Paul G Shiels
- Biological Ageing, Inflammation and Nutrition: How Might They Impact on Systemic Sclerosis?Paul G Shiels
Glasgow Ageing Research Network, Wolfson Wohl Translational Research Centre, Institute of Cancer Sciences, MVLS, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK
Curr Aging Sci 8:123-30. 2015..Importantly, this chapter will provide a context for transgenerational and other epigenetic effects, which are emerging as contributory components in disease susceptibility and progression. ..
- Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohortPaul G Shiels
Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland
PLoS ONE 6:e22521. 2011....
- Pre-transplant CDKN2A expression in kidney biopsies predicts renal function and is a future component of donor scoring criteriaMarc Gingell-Littlejohn
University of Glasgow, College of Medical, Veterinary and Life Sciences, Institute of Cancer Sciences, Glasgow, United Kingdom
PLoS ONE 8:e68133. 2013..A pre-transplant donor risk classification system based on CDKN2A and ECD criteria is shown to be feasible and commendable for implementation in the near future...
- Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health studyRajeev Krishnadas
Sackler Institute of Psychobiological Research, Southern General Hospital, Glasgow, Scotland, UK
Psychosom Med 75:616-23. 2013..The aim of this study was to examine the association between neighborhood-level deprivation and the morphology of cortical regions associated with language and executive control in adults...
- Socioeconomic status and the cerebellar grey matter volume. Data from a well-characterised population sampleJonathan Cavanagh
Sackler Institute of Psychobiological Research, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK
Cerebellum 12:882-91. 2013..These findings provide data on the relationship between socioeconomic deprivation and a brain region highly sensitive to environmental factors. ..
- Socio-economic status is associated with epigenetic differences in the pSoBid cohortDagmara McGuinness
Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
Int J Epidemiol 41:151-60. 2012....
- Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland?Geoff Der
Social and Public Health Sciences Unit, Medical Research Council, Glasgow, United Kingdom
PLoS ONE 7:e45166. 2012..Telomere length has attracted a great deal of attention as a candidate BoA. We investigate whether it meets the criteria to be considered as a single biomarker of aging, and whether it makes a useful contribution to a composite measure...
- Personality, socio-economic status and inflammation: cross-sectional, population-based studyKeith Millar
College of Medical, Veterinary and Life Sciences, Institute of Mental Health and Wellbeing, University of Glasgow, Glasgow, Scotland
PLoS ONE 8:e58256. 2013....
- Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 StudyTony Robertson
Medical Research Council s Social and Public Health Sciences Unit, Glasgow, United Kingdom
PLoS ONE 7:e41805. 2012....
- Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes?Ashley M Miller
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
PLoS ONE 7:e47830. 2012..Further mechanistic studies determining how sST2 is linked to diabetes pathways may offer new insights into the inflammatory paradigm for type 2 diabetes...
- Early life socioeconomic status, chronic physiological stress and hippocampal N-acetyl aspartate concentrationsJohn McLean
Sackler Institute of Psychobiological Research, Institute of Health and Wellbeing University of Glasgow, Glasgow G51 4TF, Scotland, United Kingdom
Behav Brain Res 235:225-30. 2012..In this study, we investigated whether early life socioeconomic status is associated with changes in the hippocampus N-acetyl aspartate (NAA), using the non-invasive technique of magnetic resonance spectroscopy (MRS)...
- Telomere attrition and decreased fetuin-A levels indicate accelerated biological aging and are implicated in the pathogenesis of colorectal cancerFraser Maxwell
Department of Surgery, Institute of Cancer Sciences, University of Glasgow, Western Infirmary, Scotland, UK
Clin Cancer Res 17:5573-81. 2011..An understanding of the biology of aging and factors which regulate it may provide insight into cancer pathogenesis. The role of telomere biology in both the cancer and aging process could prove useful in this regard...
- SIRT2: tumour suppressor or tumour promoter in operable breast cancer?Liane M McGlynn
Institute of Cancer Sciences, University of Glasgow, Glasgow G11 6NT, UK
Eur J Cancer 50:290-301. 2014..Little is known about their role in breast tumourigenesis. We sought to evaluate the seven sirtuin family members (SIRT1-7) in a human breast cancer cohort, in relation to clinico-pathological features and outcome of the disease...
- Accelerated biological ageing in HIV-infected individuals in South Africa: a case-control studySophia Pathai
aInternational Centre for Eye Health, Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK bDesmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa cDepartment of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London dInstitute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland eMRC Tropical Epidemiology Group, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
AIDS 27:2375-84. 2013..The study aimed to assess biological ageing in South African HIV-infected adults and HIV-seronegative individuals using two validated biomarkers, telomere length and CDKN2A expression (a mediator of cellular senescence)...
- Pancreatic-derived pathfinder cells enable regeneration of critically damaged adult pancreatic tissue and completely reverse streptozotocin-induced diabetesKaren Stevenson
University of Glasgow, Institute of Cancer Sciences, Western Infirmary Glasgow, Glasgow, United Kingdom
Rejuvenation Res 14:163-71. 2011..Critically, they enhance our understanding of the mechanisms relating to such repair and suggest a means for novel therapeutic intervention in loss of tissue and organ function with age...
- Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C diseaseMark W Robinson
MRC University of Glasgow Centre for Virus Research, Glasgow, UK
Aging Cell 12:1141-3. 2013..The CDKN2 locus may provide a link between C-HC and increased susceptibility to age-associated diseases and provides novel biomarkers for assessing its impact on aging processes in man. ..
- SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer PatientsLiane M McGlynn
Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
PLoS ONE 10:e0131344. 2015....
- Pathfinder cells provide a novel therapeutic intervention for acute kidney injuryLiane M McGlynn
Instititute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
Rejuvenation Res 16:11-20. 2013..It validates the use of PCs to regenerate damaged tissues and also offers a novel therapeutic intervention for repair of solid organ damage in situ...
- Association between telomere length and heart disease in a narrow age cohort of older peopleJohn M Starr
Geriatric Medicine Unit, University of Edinburgh, The Royal Victoria Hospital, Craigleith Road, Edinburgh, Scotland, UK
Exp Gerontol 42:571-3. 2007..Telomere shortening in peripheral blood leukocytes is a promising index of ischemic heart disease risk in older people and deserves further investigation as a potential mechanism...
- Dynamic study of oxidative stress in renal dialysis patients based on breath ethane measured by optical spectroscopyClaire S Patterson
Department of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ, UK
J Breath Res 1:026005. 2007..We comment on how further refinements of our technology will allow a more detailed evaluation of the ethane elevation effect and ultimately lead to the assessment of potential interventions...
- Nitrones for understanding and ameliorating the oxidative stress associated with agingSiham El Fangour
Centre for the Chemical Research of Ageing, WestCHEM Department of Chemistry, University of Glasgow, Glasgow, UK
Age (Dordr) 31:269-76. 2009..g. for slowing cellular aging, and as tools for chemical biology. Two low-molecular weight nitrones, DIPEGN-2 and DIPEGN-3, are reported, which combine high water-solubility with high lipophilicity and obey Lipinski's rule of five...
- Cellular senescence in pretransplant renal biopsies predicts postoperative organ functionLiane M McGlynn
Department of Surgery, University of Glasgow, UK
Aging Cell 8:45-51. 2009..7% ( p = 0.001) at 1 year posttransplant. Thus, these data indicate that allograft biological age is an important novel prognostic determinant for renal transplant outcome...
- Identification of Molecular Markers of Delayed Graft Function Based on the Regulation of Biological AgeingDagmara McGuinness
University of Glasgow, College of Medical, Veterinary and Life Sciences, Wolfson Wohl Translational Research Centre, Institute of Cancer Sciences, Garscube Estate, Switchback Road, Glasgow, G61 1QH, Scotland
PLoS ONE 11:e0146378. 2016..It can result in a significant increase in the necessity for hospitalisation post-transplant and is a significant risk factor for other post-transplant complications...