Laurence Loewe

Summary

Affiliation: School of Biological Sciences
Country: UK

Publications

  1. ncbi request reprint Global computing for bioinformatics
    Laurence Loewe
    Microbial Ecology Group, Department of Biosciences, Technische Universitat Munchen, Weihenstephaner Berg 3, 85354 Freising, Germany
    Brief Bioinform 3:377-88. 2002
  2. pmc On the potential for extinction by Muller's ratchet in Caenorhabditis elegans
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
    BMC Evol Biol 8:125. 2008
  3. pmc Quantifying the threat of extinction from Muller's ratchet in the diploid Amazon molly (Poecilia formosa)
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, Edinburgh EH9 3JT, UK
    BMC Evol Biol 8:88. 2008
  4. pmc Background selection in single genes may explain patterns of codon bias
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 175:1381-93. 2007
  5. ncbi request reprint Quantifying the genomic decay paradox due to Muller's ratchet in human mitochondrial DNA
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    Genet Res 87:133-59. 2006
  6. pmc Estimating selection on nonsynonymous mutations
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 172:1079-92. 2006
  7. ncbi request reprint High deleterious genomic mutation rate in stationary phase of Escherichia coli
    Laurence Loewe
    Microbial Ecology Group, Department of Biosciences, Technische Universitat Munchen, Weihenstephaner Berg 3, 85354 Freising, Germany
    Science 302:1558-60. 2003
  8. pmc Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria
    Katarzyna Kinga Modrzynska
    Institute for Immunology and Infection Research, University of Edinburgh, UK
    BMC Genomics 13:106. 2012
  9. pmc Inferring the distribution of mutational effects on fitness in Drosophila
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Biol Lett 2:426-30. 2006
  10. pmc Estimating the parameters of selection on nonsynonymous mutations in Drosophila pseudoobscura and D. miranda
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 185:1381-96. 2010

Detail Information

Publications15

  1. ncbi request reprint Global computing for bioinformatics
    Laurence Loewe
    Microbial Ecology Group, Department of Biosciences, Technische Universitat Munchen, Weihenstephaner Berg 3, 85354 Freising, Germany
    Brief Bioinform 3:377-88. 2002
    ..Then, either significant amounts of computing power can be recruited from the general public, or--if employed in an enterprise-wide Intranet for security reasons--idle desktop PCs can substitute for an expensive dedicated cluster...
  2. pmc On the potential for extinction by Muller's ratchet in Caenorhabditis elegans
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
    BMC Evol Biol 8:125. 2008
    ..The potential for such a process to occur would inform our understanding of the time since the origin of self-fertilization in C. elegans history...
  3. pmc Quantifying the threat of extinction from Muller's ratchet in the diploid Amazon molly (Poecilia formosa)
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, Edinburgh EH9 3JT, UK
    BMC Evol Biol 8:88. 2008
    ..However, no detailed quantification of the extent of this threat is available...
  4. pmc Background selection in single genes may explain patterns of codon bias
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 175:1381-93. 2007
    ..The model overpredicts the effects of background selection with large groups of nonrecombining genes, because it ignores Hill-Robertson interference among the mutations involved...
  5. ncbi request reprint Quantifying the genomic decay paradox due to Muller's ratchet in human mitochondrial DNA
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    Genet Res 87:133-59. 2006
    ..Future work will have to explore which of these actually solves the paradox. Nonetheless, the results presented here provide yet another reason to minimize anthropogenic increase of mutation rates...
  6. pmc Estimating selection on nonsynonymous mutations
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 172:1079-92. 2006
    ..We also describe a simple approximate method for estimating the harmonic mean selection coefficient from diversity data on a single species...
  7. ncbi request reprint High deleterious genomic mutation rate in stationary phase of Escherichia coli
    Laurence Loewe
    Microbial Ecology Group, Department of Biosciences, Technische Universitat Munchen, Weihenstephaner Berg 3, 85354 Freising, Germany
    Science 302:1558-60. 2003
    ..These findings may affect understanding of bacterial evolution and the emergence of bacterial pathogenicity...
  8. pmc Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria
    Katarzyna Kinga Modrzynska
    Institute for Immunology and Infection Research, University of Edinburgh, UK
    BMC Genomics 13:106. 2012
    ..chabaudi in which high level resistance to chloroquine has been progressively selected under laboratory conditions...
  9. pmc Inferring the distribution of mutational effects on fitness in Drosophila
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Biol Lett 2:426-30. 2006
    ..Our results suggest that the majority of non-synonymous mutations in Drosophila are under effective purifying selection...
  10. pmc Estimating the parameters of selection on nonsynonymous mutations in Drosophila pseudoobscura and D. miranda
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 185:1381-96. 2010
    ..Overall, the results show that both purifying selection and positive selection on nonsynonymous mutations are pervasive...
  11. pmc A framework for evolutionary systems biology
    Laurence Loewe
    Centre for Systems Biology at Edinburgh, The University of Edinburgh, Edinburgh, Scotland, UK
    BMC Syst Biol 3:27. 2009
    ..Current systems biology has accumulated much data on mutations with large effects and can predict the properties of knockout mutants in some systems. However experimental methods are too insensitive to observe small effects...
  12. pmc The population genetics of mutations: good, bad and indifferent
    Laurence Loewe
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Philos Trans R Soc Lond B Biol Sci 365:1153-67. 2010
    ..important, why do we age, which genetic processes can generate new species or drive endangered species to extinction, and how should policy on levels of potentially harmful mutagens introduced into the environment by humans be determined?..
  13. pmc Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites
    Paul Hunt
    Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    BMC Genomics 11:499. 2010
    ..Such genetic markers will further the investigation of resistance and its control in natural infections of the human malaria, P. falciparum...
  14. pmc A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction
    Steven Watterson
    Division of Pathway Medicine, University of Edinburgh Medical School, Chancellor s Building, 49 Little France Crescent, Edinburgh, Scotland, United Kingdom
    Biochimie 95:613-21. 2013
    ....
  15. pmc Computational models in systems biology
    Laurence Loewe
    Centre for Systems Biology at Edinburgh, School of Biological Sciences, The University of Edinburgh, Kings Buildings, Mayfield Road, Edinburgh EH9 3JU, UK
    Genome Biol 9:328. 2008
    ..A report of the 6th International Conference on Computational Methods in Systems Biology, Rostock, Germany, 12-15 October 2008...