Steve Bevan

Summary

Affiliation: St George's
Country: UK

Publications

  1. pmc Genetics of common polygenic ischaemic stroke: current understanding and future challenges
    Steve Bevan
    Stroke and Dementia Research Centre, St George s, University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Stroke Res Treat 2011:179061. 2011
  2. doi Genetic profiles in ischaemic stroke
    Steve Bevan
    Stroke and Dementia Research Centre, St George s, University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Curr Atheroscler Rep 15:342. 2013
  3. ncbi Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations
    Steve Bevan
    Stroke and Dementia Research Group, St Georges, University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Stroke 43:3161-7. 2012
  4. doi Adiponectin level as a consequence of genetic variation, but not leptin level or leptin: adiponectin ratio, is a risk factor for carotid intima-media thickness
    Steve Bevan
    Stroke and Dementia Research Centre, Clinical Sciences, St George s University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Stroke 42:1510-4. 2011
  5. ncbi Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study
    Steve Bevan
    Clinical Neuroscience, St Georges University of London, UK
    Stroke 40:696-701. 2009
  6. ncbi Variation in the PDE4D gene and ischemic stroke risk: a systematic review and meta-analysis on 5200 cases and 6600 controls
    Steve Bevan
    Centre for Clinical Neuroscience, St George s, University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Stroke 39:1966-71. 2008
  7. doi Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations
    Steve Bevan
    Centre for Clinical Neuroscience, St Georges University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Stroke 39:1109-14. 2008
  8. ncbi Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness
    Christine Armstrong
    Centre for Clinical Neuroscience, St George s University of London, Cranmer Terrace, Tooting, London, UK
    Stroke 38:2895-9. 2007
  9. ncbi Toll receptor polymorphisms and carotid artery intima-media thickness
    Robyn Labrum
    Centre for Clinical Neuroscience, St George s University of London, London, UK
    Stroke 38:1179-84. 2007
  10. pmc Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies
    Rainer Malik
    From the Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munich, Germany R M, M D Stroke and Dementia Research Centre, St George s University of London, London, United Kingdom S B, H S M Laboratory of Neurogenetics M A N and Laboratory of Epidemiology and Population Sciences L J L, National Institute on Aging, National Institutes of Health, Bethesda, MD Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health E G H and Center for Translational Neuroscience and Mental Health Research C L, University of Newcastle, Callaghan, NSW, Australia Center for Bioinformatics, Biomarker Discovery and Information Based Medicine, Hunter Medical Research Institute, New Lambton, NSW, Australia E G H Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA W J D, J R Department of Medicine, University of Maryland School of Medicine, Baltimore, MD Y C C, B D M Department of Veterans Affairs and Veterans Affairs Medical Center, Baltimore Geriatric Research, Education, and Clinical Center GRECC, Baltimore, MD Y C C, B D M Department of Epidemiology C A I V, B F J V, Baltimore
    Stroke 45:394-402. 2014

Detail Information

Publications23

  1. pmc Genetics of common polygenic ischaemic stroke: current understanding and future challenges
    Steve Bevan
    Stroke and Dementia Research Centre, St George s, University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Stroke Res Treat 2011:179061. 2011
    ..The review also considers the overlap from other cardiovascular diseases and whether findings from these may also be informative in ischaemic stroke...
  2. doi Genetic profiles in ischaemic stroke
    Steve Bevan
    Stroke and Dementia Research Centre, St George s, University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Curr Atheroscler Rep 15:342. 2013
    ..This review will explore our current understanding of the genetics underlying stroke risk and whether this information is currently useful in a clinical setting for patient benefit...
  3. ncbi Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations
    Steve Bevan
    Stroke and Dementia Research Group, St Georges, University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Stroke 43:3161-7. 2012
    ..Previous candidate gene studies have identified many associations with stoke but whether these are important requires replication in large independent data sets. GWAS data sets provide a powerful resource to perform replication studies...
  4. doi Adiponectin level as a consequence of genetic variation, but not leptin level or leptin: adiponectin ratio, is a risk factor for carotid intima-media thickness
    Steve Bevan
    Stroke and Dementia Research Centre, Clinical Sciences, St George s University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Stroke 42:1510-4. 2011
    ..We also examined association between genetic variants in the leptin and adiponectin genes and IMT...
  5. ncbi Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study
    Steve Bevan
    Clinical Neuroscience, St Georges University of London, UK
    Stroke 40:696-701. 2009
    ..Using a 2-stage replication design, we have examined whether polymorphisms in 8 genes related to this pathway are associated with early atherosclerosis and remodeling as measured by carotid artery intima-media thickness...
  6. ncbi Variation in the PDE4D gene and ischemic stroke risk: a systematic review and meta-analysis on 5200 cases and 6600 controls
    Steve Bevan
    Centre for Clinical Neuroscience, St George s, University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Stroke 39:1966-71. 2008
    ..Meta-analysis provides a method to combine this data and determine in a larger sample size whether the association with PDE4D can be replicated...
  7. doi Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations
    Steve Bevan
    Centre for Clinical Neuroscience, St Georges University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Stroke 39:1109-14. 2008
    ..Using a case control replication methodology, all members of the leukotriene synthesis pathway and their receptors were examined for genetic variants, which may act as risk factors for all ischemic stroke and stroke subtypes...
  8. ncbi Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness
    Christine Armstrong
    Centre for Clinical Neuroscience, St George s University of London, Cranmer Terrace, Tooting, London, UK
    Stroke 38:2895-9. 2007
    ..We have therefore sought to address this issue in a large, well-phenotyped community population to assess the effect of a number of polymorphisms in both MMP and TIMP genes on carotid artery intima-media thickness (IMT)...
  9. ncbi Toll receptor polymorphisms and carotid artery intima-media thickness
    Robyn Labrum
    Centre for Clinical Neuroscience, St George s University of London, London, UK
    Stroke 38:1179-84. 2007
    ....
  10. pmc Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies
    Rainer Malik
    From the Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munich, Germany R M, M D Stroke and Dementia Research Centre, St George s University of London, London, United Kingdom S B, H S M Laboratory of Neurogenetics M A N and Laboratory of Epidemiology and Population Sciences L J L, National Institute on Aging, National Institutes of Health, Bethesda, MD Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health E G H and Center for Translational Neuroscience and Mental Health Research C L, University of Newcastle, Callaghan, NSW, Australia Center for Bioinformatics, Biomarker Discovery and Information Based Medicine, Hunter Medical Research Institute, New Lambton, NSW, Australia E G H Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA W J D, J R Department of Medicine, University of Maryland School of Medicine, Baltimore, MD Y C C, B D M Department of Veterans Affairs and Veterans Affairs Medical Center, Baltimore Geriatric Research, Education, and Clinical Center GRECC, Baltimore, MD Y C C, B D M Department of Epidemiology C A I V, B F J V, Baltimore
    Stroke 45:394-402. 2014
    ..We aimed to generate a multilocus genetic risk score (GRS) for IS based on genome-wide association studies data from clinical-based samples and to establish its external validity in prospective population-based cohorts...
  11. pmc Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies
    Matthew Traylor
    Stroke and Dementia Research Centre, St George s University of London, London, UK
    Lancet Neurol 11:951-62. 2012
    ..We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes...
  12. ncbi Using phenotypic heterogeneity to increase the power of genome-wide association studies: application to age at onset of ischaemic stroke subphenotypes
    Matthew Traylor
    Stroke and Dementia Research Centre, St George s University of London, London, UK
    Genet Epidemiol 37:495-503. 2013
    ....
  13. ncbi NADPH oxidase polymorphisms in cerebral small vessel disease
    Usman Khan
    Centre for Clinical Neuroscience, St George s University of London, London, UK
    Cerebrovasc Dis 24:135-8. 2007
  14. pmc Evidence HDAC9 genetic variant associated with ischemic stroke increases risk via promoting carotid atherosclerosis
    Hugh S Markus
    Stroke and Dementia Research Centre, St George s University of London, London SW19 3QZ, United Kingdom
    Stroke 44:1220-5. 2013
    ..The most likely underlying gene is histone deacetylase 9 (HDAC9). The mechanism by which HDAC9 increases stroke risk is not clear; both vascular and neuronal mechanisms have been proposed...
  15. ncbi Genetic and acquired inflammatory conditions are synergistically associated with early carotid atherosclerosis
    Hugh S Markus
    Centre for Clinical Neuroscience, Department of Cardiac and Vascular Sciences, St George s University of London, UK
    Stroke 37:2253-9. 2006
    ..We replicated this finding in a second large population and extended the analysis by inclusion of other inflammatory conditions (chronic infection and obesity/abnormal glucose tolerance)...
  16. pmc Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes
    Elijah R Behr
    Cardiovascular Sciences and Genetics Research Centers, St George s University of London, London, United Kingdom
    PLoS ONE 8:e78511. 2013
    ..This study argues that common genomic variants do not contribute importantly to risk for drug-induced Torsades de Pointes across multiple drugs. ..
  17. pmc A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach
    Matthew Traylor
    Stroke and Dementia Research Centre, St George s University of London, London, United Kingdom
    PLoS Genet 10:e1004469. 2014
    ..001). Our results show that a covariate-informed design, by adjusting for age-at-onset of stroke, can detect variants not identified by conventional GWAS. ..
  18. ncbi Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL
    Christian Opherk
    From Institute for Stroke and Dementia Research C O, M G, M Duering, R M, M Dichgans, and Department of Neurology C O, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany Department of Neurology, DHU NeuroVasc, Hopital Lariboisiere, APHP, Paris, France E J, H C Université Paris Diderot, Sorbonne Paris Cité, Génétique des Maladies Vasculaires, INSERM UMR S740, Paris, France D H, E T L Stroke and Dementia Research Centre, St George s University of London, London, United Kingdom P A S, S B Neurology Division and Molecular Medicine Section, Mazzoni Hospital, Ascoli Piceno, Italy L P, S S, M R Department of Medicine, Surgery and Neurosciences, University of Siena, Italy M T D, N D S, Department of Physiology and Cell Biology
    Stroke 45:968-72. 2014
    ..The current study searched for genetic modifiers of WMH volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a monogenic small vessel disease...
  19. pmc Genome-wide analysis of blood pressure variability and ischemic stroke
    Sunaina Yadav
    From the Imperial College Cerebrovascular Research Unit ICCRU S Y, I C, M S K, N H, M P, P E R, P S and International Centre for Circulatory Health P S, Imperial College London, London, United Kingdom Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health E G H, M M, J A, School of Nursing and Midwifery J M M, and School of Biomedical Sciences and Pharmacy R J S, University of Newcastle, Newcastle, New South Wales, Australia Hunter Medical Research Institute, Newcastle, New South Wales, Australia E G H, J M M, M M, R J S, J A Institute for Stroke and Dementia Research ISD, Medical Centre, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany R M, M D Munich Cluster for Systems Neurology SyNergy, Munich, Germany R M, M D Stroke and Dementia Research Centre, St George s University of London, London, Germany
    Stroke 44:2703-9. 2013
    ..We sought to determine whether such variability has genetic causes and whether genetic variants associated with BP variability are also associated with ischemic stroke...
  20. pmc 17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status
    Poneh Adib-Samii
    Stroke and Dementia Research Centre, St George s University of London, London, UK
    Stroke 44:1609-15. 2013
    ..We aimed to replicate the association with WMH volume (WMHV) in patients with ischemic stroke. If the association acts by promoting a small vessel arteriopathy, it might be expected to also associate with lacunar stroke...
  21. pmc The role of genetic variants of matrix metalloproteinases in coronary and carotid atherosclerosis
    Sonia Abilleira
    Department of Clinical Neuroscience, St George s University of London, London, UK
    J Med Genet 43:897-901. 2006
    ....
  22. ncbi The influence of genetic and cardiovascular risk factors on the CADASIL phenotype
    Sumeet Singhal
    Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Brain 127:2031-8. 2004
    ..This implies that modulating factors influence phenotype. Smoking appears to increase the risk of stroke, while high homocysteine levels are associated with an increased risk of migraine...
  23. ncbi Polymorphisms in genes of the endothelin system and cerebral small-vessel disease
    Kelly Gormley
    Department of Clinical Neuroscience, St George s Hospital Medical School, St George s Hospital, London, England
    Stroke 36:1656-60. 2005
    ..We determined whether genetic variants in components of the ET system are a risk factor for cerebral SVD...