Genomes and Genes
A R M Coates
Affiliation: St George's
- The unusual chaperonins of Mycobacterium tuberculosisRohini Qamra
Centre for DNA Fingerprinting and Diagnostics, ECIL Road, Nacharam, Hyderabad 500 076, India
Tuberculosis (Edinb) 85:385-94. 2005..Recent work has shown intriguing structural, biochemical and signaling properties of the M. tuberculosis chaperonins. This review details the recent developments in the study of the M. tuberculosis chaperonins...
- New strategies for antibacterial drug design: targeting non-multiplying latent bacteriaAnthony R M Coates
Department of Cellular and Molecular Medicine, Medical Microbiology, Centre for Infection, St George s University of London, London, UK
Drugs R D 7:133-51. 2006..The genomic approach has been disappointing so far, but it is still hoped that this will produce novel antibacterial agents...
- Stress wars: the direct role of host and bacterial molecular chaperones in bacterial infectionBrian Henderson
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X, United Kingdom
Infect Immun 74:3693-706. 2006
- Mycobacterium tuberculosis acg gene is required for growth and virulence in vivoYanmin Hu
Division of Clinical Sciences, Infection and Immunity Research Centre, St George s University of London, London, United Kingdom
PLoS ONE 6:e20958. 2011..This suggests that Acg may not function as a nitroreductase. These data indicate that acg encodes an essential virulence factor for M. tuberculosis and enables it to grow and survive in macrophages and in mouse organs...
- A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for staphylococcal infectionsYanmin Hu
Medical Microbiology, Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, London, United Kingdom
PLoS ONE 5:e11818. 2010..These antibiotics may be able to reduce the rate of emergence of resistance, shorten the duration of therapy, and reduce relapse rates...
- Acute and persistent Mycobacterium tuberculosis infections depend on the thiol peroxidase TpXYanmin Hu
Centre of Infection, Division of Cellular and Molecular Medicine, St George s University of London, London, UK
PLoS ONE 4:e5150. 2009..Our results demonstrated that tpx is required for M. tuberculosis to deal with oxidative and nitrosative stresses, to survive in macrophages and to establish acute and persistent infections in animal tuberculosis models...
- Novel classes of antibiotics or more of the same?Anthony R M Coates
Medical Microbiology, Centre for Infection, Department of Clinical Sciences, St George s, University of London, UK
Br J Pharmacol 163:184-94. 2011..Industry needs to re-enter the market on a much larger scale, and academia should rebuild its antibiotic discovery infrastructure to support this effort. The alternative is Medicine without effective antibiotics...
- Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospectsT Coates
University College London, London, UK
J Antimicrob Chemother 64:9-15. 2009..Furthermore, a more bactericidal antibiotic than mupirocin is needed, on the grounds that it might reduce the relapse rate, and so clear the patient of MRSA for a longer period of time than mupirocin...
- Targeting non-multiplying organisms as a way to develop novel antimicrobialsAnthony R M Coates
Medical Microbiology, Centre for Infection, Department of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London, UK
Trends Pharmacol Sci 29:143-50. 2008..Lastly, we review the potential of new molecular targets and live non-multiplying bacteria as possible routes for the development of novel antimicrobial drugs...
- Novel approaches to developing new antibiotics for bacterial infectionsA R M Coates
Medical Microbiology, Department of Cellular and Molecular Medicine, St George s, University of London, London, UK
Br J Pharmacol 152:1147-54. 2007....
- Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal diseaseAlireza Shamaei-Tousi
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom
PLoS ONE 2:e1198. 2007..We have used periodontitis and its treatment as a model of inflammation in the human to determine its effects on levels of circulating HSP10, HSP60 and BiP...
- Comparison of the sterilising activities of the nitroimidazopyran PA-824 and moxifloxacin against persisting Mycobacterium tuberculosisY Hu
Medical Microbiology, Department of Cellular and Molecular Medicine, St George s Hospital, University of London, London, United Kingdom
Int J Tuberc Lung Dis 12:69-73. 2008....
- Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminantsBrian Henderson
UCL Eastman Dental Institute, University College London, UK
Cell Stress Chaperones 15:123-41. 2010..They show that sufficient evidence exists to support fully the hypothesis that molecular chaperones have cell-cell signalling actions that are likely to be part of the homeostatic mechanism of the vertebrate...
- Transposon mutagenesis identifies genes which control antimicrobial drug tolerance in stationary-phase Escherichia coliYanmin Hu
Department of Medical Microbiology, St George s Hospital Medical School, London SW17 ORE, UK
FEMS Microbiol Lett 243:117-24. 2005..coli. Furthermore, they show that it is important in murine infection during antibiotic treatment and lead to a faster kill of the mutant bacteria...