M J Clemens

Summary

Affiliation: St George's Hospital Medical School
Country: UK

Publications

  1. ncbi request reprint Translational control: the cancer connection
    M J Clemens
    Department of Biochemistry, St George s Hospital Medical School, London, UK
    Int J Biochem Cell Biol 31:1-23. 1999
  2. ncbi request reprint Translational control in virus-infected cells: models for cellular stress responses
    Michael J Clemens
    Translational Control Group, Biochemistry and Immunology, Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Semin Cell Dev Biol 16:13-20. 2005
  3. ncbi request reprint Targets and mechanisms for the regulation of translation in malignant transformation
    Michael J Clemens
    Translational Control Group, Biochemistry and Immunology, Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Oncogene 23:3180-8. 2004
  4. ncbi request reprint Interferons and apoptosis
    Michael J Clemens
    Translational Control Group, Department of Basic Medical Sciences, St George s Hospital Medical School, London SW17 0RE, UK
    J Interferon Cytokine Res 23:277-92. 2003
  5. ncbi request reprint Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins
    M J Clemens
    Department of Biochemistry and Immunology, Cellular and Molecular Sciences Group, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Cell Mol Med 5:221-39. 2001
  6. ncbi request reprint Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells
    M J Clemens
    Department of Biochemistry and Immunology, Cellular and Molecular Sciences Group, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Cell Death Differ 7:603-15. 2000
  7. ncbi request reprint Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1
    A Elia
    Translational Control Group, Division of Basic Medical Sciences, Centre for Molecular and Metabolic Signalling, St George s, University of London, London, UK
    Oncogene 27:811-22. 2008
  8. doi request reprint Roles of the translationally controlled tumour protein (TCTP) and the double-stranded RNA-dependent protein kinase, PKR, in cellular stress responses
    U A Bommer
    Division of Basic Medical Sciences, St George s, University of London, London, UK
    Oncogene 29:763-73. 2010
  9. ncbi request reprint Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages
    M Bushell
    Department of Biochemistry and Immunology, Cellular and Molecular Sciences Group, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom
    J Biol Chem 276:23922-8. 2001
  10. ncbi request reprint Regulation of translation factors eIF4GI and 4E-BP1 during recovery of protein synthesis from inhibition by p53
    C Constantinou
    Translational Control Group, Centre for Molecular and Metabolic Signalling, Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Cell Death Differ 14:576-85. 2007

Collaborators

  • S J Morley
  • M Bushell
  • U A Bommer
  • Jack Hensold
  • Constantina Constantinou
  • Androulla Elia
  • Ian W Jeffrey
  • Vivienne J Tilleray
  • C Constantinou
  • Vivienne Tilleray
  • Jashmin Vyas
  • Kenneth G Laing
  • A Elia
  • Lynn E Horton
  • Stephanie Bornes
  • Karthiga Gengatharan
  • Matthew West
  • Victoria Frost
  • Diane Barth-Baus
  • Ian Jeffrey
  • Volker Matys
  • Bernard Souberbielle

Detail Information

Publications24

  1. ncbi request reprint Translational control: the cancer connection
    M J Clemens
    Department of Biochemistry, St George s Hospital Medical School, London, UK
    Int J Biochem Cell Biol 31:1-23. 1999
    ..The purpose of this article is to give an overview of the field and to indicate where we may expect developments to occur in the next few years...
  2. ncbi request reprint Translational control in virus-infected cells: models for cellular stress responses
    Michael J Clemens
    Translational Control Group, Biochemistry and Immunology, Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Semin Cell Dev Biol 16:13-20. 2005
    ..Thus, mechanisms of translational control during virus infection can provide models for the cellular stress responses observed in a wide range of other circumstances...
  3. ncbi request reprint Targets and mechanisms for the regulation of translation in malignant transformation
    Michael J Clemens
    Translational Control Group, Biochemistry and Immunology, Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Oncogene 23:3180-8. 2004
    ....
  4. ncbi request reprint Interferons and apoptosis
    Michael J Clemens
    Translational Control Group, Department of Basic Medical Sciences, St George s Hospital Medical School, London SW17 0RE, UK
    J Interferon Cytokine Res 23:277-92. 2003
    ..The review also discusses the physiologic and clinical implications of the effects of the IFNs on apoptosis for regulation of viral infection and tumor growth...
  5. ncbi request reprint Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins
    M J Clemens
    Department of Biochemistry and Immunology, Cellular and Molecular Sciences Group, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Cell Mol Med 5:221-39. 2001
    ..The review discusses the mechanisms by which these events are regulated and the significance of the changes for the control of protein synthesis, cell proliferation and cell survival...
  6. ncbi request reprint Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells
    M J Clemens
    Department of Biochemistry and Immunology, Cellular and Molecular Sciences Group, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Cell Death Differ 7:603-15. 2000
    ..We discuss the significance of the initiation factor cleavages and other changes for protein synthesis, and the implications of these events for our understanding of the cellular changes associated with apoptosis...
  7. ncbi request reprint Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1
    A Elia
    Translational Control Group, Division of Basic Medical Sciences, Centre for Molecular and Metabolic Signalling, St George s, University of London, London, UK
    Oncogene 27:811-22. 2008
    ..We suggest that the phosphorylation of 4E-BP1 may play a dual role in the regulation of protein synthesis, both reducing the affinity of 4E-BP1 for eIF4E and promoting the conversion of 4E-BP1 to alternative, polyubiquitinated forms...
  8. doi request reprint Roles of the translationally controlled tumour protein (TCTP) and the double-stranded RNA-dependent protein kinase, PKR, in cellular stress responses
    U A Bommer
    Division of Basic Medical Sciences, St George s, University of London, London, UK
    Oncogene 29:763-73. 2010
    ..Our results imply that cellular TCTP levels influence sensitivity to apoptosis and that PKR may exert its proapoptotic effects at least in part through downregulation of TCTP via eIF2alpha phosphorylation...
  9. ncbi request reprint Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages
    M Bushell
    Department of Biochemistry and Immunology, Cellular and Molecular Sciences Group, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom
    J Biol Chem 276:23922-8. 2001
    ....
  10. ncbi request reprint Regulation of translation factors eIF4GI and 4E-BP1 during recovery of protein synthesis from inhibition by p53
    C Constantinou
    Translational Control Group, Centre for Molecular and Metabolic Signalling, Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Cell Death Differ 14:576-85. 2007
    ....
  11. ncbi request reprint Inhibition of protein synthesis in apoptosis: differential requirements by the tumor necrosis factor alpha family and a DNA-damaging agent for caspases and the double-stranded RNA-dependent protein kinase
    Ian W Jeffrey
    Department of Biochemistry and Immunology, Cellular and Molecular Sciences Group, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Cancer Res 62:2272-80. 2002
    ..However, our data suggest that neither increased phosphorylation of eIF2alpha nor increased [eIF4E.4E-BP1] complex formation is essential for the inhibition of overall translation by the DNA-damaging agent...
  12. ncbi request reprint Initiation factor eIF2 alpha phosphorylation in stress responses and apoptosis
    M J Clemens
    Department of Biochemistry and Immunology, St George's Hospital Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK
    Prog Mol Subcell Biol 27:57-89. 2001
    ..These mechanisms can provide a signal transduction pathway linking eukaryotic cellular stress responses to alterations in the control of gene expression at the translational level...
  13. pmc The mRNA of the translationally controlled tumor protein P23/TCTP is a highly structured RNA, which activates the dsRNA-dependent protein kinase PKR
    Ulrich Axel Bommer
    Department of Biochemistry and Immunology, St George s Hospital Medical School, London, UK
    RNA 8:478-96. 2002
    ..Hence, our results demonstrate that the mRNA of P23/TCTP may both activate PKR and be subject to translational regulation by this kinase...
  14. ncbi request reprint Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53
    Constantina Constantinou
    Translational Control Group, Department of Basic Medical Sciences Biochemistry and Immunology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Oncogene 24:4839-50. 2005
    ..These data suggest that the inhibition of protein synthesis by p53 is largely independent of the regulation of rapamycin-sensitive mTOR in the system under investigation...
  15. ncbi request reprint Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cells
    Vivienne Tilleray
    Translational Control Group, Centre for Molecular and Metabolic Signalling, Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    FEBS Lett 580:1766-70. 2006
    ..The inhibition of translation is not a consequence of p53-mediated apoptosis...
  16. ncbi request reprint In vivo effects of the Epstein-Barr virus small RNA EBER-1 on protein synthesis and cell growth regulation
    Kenneth G Laing
    Department of Biochemistry and Immunology, St George s Hospital Medical School, Cranmer Terrace, London, United Kingdom
    Virology 297:253-69. 2002
    ....
  17. ncbi request reprint Initiation factor modifications in the preapoptotic phase
    S J Morley
    Department of Biochemistry, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Cell Death Differ 12:571-84. 2005
    ....
  18. ncbi request reprint Epstein-Barr virus: inhibition of apoptosis as a mechanism of cell transformation
    Michael J Clemens
    Translational Control Group, Centre for Molecular and Metabolic Signalling, Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Int J Biochem Cell Biol 38:164-9. 2006
    ..This review summarizes the mechanisms of action of EBER-1 and other Epstein-Barr virus gene products in the regulation of apoptosis, and presents a model of how EBER-1 exerts its effects on PKR activity...
  19. ncbi request reprint Ribosomal protein L22 inhibits regulation of cellular activities by the Epstein-Barr virus small RNA EBER-1
    Androulla Elia
    Translational Control Group, Department of Basic Medical Sciences, St George s Hospital Medical School, London, UK
    Eur J Biochem 271:1895-905. 2004
    ..Such effects include both the inhibition of PKR and additional mechanism(s) by which EBER-1 stimulates gene expression...
  20. ncbi request reprint Interferon-alpha induces sensitization of cells to inhibition of protein synthesis by tumour necrosis factor-related apoptosis-inducing ligand
    Ian W Jeffrey
    Translational Control Group, Centre for Molecular and Metabolic Signalling, Division of Basic Medical Sciences, St George s, University of London, UK
    FEBS J 273:3698-708. 2006
    ..Interferon-alpha enhances the level and/or the extent of activation of caspase-8 by TRAIL, thus providing a likely explanation for the sensitization of cells to the inhibition of translation...
  21. ncbi request reprint Activation of p53 stimulates proteasome-dependent truncation of eIF4E-binding protein 1 (4E-BP1)
    Constantina Constantinou
    Translational Control Group, Centre for Molecular and Metabolic Signalling, Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, U K
    Biol Cell 100:279-89. 2008
    ....
  22. pmc Inhibition of the protein kinase PKR by the internal ribosome entry site of hepatitis C virus genomic RNA
    Jashmin Vyas
    Translational Control Group, Department of Basic Medical Sciences, St George s Hospital Medical School, London SW17 0RE, UK
    RNA 9:858-70. 2003
    ..These data suggest a dual function for the viral IRES, with both a structural role in promoting initiation complex formation and a regulatory role in preventing inhibition of initiation by PKR...
  23. ncbi request reprint p53-induced inhibition of protein synthesis is independent of apoptosis
    Constantina Constantinou
    Translational Control Group, Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London, UK
    Eur J Biochem 270:3122-32. 2003
    ..We conclude that the p53-regulated cleavages of eIF4GI and eIF4B, as well as the overall inhibition of protein synthesis, are caspase-independent events that can be dissociated from the induction of apoptosis per se...
  24. ncbi request reprint p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation
    Lynn E Horton
    The Department of Medicine, University Ireland Cancer Center, Case Western Reserve University School of Medicine, 10900 Euclid Ave BRB 333, Cleveland, Ohio, OH 44106 4937, USA
    Oncogene 21:5325-34. 2002
    ..These data provide evidence that modulation of translational activity constitutes a further mechanism by which the growth inhibitory effects of p53 may be mediated...