Gavin P Reynolds

Summary

Affiliation: Sheffield Hallam University
Country: UK

Publications

  1. doi request reprint The obesity risk gene FTO influences body mass in chronic schizophrenia but not initial antipsychotic drug-induced weight gain in first-episode patients
    Gavin P Reynolds
    Department of Psychiatry, Queen s University Belfast, Belfast, UK
    Int J Neuropsychopharmacol 16:1421-5. 2013
  2. doi request reprint Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia
    Olga O Yevtushenko
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Br J Psychiatry 192:424-8. 2008
  3. ncbi request reprint Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis
    Lucy A Templeman
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Pharmacogenet Genomics 15:195-200. 2005
  4. ncbi request reprint The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment
    Gavin P Reynolds
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Prog Neuropsychopharmacol Biol Psychiatry 29:1021-8. 2005
  5. ncbi request reprint Clozapine, but not haloperidol, increases neuropeptide Y neuronal expression in the rat hypothalamus
    Shona L Kirk
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Belfast, UK
    J Psychopharmacol 20:577-9. 2006
  6. ncbi request reprint Neonatal lipopolysaccharide induces pathological changes in parvalbumin immunoreactivity in the hippocampus of the rat
    Trisha A Jenkins
    Department of Psychiatry, Queen s University Belfast, Northern Ireland, UK
    Behav Brain Res 205:355-9. 2009
  7. ncbi request reprint The 5-HT2C receptor and antipsychoticinduced weight gain - mechanisms and genetics
    Gavin P Reynolds
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Belfast, UK
    J Psychopharmacol 20:15-8. 2006
  8. ncbi request reprint Pharmacogenetics of schizophrenia
    Gavin P Reynolds
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Expert Opin Pharmacother 7:1429-40. 2006
  9. ncbi request reprint Olanzapine-induced weight gain in the rat: role of 5-HT2C and histamine H1 receptors
    Shona L Kirk
    Department of Psychiatry, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, UK
    Psychopharmacology (Berl) 207:119-25. 2009
  10. ncbi request reprint Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response
    Gavin P Reynolds
    Department of Mental Health, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Eur Neuropsychopharmacol 15:143-51. 2005

Detail Information

Publications20

  1. doi request reprint The obesity risk gene FTO influences body mass in chronic schizophrenia but not initial antipsychotic drug-induced weight gain in first-episode patients
    Gavin P Reynolds
    Department of Psychiatry, Queen s University Belfast, Belfast, UK
    Int J Neuropsychopharmacol 16:1421-5. 2013
    ..These findings indicate that FTO genotype has a major effect on body weight determined by BMI in chronically treated patients with schizophrenia...
  2. doi request reprint Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia
    Olga O Yevtushenko
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Br J Psychiatry 192:424-8. 2008
    ..Obesity and metabolic syndrome are significant problems for patients taking antipsychotic drugs. Evidence is emerging of genetic risk factors...
  3. ncbi request reprint Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis
    Lucy A Templeman
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Pharmacogenet Genomics 15:195-200. 2005
    ..We have investigated whether these effects remain true in a Caucasian population and following longer term treatment...
  4. ncbi request reprint The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment
    Gavin P Reynolds
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Prog Neuropsychopharmacol Biol Psychiatry 29:1021-8. 2005
    ..Such studies clearly demonstrate the potential of pharmacogenetics in optimising treatment for the individual patient...
  5. ncbi request reprint Clozapine, but not haloperidol, increases neuropeptide Y neuronal expression in the rat hypothalamus
    Shona L Kirk
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Belfast, UK
    J Psychopharmacol 20:577-9. 2006
    ..p.) for 3 weeks. Clozapine, but not haloperidol, produced an increase in NPY immunoreactivity in the ARC, suggesting that effects on NPY may be involved in increases in body weight following clozapine treatment...
  6. ncbi request reprint Neonatal lipopolysaccharide induces pathological changes in parvalbumin immunoreactivity in the hippocampus of the rat
    Trisha A Jenkins
    Department of Psychiatry, Queen s University Belfast, Northern Ireland, UK
    Behav Brain Res 205:355-9. 2009
    ..No changes were observed in prefrontal cortex. These results show that neonatal LPS results in pathophysiological brain changes in hippocampal CA1-CA3 subregions...
  7. ncbi request reprint The 5-HT2C receptor and antipsychoticinduced weight gain - mechanisms and genetics
    Gavin P Reynolds
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Belfast, UK
    J Psychopharmacol 20:15-8. 2006
    ..These findings demonstrate the value of pharmacogenetics in determining liability to a major side effect of antipsychotic treatment, and indicate both the molecular and physiological mechanisms underlying this side effect...
  8. ncbi request reprint Pharmacogenetics of schizophrenia
    Gavin P Reynolds
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Expert Opin Pharmacother 7:1429-40. 2006
    ....
  9. ncbi request reprint Olanzapine-induced weight gain in the rat: role of 5-HT2C and histamine H1 receptors
    Shona L Kirk
    Department of Psychiatry, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, UK
    Psychopharmacology (Berl) 207:119-25. 2009
    ..Substantial increases in body weight can be induced by several antipsychotic drugs, most notably olanzapine and clozapine. Antagonism at certain receptors, particularly 5-HT2C and histamine H1 receptors, is implicated in this effect...
  10. ncbi request reprint Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response
    Gavin P Reynolds
    Department of Mental Health, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Eur Neuropsychopharmacol 15:143-51. 2005
    ..01) was apparent, again reflecting improvements in negative and general symptoms but not changes in positive symptoms...
  11. ncbi request reprint Acute and chronic tryptophan depletion differentially regulate central 5-HT1A and 5-HT 2A receptor binding in the rat
    Marie Cahir
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla, 97 Lisburn Road, Northern Ireland, UK
    Psychopharmacology (Berl) 190:497-506. 2007
    ..Tryptophan depletion is used to reduce central serotonergic function and to investigate its role in psychiatric illness. Despite widespread clinical use, its effects on serotonin (5-HT) receptors have not been well characterized...
  12. ncbi request reprint Acute tryptophan depletion does not alter central or plasma brain-derived neurotrophic factor in the rat
    Marie Cahir
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Northern Ireland, UK
    Eur Neuropsychopharmacol 18:317-22. 2008
    ..However, plasma or central BDNF protein levels in the hippocampus and midbrain were not significantly altered by ATD. These results suggest that changes in central BDNF do not contribute to the cognitive or mood effects of ATD...
  13. ncbi request reprint The impact of pharmacogenetics on the development and use of antipsychotic drugs
    Gavin P Reynolds
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Drug Discov Today 12:953-9. 2007
    ....
  14. doi request reprint Metabolic side effects of antipsychotic drug treatment--pharmacological mechanisms
    Gavin P Reynolds
    Department of Psychiatry, Queen s University Belfast, Belfast BT9 7BL, UK
    Pharmacol Ther 125:169-79. 2010
    ..Understanding the pharmacology of metabolic consequences of current antipsychotic drug treatment is clearly the key to developing improved pharmacotherapies that avoid these problematic and limiting adverse effects...
  15. doi request reprint Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain
    Matthew J Hill
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT97BL, UK
    Pharmacogenomics 12:727-34. 2011
    ..Establishing associated polymorphisms as causal variants may aid in the identification of the molecular mechanisms of phenotypic variation...
  16. doi request reprint Effect of pretreatment with risperidone on phencyclidine-induced disruptions in object recognition memory and prefrontal cortex parvalbumin immunoreactivity in the rat
    Claire E McKibben
    Department of Psychiatry, Queen s University Belfast, Northern Ireland, United Kingdom
    Behav Brain Res 208:132-6. 2010
    ..These results show the importance of the sub-chronic phencyclidine rat in modelling cognitive and prefrontal pathophysiology observed in schizophrenia, but suggest that concurrent risperidone is not neuroprotective in this model...
  17. ncbi request reprint Chronic haloperidol or clozapine treatment does not alter parvalbumin immunoreactivity in the rat frontal cortex or hippocampus
    Marie Cahir
    Department of Mental Health, The Queen s University of Belfast, Whitla Medical Building, 97 Lisburn Rd, Belfast, BT9 7BL, UK
    Neurosci Lett 373:57-60. 2005
    ....
  18. ncbi request reprint The NR1 subunit of the glutamate/NMDA receptor in the superior temporal cortex in schizophrenia and affective disorders
    Sutisa Nudmamud-Thanoi
    Division of Psychiatry and Neuroscience, Queen s University Belfast, White Medical Building, Belfast BT97BL, UK
    Neurosci Lett 372:173-7. 2004
    ..The findings in affective disorders are interesting in respect of reports of cortical NMDA receptor deficits in suicide victims, although antidepressant drug treatment may contribute to these changes...
  19. ncbi request reprint Receptor mechanisms in the treatment of schizophrenia
    Gavin P Reynolds
    Department of Mental Health, Queen s University Belfast, Belfast, UK
    J Psychopharmacol 18:340-5. 2004
    ..Some drugs, notably the D2 partial agonists, can provide antipsychotic effects without the emergence of several of the seproblematic side-effects, which bodes well for future treatment...
  20. doi request reprint Differential regional N-acetylaspartate deficits in postmortem brain in schizophrenia, bipolar disorder and major depressive disorder
    Lindsay M Reynolds
    Department of Psychiatry, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Psychiatr Res 45:54-9. 2011
    ..The deficits in NAA reported in this study confirm the importance of hippocampal and other subcortical structures in the neuropathology of the major psychiatric disorders...