Research Topics
| Jerard SeghatchianSummaryCountry: UK Publications
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Detail Information
Publications
Validation of different enrichment strategies for analysis of leucocyte sub-populations: development and application of a new approach, based on leucofiltrationJerard Seghatchian
National Blood Service, London and South East, Colindale, UK
Transfus Apher Sci 26:61-72. 2002..This one-step procedure has the advantage of concentrating both native and atypical leucocytes seen in blood components. The latter may account for lack of interchangeability of results obtained by various counting methods...
Massive transfusion: an overview of the main characteristics and potential risks associated with substances used for correction of a coagulopathyJerard Seghatchian
International Consultancy in Blood Components Technology, 50 Primrose Hill Road, London NW3 3AA, England, UK
Transfus Apher Sci 47:235-43. 2012....- Characteristics of the THERAFLEX UV-Platelets pathogen inactivation system - an updateJerard Seghatchian
Blood Components Technology and Haemostasis Thrombosis Consultancy, 50 Primrose Hill Road, London, UK
Transfus Apher Sci 46:221-9. 2012.... - What is happening? Are the current acceptance criteria for therapeutic plasma adequate?Jerard Seghatchian
Blood Component Technology and Haemostasis Thrombosis Consultant, 50 Primrose Hill Road, London NW3 3AA, UK
Transfus Apher Sci 31:67-73. 2004..Moreover additional streamlining of FFP production, using selective donor panel, will improve the uniformity of therapeutic plasma and lower the potential risks of transfusion reactions... - Blood cell apoptosis/necrosis: some clinical and laboratory aspectsJerard Seghatchiana
Blood Component Technology Consultancy London, England
Ann N Y Acad Sci 1010:540-7. 2003..It is concluded that apoptotic cells potentially contribute to transfusion reactions in donor/recipient-specific ways... - Pathogen-reduction systems for blood components: the current position and future trendsJerard Seghatchian
Blood Components Apheresis Technologies and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA England, UK
Transfus Apher Sci 35:189-96. 2006..The status of pathogen reduction of whole blood and red cells is also highlighted, though the progress in this area has been virtually stopped after the finding of antibody development in the clinical trial... - Elevated FXIIIA and serine proteases upon filtration of platelet concentrate on negatively charged filters: comparison with other established haemostatic markers of platelet activation and storage lesionJerard Seghatchian
Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
Transfus Apher Sci 29:123-5. 2003.... - A novel method for the assessment of pro- and anti-coagulant properties of platelet-derived microvesicles and its usefulness for quality monitoring of platelet haemostatic functionJ Seghatchian
Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
Transfus Apher Sci 29:119-21. 2003..While the pro-coagulant activity of the isolated MV increased on day 5 as compared to day 1, the anti-coagulant activity was significantly reduced... - Universal leucodepletion: an overview of some unresolved issues and the highlights of lessons learnedJerard Seghatchian
Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NWS 3AA, UK
Transfus Apher Sci 29:105-17. 2003..This overview briefly highlights some of the unresolved issues related to ULD, based on the experience in the UK. Technical details can be found in the reading list provided at the end... - A new platelet storage lesion index based on paired samples, without and with EDTA and cell counting: comparison of three types of leukoreduced preparationsJerard Seghatchian
Blood Components Apheresis Technologies and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, England, UK
Transfus Apher Sci 35:283-92. 2006..The relationship between this in vitro response to clinical outcome remains to be established... - Platelet storage lesion: an update on the impact of various leukoreduction processes on the biological response modifiersJerard Seghatchian
Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
Transfus Apher Sci 34:125-30. 2006.... - Effect of pathogen inactivation on the storage lesion in red cells and platelet concentratesJerard Seghatchian
Blood Components Technology Consultancy, 50 Primrose Hill Road, London, UK
Transfus Apher Sci 45:75-84. 2011..Validated haematological assays should be utilized to test the extent of the blood storage lesion. Post-marketing surveillance involving active haemovigilance is necessary regarding possible adverse outcomes of transfusion... - Updates on pathogen inactivation of plasma using Theraflex methylene blue systemJerard Seghatchian
Blood Components Technology and Haemostasis Thrombosis Consultancy, 50 Primrose Hill Road, London, UK
Transfus Apher Sci 38:271-80. 2008..Emphasises will be placed on most recent literature and updated information available... - Current opinions on safer red cell transfusion practice and the appropriate use of alternative strategiesJerard Seghatchian
Blood Components Apheresis Technology and Haemostasis Thrombosis Consultancy, London, England, UK
Transfus Apher Sci 37:201-7. 2007..The current opinions on "safer transfusion" through the use of currently available alternatives are highlighted with the goal of promoting the use of transfusion alternatives in everyday clinical practice... - An overview of unresolved inherent problems associated with red cell transfusion and potential use of artificial oxygen carriers and ECO-RBC: current status/future trendsJerard Seghatchian
Blood Components Apheresis Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
Transfus Apher Sci 37:251-9. 2007..Finally, the current progress on universal RBC, known as ECO-cells is highlighted and, in the future perspectives, some of the current efforts in making the red cells transfusion safer and more efficacious are briefly addressed... - Commentary on the current opinions on blood components safety/efficacyJerard Seghatchian
Transfus Apher Sci 34:241-2. 2006 - The combined effect of platelet storage media and intercept pathogen reduction technology on platelet activation/activability and cellular apoptosis/necrosis: Lisbon-RBS experienceHelena Carvalho
Centro de Histocompatibilidade do Sul, , 130, 1169-056 Lisboa, Portugal
Transfus Apher Sci 34:187-92. 2006.... - What's happening: Scotblood 2005. The donor, the product, the patient: how are we shaping up for the 21st century?Hagop Bessos
SNBTS National Science Lab, 21 Ellen s Glen Road, Edinburgh EH17 7QT, UK
Transfus Apher Sci 34:227-32. 2006 - International forum--the "6 Pillars" of best practice in apheresis technologies: introductory remarksGracinda de Sousa
Lisbon Regional Blood Centre (LRBC)--Lisbon, Portugal Avenida do Brasil, 53--Pav. 17 1749 - 005 Lisboa, Portugal
Transfus Apher Sci 34:107-23. 2006 - The Mirasol PRT system for pathogen reduction of platelets and plasma: an overview of current status and future trendsRaymond P Goodrich
Navigant Biotechnologies Inc, Lakewood, CO 80215, USA
Transfus Apher Sci 35:5-17. 2006..The Mirasol PRT process is based on riboflavin photochemistry. This manuscript reviews current progress and future trends... - A national quality assessment scheme for counting residual leucocytes in unfixed leucodepleted products: the effect of standardisation and 48 hour storagePranee Krailadsiri
National Blood Service, London and South East, Colindale, UK
Transfus Apher Sci 26:73-81. 2002..Unfixed RBC and platelet samples can generally be stored for 48 h before WBC counting... - A platelet quality assessment scheme for comparing the performance of quality monitoring laboratories in the UK National Blood ServiceJerard Seghatchian
National Blood Service London and South East Zone, Colindale, UK
Transfus Apher Sci 26:83-90. 2002..At day 5, mean results were often significantly different to previous days. Improved performance target (+/-15%) will allow identification of non-conformers... - Development of a microplate method for the measurement of plasma haemoglobin and its use in monitoring the storage lesion of red cell componentsJerard Seghatchian
National Blood Service, London and SE, Colindale, UK
Transfus Apher Sci 26:91-3. 2002 - Changes in haematological parameters following captive bolt stunning in relation to the increased level of Syntaxin 1-B, a CNS marker in bloodHaluk Anil
Department of Clinical Veterinary Science, University of Bristol, Langford, UK
Transfus Apher Sci 26:135-8. 2002 - Red cell storage lesion assessed by the levels of potassium, haemoglobin and Annexin V in supernatantsJerard Seghatchian
National Blood Service, London and SE, Colindale, UK
Transfus Apher Sci 26:139-43. 2002.... - Quality of platelet concentrates derived by platelet rich plasma, buffy coat and ApheresisEugenia Vasconcelos
Centro Regional de Sangue de Lisboa, Instituto Português do Sangue, Lisboa, Portugal
Transfus Apher Sci 29:13-6. 2003..Some types of methodologies, such as BC derived-PC, appear to have a higher rate of bacterial contamination... - Variables determining blockage of WBC-depleting filters by Hb sickle cell trait donationsMartin J Beard
National Blood Service, Crescent Drive, Brentwood, Essex CM15 8DP, UK
Transfusion 44:422-30. 2004..Sickle cell trait donations can block leukodepletion (LD) filters or fail to LD, but the variables affecting blockage are unclear... - Red cell storage lesion: the potential impact of storage-induced CD47 decline on immunomodulation and the survival of leucofiltered red cellsHagop Bessos
SNBTS National Science Laboratory, 21 Ellen's Glen Rd, Edinburgh EH17 7QT, UK
Transfus Apher Sci 32:227-32. 2005..In the current era of universal leucodepletion, the immunomodulatory effects of some essential markers such as CD47 and phosphatidyl serine become the focus of interest as highlighted in this manuscript... - The influence of methylene blue light treatment and methylene blue removal filter on fibrinogen activity states and fibrin polymerisation indicesFrancois Depasse
LCL, 78, avenue de Verdun, 94200 Ivry sur Seine, France
Transfus Apher Sci 33:63-9. 2005..The true mechanism of such a selective alteration is poorly understood, The effects of MBLT and MB removal filters (MBRF) on Fg concentration, functional activity and fibrin polymerisation were studied... - What's happening? The expanding role of apheresis platelet support in neonatal alloimmune thrombocytopenia: current status and future trendsHagop Bessos
SNBTS National Science Lab, 21 Ellen s Glen Rd, Edinburgh EH17 7QT, Scotland, UK
Transfus Apher Sci 33:191-7. 2005..Trans Apher Sci, in press. This manuscript summarises strategy and progress both in the improvement of apheresis platelet quality and provision in NAIT... - What's happening - Scotblood 2006 advances in immunetolerance, information technology, microarrays and pathogen inactivation in transfusion medicineHagop Bessos
The Scottish National Blood Transfusion Service, R and D Directorate, Edinburgh and Glasgow, Scotland, UK
Transfus Apher Sci 35:173-7. 2006..Dr. Jerard Seghatchian would like to express his sincere thanks to Prof... - Bacterial contamination in blood components and preventative strategies: an overviewEugenia Vasconcelos
Centre Regional de Sangue de Lisboa, Institute Português do Sangue, Avenida do Brasil, 53, Pav 17, 1700 Lisboa, Portugal
Transfus Apher Sci 31:155-63. 2004..These issues have been highlighted in this overview on the current status and future trends... - The state of the art on platelet/red cell concentrates and MBLT-treated FFP: the need for an absolute standard and standardised approachJerard Seghatchian
Transfus Apher Sci 33:53. 2005 - Scotblood 2007: Tackling local and global issues in transfusion medicine - donor recruitment, effective use of blood, stem cell plasticity, and vCJDHagop Bessos
Scottish National Blood Transfusion Service, Edinburgh, UK
Transfus Apher Sci 38:77-83. 2008..The main areas of focus addressed this year were: donor recruitment, stem cell plasticity, the effective use of blood, and vCJD... - The effects of leukodepletion on the generation and removal of microvesicles and prion protein in blood componentsPranee Krailadsiri
National Blood Service (England and North Wales, Scottish National Blood Transfusion Service, Bristol Institute for Transfusion Sciences, University of Edinburgh and University of Cambridge, United Kingdom
Transfusion 46:407-17. 2006..CONCLUSION: These findings suggest no detrimental effects of LD processes in terms of generation of MVs or PrP(c) release... - What's happening: an overview of potential adverse reactions associated with apheresis technologyRessurreição Maurício
Lisbon Regional Blood Centre, Portuguese Blood Institute, Parque da Saúde, Av Brasil, No 53 Pav 17, 1749 005 Lisboa, Portugal
Transfus Apher Sci 33:351-6. 2005....