K D Rainsford

Summary

Affiliation: Sheffield Hallam University
Country: UK

Publications

  1. ncbi Ibuprofen: pharmacology, efficacy and safety
    K D Rainsford
    Emeritus Professor of Biomedical Sciences, Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK
    Inflammopharmacology 17:275-342. 2009
  2. ncbi Anti-inflammatory drugs in the 21st century
    K D Rainsford
    Biomedical Research Centre, Faculty of Health and Wellbeing, Sheffield Hallam University, Howard Street, Sheffield, SI 1WB, UK
    Subcell Biochem 42:3-27. 2007
  3. ncbi Nimesulide -- a multifactorial approach to inflammation and pain: scientific and clinical consensus
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK
    Curr Med Res Opin 22:1161-70. 2006
  4. ncbi Professor William Watson Buchanan, MB ChB, MD, FRCP (Glas., Edin., C.), FRACP, FRCP (Hon; Ireland), FACR (Hon) (4.7.1930-28.1.2006)
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK
    Inflammopharmacology 14:103-19. 2006
  5. ncbi Influenza ("Bird Flu"), inflammation and anti-inflammatory/analgesic drugs
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK
    Inflammopharmacology 14:2-9. 2006
  6. ncbi Introduction - The coxib controversies
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, UK
    Inflammopharmacology 13:331-41. 2005
  7. ncbi Professor Derek Albert Willoughby (1930-2004)
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Sheffield S1 1WB, UK
    Inflammopharmacology 12:407-39. 2005
  8. ncbi Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, S1 1WB, UK
    Inflammopharmacology 14:120-37. 2006
  9. ncbi Paracetamol [acetaminophen]-induced gastrotoxicity: revealed by induced hyperacidity in combination with acute or chronic inflammation
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, S1 1WB, UK
    Inflammopharmacology 14:150-4. 2006
  10. ncbi The macrophage lineage as a mediator of remodelling disease: focussed topic meeting organized by the Inflammation Research Association, Hilton Hotel, East Brunswick, NJ, USA, 17th March 2006
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK
    Inflammopharmacology 14:179-84. 2006

Detail Information

Publications31

  1. ncbi Ibuprofen: pharmacology, efficacy and safety
    K D Rainsford
    Emeritus Professor of Biomedical Sciences, Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK
    Inflammopharmacology 17:275-342. 2009
    ....
  2. ncbi Anti-inflammatory drugs in the 21st century
    K D Rainsford
    Biomedical Research Centre, Faculty of Health and Wellbeing, Sheffield Hallam University, Howard Street, Sheffield, SI 1WB, UK
    Subcell Biochem 42:3-27. 2007
    ....
  3. ncbi Nimesulide -- a multifactorial approach to inflammation and pain: scientific and clinical consensus
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK
    Curr Med Res Opin 22:1161-70. 2006
    ....
  4. ncbi Professor William Watson Buchanan, MB ChB, MD, FRCP (Glas., Edin., C.), FRACP, FRCP (Hon; Ireland), FACR (Hon) (4.7.1930-28.1.2006)
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK
    Inflammopharmacology 14:103-19. 2006
  5. ncbi Influenza ("Bird Flu"), inflammation and anti-inflammatory/analgesic drugs
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK
    Inflammopharmacology 14:2-9. 2006
    ....
  6. ncbi Introduction - The coxib controversies
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, UK
    Inflammopharmacology 13:331-41. 2005
    ..Coxibs should be set aside in a group of their own within the broader category of the NSAIDs in view of both their cardiovascular risk and unique pharmacology...
  7. ncbi Professor Derek Albert Willoughby (1930-2004)
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Sheffield S1 1WB, UK
    Inflammopharmacology 12:407-39. 2005
  8. ncbi Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, S1 1WB, UK
    Inflammopharmacology 14:120-37. 2006
    ..5 and lipophilicity) as well as inhibiting of mast cell derived histamine and acid secretion in the stomach. In contrast with the coxibs, nimesulide has not been found to have appreciable cardiovascular toxicity...
  9. ncbi Paracetamol [acetaminophen]-induced gastrotoxicity: revealed by induced hyperacidity in combination with acute or chronic inflammation
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, S1 1WB, UK
    Inflammopharmacology 14:150-4. 2006
    ..Removing one of these three predisposing factors effectively blunts/abolishes expression of this paracetamol-induced gastrotoxicity in rats. These three factors, without paracetamol, did not cause significant acute gastropathy...
  10. ncbi The macrophage lineage as a mediator of remodelling disease: focussed topic meeting organized by the Inflammation Research Association, Hilton Hotel, East Brunswick, NJ, USA, 17th March 2006
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK
    Inflammopharmacology 14:179-84. 2006
  11. ncbi Review of the pharmaceutical properties and clinical effects of the topical NSAID formulation, diclofenac epolamine
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK
    Curr Med Res Opin 24:2967-92. 2008
    ..Topical formulations of non-steroidal anti-inflammatory drugs (NSAIDs), in particular diclofenac (DI), have become popular for treating various acute and chronic painful inflammatory conditions...
  12. ncbi Effects of nimesulide and its metabolites or manufacturing intermediates on the viability and growth of the human hepatoma HepG2 cell line
    K D Rainsford
    Biomedical Research Centre, Divisions of Biomedical Sciences and Chemistry, Sheffield Hallam University, UK
    Life Sci 69:2965-73. 2001
    ..The results showed that there was no appreciable cytotoxic activity exhibited by nimesulide and its principle metabolites or production intermediates on HepG2 cells...
  13. ncbi The ever-emerging anti-inflammatories. Have there been any real advances?
    K D Rainsford
    Biomedical Research Centre and Division of Biomedical Sciences, Sheffield Hallam University, Sheffield S1 1WB, UK
    J Physiol Paris 95:11-9. 2001
    ..g. vasoconstriction, leucocyte accumulation). Clearly, the need to develop newer NSAIDs with lower risks of ulcers and bleeding as well as symptomatic ADRs is still representing a major challenge...
  14. ncbi Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro
    Estery C Mbvundula
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, S1 1WB, UK
    J Pharm Pharmacol 58:351-8. 2006
    ..Cannabinoids could also be producing these effects via inhibition of NF-kappaB activation...
  15. ncbi Osteoarthritis of the knee and hip. Part II: therapy with ibuprofen and a review of clinical trials
    Aleem Adatia
    Department of Medicine, McMaster University Faculty of Health Sciences, Hamilton, ON, Canada
    J Pharm Pharmacol 64:626-36. 2012
    ..In the context of our previous paper's exploration of the aetiology and pathogenesis of OA as a basis for pharmacotherapy, we discuss the pharmacokinetics (PK) and clinical pharmacodynamics (PD) of ibuprofen relevant to OA...
  16. ncbi Geoffrey Buckle West DSc, FRPharmS
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, UK
    Inflammopharmacology 14:77-88. 2006
  17. ncbi Differential effects of non-genotoxic carcinogens and proliferating agents on cell growth, survival and apoptosis in hepatic cells in vitro
    T J Holmes
    Biomedical Research Centre and Division of Biomedical Sciences, Sheffield Hallam University, UK
    Life Sci 69:2975-92. 2001
    ..The results emphasize the importance of considering necrotic reactions from effects on apoptosis in detecting non-genotoxic carcinogens...
  18. ncbi Gastrointestinal mucosal injury following repeated daily oral administration of conventional formulations of indometacin and other non-steroidal anti-inflammatory drugs to pigs: a model for human gastrointestinal disease
    K D Rainsford
    Biomedical Research Centre, Sheffield Hallam University, Sheffield S1 1WB, UK
    J Pharm Pharmacol 55:661-8. 2003
    ..g. the proximal regions of the large intestine)...
  19. ncbi Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage
    Estery C Mbvundula
    Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield S11WB, UK
    Biochem Pharmacol 69:635-40. 2005
    ..The results suggest that some cannabinoids may prevent cartilage resorption, in part, by inhibiting cytokine-induced NO production by chondrocytes and also by inhibiting proteoglycan degradation...
  20. ncbi Synthesis and anti-inflammatory properties of some aromatic and heterocyclic aromatic curcuminoids
    M Akram Khan
    Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield S11WB, UK
    Bioorg Chem 40:30-8. 2012
    ..Thus, these novel curcuminoids, such as RK-106, may warrant the development of new low gastro-toxic anti-inflammatory agents with selective inhibitory activity of cytokine inflammatory mediators...
  21. ncbi Cannabinoids in pain and inflammation
    Estery C Mbvundula
    Biomedical Research Centre, Sheffield Hallam University, School of Science and Mathematics, Howard Street, Sheffield, S1 1WB, UK
    Inflammopharmacology 12:99-114. 2004
    ....
  22. ncbi Inhibition by leukotriene inhibitors, and calcium and platelet-activating factor antagonists, of acute gastric and intestinal damage in arthritic rats and in cholinomimetic-treated mice
    K D Rainsford
    Division of Biomedical Sciences and Biomedical Research Centre, Sheffield Hallam University, England, UK
    J Pharm Pharmacol 51:331-9. 1999
    ..These results show that 5-lipoxygenase products and intracellular calcium play a major role in acute gastric and intestinal damage by the NSAIDs, but platelet-activating factor has little or no appreciable involvement...
  23. ncbi Osteoarthritis of the knee and hip. Part I: aetiology and pathogenesis as a basis for pharmacotherapy
    Aleem Adatia
    Department of Medicine, McMaster University Faculty of Health Sciences, Hamilton, ON, Canada
    J Pharm Pharmacol 64:617-25. 2012
    ..To obtain insight into the extent of pathological changes in hip and knee OA we reviewed current literature on the pathogenesis of this state as a basis for current pharmacotherapy options...
  24. ncbi A novel compound from celery seed with a bactericidal effect against Helicobacter pylori
    Yong Zhou
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK
    J Pharm Pharmacol 61:1067-77. 2009
    ..The aim was to purify and characterise an antimicrobial component from celery (Apium graveolens) seeds, which have been used for centuries as a herbal medicine with reported antibacterial effects...
  25. ncbi Chronic effects of celecoxib, a cyclooxygenase-2 inhibitor, cause enhanced alcohol-induced liver steatosis in rats
    I L Bykov
    Department of Mental Health and Alcohol Research, Alcohol Research Center, National Public Health Institute, POB 33, 00251 Helsinki, Finland
    Inflammopharmacology 14:36-41. 2006
    ..It is suggested that reduction in PGE(2) by treatment with celecoxib removes the endogenous protective effect of this prostaglandin...
  26. ncbi Management of chronic musculoskeletal pain in the elderly: opinions on oral medication use
    W F Kean
    Department of Medicine Rheumatology, Faculty of Health Sciences, McMaster University, 401 1 Young Street, Hamilton, Ontario, Canada L8N IT8
    Inflammopharmacology 16:53-75. 2008
    ....
  27. ncbi Lipoxygenase inhibition: the neglected frontier for regulating chronic inflammation and pain
    M W Whitehouse
    Inflammopharmacology 14:99-102. 2006
  28. ncbi Requirements for manuscripts on the pharmacological or inflammatory properties of natural products
    K D Rainsford
    Inflammopharmacology 15:179-80. 2007
  29. ncbi Determinants of the short-term gastric damage caused by NSAIDs in man
    I Bjarnason
    Department of Medicine, Guy s, King s, St Thomas Medical School, London, UK
    Aliment Pharmacol Ther 26:95-106. 2007
    ..4))...
  30. ncbi New combinations of anti-inflammatories for therapy of arthritic, neurological and malignant diseases
    K D Rainsford
    Inflammopharmacology 12:211-3. 2004
  31. ncbi Effects of misoprostol on the pharmacokinetics of indomethacin in human volunteers
    K D Rainsford
    Department of Biomedical Sciences, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    Clin Pharmacol Ther 51:415-21. 1992
    ..Thus misoprostol does not interfere with the absorption of indomethacin despite the known inhibitory effects of this protaglandin analog on acid secretion...