- The effect of rituximab therapy on immunoglobulin levels in patients with multisystem autoimmune diseaseHelena Marco
Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK
BMC Musculoskelet Disord 15:178. 2014..CD20 is not expressed on mature plasma cells and accordingly rituximab does not have immediate effects on immunoglobulin levels. However, after rituximab some patients develop hypogammaglobulinaemia...
- Progress in treatment of ANCA-associated vasculitisRona M Smith
Department of Renal Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB20QQ, UK
Arthritis Res Ther 14:210. 2012..As rare diseases, treatment advances in vasculitis depend on international collaborative research networks both to establish an evidence base for newer agents and to develop recommendations for patient management...
- Rituximab for remission maintenance in relapsing antineutrophil cytoplasmic antibody-associated vasculitisRona M Smith
Addenbrooke s Hospital, Cambridge, UK
Arthritis Rheum 64:3760-9. 2012..However, further relapse is common, and maintenance strategies are required. The aim of this study was to reduce relapse rates using a fixed-interval rituximab re-treatment protocol...
- Biological therapy for lupus nephritis-tribulations and trialsRona M Smith
Department of Renal Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
Nat Rev Rheumatol 6:547-52. 2010..The complexities of clinical trials in lupus nephritis have impeded the demonstration of the efficacy of new agents, but if these difficulties can be overcome, there is a real chance that outcomes in lupus nephritis will improve...