-21. 2005
    ....
  16. ncbi request reprint Functional importance of Ca2+-activated K+ channels for lysophosphatidic acid-induced microglial migration
    Tom Schilling
    Institute of Physiology, Humboldt University Berlin, Tucholsky Strasse 2, D 10117 Berlin, Germany
    Eur J Neurosci 19:1469-74. 2004
    ..Microglial migration was not inhibited by 5 micro m paxilline. It is concluded that IKCa1 Ca(2+)-activated K(+) channels are required for LPA-stimulated migration of microglial cells...
  17. pmc Physiological mechanisms of lysophosphatidylcholine-induced de-ramification of murine microglia
    Tom Schilling
    Institute of Physiology, Humboldt University, Tucholskystr 2, D 10117 Berlin, Germany
    J Physiol 557:105-20. 2004
    ..LPC-induced microglial de-ramification was prevented by simultaneous inhibition of non-selective cation channels and K(+)-Cl(-) cotransporters, suggesting their functional importance for microglial activation...
  18. pmc Voltage-activated proton currents in human lymphocytes
    Tom Schilling
    Institute of Physiology, Humboldt University, Tucholskystrasse 2, D 10117 Berlin, Germany
    J Physiol 545:93-105. 2002
    ..The pattern of expression of H(+) channels in lymphocytes appears well suited to their proposed role of charge compensation during the respiratory burst...