Giuliano Siligardi

Summary

Country: UK

Publications

  1. Bortolini C, Kartanas T, Copic D, Condado Morales I, Zhang Y, Challa P, et al. Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism. Lab Chip. 2018;19:50-58 pubmed publisher
  2. Hussain R, Longo E, Siligardi G. UV-Denaturation Assay to Assess Protein Photostability and Ligand-Binding Interactions Using the High Photon Flux of Diamond B23 Beamline for SRCD. Molecules. 2018;23: pubmed publisher
  3. Veraldi N, Hughes A, Rudd T, Thomas H, Edwards S, Hadfield L, et al. Heparin derivatives for the targeting of multiple activities in the inflammatory response. Carbohydr Polym. 2015;117:400-7 pubmed publisher
    ..It is therefore feasible in principle to modulate several activities, while minimising anticoagulant side effects, providing a platform from which improved anti-inflammatory agents might be developed. ..
  4. Siligardi G, Hussain R. CD spectroscopy: an essential tool for quality control of protein folding. Methods Mol Biol. 2015;1261:255-76 pubmed publisher
  5. Longo E, Hussain R, Siligardi G. Application of circular dichroism and magnetic circular dichroism for assessing biopharmaceuticals formulations photo-stability and small ligands binding properties. Int J Pharm. 2015;480:84-91 pubmed publisher
    ..Finally, we applied MCD in ligand interaction to key proteins such as lysozyme, comparing the human with the hen enzyme in the binding of N,N',N''-triacetylchitotriose. ..
  6. Ruzza P, Hussain R, Biondi B, Calderan A, Tessari I, Bubacco L, et al. Effects of Trehalose on Thermodynamic Properties of Alpha-synuclein Revealed through Synchrotron Radiation Circular Dichroism. Biomolecules. 2015;5:724-34 pubmed publisher
    ..These results suggested that trehalose could be associated with other drugs leading to a new approach for treating Parkinson's and other brain-related diseases. ..