Philip J Cooper

Summary

Affiliation: St George's
Country: UK

Publications

  1. doi request reprint Effects of maternal geohelminth infections on allergy in early childhood
    Philip J Cooper
    Laboratorio de Investigaciones FEPIS, Avenida Via Guayllabamba, Quininde, Ecuador Centro de Investigación en Enfermedades Infecciosas, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador Institute of Infection and Immunity, St George s University of London, London, United Kingdom Electronic address
    J Allergy Clin Immunol 137:899-906.e2. 2016
  2. doi request reprint Cohort Profile: The Ecuador Life (ECUAVIDA) study in Esmeraldas Province, Ecuador
    Philip J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador, Institute of Infection and Immunity Research, Institute of Population Health Research, St George s University of London, London, UK, Centro de Investigación en Enfermedades Infecciosas, Escuela de Biologia, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador
    Int J Epidemiol 44:1517-27. 2015
  3. pmc Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America
    Neuza Maria Alcântara-Neves
    Departamento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil
    BMC Res Notes 7:817. 2014
  4. pmc Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity
    P Endara
    Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, Ecuador
    Clin Exp Allergy 40:1669-77. 2010
  5. pmc Poverty, dirt, infections and non-atopic wheezing in children from a Brazilian urban center
    Mauricio L Barreto
    Instituto De Saude Coletiva, Universidade Federal da Bahia, Salvador, Brazil
    Respir Res 11:167. 2010
  6. pmc Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment
    Camila A Figueiredo
    Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    Clin Immunol 139:57-64. 2011
  7. pmc Interactions between helminth parasites and allergy
    Philip J Cooper
    Centre for Infection, St George s University of London, London, UK
    Curr Opin Allergy Clin Immunol 9:29-37. 2009
  8. pmc Hygiene, atopy and wheeze-eczema-rhinitis symptoms in schoolchildren from urban and rural Ecuador
    Philip J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    Thorax 69:232-9. 2014
  9. pmc Environmental determinants of total IgE among school children living in the rural Tropics: importance of geohelminth infections and effect of anthelmintic treatment
    Philip J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    BMC Immunol 9:33. 2008
  10. pmc Evidence for in utero sensitization to Ascaris lumbricoides in newborns of mothers with ascariasis
    Irene Guadalupe
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    J Infect Dis 199:1846-50. 2009

Collaborators

  • Ana Lucia Moncayo
  • Edward Mitre
  • David P Strachan
  • Agostino Strina
  • Rommy Teran
  • Jan Vinje
  • Neuza M Alcantara-Neves
  • David J Lewis
  • Darci N Santos
  • Umesh D Parashar
  • Renato T Stein
  • Alejandro Rodriguez
  • Mauricio L Barreto
  • Nely Broncano
  • Laura C Rodrigues
  • Martha E Chico
  • Irene Guadalupe
  • Martha Chico
  • Paul A Gastañaduy
  • Stefanie K Menzies
  • Carlos Sandoval
  • Raaj S Mehta
  • Miguel Reina Ortiz
  • Camila A Figueiredo
  • Maritza Vaca
  • Leila D Amorim
  • P Endara
  • Susana Benitez
  • Fabián Salazar
  • Maritza G Vaca
  • Yosselin Vicuña
  • Nicole Gregoricus
  • Ben Lopman
  • Fernanda Tupiza
  • Neal Alexander
  • Silvia Erazo
  • Gordon Dougan
  • Carlos Teles
  • Lain C Pontes de Carvalho
  • Nivea B Silva
  • Gisela Oviedo
  • Fernanda Schreiber
  • M Vaca
  • S Erazo
  • Matildes Prado
  • Rosemeire Fiaccone
  • Sergio S Cunha
  • R Lovato
  • Sheila Alvim
  • L C Rodrigues
  • I Quinzo
  • Renata Esquivel
  • M E Chico
  • A Rodriguez
  • M L Barreto
  • Alvaro A Cruz
  • G Oviedo
  • Thomas B Nutman

Detail Information

Publications22

  1. doi request reprint Effects of maternal geohelminth infections on allergy in early childhood
    Philip J Cooper
    Laboratorio de Investigaciones FEPIS, Avenida Via Guayllabamba, Quininde, Ecuador Centro de Investigación en Enfermedades Infecciosas, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador Institute of Infection and Immunity, St George s University of London, London, United Kingdom Electronic address
    J Allergy Clin Immunol 137:899-906.e2. 2016
    ..Maternal geohelminth infections during pregnancy may protect against allergy development in childhood...
  2. doi request reprint Cohort Profile: The Ecuador Life (ECUAVIDA) study in Esmeraldas Province, Ecuador
    Philip J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador, Institute of Infection and Immunity Research, Institute of Population Health Research, St George s University of London, London, UK, Centro de Investigación en Enfermedades Infecciosas, Escuela de Biologia, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador
    Int J Epidemiol 44:1517-27. 2015
    ..Allergen skin prick test reactivity is done from 2 years and measures of airway function and inflammation at 8 years. ..
  3. pmc Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America
    Neuza Maria Alcântara-Neves
    Departamento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil
    BMC Res Notes 7:817. 2014
    ..cati), intestinal roundworms of dogs and cats that cause systemic larval infection in humans. These parasites were selected as the most prevalent helminth parasites in our study population...
  4. pmc Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity
    P Endara
    Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, Ecuador
    Clin Exp Allergy 40:1669-77. 2010
    ..There is concern that treatment-based control programmes for these parasites may lead to an increase in the prevalence of allergic diseases...
  5. pmc Poverty, dirt, infections and non-atopic wheezing in children from a Brazilian urban center
    Mauricio L Barreto
    Instituto De Saude Coletiva, Universidade Federal da Bahia, Salvador, Brazil
    Respir Res 11:167. 2010
    ..Risk factors for atopic and non-atopic asthma may be different. This study aimed to analyze the associations between markers of poverty, dirt and infections and wheezing in atopic and non-atopic children...
  6. pmc Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment
    Camila A Figueiredo
    Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    Clin Immunol 139:57-64. 2011
    ..These results provide a possible biologic explanation for the temporal trends of increasing risk of inflammatory diseases observed in populations living in affluent countries...
  7. pmc Interactions between helminth parasites and allergy
    Philip J Cooper
    Centre for Infection, St George s University of London, London, UK
    Curr Opin Allergy Clin Immunol 9:29-37. 2009
    ..To review the findings of recent human studies of the association between helminth parasite infections and allergy and discuss their potential relevance to public health...
  8. pmc Hygiene, atopy and wheeze-eczema-rhinitis symptoms in schoolchildren from urban and rural Ecuador
    Philip J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    Thorax 69:232-9. 2014
    ..There are few data from developing countries addressing this question. We compared atopy and wheeze-rhinitis-eczema symptoms between urban and rural Ecuador, and explored the effects of farming and poor hygiene exposures...
  9. pmc Environmental determinants of total IgE among school children living in the rural Tropics: importance of geohelminth infections and effect of anthelmintic treatment
    Philip J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    BMC Immunol 9:33. 2008
    ..We measured levels of total IgE and anti-A. lumbricoides IgG (used as a measure of past and current geohelminth infectious exposure) in blood samples collected at the start of the study and after 12 months...
  10. pmc Evidence for in utero sensitization to Ascaris lumbricoides in newborns of mothers with ascariasis
    Irene Guadalupe
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    J Infect Dis 199:1846-50. 2009
    ..Our data provide evidence of in utero sensitization to A. lumbricoides and raise the possibility that the immunological effects of infection start in the fetus...
  11. pmc Repeated treatments with albendazole enhance Th2 responses to Ascaris Lumbricoides, but not to aeroallergens, in children from rural communities in the Tropics
    Philip J Cooper
    Centro de Investigaciones FEPIS, Quininde, Ecuador
    J Infect Dis 198:1237-42. 2008
    ..The data indicate that long-term treatment may be associated with increased Th2 antiparasite immunity...
  12. pmc Urbanisation is associated with prevalence of childhood asthma in diverse, small rural communities in Ecuador
    Alejandro Rodriguez
    Centro de Investigaciones FEPIS, Fundación Ecuatoriana para la Investigación en Salud, Quininde, Esmeraldas, Ecuador
    Thorax 66:1043-50. 2011
    ..The aim of the present study was to explore how the process of urbanisation may explain differences in asthma prevalence in transitional communities in north-eastern Ecuador...
  13. pmc Impact of long-term treatment with ivermectin on the prevalence and intensity of soil-transmitted helminth infections
    Ana Lucia Moncayo
    Instituto de Microbiologia, Universidad San Francisco de Quito, Diego Robles y Via Interoceanica S N, Cumbaya, Quito, Ecuador
    PLoS Negl Trop Dis 2:e293. 2008
    ..The current study investigated the impact of 15 to 17 years of treatment with the broad-spectrum anthelmintic ivermectin, used for the control of onchocerciasis, on STH prevalence and intensity in school-age and pre-school children...
  14. pmc Maternal geohelminth infections are associated with an increased susceptibility to geohelminth infection in children: a case-control study
    Raaj S Mehta
    Laboratorio de Investigaciones, Fundacion Ecuatoriana Para la Investigacion en Salud FEPIS, Quininde, Esmeraldas Province, Ecuador
    PLoS Negl Trop Dis 6:e1753. 2012
    ..Children of mothers infected with soil-transmitted helminths (STH) may have an increased susceptibility to STH infection...
  15. pmc Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study
    Miguel Reina Ortiz
    Centro de Investigaciones, Fundación Ecuatoriana Para Investigación en Salud, Quininde, Ecuador
    PLoS Negl Trop Dis 5:e1157. 2011
    ..To investigate this, we measured the impact in children of STH infections on cytokine responses and gene expression in unstimulated blood...
  16. pmc Risk factors for soil-transmitted helminth infections during the first 3 years of life in the tropics; findings from a birth cohort
    Stefanie K Menzies
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador Centro de Investigación en Enfermedades Infecciosas, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador
    PLoS Negl Trop Dis 8:e2718. 2014
    ..There are few data on the epidemiology and risk factors for infection in pre-school children. To investigate risk factors for infection in early childhood, we analysed data prospectively collected in the ECUAVIDA birth cohort in Ecuador...
  17. pmc Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response
    Rommy Teran
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    Clin Immunol 138:299-310. 2011
    ..Enhanced innate immunity in early life may be important for host defense against pathogens but may increase the risk of immunopathology...
  18. pmc Ascaris lumbricoides-induced interleukin-10 is not associated with atopy in schoolchildren in a rural area of the tropics
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Quito, Ecuador
    J Infect Dis 197:1333-40. 2008
    ..This study investigated whether IL-10 and populations of IL-10+ T cells may modulate atopy in children living in an area where intestinal helminth infections are endemic...
  19. doi request reprint Lifestyle domains as determinants of wheeze prevalence in urban and rural schoolchildren in Ecuador: cross sectional analysis
    Alejandro Rodriguez
    Laboratorio de Investigación FEPIS, Quininde, Esmeraldas Province, Ecuador
    Environ Health 14:15. 2015
    ..The aim of the present study was to identify modern lifestyle domains and assess how these domains might explain wheeze prevalence in urban and rural areas...
  20. doi request reprint Influence of poverty and infection on asthma in Latin America
    Philip J Cooper
    Centro de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    Curr Opin Allergy Clin Immunol 12:171-8. 2012
    ....
  21. doi request reprint Transmission of Norovirus Within Households in Quininde, Ecuador
    Paul A Gastañaduy
    From the Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia Fundación Ecuatoriana Para Investigación en Salud, Quininde, Esmeraldas Province, Ecuador Centro de Investigación en Enfermedades Infecciosas, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador and Institute of Infection and Immunity, St George s University of London, London, UK
    Pediatr Infect Dis J 34:1031-3. 2015
    ..Infection attack rates were higher when index children had a higher viral load. ..
  22. pmc Risk factors for asthma and allergy associated with urban migration: background and methodology of a cross-sectional study in Afro-Ecuadorian school children in Northeastern Ecuador (Esmeraldas-SCAALA Study)
    Philip J Cooper
    Instituto de Microbiologia, Universidad San Francisco de Quito, Quito, Ecuador
    BMC Pulm Med 6:24. 2006
    ..Understanding better why the prevalence of asthma is greater in urban migrant populations and the role of risk factors such as life style and environmental exposures, may be key to understand what is behind this trend...