St George's Hospital Medical School

..The emergence of Internet as an unregulated source of controlled substances is an important development that may have significant public health implications. This issue needs to be dealt with at both international and national level...

..The issue of ecstasy-related fatalities has extensively attracted the attention of both the media and the general public, but less so of the scientific literature...

..The aim of this study was to determine time trends in hospital admissions for acute appendicitis in England between 1989-1990 and 1999-2000, and in population mortality rates for appendicitis from 1979 to 1999...

..If this proved possible it would provide, for the first time, an objective quantitative measure of computer use and a measure of the attention and responsiveness of the general practitioner towards the patient...

..Assertive outreach teams have been introduced in the UK, based on the assertive community treatment (ACT) model. It is unclear how models of community care translate from one culture to another or the degree of adaptation that may result...

..The mutant mice also provide valuable models for the study of human disease...

..We suggest that this is a newly recognized autosomal recessive syndrome...

..Health professionals should encourage older people to exercise and when making home safety visits should confer with their clients, taking their preferences about adaptations into account...

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..In this review current technical aspects, clinical applications and the suggested future development of spinal cord diffusion imaging are discussed...

..This is the first study to show that non-invasive screening in early pregnancy is feasible in the community. Although swabs detected 10% more infections, nearly half the women preferred providing urine specimens...

..52), underlying disease ( P =0.94), medication and gender (2.84+/-0.72 in females vs 2.97+/-0.67 in males; P =0.431). In conclusion, our findings do not indicate any role of mtDNA in the pathophysiology of AF...

..Detection rates are suboptimal in both men and women, especially in rural areas. Adequate treatment of high BP is at a very low level. There is an urgent need for preventive strategies on hypertension control in Ghana...

..Patients involvement in teaching, assessment and formal examinations is discussed...

..Future developments will include computerising these methodologies to permit faster and more individual patient-centred measurements...

..An initial study with a small sample size suggested it provided excellent discrimination. We performed a validation study in subjects with embolic signals of known nature...

..The social networks of people with mental illness have received much attention, but users of day care services have rarely been considered...

..Sixteen previously unpublished mutations are reported, plus an estimate of the frequency of new mutations in this disorder...

..To assess a role in early atherosclerosis, we also sought associations with underlying asymptomatic atherosclerosis itself, assessed by carotid ultrasound in a community population...

..Health care interventions are often complex in themselves and are always applied in complex settings. Such interventions require a process of careful 'modelling' to maximize the chances of successful trials that will add to knowledge...

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..To investigate the effect of SR141716, a selective CB1 receptor antagonist, on energy expenditure and on glucose uptake in isolated soleus muscle of Lep(ob)/Lep(ob) mice...

..Hexa-substitution accounts for around 5-10% the glycoforms. This is, we believe, the first report of hexa-O-substitution with GalNAc of human serum IgA1...

..The purpose of this study was to investigate whether SAE might be detected by transvaginal sonography and whether this technique may be useful in the assessment of tubal patency by hysterosalpingo-contrast sonography (SAE-HyCoSy)...

..A total of 62% of patients received amisulpride doses in the range 400-800 mg/day and most (72%) required no dose adjustment. The great majority of patients (87%) switched to amisulpride without problems...

..Nicotine replacement therapy (NRT) in varying forms is becoming widely used. Clinicians, therapists and regulatory authorities are interested in the abuse liability and dependence potential of the different forms...

..7+/-0.1 kPa during respiration). The significance of these results is discussed in the context of the role(s) of vomiting as a protective reflex and as a mechanism for removal of indigestible food residues (e.g. fur, claws) from the gut...

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..The study showed a satisfactory short- and long-term reproducibility of Ptot in the atrial SAECG in healthy subjects. However, low reproducibility of the voltage parameters should be considered in clinical applications...

..Previous research suggests that glucose may reduce desire to smoke during periods of abstinence but a definitive test is needed...

..g. 5FU, ifosfamide) and their metabolites at their sites of action. The role of these state-of-the-art MR methods in imaging tumour physiology and their potential role in the clinic are discussed...

..To investigate whether changes in anthropometric measures are related to lung function decline...

..In order to test this hypothesis further we have examined whether gp120 itself can bind and present specific peptides which may be capable of eliciting 'allo' activation responses in particular hosts...

..Long-term goals of antiarrhythmic therapy include upstream approaches, such as identification of the biochemical intermediaries of the process and, eventually, of molecular and genetic lesions involved in arrhythmogenesis...

..Among those who showed evidence of active infection with a positive PCR, the most common genotype was type 2 but the subtype could not be specifically determined; these type 2 hepatitis C viruses may be indigenous to Africa...

..The proportion of lone parent families explained 42% of the variation in coverage for D3 in November 1991. This study has identified lone parenthood as an important independent risk factor in London for failure to complete immunisation...

..It is further suggested that the ventral striatum may encode the element-based representations. The model allows some new and detailed predictions for the performance of amnesic subjects related to lesion location...

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..However, QTd may be largely due to projections of the repolarization dipole rather than "nondipolar" signals...

..We describe the cases of four patients with eating disorders in whom complex interactions occurred among religious faith, pathogenesis of the eating disorder, and clinical management...

..With several different forms of nicotine replacement therapy available for smokers, it is useful to know about factors that may influence choice of form...

..Finally, in order for any strategy to be successful, the full support of hospital management is essential...

..We studied the content of CK-MB and cTnT in skeletal muscle of the renal-insufficient rat...

..These results provide the first data to indicate a functional similarity between the lizard striato-amygdaloid transition area and the mammalian central amygdala...

..article reviews current knowledge regarding the role of oestrogen deficiency in the pathogenesis of syndrome X and the potential therapeutic role of oestrogen replacement therapy in women with chest pain and normal coronary arteriograms..

..These changes correlated with executive dysfunction assessed by the Wisconsin Card Sorting Test...

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..The definitive functional significance of these oscillators is unknown at present. However, it is expected that through dynamic relationships with modulating and driving inputs, such oscillators would permit graded vascular responses...

..In contrast, myocardial fibrosis is the substrate for premature deaths from heart failure and is associated with an increased risk of a primary ventricular arrhythmia...

..Definitive trials are now required but, given their low cost, glucose tablets may be a useful aid for some smokers...

..To assess the changes in quality of life, arrhythmia symptoms, and hospital resource utilisation following catheter ablation of typical atrial flutter...

..Recent advances in molecular genetics may assist better understanding of the disease mechanisms and the search for more effective treatments...

..Unlike the human, there is little distinction between the apical trabeculations of the left and right ventricles of the mouse heart...

..The results will provide further insight into how these systems are involved in control of alcohol consumption and will form a basis for the development of novel therapeutic strategies...

..A further objective is to determine the cellular location of the increases in corticosterone and the relationship of the concentration increases to glucocorticoid receptor binding in the brain. ..