Jerard Seghatchian

Summary

Country: UK

Publications

  1. ncbi request reprint Validation of different enrichment strategies for analysis of leucocyte sub-populations: development and application of a new approach, based on leucofiltration
    Jerard Seghatchian
    National Blood Service, London and South East, Colindale, UK
    Transfus Apher Sci 26:61-72. 2002
  2. ncbi request reprint The state of the art on platelet/red cell concentrates and MBLT-treated FFP: the need for an absolute standard and standardised approach
    Jerard Seghatchian
    Transfus Apher Sci 33:53. 2005
  3. doi request reprint Massive transfusion: an overview of the main characteristics and potential risks associated with substances used for correction of a coagulopathy
    Jerard Seghatchian
    International Consultancy in Blood Components Technology, 50 Primrose Hill Road, London NW3 3AA, England, UK
    Transfus Apher Sci 47:235-43. 2012
  4. doi request reprint Characteristics of the THERAFLEX UV-Platelets pathogen inactivation system - an update
    Jerard Seghatchian
    Blood Components Technology and Haemostasis Thrombosis Consultancy, 50 Primrose Hill Road, London, UK
    Transfus Apher Sci 46:221-9. 2012
  5. ncbi request reprint What is happening? Are the current acceptance criteria for therapeutic plasma adequate?
    Jerard Seghatchian
    Blood Component Technology and Haemostasis Thrombosis Consultant, 50 Primrose Hill Road, London NW3 3AA, UK
    Transfus Apher Sci 31:67-73. 2004
  6. ncbi request reprint Blood cell apoptosis/necrosis: some clinical and laboratory aspects
    Jerard Seghatchiana
    Blood Component Technology Consultancy London, England
    Ann N Y Acad Sci 1010:540-7. 2003
  7. ncbi request reprint Pathogen-reduction systems for blood components: the current position and future trends
    Jerard Seghatchian
    Blood Components Apheresis Technologies and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA England, UK
    Transfus Apher Sci 35:189-96. 2006
  8. ncbi request reprint Elevated FXIIIA and serine proteases upon filtration of platelet concentrate on negatively charged filters: comparison with other established haemostatic markers of platelet activation and storage lesion
    Jerard Seghatchian
    Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
    Transfus Apher Sci 29:123-5. 2003
  9. ncbi request reprint A novel method for the assessment of pro- and anti-coagulant properties of platelet-derived microvesicles and its usefulness for quality monitoring of platelet haemostatic function
    J Seghatchian
    Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
    Transfus Apher Sci 29:119-21. 2003
  10. ncbi request reprint Universal leucodepletion: an overview of some unresolved issues and the highlights of lessons learned
    Jerard Seghatchian
    Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NWS 3AA, UK
    Transfus Apher Sci 29:105-17. 2003

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Validation of different enrichment strategies for analysis of leucocyte sub-populations: development and application of a new approach, based on leucofiltration
    Jerard Seghatchian
    National Blood Service, London and South East, Colindale, UK
    Transfus Apher Sci 26:61-72. 2002
    ..This one-step procedure has the advantage of concentrating both native and atypical leucocytes seen in blood components. The latter may account for lack of interchangeability of results obtained by various counting methods...
  2. ncbi request reprint The state of the art on platelet/red cell concentrates and MBLT-treated FFP: the need for an absolute standard and standardised approach
    Jerard Seghatchian
    Transfus Apher Sci 33:53. 2005
  3. doi request reprint Massive transfusion: an overview of the main characteristics and potential risks associated with substances used for correction of a coagulopathy
    Jerard Seghatchian
    International Consultancy in Blood Components Technology, 50 Primrose Hill Road, London NW3 3AA, England, UK
    Transfus Apher Sci 47:235-43. 2012
    ....
  4. doi request reprint Characteristics of the THERAFLEX UV-Platelets pathogen inactivation system - an update
    Jerard Seghatchian
    Blood Components Technology and Haemostasis Thrombosis Consultancy, 50 Primrose Hill Road, London, UK
    Transfus Apher Sci 46:221-9. 2012
    ....
  5. ncbi request reprint What is happening? Are the current acceptance criteria for therapeutic plasma adequate?
    Jerard Seghatchian
    Blood Component Technology and Haemostasis Thrombosis Consultant, 50 Primrose Hill Road, London NW3 3AA, UK
    Transfus Apher Sci 31:67-73. 2004
    ..Moreover additional streamlining of FFP production, using selective donor panel, will improve the uniformity of therapeutic plasma and lower the potential risks of transfusion reactions...
  6. ncbi request reprint Blood cell apoptosis/necrosis: some clinical and laboratory aspects
    Jerard Seghatchiana
    Blood Component Technology Consultancy London, England
    Ann N Y Acad Sci 1010:540-7. 2003
    ..It is concluded that apoptotic cells potentially contribute to transfusion reactions in donor/recipient-specific ways...
  7. ncbi request reprint Pathogen-reduction systems for blood components: the current position and future trends
    Jerard Seghatchian
    Blood Components Apheresis Technologies and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA England, UK
    Transfus Apher Sci 35:189-96. 2006
    ..The status of pathogen reduction of whole blood and red cells is also highlighted, though the progress in this area has been virtually stopped after the finding of antibody development in the clinical trial...
  8. ncbi request reprint Elevated FXIIIA and serine proteases upon filtration of platelet concentrate on negatively charged filters: comparison with other established haemostatic markers of platelet activation and storage lesion
    Jerard Seghatchian
    Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
    Transfus Apher Sci 29:123-5. 2003
    ....
  9. ncbi request reprint A novel method for the assessment of pro- and anti-coagulant properties of platelet-derived microvesicles and its usefulness for quality monitoring of platelet haemostatic function
    J Seghatchian
    Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
    Transfus Apher Sci 29:119-21. 2003
    ..While the pro-coagulant activity of the isolated MV increased on day 5 as compared to day 1, the anti-coagulant activity was significantly reduced...
  10. ncbi request reprint Universal leucodepletion: an overview of some unresolved issues and the highlights of lessons learned
    Jerard Seghatchian
    Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NWS 3AA, UK
    Transfus Apher Sci 29:105-17. 2003
    ..This overview briefly highlights some of the unresolved issues related to ULD, based on the experience in the UK. Technical details can be found in the reading list provided at the end...
  11. ncbi request reprint A new platelet storage lesion index based on paired samples, without and with EDTA and cell counting: comparison of three types of leukoreduced preparations
    Jerard Seghatchian
    Blood Components Apheresis Technologies and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, England, UK
    Transfus Apher Sci 35:283-92. 2006
    ..The relationship between this in vitro response to clinical outcome remains to be established...
  12. ncbi request reprint Platelet storage lesion: an update on the impact of various leukoreduction processes on the biological response modifiers
    Jerard Seghatchian
    Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
    Transfus Apher Sci 34:125-30. 2006
    ....
  13. doi request reprint Effect of pathogen inactivation on the storage lesion in red cells and platelet concentrates
    Jerard Seghatchian
    Blood Components Technology Consultancy, 50 Primrose Hill Road, London, UK
    Transfus Apher Sci 45:75-84. 2011
    ..Validated haematological assays should be utilized to test the extent of the blood storage lesion. Post-marketing surveillance involving active haemovigilance is necessary regarding possible adverse outcomes of transfusion...
  14. doi request reprint Updates on pathogen inactivation of plasma using Theraflex methylene blue system
    Jerard Seghatchian
    Blood Components Technology and Haemostasis Thrombosis Consultancy, 50 Primrose Hill Road, London, UK
    Transfus Apher Sci 38:271-80. 2008
    ..Emphasises will be placed on most recent literature and updated information available...
  15. ncbi request reprint Current opinions on safer red cell transfusion practice and the appropriate use of alternative strategies
    Jerard Seghatchian
    Blood Components Apheresis Technology and Haemostasis Thrombosis Consultancy, London, England, UK
    Transfus Apher Sci 37:201-7. 2007
    ..The current opinions on "safer transfusion" through the use of currently available alternatives are highlighted with the goal of promoting the use of transfusion alternatives in everyday clinical practice...
  16. ncbi request reprint An overview of unresolved inherent problems associated with red cell transfusion and potential use of artificial oxygen carriers and ECO-RBC: current status/future trends
    Jerard Seghatchian
    Blood Components Apheresis Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
    Transfus Apher Sci 37:251-9. 2007
    ..Finally, the current progress on universal RBC, known as ECO-cells is highlighted and, in the future perspectives, some of the current efforts in making the red cells transfusion safer and more efficacious are briefly addressed...
  17. ncbi request reprint Commentary on the current opinions on blood components safety/efficacy
    Jerard Seghatchian
    Transfus Apher Sci 34:241-2. 2006
  18. ncbi request reprint The combined effect of platelet storage media and intercept pathogen reduction technology on platelet activation/activability and cellular apoptosis/necrosis: Lisbon-RBS experience
    Helena Carvalho
    Centro de Histocompatibilidade do Sul, Campo dos Mártires da Pátria, 130, 1169 056 Lisboa, Portugal
    Transfus Apher Sci 34:187-92. 2006
    ....
  19. ncbi request reprint What's happening: Scotblood 2005. The donor, the product, the patient: how are we shaping up for the 21st century?
    Hagop Bessos
    SNBTS National Science Lab, 21 Ellen s Glen Road, Edinburgh EH17 7QT, UK
    Transfus Apher Sci 34:227-32. 2006
  20. ncbi request reprint International forum--the "6 Pillars" of best practice in apheresis technologies: introductory remarks
    Gracinda de Sousa
    Lisbon Regional Blood Centre LRBC Lisbon, Portugal Avenida do Brasil, 53 Pav 17 1749 005 Lisboa, Portugal
    Transfus Apher Sci 34:107-23. 2006
  21. ncbi request reprint The Mirasol PRT system for pathogen reduction of platelets and plasma: an overview of current status and future trends
    Raymond P Goodrich
    Navigant Biotechnologies Inc, Lakewood, CO 80215, USA
    Transfus Apher Sci 35:5-17. 2006
    ..The Mirasol PRT process is based on riboflavin photochemistry. This manuscript reviews current progress and future trends...
  22. ncbi request reprint A national quality assessment scheme for counting residual leucocytes in unfixed leucodepleted products: the effect of standardisation and 48 hour storage
    Pranee Krailadsiri
    National Blood Service, London and South East, Colindale, UK
    Transfus Apher Sci 26:73-81. 2002
    ..The between-laboratory variability and effects of 24-48 h storage were investigated using three major counting technologies...
  23. ncbi request reprint A platelet quality assessment scheme for comparing the performance of quality monitoring laboratories in the UK National Blood Service
    Jerard Seghatchian
    National Blood Service London and South East Zone, Colindale, UK
    Transfus Apher Sci 26:83-90. 2002
    ..At day 5, mean results were often significantly different to previous days. Improved performance target (+/-15%) will allow identification of non-conformers...
  24. ncbi request reprint Development of a microplate method for the measurement of plasma haemoglobin and its use in monitoring the storage lesion of red cell components
    Jerard Seghatchian
    National Blood Service, London and SE, Colindale, UK
    Transfus Apher Sci 26:91-3. 2002
  25. ncbi request reprint Changes in haematological parameters following captive bolt stunning in relation to the increased level of Syntaxin 1-B, a CNS marker in blood
    Haluk Anil
    Department of Clinical Veterinary Science, University of Bristol, Langford, UK
    Transfus Apher Sci 26:135-8. 2002
  26. ncbi request reprint Red cell storage lesion assessed by the levels of potassium, haemoglobin and Annexin V in supernatants
    Jerard Seghatchian
    National Blood Service, London and SE, Colindale, UK
    Transfus Apher Sci 26:139-43. 2002
    ....
  27. ncbi request reprint Quality of platelet concentrates derived by platelet rich plasma, buffy coat and Apheresis
    Eugenia Vasconcelos
    Centro Regional de Sangue de Lisboa, Instituto Português do Sangue, Lisboa, Portugal
    Transfus Apher Sci 29:13-6. 2003
    ..Some types of methodologies, such as BC derived-PC, appear to have a higher rate of bacterial contamination...
  28. ncbi request reprint Variables determining blockage of WBC-depleting filters by Hb sickle cell trait donations
    Martin J Beard
    National Blood Service, Crescent Drive, Brentwood, Essex CM15 8DP, UK
    Transfusion 44:422-30. 2004
    ..Sickle cell trait donations can block leukodepletion (LD) filters or fail to LD, but the variables affecting blockage are unclear...
  29. ncbi request reprint Red cell storage lesion: the potential impact of storage-induced CD47 decline on immunomodulation and the survival of leucofiltered red cells
    Hagop Bessos
    SNBTS National Science Laboratory, 21 Ellen s Glen Rd, Edinburgh EH17 7QT, UK
    Transfus Apher Sci 32:227-32. 2005
    ..In the current era of universal leucodepletion, the immunomodulatory effects of some essential markers such as CD47 and phosphatidyl serine become the focus of interest as highlighted in this manuscript...
  30. ncbi request reprint The influence of methylene blue light treatment and methylene blue removal filter on fibrinogen activity states and fibrin polymerisation indices
    Francois Depasse
    LCL, 78, avenue de Verdun, 94200 Ivry sur Seine, France
    Transfus Apher Sci 33:63-9. 2005
    ..The true mechanism of such a selective alteration is poorly understood, The effects of MBLT and MB removal filters (MBRF) on Fg concentration, functional activity and fibrin polymerisation were studied...
  31. ncbi request reprint What's happening? The expanding role of apheresis platelet support in neonatal alloimmune thrombocytopenia: current status and future trends
    Hagop Bessos
    SNBTS National Science Lab, 21 Ellen s Glen Rd, Edinburgh EH17 7QT, Scotland, UK
    Transfus Apher Sci 33:191-7. 2005
    ..Trans Apher Sci, in press. This manuscript summarises strategy and progress both in the improvement of apheresis platelet quality and provision in NAIT...
  32. ncbi request reprint What's happening - Scotblood 2006 advances in immunetolerance, information technology, microarrays and pathogen inactivation in transfusion medicine
    Hagop Bessos
    The Scottish National Blood Transfusion Service, R and D Directorate, Edinburgh and Glasgow, Scotland, UK
    Transfus Apher Sci 35:173-7. 2006
    ..Dr. Jerard Seghatchian would like to express his sincere thanks to Prof...
  33. ncbi request reprint Bacterial contamination in blood components and preventative strategies: an overview
    Eugenia Vasconcelos
    Centre Regional de Sangue de Lisboa, Institute Português do Sangue, Avenida do Brasil, 53, Pav 17, 1700 Lisboa, Portugal
    Transfus Apher Sci 31:155-63. 2004
    ..These issues have been highlighted in this overview on the current status and future trends...
  34. doi request reprint Scotblood 2007: Tackling local and global issues in transfusion medicine - donor recruitment, effective use of blood, stem cell plasticity, and vCJD
    Hagop Bessos
    Scottish National Blood Transfusion Service, Edinburgh, UK
    Transfus Apher Sci 38:77-83. 2008
    ..The main areas of focus addressed this year were: donor recruitment, stem cell plasticity, the effective use of blood, and vCJD...
  35. ncbi request reprint The effects of leukodepletion on the generation and removal of microvesicles and prion protein in blood components
    Pranee Krailadsiri
    National Blood Service England and North Wales, Scottish National Blood Transfusion Service, Bristol Institute for Transfusion Sciences, University of Edinburgh and University of Cambridge, United Kingdom
    Transfusion 46:407-17. 2006
    ..If LD causes microvesiculation of blood cells, however, potentially infectious membrane-associated prion could reach the final products...
  36. ncbi request reprint What's happening: an overview of potential adverse reactions associated with apheresis technology
    Ressurreição Maurício
    Lisbon Regional Blood Centre, Portuguese Blood Institute, Parque da Saúde, Av Brasil, No 53 Pav 17, 1749 005 Lisboa, Portugal
    Transfus Apher Sci 33:351-6. 2005
    ....