Genomes and Genes
Affiliation: St Georges, University of London
Location: London, United Kingdom
Research into recognition of MHC class I proteins, particularly by members of the Leukocyte Ig Like Receptor LILR/ILT/LIR) family in the context of infectious disease, autoimmune disease and cancer.
1) Recognition of HLA B27 by Leukocyte Ig Like Receptors, and their relevance in arthritis, 2008
Arthritis Research Campaign
(2) Host-pathogen interactions involving members of the leukocyte Ig-like receptor (LILR) innate immune receptor family and Mycobacterium bovis. 2009
Veterinary Laboratories Agency/SGUL
(3) Modulation of antigen presenting cell plasticity by leukocyte Ig-like receptors (LILR) 2008. CRUK
(4) 2007 Beit Memorial Fellowship for Medical Research
(5) The role of immunomodulatory receptors in B and T cell malignancies. 2003. LRF
(6) Non-classical recognition of MHC in spondyloarthropathy. 2001. ARC.
1. HLA Class I allelic sequence and conformation regulate Leukocyte Ig-like Receptor (LILR) binding. 2011 J Immunol.186:2990-97
2. Modulation of Toll like receptor activity by Leukocyte Ig-like Receptors and their effects during bacterial infection. Mediators Inflamm 2010;2010: 536478
3. The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection. 2009. BMC Immunology 10:56
4. A common mechanism of alternative mRNA splicing generates soluble forms of LILR. 2009. Eur J. Immunol. 39: 1–12
5. Regulation of T cell immunity by LILR, innate immune receptors for self on antigen presenting cells. 2009.Immunology 127:8-17
6. A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells. 2007. J Exp Med 204(12):2813-24.
7. Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathological roles. 2006. Rheumatology 45:1338
8. MHC-I recognition by receptors on myelomonocytic cells: New tricks for old dogs? 2005. BioEssays 27:542
9. The LILR family: modulators of innate and adaptive immune pathways in health and disease. 2004. Tissue Antigens. 64:215
10. Killer Cell Ig-like receptor and leukocyte Ig-like receptor transgenic mice exhibit tissue-specific and cell-specific transgene expression 2003. J Immunol 171:3056
11. Recognition of forms of HLA B27 by leukocyte receptors. 2003. Curr Mol Med. 4:59
12. Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures. 2001. J Immunol 167:5543
13. Primitive Toll signalling: bugs, flies, worms and man 2001. Trends in Immunology 22:63
14. Evolution and transmission of stable CTL escape mutations in HIV infection. 2001. Nature. 412:334
15. Clustered Mutations in HIV-1 gag Are Consistently Required for Escape from HLA-B27-restricted Cytotoxic T Lymphocyte Responses. 2001. J Exp Med 193:375
16. Pellino-related sequences from Caenorhabditis elegans and Homo sapiens. 2000. Immunogenetics 52:145
17. Defying death after DNA damage. 2000. Nature 407:777
18. Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection. 2000. AIDS 14:225
19. The role of HLA-B27 in spondyloarthritis. 1999. Immunogenetics 50:220
20. Disassembly of nuclear inclusions in the dividing cell--a novel insight into neurodegeneration. 1999. Hum Mol Genet 8:2451
21. Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure. 1999. J Immunol 162:5045
22. Importance of a conserved TCR J alpha-encoded tyrosine for T cell recognition of an HLA B27/peptide complex. 1998. Eur J Immunol 28:2704
23. Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific. 1998. J Exp Med 188:785
24. Cutting Edge: Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC Class I molecules. 1998. J. Immunol. 160:3096
25. Multiple T cell expansions are found in the blood and synovial fluid of patients with reactive arthritis. J. Rheumatol. 1997. 24:1750
26. Identification of T cell receptor residues for a viral peptide presented by HLA B27. 1994. Eur. J. Immunol. 24:2357
- Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I moleculesM Colonna
Basel Institute for Immunology, Switzerland
J Immunol 160:3096-100. 1998..ILT4 may control inflammatory responses and cytotoxicity mediated by myelomonocytic cells and may modulate their Ag-presenting functions, focusing immune responses to microbial challenges and avoiding autoreactivity...
- A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cellsMathias Lichterfeld
Partners AIDS Research Center, Massachusetts General Hospital, and Harvard University Center for AIDS Research, Boston, MA 02129, USA
J Exp Med 204:2813-24. 2007....
- Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathological rolesT Raine
Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK
Rheumatology (Oxford) 45:1338-44. 2006..CONCLUSIONS: Our findings define normal levels and tissue expression of FHCs, and support the hypothesis that disregulation of heavy chain expression may play a pathogenic role in spondyloarthropathy...
- MHC-I recognition by receptors on myelomonocytic cells: new tricks for old dogs?Tim Raine
Department of Pathology, Cambridge University, Cambridge, UK
Bioessays 27:542-50. 2005..Our model also offers an alternative explanation of immune dysregulation rather than autoimmunity during HLA-B27-associated spondyloarthropathies and addresses a number of conundrums in this field...
- The LILR family: modulators of innate and adaptive immune pathways in health and diseaseD Brown
Immunology Division, Department of Pathology, University of Cambridge, Cambridge, England
Tissue Antigens 64:215-25. 2004..In this review, we summarize current knowledge on the nature and function of LILRs, focusing on their regulation of immune cell activity and their potential role in disease...
- Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structuresR L Allen
Department of Pathology, University of Cambridge, Cambridge, United Kingdom
J Immunol 167:5543-7. 2001..Alternative recognition of different forms of HLA-B27 by KIR or ILT could influence their immunomodulatory function and may imply a role in inflammatory disease...
- Evolution and transmission of stable CTL escape mutations in HIV infectionP J Goulder
Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 412:334-8. 2001..These data suggest that CTL escape mutations in epitopes associated with suppression of viraemia will accumulate as the epidemic progresses, and therefore have important implications for vaccine design...
- Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responsesA D Kelleher
Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
J Exp Med 193:375-86. 2001..Outgrowth of CTL escape viruses required high viral loads and additional, possibly compensatory, mutations in the gag protein...
- Pellino-related sequences from Caenorhabditis elegans and Homo sapiensT Rich
Department of Pathology, Cambridge University, UK
Immunogenetics 52:145-9. 2000
- Disassembly of nuclear inclusions in the dividing cell--a novel insight into neurodegenerationT Rich
Department of Pathology, Division of Immunology, University of Cambridge, Cambridge CB2 1QP, UK
Hum Mol Genet 8:2451-9. 1999....
- Importance of a conserved TCR J alpha-encoded tyrosine for T cell recognition of an HLA B27/peptide complexP Bowness
Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, GB
Eur J Immunol 28:2704-13. 1998..Modeling of the GRb TCR CDR3alpha loop suggests that residue Y102 contacts the HLA B*2705 alpha1 helix. It is thus possible that selection of germ-line TCRAJ-encoded residues at position 102 may be MHC driven...
- Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specificJ D Wilson
Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
J Exp Med 188:785-90. 1998....
- Modulation of Toll-like receptor activity by leukocyte Ig-like receptors and their effects during bacterial infectionLouise E Pilsbury
Centre for Infection, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
Mediators Inflamm 2010:536478. 2010..Agents have already been identified which enhances or inhibits LILR activity raising the future possibility that modulation of LILR function could be used as a means to modulate TLR activity...
- The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infectionDamien P Brown
Division of Cellular and Molecular Medicine, St Georges, University of London, Centre for Infection, London, UK
BMC Immunol 10:56. 2009..There are relatively few studies regarding these receptors in the context of infection and it is not yet clear how LILRB4 exerts its inhibitory effects...