R N Cunliffe

Summary

Affiliation: St. Bartholomew's Hospital
Country: UK

Publications

  1. ncbi request reprint Alpha-defensins in the gastrointestinal tract
    R N Cunliffe
    Division of Gastroenterology, University Hospital, Nottingham NG7 2UH, UK
    Mol Immunol 40:463-7. 2003
  2. pmc Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease
    R N Cunliffe
    Division of Gastroenterology, University of Nottingham, UK
    Gut 48:176-85. 2001
  3. pmc Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa
    R N Cunliffe
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Clin Pathol 55:298-304. 2002
  4. ncbi request reprint Defensins and mucosal protection
    Y R Mahida
    Division of Gastroenterology, Institute of Infection, Immunity and Inflammation, University of Nottingham and University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Novartis Found Symp 263:71-7; discussion 77-84, 211-8. 2004
  5. ncbi request reprint Expression and regulation of antimicrobial peptides in the gastrointestinal tract
    R N Cunliffe
    Institute of Infection, Immunity and Inflammation and Division of Gastroenterology, University of Nottingham, United Kingdom
    J Leukoc Biol 75:49-58. 2004
  6. pmc Alteration in human defensin-5 expression following gastric bypass surgery
    M Sundbom
    Department of Surgery, University Hospital, Uppsala, Sweden
    J Clin Pathol 60:1029-34. 2007

Collaborators

  • Y R Mahida
  • M Sundbom
  • C Rubio
  • T Midtvedt
  • D A Elphick
  • L Göran Axelsson
  • L Engstrand

Detail Information

Publications6

  1. ncbi request reprint Alpha-defensins in the gastrointestinal tract
    R N Cunliffe
    Division of Gastroenterology, University Hospital, Nottingham NG7 2UH, UK
    Mol Immunol 40:463-7. 2003
    ..These studies suggest that antimicrobial defensin peptides may be important in protection of the host against microbial invasion in states of intestinal inflammation...
  2. pmc Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease
    R N Cunliffe
    Division of Gastroenterology, University of Nottingham, UK
    Gut 48:176-85. 2001
    ....
  3. pmc Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa
    R N Cunliffe
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Clin Pathol 55:298-304. 2002
    ..The aim of this study was to investigate the expression of HNP 1-3 and lysozyme in normal and active inflammatory bowel disease (IBD) mucosa...
  4. ncbi request reprint Defensins and mucosal protection
    Y R Mahida
    Division of Gastroenterology, Institute of Infection, Immunity and Inflammation, University of Nottingham and University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Novartis Found Symp 263:71-7; discussion 77-84, 211-8. 2004
    ..HBDs have also been shown to be chemotactic for immature dendritic cells and memory T cells. Thus, they may not only mediate innate immunity, but also regulate adaptive immune responses in inflammatory bowel disease...
  5. ncbi request reprint Expression and regulation of antimicrobial peptides in the gastrointestinal tract
    R N Cunliffe
    Institute of Infection, Immunity and Inflammation and Division of Gastroenterology, University of Nottingham, United Kingdom
    J Leukoc Biol 75:49-58. 2004
    ..The ability of these peptides to act as chemoattractants for cells of the innate- and adaptive-immune system may also play an important role in perpetuating chronic inflammation in the GI tract...
  6. pmc Alteration in human defensin-5 expression following gastric bypass surgery
    M Sundbom
    Department of Surgery, University Hospital, Uppsala, Sweden
    J Clin Pathol 60:1029-34. 2007
    ..Roux-en-Y gastric bypass surgery provides a novel human model to investigate small bowel mucosal innate immunity, in which there is loss of gastric acid-mediated protection against orally-acquired microorganisms...