Peter B Simpson

Summary

Country: UK

Publications

  1. ncbi request reprint New directions in kinetic high information content assays
    Peter B Simpson
    Automated Imaging and Electrophysiology Group, Department of Molecular and Cellular Neuroscience, Neuroscience Research Centre, Merck Sharp and Dohme, Terlings Park, Harlow, Essex CM20 2QR, UK
    Drug Discov Today 11:237-44. 2006
  2. ncbi request reprint A morphology- and kinetics-based cascade for human neural cell high content screening
    Gillian R Richards
    The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK
    Assay Drug Dev Technol 4:143-52. 2006
  3. ncbi request reprint Methodological approaches for the study of GABA(A) receptor pharmacology and functional responses
    Alison J Smith
    Neuroscience Research Centre, Terlings Park, Merck, Sharp and Dohme Research Laboratories, Eastwick Rd, CM20 2QR, Harlow, Essex, UK
    Anal Bioanal Chem 377:843-51. 2003
  4. ncbi request reprint Native and recombinant human Edg4 receptor-mediated Ca(2+) signalling
    Peter B Simpson
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK
    Assay Drug Dev Technol 1:31-40. 2002
  5. ncbi request reprint Multiple structural features of steroids mediate subtype-selective effects on human alpha4beta3delta GABAA receptors
    Gopalan V Pillai
    Neuroscience Research Centre, Merck Sharp and Dohme, Terlings Park, Harlow, Essex CM20 2QR, UK
    Biochem Pharmacol 68:819-31. 2004
  6. ncbi request reprint High content kinetic assays of neuronal signaling implemented on BD pathway HT
    Grace K Y Chan
    Automated Imaging and Electrophysiology Group, The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK
    Assay Drug Dev Technol 3:623-36. 2005
  7. ncbi request reprint Measurement and analysis of calcium signaling in heterogeneous cell cultures
    Gillian R Richards
    The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Essex, United Kingdom
    Methods Enzymol 414:335-47. 2006
  8. ncbi request reprint High-content assays in oncology drug discovery: opportunities and challenges
    Elizabeth H Mouchet
    AstraZeneca Cancer Bioscience, Alderley Park, Macclesfield, Cheshire, SK10 3JZ, UK
    IDrugs 11:422-7. 2008

Collaborators

Detail Information

Publications8

  1. ncbi request reprint New directions in kinetic high information content assays
    Peter B Simpson
    Automated Imaging and Electrophysiology Group, Department of Molecular and Cellular Neuroscience, Neuroscience Research Centre, Merck Sharp and Dohme, Terlings Park, Harlow, Essex CM20 2QR, UK
    Drug Discov Today 11:237-44. 2006
  2. ncbi request reprint A morphology- and kinetics-based cascade for human neural cell high content screening
    Gillian R Richards
    The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK
    Assay Drug Dev Technol 4:143-52. 2006
    ....
  3. ncbi request reprint Methodological approaches for the study of GABA(A) receptor pharmacology and functional responses
    Alison J Smith
    Neuroscience Research Centre, Terlings Park, Merck, Sharp and Dohme Research Laboratories, Eastwick Rd, CM20 2QR, Harlow, Essex, UK
    Anal Bioanal Chem 377:843-51. 2003
    ....
  4. ncbi request reprint Native and recombinant human Edg4 receptor-mediated Ca(2+) signalling
    Peter B Simpson
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK
    Assay Drug Dev Technol 1:31-40. 2002
    ..This indicates that the Edg4-overexpressing Rh7777 cell line is a very useful model system for studying receptor pharmacology and signalling mechanisms, and for investigating the Edg4 receptor's downstream effects...
  5. ncbi request reprint Multiple structural features of steroids mediate subtype-selective effects on human alpha4beta3delta GABAA receptors
    Gopalan V Pillai
    Neuroscience Research Centre, Merck Sharp and Dohme, Terlings Park, Harlow, Essex CM20 2QR, UK
    Biochem Pharmacol 68:819-31. 2004
    ..Molecular modelling on this compound series using principal components analysis indicates that several structural features of steroids underlie their relative functional selectivity for potentiation of delta-containing GABAA receptors...
  6. ncbi request reprint High content kinetic assays of neuronal signaling implemented on BD pathway HT
    Grace K Y Chan
    Automated Imaging and Electrophysiology Group, The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK
    Assay Drug Dev Technol 3:623-36. 2005
    ..To maximize both throughput and reproducibility, walk-away automation integration of this bioimaging technology has been implemented, producing an affordable, compact platform for fully automated kinetic HCS...
  7. ncbi request reprint Measurement and analysis of calcium signaling in heterogeneous cell cultures
    Gillian R Richards
    The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Essex, United Kingdom
    Methods Enzymol 414:335-47. 2006
    ..The combination of these techniques represents a powerful tool for drug discovery...
  8. ncbi request reprint High-content assays in oncology drug discovery: opportunities and challenges
    Elizabeth H Mouchet
    AstraZeneca Cancer Bioscience, Alderley Park, Macclesfield, Cheshire, SK10 3JZ, UK
    IDrugs 11:422-7. 2008
    ..The trends, challenges and considerations for HCS that affect the successful and pragmatic implementation of this process in drug discovery will be outlined...