A R M Coates

Summary

Affiliation: St George's
Country: UK

Publications

  1. ncbi request reprint The unusual chaperonins of Mycobacterium tuberculosis
    Rohini Qamra
    Centre for DNA Fingerprinting and Diagnostics, ECIL Road, Nacharam, Hyderabad 500 076, India
    Tuberculosis (Edinb) 85:385-94. 2005
  2. ncbi request reprint New strategies for antibacterial drug design: targeting non-multiplying latent bacteria
    Anthony R M Coates
    Department of Cellular and Molecular Medicine, Medical Microbiology, Centre for Infection, St George s University of London, London, UK
    Drugs R D 7:133-51. 2006
  3. pmc Stress wars: the direct role of host and bacterial molecular chaperones in bacterial infection
    Brian Henderson
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X, United Kingdom
    Infect Immun 74:3693-706. 2006
  4. pmc Mycobacterium tuberculosis acg gene is required for growth and virulence in vivo
    Yanmin Hu
    Division of Clinical Sciences, Infection and Immunity Research Centre, St George s University of London, London, United Kingdom
    PLoS ONE 6:e20958. 2011
  5. pmc A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for staphylococcal infections
    Yanmin Hu
    Medical Microbiology, Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, London, United Kingdom
    PLoS ONE 5:e11818. 2010
  6. pmc Acute and persistent Mycobacterium tuberculosis infections depend on the thiol peroxidase TpX
    Yanmin Hu
    Centre of Infection, Division of Cellular and Molecular Medicine, St George s University of London, London, UK
    PLoS ONE 4:e5150. 2009
  7. pmc Novel classes of antibiotics or more of the same?
    Anthony R M Coates
    Medical Microbiology, Centre for Infection, Department of Clinical Sciences, St George s, University of London, UK
    Br J Pharmacol 163:184-94. 2011
  8. pmc Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospects
    T Coates
    University College London, London, UK
    J Antimicrob Chemother 64:9-15. 2009
  9. doi request reprint Targeting non-multiplying organisms as a way to develop novel antimicrobials
    Anthony R M Coates
    Medical Microbiology, Centre for Infection, Department of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London, UK
    Trends Pharmacol Sci 29:143-50. 2008
  10. pmc Novel approaches to developing new antibiotics for bacterial infections
    A R M Coates
    Medical Microbiology, Department of Cellular and Molecular Medicine, St George s, University of London, London, UK
    Br J Pharmacol 152:1147-54. 2007

Collaborators

Detail Information

Publications14

  1. ncbi request reprint The unusual chaperonins of Mycobacterium tuberculosis
    Rohini Qamra
    Centre for DNA Fingerprinting and Diagnostics, ECIL Road, Nacharam, Hyderabad 500 076, India
    Tuberculosis (Edinb) 85:385-94. 2005
    ..Recent work has shown intriguing structural, biochemical and signaling properties of the M. tuberculosis chaperonins. This review details the recent developments in the study of the M. tuberculosis chaperonins...
  2. ncbi request reprint New strategies for antibacterial drug design: targeting non-multiplying latent bacteria
    Anthony R M Coates
    Department of Cellular and Molecular Medicine, Medical Microbiology, Centre for Infection, St George s University of London, London, UK
    Drugs R D 7:133-51. 2006
    ..The genomic approach has been disappointing so far, but it is still hoped that this will produce novel antibacterial agents...
  3. pmc Stress wars: the direct role of host and bacterial molecular chaperones in bacterial infection
    Brian Henderson
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X, United Kingdom
    Infect Immun 74:3693-706. 2006
  4. pmc Mycobacterium tuberculosis acg gene is required for growth and virulence in vivo
    Yanmin Hu
    Division of Clinical Sciences, Infection and Immunity Research Centre, St George s University of London, London, United Kingdom
    PLoS ONE 6:e20958. 2011
    ..This suggests that Acg may not function as a nitroreductase. These data indicate that acg encodes an essential virulence factor for M. tuberculosis and enables it to grow and survive in macrophages and in mouse organs...
  5. pmc A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for staphylococcal infections
    Yanmin Hu
    Medical Microbiology, Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, London, United Kingdom
    PLoS ONE 5:e11818. 2010
    ..These antibiotics may be able to reduce the rate of emergence of resistance, shorten the duration of therapy, and reduce relapse rates...
  6. pmc Acute and persistent Mycobacterium tuberculosis infections depend on the thiol peroxidase TpX
    Yanmin Hu
    Centre of Infection, Division of Cellular and Molecular Medicine, St George s University of London, London, UK
    PLoS ONE 4:e5150. 2009
    ..Our results demonstrated that tpx is required for M. tuberculosis to deal with oxidative and nitrosative stresses, to survive in macrophages and to establish acute and persistent infections in animal tuberculosis models...
  7. pmc Novel classes of antibiotics or more of the same?
    Anthony R M Coates
    Medical Microbiology, Centre for Infection, Department of Clinical Sciences, St George s, University of London, UK
    Br J Pharmacol 163:184-94. 2011
    ..Industry needs to re-enter the market on a much larger scale, and academia should rebuild its antibiotic discovery infrastructure to support this effort. The alternative is Medicine without effective antibiotics...
  8. pmc Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospects
    T Coates
    University College London, London, UK
    J Antimicrob Chemother 64:9-15. 2009
    ..Furthermore, a more bactericidal antibiotic than mupirocin is needed, on the grounds that it might reduce the relapse rate, and so clear the patient of MRSA for a longer period of time than mupirocin...
  9. doi request reprint Targeting non-multiplying organisms as a way to develop novel antimicrobials
    Anthony R M Coates
    Medical Microbiology, Centre for Infection, Department of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London, UK
    Trends Pharmacol Sci 29:143-50. 2008
    ..Lastly, we review the potential of new molecular targets and live non-multiplying bacteria as possible routes for the development of novel antimicrobial drugs...
  10. pmc Novel approaches to developing new antibiotics for bacterial infections
    A R M Coates
    Medical Microbiology, Department of Cellular and Molecular Medicine, St George s, University of London, London, UK
    Br J Pharmacol 152:1147-54. 2007
    ....
  11. pmc Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal disease
    Alireza Shamaei-Tousi
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom
    PLoS ONE 2:e1198. 2007
    ..We have used periodontitis and its treatment as a model of inflammation in the human to determine its effects on levels of circulating HSP10, HSP60 and BiP...
  12. ncbi request reprint Comparison of the sterilising activities of the nitroimidazopyran PA-824 and moxifloxacin against persisting Mycobacterium tuberculosis
    Y Hu
    Medical Microbiology, Department of Cellular and Molecular Medicine, St George s Hospital, University of London, London, United Kingdom
    Int J Tuberc Lung Dis 12:69-73. 2008
    ....
  13. pmc Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants
    Brian Henderson
    UCL Eastman Dental Institute, University College London, UK
    Cell Stress Chaperones 15:123-41. 2010
    ..They show that sufficient evidence exists to support fully the hypothesis that molecular chaperones have cell-cell signalling actions that are likely to be part of the homeostatic mechanism of the vertebrate...
  14. ncbi request reprint Transposon mutagenesis identifies genes which control antimicrobial drug tolerance in stationary-phase Escherichia coli
    Yanmin Hu
    Department of Medical Microbiology, St George s Hospital Medical School, London SW17 ORE, UK
    FEMS Microbiol Lett 243:117-24. 2005
    ..coli. Furthermore, they show that it is important in murine infection during antibiotic treatment and lead to a faster kill of the mutant bacteria...