Emma H Baker

Summary

Affiliation: St George's Hospital Medical School
Country: UK

Publications

  1. ncbi request reprint Association of hypertension with T594M mutation in beta subunit of epithelial sodium channels in black people resident in London
    E H Baker
    Department of Pharmacology, St George s Hospital Medical School, London, UK
    Lancet 351:1388-92. 1998
  2. pmc Abnormalities of nasal potential difference measurement in Liddle's syndrome
    E Baker
    Blood Pressure Unit, St George s Hospital Medical School, London, England SW17 0RE
    J Clin Invest 102:10-4. 1998
  3. ncbi request reprint Epithelial sodium channel activity is not increased in hypertension in whites
    E H Baker
    Blood Pressure Unit, Department of Pharmacology, St George s Hospital Medical School, London, UK
    Hypertension 33:1031-5. 1999
  4. pmc Ion channels and the control of blood pressure
    E H Baker
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London, UK
    Br J Clin Pharmacol 49:185-98. 2000
  5. ncbi request reprint Transepithelial sodium absorption is increased in people of African origin
    E H Baker
    Department of Physiological Medicine, St George s Hospital Medical School, Cranmer Terrace, London, United Kingdom
    Hypertension 38:76-80. 2001
  6. ncbi request reprint Amiloride, a specific drug for hypertension in black people with T594M variant?
    Emma H Baker
    Department of Physiological Medicine, St George s Hospital Medical School, Cranmer Terrace, London, United Kingdom
    Hypertension 40:13-7. 2002
  7. ncbi request reprint Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis
    Emma H Baker
    Cardiac and Vascular Sciences Respiratory, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    J Appl Physiol (1985) 102:1969-75. 2007
  8. ncbi request reprint Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis
    Amanda L Brennan
    Glucose and Pulmonary Infection Group, St George s, University of London, Room 66, Ground Floor Jenner Wing, Cardiac and Vascular Sciences Respiratory, Cranmer Terrace, SW17 0RE, London, United Kingdom
    J Cyst Fibros 6:101-9. 2007
  9. pmc Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose
    James P Garnett
    Division of Biomedical Sciences, Centre for Cell Physiology and Pharmacology, St George s, University of London, London, UK
    Thorax 68:835-45. 2013
  10. doi request reprint Glucose homeostasis across human airway epithelial cell monolayers: role of diffusion, transport and metabolism
    Kameljit K Kalsi
    Centre for Ion Channel and Cell Signalling, St George s, University of London, Cranmer Terrace, UK
    Pflugers Arch 457:1061-70. 2009

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Association of hypertension with T594M mutation in beta subunit of epithelial sodium channels in black people resident in London
    E H Baker
    Department of Pharmacology, St George s Hospital Medical School, London, UK
    Lancet 351:1388-92. 1998
    ..Essential hypertension in black patients also shows clinical features of sodium retention so we screened black people for the T594M mutation, the most commonly identified sodium-channel mutation...
  2. pmc Abnormalities of nasal potential difference measurement in Liddle's syndrome
    E Baker
    Blood Pressure Unit, St George s Hospital Medical School, London, England SW17 0RE
    J Clin Invest 102:10-4. 1998
    ..If these results are confirmed in other kindreds with this condition, then nasal potential difference measurements could provide a simple clinical test for Liddle's syndrome...
  3. ncbi request reprint Epithelial sodium channel activity is not increased in hypertension in whites
    E H Baker
    Blood Pressure Unit, Department of Pharmacology, St George s Hospital Medical School, London, UK
    Hypertension 33:1031-5. 1999
    ..Increased postamiloride potential may reflect increased activity of chloride channels or amiloride-insensitive sodium channels...
  4. pmc Ion channels and the control of blood pressure
    E H Baker
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London, UK
    Br J Clin Pharmacol 49:185-98. 2000
    ..It is possible that new drugs, as well as antisense nucleotide technology or gene therapy directed towards ion channels, may form a new class of treatments for high and low blood pressure in the future...
  5. ncbi request reprint Transepithelial sodium absorption is increased in people of African origin
    E H Baker
    Department of Physiological Medicine, St George s Hospital Medical School, Cranmer Terrace, London, United Kingdom
    Hypertension 38:76-80. 2001
    ....
  6. ncbi request reprint Amiloride, a specific drug for hypertension in black people with T594M variant?
    Emma H Baker
    Department of Physiological Medicine, St George s Hospital Medical School, Cranmer Terrace, London, United Kingdom
    Hypertension 40:13-7. 2002
    ..Our study supports the concept that the T594M polymorphism contributes to the elevation of blood pressure and suggests that consideration should be given to the use of amiloride in affected individuals...
  7. ncbi request reprint Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis
    Emma H Baker
    Cardiac and Vascular Sciences Respiratory, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    J Appl Physiol (1985) 102:1969-75. 2007
    ..This method will support future in vivo investigation of the cause and effect of elevated respiratory fluid glucose in human lung disease...
  8. ncbi request reprint Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis
    Amanda L Brennan
    Glucose and Pulmonary Infection Group, St George s, University of London, Room 66, Ground Floor Jenner Wing, Cardiac and Vascular Sciences Respiratory, Cranmer Terrace, SW17 0RE, London, United Kingdom
    J Cyst Fibros 6:101-9. 2007
    ..In people without CF, airway glucose (AG) concentrations are elevated when blood glucose (BG)> or =8 mmol L(-1) (airway threshold), and are associated with acquisition of respiratory infection...
  9. pmc Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose
    James P Garnett
    Division of Biomedical Sciences, Centre for Cell Physiology and Pharmacology, St George s, University of London, London, UK
    Thorax 68:835-45. 2013
    ..Diabetes is a risk factor for respiratory infection, and hyperglycaemia is associated with increased glucose in airway surface liquid and risk of Staphylococcus aureus infection...
  10. doi request reprint Glucose homeostasis across human airway epithelial cell monolayers: role of diffusion, transport and metabolism
    Kameljit K Kalsi
    Centre for Ion Channel and Cell Signalling, St George s, University of London, Cranmer Terrace, UK
    Pflugers Arch 457:1061-70. 2009
    ..We suggest that glucose transport through GLUT transporters and its subsequent metabolism in lung epithelial cells help to maintain low glucose concentrations in human ASL which is important for protecting the lung against infection...
  11. ncbi request reprint Hyperglycaemia and pulmonary infection
    Emma H Baker
    Glucose and Pulmonary Infection Group, Cardiac and Vascular Sciences Respiratory, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Proc Nutr Soc 65:227-35. 2006
    ..Therapeutic options, including systemic control of blood glucose and local manipulation of airway glucose homeostasis, will be considered...
  12. pmc Apical and basolateral localisation of GLUT2 transporters in human lung epithelial cells
    Kameljit K Kalsi
    Centre for Ion Channel and Cell Signalling, Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London, SW17 0RE, UK
    Pflugers Arch 456:991-1003. 2008
    ..We speculate that these transporters could contribute to glucose uptake/homeostasis in the human airway...
  13. ncbi request reprint Relationship between glycosylated haemoglobin and mean plasma glucose concentration in cystic fibrosis
    Amanda L Brennan
    Cardiac and Vascular Sciences Respiratory, St George s, University of London, Cranmer Terrace, London, SW17 0RE, UK
    J Cyst Fibros 5:27-31. 2006
    ..However the relationship between HbA(1c) and mean plasma glucose concentration (MPG) has not been established in CFRD, as in other forms of diabetes mellitus...
  14. doi request reprint Sweet talk: insights into the nature and importance of glucose transport in lung epithelium
    James P Garnett
    Division of Biomedical Sciences St George s, University of London, London, UK
    Eur Respir J 40:1269-76. 2012
    ..Understanding of mechanisms underlying lung glucose homeostasis could identify new therapeutic targets for control of ASL glucose and prevention and treatment of lung infection...
  15. pmc Elevated paracellular glucose flux across cystic fibrosis airway epithelial monolayers is an important factor for Pseudomonas aeruginosa growth
    James P Garnett
    Division of Biomedical Sciences, St George s University of London, London, United Kingdom
    PLoS ONE 8:e76283. 2013
    ..Together these studies highlight the importance of glucose as an additional factor in promoting Ps. aeruginosa growth and respiratory infection in CF disease. ..
  16. ncbi request reprint Clinical importance of cystic fibrosis-related diabetes
    Amanda L Brennan
    Physiological Medicine, St George s Hospital Medical School, London, SW17 ORE, UK
    J Cyst Fibros 3:209-22. 2004
    ....
  17. ncbi request reprint Factors determining the appearance of glucose in upper and lower respiratory tract secretions
    Barbara J Philips
    Department of Anaesthesia and Intensive Care, St George s Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK
    Intensive Care Med 29:2204-10. 2003
    ..a). To describe the glucose content of normal human airways secretions; (b). to observe the effects of hyperglycemia and airways inflammation on airways glucose...
  18. ncbi request reprint Effect of hyperglycaemia on glucose concentration of human nasal secretions
    David M Wood
    Pharmacology and Clinical Pharmacology, St George s Hospital, Medical School, London SW17 0RE, UK
    Clin Sci (Lond) 106:527-33. 2004
    ....